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PedAM

Pediatric Disease Annotations & Medicines




Disease breast cancer
Symptom C0220650|brain metastasis
Sentences 48
PubMedID- 26164063 We report, the case of a patient suffering from breast cancer with brain metastasis in whom the biological documentation of the metastatic disease permitted to tailor the systemic treatment.
PubMedID- 25715765 brain metastasis affects one third of patients with her2-positive breast cancer after treatment with trastuzumab.
PubMedID- 23591844 This versatile model mimics triple negative breast cancer clinical brain metastasis growth, which can be analyzed in vivo when mice are submitted to different therapeutic protocols.
PubMedID- 24278371 In fact hbegf is a gene known to have a role in brain metastasis of breast cancer , while ereg is a gene known to be mediating lung metastasis of breast cancer 4.
PubMedID- 22839200 A retrospective analysis of 126 metastatic breast cancer patients with brain metastasis revealed prolonged survival associated with hormone receptor-positive compared to hormone receptor-negative subtype in her2-positive disease when measured from the date of systemic recurrence (median, 27.4 months vs 20.9 months) or from brain metastasis (median, 9.2 months vs 5.0 months) .
PubMedID- 25032884 Chemotherapy and biological treatment options in breast cancer patients with brain metastasis: an update.
PubMedID- 20824144 In addition, st6galnac v has recently been reported to mediate brain metastasis of breast cancer cells .
PubMedID- 25743811 This systematic review aimed to summarize the role of her2 in brain metastasis in patients with breast cancer.
PubMedID- 24586742 In this study we analyzed the specific risk of brain metastasis associated with different breast cancer subtype in several age groups.
PubMedID- 26267412 Survival benefit of anti-her2 therapy after whole-brain radiotherapy in her2-positive breast cancer patients with brain metastasis.
PubMedID- 19937674 Results: the study included 29 breast cancer patients with brain metastasis who had undergone brain tumor resections.
PubMedID- 22304337 Burden of breast cancer with brain metastasis: a french national hospital database analysis.
PubMedID- 23344048 Chemokines seem to be important in the brain metastasis formation of breast cancer cells as well, since the cxcr4/sdf1 signaling pathway was shown to have a decisive role in the migration of breast cancer cells through brain endothelial monolayers .
PubMedID- 26216259 Conclusion: chinese breast cancer patients with brain metastasis were more likely to have high-grade tumors and negative estrogen receptor status.
PubMedID- 25714030 S. typhimurium a1-r also greatly inhibited bone and brain metastasis of breast cancer in orthotopic mouse models .
PubMedID- 25285241 In a series of over 3,000 patients with brain metastasis arising from breast cancer treated from 1989 to 2006, multivariate analysis indicated that triple negative status was the greatest risk factor for the development of cerebral metastasis (odds ratio=4.16; p<0.001), above that of her2 positive status (or=3.43; p=0.005) .
PubMedID- 23267980 A long-surviving case of her2-positive breast cancer with brain metastasis treated by multidisciplinary therapy.
PubMedID- 26400100 However, until present, there are no convincing reports that suggest whether the slit2/robo1 axis has any role in brain metastasis of breast cancer.
PubMedID- 23049262 Nonetheless, the finding that bevacizumab has significant activity against breast cancer with brain metastasis is important.
PubMedID- 22236677 Whole brain radiation therapy (wbrt) is still the standard treatment for breast cancer patients with brain metastasis.
PubMedID- 23335064 Purpose: in this study, we investigated the effect of lapatinib plus capecitabine treatment in her2-positive breast cancer patients with brain metastasis.
PubMedID- 23400960 Predictive factors of brain metastasis in patients with breast cancer.
PubMedID- 23578424 Objective: to investigate the clinicopathological characteristics and prognosis in breast cancer with brain metastasis (bcbm).
PubMedID- 23224985 We and others recently demonstrated a potential role for wnt signaling in brain metastasis of breast cancer patients .
PubMedID- 24811334 The presence of ctcs in cerebrospinal fluid (csf) has also been validated for breast cancer patients with brain metastasis, and can serve potentially as an early marker for the involvement of brain as a secondary site 6.
PubMedID- 23361272 Background: to evaluate the factors that have an impact on the development of brain metastasis in patients with breast cancer.
PubMedID- 24137472 The other case was of an isolated brain metastasis in a patient with breast cancer nine years after the initial therapy (13).
PubMedID- 23569464 Additional studies using cancer-cell targeted nanoparticles warrant investigations given the potential improvement in anticancer therapy against brain metastasis of breast cancer afforded by the synergistic effect of s1p with typical cancer chemotherapeutic drugs.
PubMedID- PMC3248131 Interestingly, in a recent report comparing the expression profile of primary breast cancers with unlinked brain metastasis, hk2 was found to be consistently up-regulated in the brain metastatic tumors but not the primary breast cancers.
PubMedID- 25031923 Thrombocytopenia due to chemotherapy can lead to intracranial hemorrhage.non–small cell lung cancer (nsclc) and breast cancer patients with brain metastasishave a high predisposition for spontaneous cerebral hemorrhage.
PubMedID- 20308667 Conclusion we have developed a robust tool that is able to predict subsequent brain metastasis in patients with breast cancer with nonbrain metastatic disease.
PubMedID- 25963555 A pdx line established from a brain metastasis of a her2-positive breast cancer showed strong membranous positivity (3+) for her2, and weak dispersed positivity for er and pgr, and therefore shared the same characteristics as the engrafted tumor (fig.
PubMedID- 25834608 We conducted a retrospective review of breast cancer patients with brain metastasis after primary surgery.
PubMedID- 23595625 Celecoxib and anti-gr1 treatment may be useful for blockade of these processes, thereby preventing brain metastasis in patients with breast cancer.
PubMedID- 22082486 In a series of 3000 breast cancer patients with brain metastasis , the tn status was the strongest risk factor for brain relapse.
PubMedID- 23954201 The number of involved extracranial organs: a new predictor of survival in breast cancer patients with brain metastasis.
PubMedID- 26098772 Additionally, we analyzed a subset of primary breast cancer patients, and certain patients with brain metastasis of lung and breast cancer and found high csf-1r, csf-1 and/or il-34 expression, respectively.
PubMedID- 23826254 The prognosis of breast cancer patients with brain metastasis is generally poor and the survival of the patients ranges from 3–5 months –.
PubMedID- 19840953 Materials and methods: the group of 222 breast cancer patients with brain metastasis was divided into three biological subgroups.
PubMedID- 23495140 Kaplan–meier analysis for brain metastasis-free survival of 204 breast cancer patients (gse12276).
PubMedID- 23743596 Systemic treatment after whole-brain radiotherapy may improve survival in rpa class ii/iii breast cancer patients with brain metastasis.
PubMedID- 25756607 brain metastasis (bm) in patients with breast cancer is a catastrophic event that results in poor prognosis.
PubMedID- 22908046 For example, in the 231-br brain metastasis model of the human breast cancer cell line mda-mb-231, palmieri et al.
PubMedID- 25060327 Distinct mr imaging features of triple-negative breast cancer with brain metastasis.
PubMedID- 22790050 In our case of her2-positive breast cancer with brain metastasis that presented with hydrocephalus, vp shunting relieved the symptoms and improved the qol of the patient, enabling treatment with lapatinib+capecitabine to be continued.
PubMedID- 24013510 Circulating tumor cells and brain metastasis outcome in patients with her2-positive breast cancer: the landscape trial.
PubMedID- 26516313 In additions, mir-7 also can inhibit brain metastasis of breast cancer and the self-renewal capacity of breast cancer stem-like cells by regulating the expression of krüppel-like factor4 (klf4) .
PubMedID- 25659578 The median survival time of breast cancer patients with brain metastasis is less than 6 months, and even a small metastatic lesion often causes severe neurological disabilities.

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