PedAM
Pediatric Disease Annotations & Medicines
| Disease | dermatitis |
| Symptom | C0206141|hypereosinophilic syndrome |
| Sentences | 1 |
| PubMedID- 20811394 | Here, we demonstrate that loss of function of shank-associated rh domain interacting protein (sharpin) leads to activation of nf-kappab signaling in skin, resulting in the development of an idiopathic hypereosinophilic syndrome (ihes) with eosinophilic dermatitis in c57bl/kalawrij-sharpin(cpdm)/rijsunj mice, and clonal expansion of b-1 b cells and cd3(+)cd4(-)cd8(-) t cells. |
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