PedAM
Pediatric Disease Annotations & Medicines
| Disease | ewing sarcoma |
| Symptom | C1608408|malignant transformation |
| Sentences | 1 |
| PubMedID- 22114504 | However, mtm has shown promise with respect to treating neurological diseases, glioblastomas, and other tumors in addition to showing the ability to inhibit the multidrug resistance gene, mdr1, in which smaller, less toxic doses are required.32–37 recently, mtm was identified as the lead compound against the friend leukemia virus integration 1 (ews-fli1) transcription factor.38 ews-fli1 is believed to be responsible for malignant transformation and progression of ewing sarcoma family tumors and was widely regarded as undruggable because it is a transcription factor.38 a high-throughput screening of over 50,000 compounds identified mtm as the top candidate from the screen and greatly reduced and inhibited tumor volume in ewing sarcoma family tumors in mouse xenograft models, and it is planned to reinstitute clinical trials for this application of mtm.38 additionally, a combinational approach of mtm with betulinic acid to treat pancreatic cancer showed the ability to synergistically treat the cancer with a nontoxic dose of the drugs to produce less discernible side effects.35 as new treatments and uses for mtm continue to be uncovered, the development and optimization of a compatible drug-delivery system will be necessary. |
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