| Disease | gingival disease |
| Symptom | C0238790|bone destruction |
| Sentences | 2 |
| PubMedID- 22792106 | Rankl and opg play critical roles in the development of periodontal disease, with periodontal bone destruction resulting from the upregulation of rankl with downregulation of opg . |
| PubMedID- 26140059 | Both are chronic diseases that may influence environmental, immunologic, and genetic factors leading to tissue and bone destruction during periods of outbreaks of periodontal disease . |
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