PedAM
Pediatric Disease Annotations & Medicines
| Disease | breast cancer |
| Symptom | C0153690|bone metastasis |
| Sentences | 98 |
| PubMedID- 19949374 | Runx2 mrna level is reported to be significantly increased in human pancreatic ductal adenocarcinoma tissues32 and esophageal squamous cell carcinoma.38 runx2 expression has also been implicated in bone metastasis of breast cancer,39 and in human prostate cancer tissues and cells lines the expression of runx2 protein has been reported.40 here we describe elevated expression of runx2 protein in human prostate cancer cell lines relative to non-tumorigenic cell lines. |
| PubMedID- 25405387 | Among all these results, crkl was the target gene on both sides, indicating this gene was probably a fundamental node in controlling bone metastasis of breast cancer. |
| PubMedID- 24337539 | Cancer-induced bone pain (cibp) is a common clinical problem in breast cancer patients with bone metastasis. |
| PubMedID- 23788873 | breast cancer patients with bone metastasis were selected and their data investigated retrospectively. |
| PubMedID- 22049226 | Conclusions: rank expression might be an independent predictor of poor prognosis in breast cancer patients with bone metastasis, and rank expression does not associate with the prognosis in patients with visceral metastasis. |
| PubMedID- 25511591 | Conclusion: the expression level of il-11 is associated with the occurrence of bone metastasis in breast cancer. |
| PubMedID- 22807949 | The following case report describes a breast cancer patient with bone metastasis, in whom atypical subtrochanteric fractures developed after treatment with zoledronic acid. |
| PubMedID- 23152022 | A 63-year-old woman was suffering from her2-positive and hormone receptor-negative breast cancer with bone metastasis. |
| PubMedID- 22482058 | Experimental validation using a xenograft mouse model confirmed that rkip and let-7 suppress bach1 and hmga2 expression and showed that bach1 promotes invasion, intravasation, and bone metastasis of breast cancer cells. |
| PubMedID- 21935711 | Its expression promotes bone metastasis of breast cancer cells , whereas inhibition of αvβ3 diminishes their osteotropism 7. |
| PubMedID- 24172068 | Denosumab, a humanized monoclonal antibody neutralizing cytokine rankl (receptor activator of nuclear factor kappa-b ligand) and inhibiting rankl/rank-mediated nik/ikkα activation and approved to treat breast cancer patients with bone metastasis, represents a potential agent for neoadjuvant therapy of rank-positive basal breast cancer to target cscs. |
| PubMedID- 23533807 | In one such study that focused on bone metastasis of breast cancer, mir-21 and mir-181a were found to be enriched in bone metastatic breast cancers leading to poor prognosis . |
| PubMedID- 22627092 | Prolonged administration of bisphosphonates is well-tolerated and effective for skeletal-related events in chinese breast cancer patients with bone metastasis. |
| PubMedID- 22923892 | Background: bisphosphonate therapy is widely used for the treatment of bone metastasis in breast cancer patients. |
| PubMedID- 26122018 | Significantly, our therapy for the bone metastasis of breast cancer, mwnts plus nir irradiation, achieved high antitumor efficacy without significant side effects, as proved by nociceptive tests and body weight measurements. |
| PubMedID- 25978366 | Clinical trials have shown that breast cancer patients (with or without bone metastasis) increase their disease free survival when treated with bisphosponates . |
| PubMedID- 26237142 | Bone targeted therapies for bone metastasis in breast cancer. |
| PubMedID- 24752566 | A cross-sectional survey of the diagnosis and management of bone metastasis in breast cancer patients in turkey. |
| PubMedID- 23349840 | Creb has been reported to promote proliferation, migration, invasion and bone metastasis of breast cancer cells . |
| PubMedID- 24101191 | The cxcr4+ phenotype may be a useful predictor for the prevention of early treatment failure and bone metastasis in breast cancer patients. |
| PubMedID- 25421824 | Thus, this study suggests that wdl may be a potential natural agent for preventing and treating bone destruction in patients with bone metastasis due to breast cancer. |
| PubMedID- 26343727 | In a bone metastasis model of breast cancer cell mda-231, gli2 in cancer cell induces secretion of pthrp, an important osteolytic factor, and promotes bone destruction . |
| PubMedID- 22690107 | A 48-yr-old woman with severe pain caused by bone metastasis of breast cancer received epidural block. |
| PubMedID- 24576174 | Cells have the ability to recognize extracellular calcium by casr , which in some cancer entities, such as breast cancer, correlates with bone metastasis . |
| PubMedID- 20416078 | Serum tartrate-resistant acid phosphatase 5b activity as a prognostic marker of survival in breast cancer with bone metastasis. |
| PubMedID- 23119009 | Serum bsp has been shown to predict bone metastasis of primary breast cancer and survival and bone metastasis of prostate cancer patients . |
| PubMedID- 20646320 | These results should provide an impetus for the adjuvant bisphosphonates as an important intervention in the prevention bone metastasis of breast cancer patients following surgery. |
| PubMedID- 22855035 | Objective: to study the effects of brucine on vascular endothelial growth factor (vegf) expression and microvessel density (mvd) in a nude mouse model of bone metastasis due to breast cancer, and to assess the possible antitumor mechanism of brucine. |
| PubMedID- 25605256 | Moreover, erp57 has a role in conferring resistance to apoptosis under hypoxia and endoplasmic reticulum stress , and it is involved in bone metastasis of breast cancer . |
| PubMedID- 22147993 | Osteolytic destruction in breast cancer patients with bone metastasis is caused by the activation of osteoclasts secondary to numerous factors secreted by breast cancer cells and the stimulation of osteoclast production by osteoblasts through the receptor activator of nuclear factor-κb ligand (4, 5). |
| PubMedID- 23734861 | Eradication of breast cancer with bone metastasis by autologous formalin-fixed tumor vaccine (aftv) combined with palliative radiation therapy and adjuvant chemotherapy: a case report. |
| PubMedID- 26464732 | The original clinical diagnosis was right breast cancer with lung and bone metastasis, or breast and lung double primary cancers. |
| PubMedID- 23468985 | Our recent studies also demonstrated that p. corylifolia and c. monnieri inhibit the bone metastasis of breast cancer in vivo, possibly by affecting the opg/rankl/rank system , . |
| PubMedID- 25667653 | Nilsen et al (25) observed that ktrans and kep had a statistically significant difference between breast cancer lesions associated with bone metastasis and that without bone metastases; the perfusion and vascular permeability of breast cancer lesions with metastasis were significantly lower than those of non-metastatic breast cancer lesions. |
| PubMedID- 22032690 | Csf-2 encodes the cytokine gm-csf, which has previously been shown to contribute to osteolytic bone metastasis of breast cancer by stimulating osteoclasts . |
| PubMedID- 22139406 | However, it should be noted that these capacities are not specifically attributable to bone metastasis of breast cancer and that additional yet unknown properties are likely involved. |
| PubMedID- 23392720 | Our study suggested that er/pr status and histological grade are risk factors for the development of bone metastasis in breast cancer patients. |
| PubMedID- 23267883 | We evaluated the clinical significance of indoleamine 2, 3-dioxygenase (ido) expression in breast cancer patients with bone metastasis. |
| PubMedID- 23427025 | Is retention of zoledronic acid onto bone different in multiple myeloma and breast cancer patients with bone metastasis. |
| PubMedID- 23043593 | Objective: this retrospective observational study describes treatment patterns and longitudinal health-related quality-of-life (hrqol) among metastatic breast cancer patients with bone metastasis from nine community oncology clinics. |
| PubMedID- 23589692 | In breast cancer patients with bone metastasis, several bisphosphonates demonstrated clinical efficacy. |
| PubMedID- 22716210 | Our findings demonstrate that c-src expression is a potential independent predictor of poor prognosis in breast cancer patients with bone metastasis. |
| PubMedID- 20010942 | In a bone metastasis model of breast cancer, bone-metastatic variants of the mda-mb-231 breast cancer cell line were found to overexpress two metalloproteinases, mmp1 and adamts1. |
| PubMedID- 23956898 | The patient's history revealed a long term use of zoledronic acid for the treatment of breast cancer with bone metastasis. |
| PubMedID- 23649605 | bone metastasis, the leading cause of breast cancer-related deaths, is characterized by bone degradation due to increased osteoclastic activity. |
| PubMedID- 25595283 | Bisphosphonates have played an important role in the treatment of breast cancer, mainly in patients with bone metastasis, by reducing the risk of fracture, spinal cord compression, and hypercalcemia. |
| PubMedID- 22929916 | bone metastasis in breast cancer: the story of rank-ligand. |
| PubMedID- 25526456 | The aim of the present study was to investigate the relationships between the automated bone scan index (absi) and skeletal-related events (sre) in breast cancer patients with bone metastasis. |
| PubMedID- 25453260 | bone metastasis occurs frequently in patients with advanced breast cancer and is a major cause of morbidity and mortality in these patients. |
| PubMedID- 24959222 | Consequently, we hypothesize that the cxcr4/pi3k/akt/mmp-9 signaling pathway is involved in the bone metastasis of breast cancer. |
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