PedAM
Pediatric Disease Annotations & Medicines
| Disease | cholestasis |
| Symptom | C0020433|hyperbilirubinemia |
| Sentences | 4 |
| PubMedID- 25504385 | Laboratory tests showed cholestasis (100%) associated with hyperbilirubinemia (72%) and a moderate cytolysis (78%). |
| PubMedID- 25574367 | Molecular analysis for primary hlh such as mutation of perforin and syntaxin gene was performed in one patient (8 month male child) only.11 a recent study on pediatric hlh patients (n=38; 20 primary hlh, 18 secondary hlh) reported that hyperbilirubinemia with cholestasis was highly suggestive of primary hlh; whereas high c-reactive protein levels was more in favor of a secondary hlh. |
| PubMedID- 26392257 | Research has focused on the possibility that mild hyperbilirubinemia, instead of indicating inadvertent cholestasis, may be adaptive and beneficial. |
| PubMedID- 23134597 | All of these alterations contribute to hyperbilirubinemia associated with an intrahepatic cholestasis, the severity of which likely depends on the intensity of the impaired steps in bile formation. |
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