PedAM
Pediatric Disease Annotations & Medicines
| Disease | breast cancer |
| Symptom | C0220650|brain metastases |
| Sentences | 95 |
| PubMedID- 20439340 | Background: the purpose of this study was to determine the incidence of and survival following brain metastases among women with inflammatory breast cancer (ibc). |
| PubMedID- 24625110 | Survival for breast cancer patients with brain metastases is poor, with a one-year survival probability of approximately 20% 2. |
| PubMedID- 24761771 | Analysed 213 breast cancer patients with brain metastases . |
| PubMedID- 25802405 | breast cancer with brain metastases: clinicopathologic features, survival, and paired biomarker analysis. |
| PubMedID- 20389140 | Clinical outcomes and breast cancer subtypes in patients with brain metastases. |
| PubMedID- 23305997 | Promoting novel targeted approaches and innovative therapeutic combinations is a critical need to improve survival of breast cancer patients with brain metastases. |
| PubMedID- 21928364 | Results: we identified that kiss1 expression is significantly higher in primary breast cancer compared with brain metastases (p < .05). |
| PubMedID- 20346218 | The purpose of this retrospective study was to analyze the clinical characteristics and survival of patients with brain metastases due to breast cancer of different subtypes and to identify the prognostic factors that affect clinical outcome. |
| PubMedID- 21472708 | Background: brain metastases (bm) arising from triple-negative breast cancer (tnbc) portend a poor prognosis. |
| PubMedID- 25472758 | Conclusions: in breast cancer patients with few brain metastases, radiosurgery plus whole-brain radiotherapy resulted in significantly better freedom from new brain metastases than radiosurgery alone. |
| PubMedID- 23028253 | The same number of publications covered surgical or radiosurgical approaches and 3 brain metastases in patients with breast cancer. |
| PubMedID- 21643988 | Preliminary experience of whole-brain radiation therapy (wbrt) in breast cancer patients with brain metastases previously treated with bevacizumab-based chemotherapy. |
| PubMedID- 20625374 | Over the past 10 years, improving the outcome of breast cancer patients with brain metastases has become an important challenge. |
| PubMedID- 21656328 | Triple-negative breast cancer with brain metastases: a comparison between basal-like and non-basal-like biological subtypes. |
| PubMedID- 25893380 | Mirnas have also been implicated in the brain metastases of breast cancers and the ones investigated in this context include mir-7 and mir-146a . |
| PubMedID- 25528021 | The clinical course and prognostic factors of her2-positive breast cancer patients with brain metastases are not well known because of the relatively small population. |
| PubMedID- 22918394 | Background: in asia, large-scale studies on anti-her2 treatment in her2-positive breast cancer patients with brain metastases are limited. |
| PubMedID- 26055175 | Objectives: brain metastases due to breast cancer are increasing, and the prognosis is poor. |
| PubMedID- 23152022 | A case of effective lapatinib/capecitabine therapy for her2-positive breast cancer with multiple brain metastases. |
| PubMedID- 25564062 | Objective: to analyze the clinical characteristics and survival depending on biological subtypes in breast cancer patients with brain metastases (bm). |
| PubMedID- 23731980 | Is an ongoing phase ii study, which randomizes her2 positive breast cancer patients with progressive brain metastases (after trastuzumab or lapatinib based therapy) to single-agent afatinib versus afatinib + vinorelbine versus the investigator’s choice of approved therapy . |
| PubMedID- 23374226 | It is well accepted in the literature that blood vessels within brain metastases of breast cancer are more permeable than bbb microvessels, as they are characteristic of the breast tissue origin of the tumour cells causing substantial cerebral oedema . |
| PubMedID- 26472289 | Calcification of brain metastases in patients with breast cancer is very rare. |
| PubMedID- 22915160 | The clinicopathological evaluation of the breast cancer patients with brain metastases: predictors of survival. |
| PubMedID- 24191208 | Most clinical or preclinical data showed that lapatinib and capacitabine combination therapy is more effective than lapatinib or capacitabine monotherapy in breast cancer with brain metastases. |
| PubMedID- 23772419 | As a first example, we found that bkm120, a pi3k inhibitor that penetrates the blood-brain barrier, effectively inhibited brain metastases of her-2+ breast cancer (nanni et al., 2012). |
| PubMedID- 22638937 | Radiotherapy and re-irradiation of breast cancer patients with brain metastases: survival in the trastuzumab era. |
| PubMedID- 21424932 | In the group of breast cancers with brain metastases, the brain metastases showed higher her2, ck5/6, and ki67 expression compared to the breast primaries. |
| PubMedID- 22024205 | Purpose: to analyze factors affecting outcomes in breast cancer patients with brain metastases (bm) and characterize the role of her2 status. |
| PubMedID- 23886170 | Cisplatin plus gemcitabine for treatment of breast cancer patients with brain metastases; a preferential option for triple negative patients. |
| PubMedID- 26482599 | Antiepileptic drug use improves overall survival in breast cancer patients with brain metastases in the setting of whole brain radiotherapy. |
| PubMedID- 24390418 | Among 57 breast cancer patients with brain metastases, 28 patients were her2-positive. |
| PubMedID- 22436795 | Purpose: to elucidate survival times and identify potential prognostic factors in patients with triple-negative (tn) phenotype who harbored brain metastases arising from breast cancer and who underwent stereotactic radiosurgery (srs). |
| PubMedID- 25320339 | The overall prognosis of breast cancer patients with brain metastases remains poor, and these metastases are less responsive to systemic therapies. |
| PubMedID- 24312053 | Due to the difficulty in performing the in situ brain perfusion in mice, we modified the in situ brain perfusion to a cardiac perfusion method in female nu/nu mice bearing brain metastases of breast cancer to characterize p-gp function in vivo. |
| PubMedID- 25075060 | We describe the case of an elderly woman affected by triple-negative breast cancer with bone and brain metastases who has been treated for five years with metronomic capecitabine. |
| PubMedID- 23143215 | Emerging treatment options for the management of brain metastases in patients with her2-positive metastatic breast cancer. |
| PubMedID- 22741041 | In vivo magnetic resonance imaging for investigating the development and distribution of experimental brain metastases due to breast cancer. |
| PubMedID- 24932298 | By applying a well-validated nomogram, designed to predict the likelihood of subsequent brain metastases in patients with metastatic breast cancer (10), the current case report estimated the risk of brain metastases in the patient to be ~14%. |
| PubMedID- 22127284 | Impact of anti-her2 therapy on overall survival in her2-overexpressing breast cancer patients with brain metastases. |
| PubMedID- 23011099 | Conclusion: these results suggest that lapatinib monotherapy 750 mg given twice daily can exert some efficacy and has potential as a clinically meaningful treatment option for japanese her2-overexpressing breast cancer patients with brain metastases after cranial radiation. |
| PubMedID- 22814315 | Background: the aim of this study is to determine the relationship between the survival outcomes and biological subtype in breast cancer patients with brain metastases. |
| PubMedID- 24013582 | Phase i trial combining temozolomide plus lapatinib for the treatment of brain metastases in patients with her2-positive metastatic breast cancer: the laptem trial. |
| PubMedID- 21929800 | breast cancer patients with brain metastases form a heterogeneous population with respect to their prognosis . |
| PubMedID- 25678799 | Efficacy of nab-paclitaxel plus trastuzumab in a long-surviving heavily pretreated her2-positive breast cancer patient with brain metastases. |
| PubMedID- 22009460 | Impact of preexisting tumor necrosis on the efficacy of stereotactic radiosurgery in the treatment of brain metastases in women with breast cancer. |
| PubMedID- 25853260 | breast cancer with brain metastases in pregnancy. |
| PubMedID- 26199252 | A case of effective whole-brain irradiation and lapatinib/capecitabine combination therapy for her2-positive breast cancer with multiple brain metastases. |
| PubMedID- 24481998 | Use of liposomal doxorubicin-cyclophosphamide combination in breast cancer patients with brain metastases: a monocentric retrospective study. |
| PubMedID- 24614081 | Enumeration of tumor cells in the peripheral blood (circulating tumor cells, ctc) and csf (cerebrospinal fluid tumor cells, csftc) of nine breast cancer patients with brain metastases revealed dynamic changes in tumor cell burden in both the peripheral blood and csf compartments that correlated with clinical disease progression. |
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