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PedAM

Pediatric Disease Annotations & Medicines




Disease hyperglycemia
Symptom C0856169|endothelial dysfunction
Sentences 11
PubMedID- 21711570 Acute hyperglycemia induces endothelial dysfunction by generating oxidative stress resulting in impaired vasodilatation .
PubMedID- 21799868 endothelial dysfunction due to prolonged hyperglycemia is commonly seen in diabetic patients and results in micro- as well as macro-vascular and neurologic complications , 3.
PubMedID- 21414227 Post-prandial hyperglycemia is associated with endothelial dysfunction and an increase in intima-media thickness as well as a higher prevalence of atherosclerotic plaques.
PubMedID- 20042654 Acute hyperglycemia-induced endothelial dysfunction in retinal arterioles in cats.
PubMedID- 23653839 Chronic hyperglycemia provokes the endothelial dysfunction, causes the thickening of capillary basement membranes, enhances vasopermeability, and increases ros (reactive oxygen species) production (69).
PubMedID- 24843558 In addition, hyperglycemia is associated with inflammation, endothelial dysfunction23, and oxidative stress24.
PubMedID- 20448799 To add another level of complexity, ceriello et al20 showed that not only was hyperglycemia associated with endothelial dysfunction in patients with and without type 2 diabetes, but also that oscillating glucose levels in 6-hour increments led to even greater dysfunction over time.
PubMedID- 26106624 In addition, there are several reports highlighting that histone modifications represent an important mechanism triggered by hyperglycemia that leads to endothelial dysfunction (table 2).
PubMedID- 22675380 Traditional risk factors such as hypertension, dyslipidemia, and hyperglycemia are associated with endothelial dysfunction .
PubMedID- 22432110 For example, previous research demonstrates associations of hyperglycemia with endothelial dysfunction and vascular stiffness, both of which are linked to increased hypertension and cardiovascular disease risk (10–12).
PubMedID- 23497378 However, even if regulation of ho-1 expression in dm is still uncertain, doubtlessly hyperglycemia leads to endothelial dysfunction, impaired cell replication and increased apoptosis and these effects are reversed by overexpression of anti-oxidative enzymes, such as ho-1 .

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