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PedAM

Pediatric Disease Annotations & Medicines




Disease hyperglycemia
Symptom C1393529|vascular complications
Sentences 32
PubMedID- 24347828 Diabetes is a metabolic disorder characterized by hyperglycemia and often leads to numerous microvascular complications, including retinopathy.
PubMedID- 20465785 There are evidences that, the formation of ros is a direct consequence of hyperglycemia and is associated with the vascular complications seen in diabetic patients .
PubMedID- 21217063 Perivascular sympathetic nerves are important determinants of vascular function that are likely to contribute to vascular complications associated with hyperglycemia and diabetes.
PubMedID- 26582441 Diabetes is a complex metabolic disorder characterized by chronic hyperglycemia and associated with macrovascular and microvascular complications 1.
PubMedID- 24439344 There is a growing consensus that optimal preventive strategies to control type 2 diabetes and cardiovascular disease (cvd) should combine individual and population approaches—the former to identify and intervene in those at high risk of future disease, and the latter to instigate positive health changes in a large percentage of the population.1–4 the international diabetes federation (idf) endorsed this preventive approach for controlling modifiable risk factors and recommends targeting both people at high risk of diabetes and the entire population.2 however, a paucity of data support the beneficial effects of a combined individual and population approach for reducing population cardiovascular risk, with most data arising from theoretical and modeling studies.2,3 this is largely due to a lack of longitudinal population risk distribution data and an overwhelming focus on individual high-risk approaches to prevention.5,6 because there is a positive continuous relationship between glycemia and cvd risk that extends below the diabetic threshold,7–9 the combined prevention approach holds great potential for reducing the macro-vascular complications associated with hyperglycemia in particular.
PubMedID- 24432042 It is well established that hyperglycemia is associated with microvascular and macrovascular complications in patients with t2dm.
PubMedID- 22027070 Chronic hyperglycemia leads to microvascular and macrovascular complications including retinopathy, nephropathy, neuropathy and cardiomyopathy.
PubMedID- 26089885 Decreasing the risk of macro- and microvascular complications due to hyperglycemia is the cornerstone of t2dm therapy 5.
PubMedID- 24471057 Type 2 diabetes is a chronic disease characterized by simultaneous insulin deficiency and insulin resistance events, with the resultant hyperglycemia leading to microvascular and macrovascular complications.
PubMedID- 24843699 Epidemiological data show that the degree and duration of hyperglycemia is associated with the microvascular complications of diabetes1.
PubMedID- 20530748 Chronic glycemic exposure (the degree and duration of hyperglycemia) has been associated with macrovascular complications and increased cardiovascular risk in adult diabetic patients (2,8,9).
PubMedID- 22375142 Cardiovascular complications associated with hyperglycemia include cardiomyopathy and vasculopathy (van gaal et al., 2006).
PubMedID- 21537407 In the past, many studies on the mechanisms of diabetic complications have focused on the mechanisms by which hyperglycemia might lead to the chronic vascular complications via the formation of toxic metabolites such as oxidants and advanced glycosylated products.
PubMedID- 23322142 The role of hyperglycemia in macrovascular complications is not well defined.
PubMedID- 22209677 Chronic hyperglycemia of diabetes leads to microvascular complications that severely impact quality of life.
PubMedID- 25817504 Diabetes mellitus is a chronic metabolic disease characterized by sustained hyperglycemia leading to macro and microvascular complications.
PubMedID- 26519027 The incidence of cardiovascular complications associated with hyperglycemia is a growing, global health problem.
PubMedID- 22338105 These studies suggest that reduced cd55 and cd59 may arise as a consequence of hyperglycemia and lead to complement-induced vascular complications.
PubMedID- 26300908 These facts have guided benefits of early intensive glycemic control (hba1c below 6%) compared to conventional approach (hba1c between 7 and 7.9%) in t1d patients as demonstrated in diabetes control and complications trial (dcct) and follow-up epidemiology of diabetes interventions and complications (edic) clinical trials which showed significant reduction in the risk of developing both micro and macrovascular complications associated with chronic hyperglycemia (diabetes control and complications trial, 2005).
PubMedID- 23990364 Since retinopathy and nephropathy are more specific to diabetes than cvd, the stronger correlation of chronic hyperglycemia with the microvascular complications is not surprising.
PubMedID- 24223310 hyperglycemia is major cause of vascular complications and delayed wound healing in diabetes mellitus.
PubMedID- 21298405 The use of exogenous insulin replaces the function of absent islets in type 1 diabetes mellitus but does not provide the physiological blood glucose control necessary to stave off the neurovascular complications due to hyperglycemia .
PubMedID- 24381880 4 genetic background and environment factors are likely to be important in determining susceptibility to associated micro and macro-vascular complications, but exposure of tissues to chronic hyperglycemia is the main initiating factor.
PubMedID- 20448799 Several landmark clinical trials have convincingly demonstrated that hyperglycemia is associated with the microvascular complications of diabetes.1–3 these trials, along with epidemiological evidence, have provided the basis for treatment targets and algorithms recommended by the american diabetes association (ada), the american association of clinical endocrinologists (aace), and the european association for the study of diabetes (easd).4–6 adequacy of glycemic control is almost universally assessed by glycated hemoglobin (hba1c) – a measure of hemoglobin glycation over the erythrocyte life span that is proportional to the mean plasma glucose level over the preceding 2 to 3 months.
PubMedID- 25802730 Postprandial hyperglycemia is also associated with microvascular complications of diabetes independent of hba1c or fbg29.
PubMedID- 23697612 The micro- and macrovascular complications, associated with chronic hyperglycemia, represent a major public health problem.
PubMedID- 21806772 Type 2 diabetes mellitus (t2dm) is characterized by progressively worsening hyperglycemia that leads to microvascular and macrovascular complications.
PubMedID- 23423872 The degree and duration of hyperglycemia has been associated with macrovascular complications and increased cardiovascular risk in adults and preadolescent children with t1dm 5, 33-36. in the present study no association between cimt and hba1c at the time of visit (a marker of glycemic control) was observed in diabetic subjects.
PubMedID- 20463414 Diabetes mellitus is a complex and increasingly common metabolic disease that is characterized by hyperglycemia and associated with microvascular and macrovascular complications.
PubMedID- 23844086 Recently, in the diabetes epidemiology: collaborative analysis of diagnostic criteria in europe (decode) study, it was demonstrated that fpg concentrations alone could not identify individuals at increased risk of cardiovascular complications associated with hyperglycemia, and the oral glucose tolerance test (ogtt) could provide additional prognostic information .
PubMedID- 22828168 hyperglycemia could lead to vascular complications via several mechanisms.
PubMedID- 24691694 In some patients with diabetes mellitus (dm) chronic hyperglycemia leads to microvascular complications in retina, kidney and nerves.

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