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PedAM

Pediatric Disease Annotations & Medicines




Disease colorectal cancer
Symptom C1333990|lynch syndrome
Sentences 51
PubMedID- 25534380 Short-term risk of colorectal cancer in individuals with lynch syndrome: a meta-analysis.
PubMedID- 22480969 Background: recommended strategies to screen for lynch syndrome in colorectal cancer are not applied in daily practice and most of lynch cases remain undiagnosed.
PubMedID- 24759670 Some colorectal cancers with lynch syndrome-like pedigrees remain mutation-negative in a dna mismatch repair (mmr) gene analysis .
PubMedID- 26249337 Lower prevalence of lynch syndrome in colorectal cancer patients in a japanese hospital-based population.
PubMedID- 25213040 Aim: colonic surveillance reduces the lifetime risk of colorectal cancer in patients with lynch syndrome (hereditary nonpolyposis colorectal cancer) from 60 to 80% to 10% and confers a 7-year survival advantage.
PubMedID- 25910169 The objective of this project was to estimate the cost-utility of strategies to identify lynch syndrome in individuals with early-onset colorectal cancer in the nhs.
PubMedID- 23125224 Cell cycle-related genes as modifiers of age of onset of colorectal cancer in lynch syndrome: a large-scale study in non-hispanic white patients.
PubMedID- 20206180 One to 2-year surveillance intervals reduce risk of colorectal cancer in families with lynch syndrome.
PubMedID- 23657759 lynch syndrome (ls) is one of the inherited colorectal cancer (crc) syndromes and is due to germline mutations in one of the mismatch repair (mmr) genes.
PubMedID- 25081898 Background: recognising colorectal cancer (crc) patients with lynch syndrome (ls) can increase life expectancy of these patients and their close relatives.
PubMedID- 26064726 To the best of our knowledge, no previous study has documented colorectal cancer resulting from lynch syndrome during pregnancy.
PubMedID- 23484096 Affected individuals have approximately 60–80% lifetime risk of developing colorectal cancer and women with lynch syndrome have 54% risk of developing endometrial cancer 2.
PubMedID- 21768580 Strategies to identify the lynch syndrome among patients with colorectal cancer: a cost-effectiveness analysis.
PubMedID- 23508345 The surgical management of the lynch syndrome patient with colorectal cancer needs to be individualized.
PubMedID- PMC2876284 This study analyzes precursor polyp burdens occurring within patients with msi-h colorectal cancers associated with lynch syndrome (ls) or those with a methylator pathway cancer phenotype.
PubMedID- PMC3288925 Msi is present in 80-85% of colorectal cancers associated with lynch syndrome.
PubMedID- 26284327 The lifetime risk of colorectal cancer for males with lynch syndrome generally is significantly higher and the age of first manifestation significantly earlier compared to females.
PubMedID- 23733757 Purpose: molecular screening techniques are available to identify hereditary lynch syndrome in people with newly diagnosed colorectal cancer (crc).
PubMedID- 20495877 Magnetic resonance colonography for colorectal cancer screening in patients with lynch syndrome gene mutation.
PubMedID- 25816162 However, a higher frequency of mmr-dcf was observed in lynch syndrome patients with distal colorectal cancer localisation.
PubMedID- 21159521 Perspectives for tailored chemoprevention and treatment of colorectal cancer in lynch syndrome.
PubMedID- 22237445 Implementing screening for lynch syndrome among patients with newly diagnosed colorectal cancer: summary of a public health/clinical collaborative meeting.
PubMedID- 23896635 Although variable, the lifetime risk of developing colorectal cancer (crc) in patients with lynch syndrome is approximately 80 %, with male carriers having a higher cumulative risk than female carriers 2.
PubMedID- 25731324 Effect of chemotherapy on the inoperable or recurrent colorectal cancers in patients with lynch syndrome.
PubMedID- 23245329 Gain of material on chromosome 20q and loss on chromosome 18 significantly discriminated colorectal cancers associated with fcctx from lynch syndrome, which likely signifies different preferred tumourigenic pathways.
PubMedID- 22359099 Up to 5% of all colorectal cancer cases are attributed to the lynch syndrome .
PubMedID- 21743847 In addition, about half of the first-degree biological relatives of those colorectal cancer patients with lynch syndrome, about 8,000 individuals, also have lynch syndrome mutation and are at increased risk of developing a lynch syndrome-associated cancer.
PubMedID- 22056658 Interpretation of genetic testing for lynch syndrome in patients with putative familial colorectal cancer.
PubMedID- 23392144 Background: lynch syndrome contributes to 5% of all colorectal cancers.
PubMedID- 23598716 Purpose: routine screening for evidence of dna mismatch repair abnormalities can identify colorectal cancer patients with lynch syndrome, but impact in usual care settings requires study.
PubMedID- 21233718 Purpose: lynch syndrome accounts for 2-4% of all colorectal cancer, and is mainly caused by germline mutations in the dna mismatch repair genes.
PubMedID- 23470269 Background: colorectal cancer (crc) associated with lynch syndrome usually presents at a relatively young age.
PubMedID- 24056992 Some studies reported since publication of the egapp analysis have added to the evidence regarding clinical utility to the relatives of colorectal cancer patients diagnosed with lynch syndrome.
PubMedID- 19957108 Serum antibodies against frameshift peptides in microsatellite unstable colorectal cancer patients with lynch syndrome.
PubMedID- 23073955 lynch syndrome in patients with colorectal cancer: finding the needle in the haystack.
PubMedID- 22940821 Thus, in patients with lynch syndrome the risk of developing colorectal cancer throughout life is approximately 80% and 40–60% in males and females, respectively, while that of developing endometrial cancer throughout life is 40–60%.
PubMedID- 25088490 Background & aims: lynch syndrome, a nonpolyposis form of hereditary colorectal cancer, is caused by inherited defects in dna mismatch repair (mmr) genes.
PubMedID- 22175017 However, there have been fewer studies on endometrial cancer compared to colorectal cancer in patients with lynch syndrome.
PubMedID- 20303416 We reviewed an integrated electronic health record (ehr) to determine diagnostic evaluation for lynch syndrome in patients diagnosed with colorectal cancer (crc).
PubMedID- 25323653 Applying public health screening criteria: how does universal newborn screening compare to universal tumor screening for lynch syndrome in adults with colorectal cancer.
PubMedID- 20010342 Prevention of metachronous colorectal cancer in patients with lynch syndrome.
PubMedID- 22411104 Daily aspirin reduces colorectal cancer incidence in patients with lynch syndrome.
PubMedID- 23073952 Identification of lynch syndrome among patients with colorectal cancer.
PubMedID- 25583420 Relationship between smoking and multiple colorectal cancers in patients with japanese lynch syndrome: a cross-sectional study conducted by the japanese society for cancer of the colon and rectum.
PubMedID- 24225971 Molecular tumor testing for lynch syndrome in patients with colorectal cancer.
PubMedID- 26473097 Testing for lynch syndrome in patients with newly-diagnosed colorectal cancer and their relatives.
PubMedID- 25794514 Approximately 3% of colorectal cancers are associated with lynch syndrome.
PubMedID- 22262812 colorectal cancers associated with lynch syndrome are characterized by deficient dna mismatch repair (mmr) function.
PubMedID- 24533633 colorectal cancer in lynch syndrome have distinctive clinical features that are well known in literature, such as younger age at presentation, proximal location, mucinous differentiation, advanced stage, associated extracolonic tumors and better stage-normalized prognosis .
PubMedID- 25142628 The percentage of cancers revealed in 1st (2%) and 2nd degree (8%) relatives were increasing through surveys, especially colorectal cancer related with lynch syndrome (4%).

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