PedAM
Pediatric Disease Annotations & Medicines
| Disease | hiv infections |
| Symptom | C0392674|exhaustion |
| Sentences | 4 |
| PubMedID- 24436634 | 1).3 additionally, cd4+ t cell development is controlled by a constellation of transcription factors that activate and repress batteries of genes that influence proliferation, differentiation and lineage commitment.1,2,4 human immunodeficiency virus (hiv) infection decreases the overall number of cd4+ t cells and results in a general imbalance of all t cell populations, facilitating the immune dysregulation associated with autoimmune deficiency syndrome (aids).5–7 in addition to directly impacting the number of cd4+ t cells, hiv infection leads to indirect immune exhaustion by activating neighboring or bystander cells. |
| PubMedID- 21188556 | Persistent antigenic stimulation during hiv infection may also lead to immune exhaustion, a phenomenon in which effector t cells become dysfunctional and lose effector functions and proliferative capacity. |
| PubMedID- 25023621 | B-cell exhaustion in hiv infection: the role of immune activation. |
| PubMedID- 25023624 | Editorial overview: cell dysfunction and exhaustion in hiv infection. |
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