PedAM
Pediatric Disease Annotations & Medicines
| Disease | epilepsy |
| Symptom | C0235169|excitability |
| Sentences | 13 |
| PubMedID- 23662118 | Especially under physiological conditions, the persistent sodium currents serve to amplify or spatially integrate synaptic potentials, allow excitable cells to generate subthreshold oscillations, reduce the threshold for repetitive action potential firing, and therefore increase excitability of neurons associated with epilepsy . |
| PubMedID- 21889592 | Network excitability in a model of chronic temporal lobe epilepsy critically depends on sk channel-mediated ahp currents. |
| PubMedID- 23146067 | However, a growing body of evidence suggests that newer ('second generation') antidepressants, such as selective serotonin reuptake inhibitors or serotonin-noradrenaline reuptake inhibitors, have markedly less effect on excitability and may lead to improvements in epilepsy severity. |
| PubMedID- 25436086 | As it is widely known, epilepsy is associated with increase of excitability in brain epilepsy related structures such as hippocampus and glutamate as the main excitatory neurotransmitter plays a pivotal role in this regard (bradford, 1995; delorenzo, sun, & deshpande, 2005; rowley, martin, & marsden, 1995). |
| PubMedID- 21779718 | epilepsy results from hyperexcitability, perhaps through excessive ltp at glutamatergic synapses, or through other mechanisms such as increased intrinsic excitability or reduced inhibition. |
| PubMedID- 23196211 | epilepsy was associated with increased behavioral excitability and impaired learning and memory in a water maze, most likely as a result of hippocampal pathology, which was characterized by extensive neuronal loss in ca3 and dentate hilus and dispersion of granule cells in the ipsilateral hippocampus. |
| PubMedID- 24649458 | Single-pulse and paired-pulse tms can detect abnormalities of motor excitability in patients with epilepsy and is useful in delineating specific aed effects in healthy subjects as well as in epilepsy patients. |
| PubMedID- 25769374 | This study aimed to address the spatial profile of cortical excitability changes in patients with temporal lobe epilepsy (tle) by using tms and magnetoencephalography (meg). |
| PubMedID- 24553462 | Recent findings: a number of tms-electromyography (emg) and tms-electroencephalography (eeg) studies have identified distinct changes of cortical excitability associated with specific epilepsy syndromes and in asymptomatic siblings of patients with epilepsy. |
| PubMedID- 24174287 | Alterations in cortical excitability were shown in patients with epilepsy as well as hyper- or hypoparathyroidism. |
| PubMedID- 20186859 | We used transcranial magnetic stimulation to determine the effect of aeds on cortical excitability in patients with epilepsy and correlated this with a successful response to treatment. |
| PubMedID- 21824791 | Transcranial magnetic stimulation has been successfully used to evaluate cortical excitability in epilepsy patients. |
| PubMedID- 22787647 | Perturbations of dendritic excitability in epilepsy |
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