PedAM
Pediatric Disease Annotations & Medicines
| Disease | cholestasis |
| Symptom | C0033774|pruritus |
| Sentences | 12 |
| PubMedID- 22695903 | Objectives: to test whether ursodeoxycholic acid reduces pruritus in women with intrahepatic cholestasis of pregnancy, whether early term delivery does not increase the incidence of caesarean section, and the feasibility of recruiting women with intrahepatic cholestasis of pregnancy to trials of these interventions. |
| PubMedID- 21779339 | Many substances have been proposed as possible causes of pruritus in cholestasis, including bile salts, steroids and steroid metabolites, histamine and endogenous opioids. |
| PubMedID- 23995243 | Liver diseases such as cirrhosis or cholestasis are often associated with pruritus . |
| PubMedID- 23227416 | At 24 weeks, she developed severe, diffuse pruritus due to intrahepatic cholestasis of pregnancy (icp). |
| PubMedID- 20301474 | Treatment of manifestations: standard pharmacologic therapies for pruritus associated with cholestasis (e.g., ursodeoxycholic acid, cholestyramine, and/or rifampin) may be temporarily effective but in the long term are relatively ineffective in severe disease. |
| PubMedID- 23166903 | The clinical benefit of mars in cholestasis patients with intractable pruritus may not exclusively result from filtration of pruritogens, but also from systemic changes in cytokinechemokine levels and changes in gene expression of blood cells. |
| PubMedID- 22541702 | The management of pruritus in cholestasis is challenging. |
| PubMedID- 26473137 | The most common indications for liver transplantation in the ags population were persistent cholestasis leading to severe pruritus and xanthomata, recurrent and poorly healing bone fractures, end-stage liver disease, and portal hypertension with gastrointestinal bleeding . |
| PubMedID- 24511525 | pruritus due to cholestasis occurs commonly, and gall stone, dyslipidemia, malabsorption, xanthoma of the eyelid, and fat soluble vitamin deficiency are not rare. |
| PubMedID- 23919027 | The pruritus associated with mild cholestasis responds to bland anti pruritic emollients, soothing baths, primrose oil and topical anti-pruritics. |
| PubMedID- 24052788 | We report anecdotal success with the use of ondansetron to treat pruritus associated with cholestasis following prolonged intensive care unit course of a 16-year-old. |
| PubMedID- 21809485 | Nevertheless, the pathogenesis of pruritus in cholestasis is still not clearly defined and current antipruritic treatment strategies provide relief only in a part of the affected patients. |
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