PedAM
Pediatric Disease Annotations & Medicines
| Disease | glucose intolerance |
| Symptom | C0028754|obesity |
| Sentences | 23 |
| PubMedID- 21515850 | (37) showed il-1ri−/− mice maintained on a chow diet develop mature-onset obesity coincident with moderate glucose intolerance and hyperinsulinemia. |
| PubMedID- 23928458 | For instance, short sleep duration (<7 hours of sleep per night) and poor sleep quality are associated with cardiovascular morbidity and metabolic disorders such as glucose intolerance, which may lead to obesity, diabetes, heart disease, and hypertension (1). |
| PubMedID- 21660293 | These cardiovascular risk factors interact with each other and accelerate the progression of atherosclerosis and arterial thrombosis.1–3 although mets is considered to represent heterogeneous traits, insulin resistance and glucose intolerance associated with obesity are considered to be central to the pathophysiology. |
| PubMedID- 25348739 | Carnosic acid attenuates obesity-induced glucose intolerance and hepatic fat accumulation by modulating genes of lipid metabolism in c57bl/6j-ob/ob mice. |
| PubMedID- 26576929 | Diet-induced obesity is associated with dyslipidemia, glucose intolerance and insulin resistance in rats . |
| PubMedID- 21037584 | A selective 5-ht2cr agonist, metachlorophenylpiperazine (mcpp), ameliorates insulin resistance and glucose intolerance in mice with diet-induced obesity (dio)2. |
| PubMedID- 26316333 | Because obesity is associated with glucose intolerance and insulin resistance1920, we examined whether gadd34-deficient mice developed age-related glucose and insulin disorders. |
| PubMedID- 21475632 | obesity has been associated with glucose intolerance, insulin resistance, dyslipidemia and cardiovascular disease.1 the liver has specifically been implicated as a primary site of insulin resistance observed with visceral obesity. |
| PubMedID- 23557705 | Thus, balb.2bc mice displayed an increased propensity for development of obesity associated with glucose intolerance. |
| PubMedID- 24386638 | Other studies showed that mice lacking dio2 were demonstrated to have deficits in the hippocampus-dependent learning , obesity with glucose intolerance that is a well-established indicator of depressive disorder. |
| PubMedID- 24205160 | Heme binding to rev-erb-α reduces gluconeogenesis in hepatocytes in vitro, and rev-erb agonists ameliorate glucose intolerance in mice with diet-induced obesity 8. |
| PubMedID- 21331068 | In sum, the caf provided a robust model of human metabolic syndrome compared to traditional lard-based hfd, creating a phenotype of exaggerated obesity with glucose intolerance and inflammation. |
| PubMedID- 21335378 | Disruption of thyroid hormone activation in type 2 deiodinase knockout mice causes obesity with glucose intolerance and liver steatosis only at thermoneutrality. |
| PubMedID- 24386218 | The kkay mouse was used because it is a polygenic model of obesity and t2d with severe glucose intolerance, insulin resistance, islet hypertrophy and hyperplasia, elevated hba1c, microalbuminuria, and developed diabetic glomerular nephritis and arteriosclerosis in males, which are more similar to the pathologic phenotypes of t2d in humans –. |
| PubMedID- 26378573 | H rats showed signs of metabolic syndrome leading to visceral obesity with hypertension, glucose intolerance, cardiovascular remodelling and nonalcoholic fatty liver disease. |
| PubMedID- 25972766 | Macrophage dysregulation would, in turn, predispose to diet-induced obesity, reduced production of adiponectin, glucose intolerance and insulin resistance 8. |
| PubMedID- 26329304 | Recently, kornfeld and colleagues found that obesity-induced overexpression of mir-802 causes glucose intolerance, impairs insulin signaling, and promotes hepatic gluconeogenesis in the liver through direct silencing of hnf1b, and showed an important role for hnf1b in the control of hepatic insulin sensitivity and glucose metabolism in vivo . |
| PubMedID- 25941467 | Chronic endogenous gc exposure determines several clinical complications, including metabolic complications such as visceral obesity, insulin resistance with glucose intolerance and diabetes mellitus, and dyslipidemia, which configure a metabolic syndrome, cardiovascular complications such as systemic arterial hypertension, atherosclerosis, thromboembolism, bone complications such as osteoporosis and osteoarthritis, infective complications, ranging from an increase susceptibility to infections up to a fatal sepsis, as well as neuropsychiatric disorders (pivonello et al., 2005, 2010; tauchmanovà et al., 2006; de leo et al., 2010; pereira et al., 2010; van der pas et al., 2013). |
| PubMedID- 25979684 | Conclusion: our study showed a positive association of the overweight and obesity with glucose intolerance, dyslipidemia, type 2 diabetes, hypertension, osteoarthritis, and kidney failure. |
| PubMedID- 21574956 | Aging affects energy homeostasis and fuel metabolism in a form of either an increased body mass and glucose intolerance that may lead to obesity and type 2 diabetes or loss of appetite that also may seriously compromise health status. |
| PubMedID- 24236159 | Our results from a polygenic mouse model demonstrate that genetically pre-determined and life-long obesity is no precondition of glucose intolerance later in life. |
| PubMedID- 24673860 | The classic link of glucose intolerance with increasing obesity was confirmed. |
| PubMedID- 24454742 | Given that sdg-p mice show evident glucose intolerance with mild obesity after hfd feeding as compared with sdg-r mice, these mice may serve as appropriate models for investigating hereditary predisposition to diet-induced diabetes. |
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