PedAM
Pediatric Disease Annotations & Medicines
| Disease | breast cancer |
| Symptom | C1851467|estrogen resistance |
| Sentences | 9 |
| PubMedID- 22041887 | Anti-estrogen resistance in breast cancer is induced by the tumor microenvironment and can be overcome by inhibiting mitochondrial function in epithelial cancer cells. |
| PubMedID- 21595894 | Our data provide evidence that the igf-1/igf-1r signaling axis may play a causal role in antiestrogen resistance of breast cancer cells, despite continuous suppression of er transcriptional function by antiestrogens. |
| PubMedID- 23704208 | The emergence of anti-estrogen resistance in breast cancer is an important clinical phenomenon affecting long-term survival in this disease. |
| PubMedID- 22500240 | Overexpression of pkcα is a marker of poor prognosis of breast cancers and is associated with antiestrogen resistance, erα-negative tumors, and tumor aggressiveness . |
| PubMedID- 22417013 | In detail, cxcr4 activity was involved in the oestrogen resistance of breast cancer . |
| PubMedID- 23087906 | Overexpression of her2 or fgfr1, or loss of inpp4b, molecular lesions which activate the pi3k pathway, also confer antiestrogen resistance in patients with er+ breast cancer (arpino et al., 2004; de laurentiis et al., 2005; ellis et al., 2006; gewinner et al., 2009; turner et al., 2010). |
| PubMedID- 24564526 | Transcriptional regulation prediction of antiestrogen resistance in breast cancer based on rna polymerase ii binding data. |
| PubMedID- 21128112 | Mitochondrial amplification selectively increases doxorubicin sensitivity in breast cancer cells with acquired antiestrogen resistance. |
| PubMedID- 25961241 | Conclusions: the greater sensitivity to growth inhibition by rapamycin in all three cell lines following long-term oestrogen/insulin deprivation suggests rapamycin-based therapies might be more effective in breast cancers with acquired oestrogen resistance. |
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