PedAM
Pediatric Disease Annotations & Medicines
| Disease | diphtheria |
| Symptom | C0008109|chimera |
| Sentences | 1 |
| PubMedID- 21264238 | Similarly to the concept that was applied to diphtheria toxin chimera described earlier, in the cleavable toxin (“pe-rta-cleavage site-stalk peptide”) the ns3 protease minimal cleavage sequence (p6-p4′) from genotype 1b/1a ns5a/b junction was inserted between rta and the ribosome stalk peptide, while in the control uncleavable toxin (“pe-rta- mutated cleavage site-stalk peptide”) a mutated cleavage site was positioned at this location. |
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