PedAM
Pediatric Disease Annotations & Medicines
| Disease | breast cancer |
| Symptom | C0011847|diabetes |
| Sentences | 65 |
| PubMedID- 22502657 | diabetes, overweight and risk of postmenopausal breast cancer: a case-control study in uruguay. |
| PubMedID- 26472977 | We searched the pubmed and embase databases (from inception to february 10, 2015) for randomized and observational studies that discussed the association between metformin and breast cancer in patients with diabetes mellitus, by using the following search terms: "metformin" and "breast cancer." |
| PubMedID- 22674293 | The association of diabetes with breast cancer incidence and mortality in the long island breast cancer study project. |
| PubMedID- 25679392 | Association of type 2 diabetes genetic variants with breast cancer survival among chinese women. |
| PubMedID- 20181294 | Previous studies suggest a modest increase in risk of breast cancer among women with type 2 diabetes and gestational diabetes 5. |
| PubMedID- 26185535 | Second, the analysis for type 1 diabetes and risk of breast cancer may be underpowered because type 1 diabetes is diagnosed in young individuals and there is not enough follow-up on those individuals who may develop breast cancer. |
| PubMedID- 24937172 | Background and aims: although underlying mechanisms have been described to account for the association between prediabetes and diabetes with breast cancer, reported results have been inconsistent. |
| PubMedID- 25779100 | diabetes was associated with more advanced-stage breast cancer, even after accounting for differences in screening mammogram use and other factors. |
| PubMedID- 26010254 | While metabolic abnormalities associated with cardiovascular disease and type-2 diabetes, common co-morbidities of breast cancer survivors, are improved with weight loss within the range of 5 to 10% of initial body weight, overall mortality rates and cancer and cardiovascular disease specific death rates are lower in the general population when body mass index is in the normal range (18.5 to 24.9kg/m2). |
| PubMedID- 22296353 | Objective: to investigate the clinical features, molecular phenotypes and clinical prognosis of breast cancer patients with type-2 diabetes mellitus, thereby providing a basis for individualized therapy of breast cancer. |
| PubMedID- 25425578 | Using multivariable cox proportional hazards regression, we estimated hrs and 95% confidence intervals (ci) for overall and breast cancer-specific mortality associated with previous cancer, diabetes, high blood pressure (hbp), and myocardial infarction. |
| PubMedID- 24564865 | For example, thioethershave therapeutic potential for treatment of hiv,1 breast cancer,2 inflammatorydiseases,3,4 diabetes,5 andalzheimer’s disease.6 despite theirabundance, until recently few general methods were available for theirsynthesis under mild conditions that would tolerate sensitive heterocycles.in this manuscript, we report synthesis of diaryl sulfides by in situformation of highly reactive sulfenyl chlorides and subsequent trappingwith arylzinc reagents. |
| PubMedID- 26171401 | Because there were only 5 cases of breast cancer mortality in patients with type 1 diabetes mellitus (table 1 and figure 1) and the results did not markedly change when only patients with type 2 diabetes mellitus were analyzed in secondary analyses (data not shown), it is believed that the results of the present study would best be applied to patients with type 2 diabetes mellitus. |
| PubMedID- 26446233 | Results: a total of 11 studies consisting of 5,464 breast cancer patients with diabetes were included, comprising 2,760 patients who had received metformin and 2,704 patients who had not. |
| PubMedID- 23033240 | It has been suggested that diabetes increases the risk of breast cancer (bc) (2); however, physical activity appears to reduce the risk of bc (3) by increasing insulin sensitivity (4). |
| PubMedID- 24349656 | Pre-existing diabetes increased the risk of breast cancer significantly only in the post-menopause group (or, 1.44; 95% ci, 1.03 to 2.01), whereas it showed no significant association in the pre-menopause group. |
| PubMedID- 23833528 | A single-stop approach, especially in high risk women (obesity, diabetes, family history of endometrial, ovarian or breast cancer) as well as in women with endometrial hyperplasia of combining the office hysteroscopy, directed biopsy in presence of a focal lesion, and vacuum sampling of endometrium in normal looking endometrium, all without anesthesia is the most minimally invasive and yet accurate approach in current practice. |
| PubMedID- 23829168 | Both cohort and case–control epidemiological observations have demonstrated the association of metabolic syndrome, obesity and diabetes with increased breast cancer risk . |
| PubMedID- 22996614 | Figure 6 presents a cumulative meta-analysis, and it is apparent that the increased risk of breast cancer in women with diabetes was statistically significant in publications up until and including 1997, and has remained statistically elevated subsequently. |
| PubMedID- 23909037 | More than that, familial diabetes in diabetics with breast cancer goes together with lesser size of tumor and demonstrates an inclination to the rarer distant metastases in breast and endometrial cancer patients. |
| PubMedID- 21632448 | diabetes is associated with postmenopausal breast cancer, too, with summary rrs from meta-analyses of 1.15-1.20, but not with premenopausal breast cancer (rr, 0.9). |
| PubMedID- 22723840 | The results from the meta-analysis showed diabetes and the risk of breast cancer revealed that diabetes increased the risk of breast cancer by 20% . |
| PubMedID- 23401790 | A recent meta-analysis showed that the relative risk for breast cancer in women with diabetes was 1.27 (95% confidence interval (ci), 1.16–1.39). |
| PubMedID- 25854171 | The objective of this study was to investigate the clinical pathological characteristics of breast cancer (bc) patients with secondary diabetes after systemic therapy without preexisting diabetes. |
| PubMedID- 26537234 | Mammalian target of rapamycin (mtor) is activated by insulin and insulin-mediated breast cancer progression in patients with type 2 diabetes mellitus may be abrogated by inhibition of mtor 5. |
| PubMedID- 21972408 | Previous epidemiologic research suggests a modestly elevated risk of breast cancer in women with type 2 diabetes (t2d), particularly after menopause (1). |
| PubMedID- 25723884 | Dexrazoxane protects breast cancer patients with diabetes from chemotherapy-induced cardiotoxicity. |
| PubMedID- 23292119 | In total, the study included 1,013 breast cancer patients with diabetes and 4,621 breast cancer patients without diabetes. |
| PubMedID- 21115861 | Purpose: self-reported diabetes has been associated with poor breast cancer outcomes. |
| PubMedID- 25261292 | Thus, the continuum of care for breast cancer patients with diabetes should include careful attention to cvd risk factors and other non-cancer conditions. |
| PubMedID- 24026538 | Conclusion: when taking competing mortality into account, rfp was better in elderly breast cancer patients with diabetes compared with patients without diabetes. |
| PubMedID- 23244125 | Objective: the aim was to investigate indicators related to dna damage and cancer pathogenesis in type ii diabetes cases with breast cancer. |
| PubMedID- 24899083 | We examined whether receipt of guideline-concordant breast cancer treatment varied with diabetes severity. |
| PubMedID- 22848683 | Increased risk of breast cancer has been associated with diabetes in numerous epidemiological studies , therefore we also studied the effect of insulin analogues on the production of pip3 in breast cancer derived cell lines using a new, highly sensitive bret-based assay. |
| PubMedID- 24281091 | Another meta-analysis also observed an increased mortality hr of 1.61(95% ci, 1.46–1.78) for breast cancer with pre-existing diabetes mellitus . |
| PubMedID- 24338167 | The aim of this study was to study the prevalence and clinicopathologic features of breast cancer patients with type 2 diabetes mellitus in southwest of china for providing clinical guidance and prognosis appreciation for these patients. |
| PubMedID- 25877238 | Objective: to explore the expression of hypoxia-inducible factor 1 alpha (hif-1alpha) in tissue of breast cancer complicated with diabetes and examine the correlation with vascular endothelial growth factor (vegf) and microvascular density (mvd). |
| PubMedID- 23259613 | Our objectives were to identify factors associated with previously undiagnosed diabetes in breast cancer, and to examine associations between previously undiagnosed diabetes and cancer stage, treatment patterns, and mortality. |
| PubMedID- 24834121 | In a second study, dr fontanella and colleagues investigated the incidence of type 2 diabetes in patients with early breast cancer at the time of diagnosis, as well as its effect on the outcome after neoadjuvant chemotherapy. |
| PubMedID- 20490716 | The coexistence of type 2 diabetes with breast cancer may result in poorer cancer-related survival due to a number of mediating factors including an alteration of tumor tissue hormonal sensitivity. |
| PubMedID- 25971328 | diabetes mellitus is associated with breast cancer: systematic review, meta-analysis, and in silico reproduction. |
| PubMedID- 25107658 | Studies have shown an increased risk of breast cancer associated with diabetes which may be due to differences in mammography use among women who have diabetes compared with women who do not have diabetes. |
| PubMedID- 20376506 | In particular, several studies clearly indicate an association between type 2 diabetes and the risk of colorectal, pancreatic, and breast cancer. |
| PubMedID- 26148588 | Aim: we tend to explore the expression characteristics of proteins in igf/ir axis in breast cancer with type 2 diabetes mellitus (t2dm). |
| PubMedID- 25866823 | In the taiwan study, breast cancer patients with diabetes had a significantly increased mortality with a hazard ratio (hr) of 1.57 (95% ci: 1.15–2.15) . |
| PubMedID- 25866793 | One study by ferro and colleagues showed that metformin caused radiotoxicity in breast cancer patients with diabetes compared to nondiabetic patients and diabetic patients receiving alternative medications . |
| PubMedID- 23238788 | Methods: we used population-based data from ontario, canada to compare the incidence of diabetes among women with breast cancer, aged 55 years or older, from 1996 to 2008, with that of age-matched women without breast cancer. |
| PubMedID- 26171112 | Epidemiological findings indicate a close relationship between diabetes and many types of cancer (including breast cancer risk), which regards not only the dysmetabolic condition, but also its underlying risk factors and therapeutic interventions. |
| PubMedID- 21357383 | No association of risk variants for diabetes and obesity with breast cancer: the multiethnic cohort and page studies. |
| PubMedID- 25935404 | Our present findings support the hypothesis that metformin improves the survival of breast cancer patients with concurrent diabetes, particularly in cases with hormone-responsive and her2-positive tumors, receiving adjuvant systemic therapy. |
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