PedAM

Pediatric Disease Annotations & Medicines

Disease	asthma
Symptom	C0014457\|eosinophilia
Sentences	35
PubMedID- 22315625	Subsequent trials of mepolizumab in severe asthma patients with persistent sputum eosinophilia have demonstrated a significant reduction in airway wall thickness measured by quantitative ct scanning (rb1 wa%/body surface area).
PubMedID- 24074331	Recent studies show that il-16, soluble st2 or anti-il-33 reduce type 2 cytokines (such as il-5) and eosinophilia in murine models of allergic asthma or allergic rhinitis respectively.
PubMedID- 20623310	Churg-strauss syndrome (css) is a rare, systemic, necrotizing, small- and middle-sized vessel vasculitis which is accompanied by blood eosinophilia, eosinophil infiltration of various tissues, and bronchial asthma.
PubMedID- 25981191	Methods: we conducted a randomized, double-blind, placebo-controlled, multicenter clinical trial of sb010 involving patients who had allergic asthma with sputum eosinophilia and who also had biphasic early and late asthmatic responses after laboratory-based allergen provocation.
PubMedID- 21505837	19-year-old asthma patient with pronounced eosinophilia and acute coronary syndrome.
PubMedID- 22291829	It is well known that ics decrease airway eosinophilia, which usually leads to better asthma control, while in contrast asthma exacerbation leads to a rise in eosinophil level.
PubMedID- 21625544	Allergic asthma is associated with airway eosinophilia, which is regulated by different t-effector cells.
PubMedID- 23253516	Atopic asthma was associated with eosinophilia and non-atopic asthma was associated with ifn-γ and elevated monocytes in blood.
PubMedID- 21320344	Total serum ige, atopy, testing positive for food allergens, and eosinophilia were significantly associated with asthma (table 1) and evaluated as outcomes in separate statistical models.
PubMedID- 24010571	Cases of tropical pulmonary eosinophilia were associated with refractory bronchial asthma.
PubMedID- 26131418	In addition to asthma, other causes of eosinophilia such as other allergic diseases, underlying cancer, and other parasitic infections should also be ruled out for the evaluation of eosinophilia.
PubMedID- 24628018	Treatment with ppar agonists has been shown to inhibit airway eosinophilia in murine models of allergic asthma, which can occur through several mechanisms including attenuated generation of chemoattractants (e.g.
PubMedID- 26502193	Hmabs targeting il-5 have shown great promise in severe refractory asthma with a persisting eosinophilia, and clinical trials with hmabs against il-13 and il4ralpha have also shown clinical benefit.
PubMedID- 25801413	Their use as a single surrogate marker for airway eosinophilia in patients with asthma will lead to a substantial number of false positives or false negatives.
PubMedID- 23715171	Investigating the association of skin test reactivity, total serum ige levels, and peripheral blood eosinophilia with asthma, khadadah et al.
PubMedID- 24431239	Serum eosinophilia and prevalence of self-reported asthma was lower in active smokers than never-smokers.
PubMedID- 21113938	Autopsies in both individuals demonstrated pulmonary airway smooth muscle hyperplasia, basement membrane thickening, and eosinophilia, consistent with bronchial asthma.
PubMedID- 24530234	asthma is severe, associated with eosinophilia and extrapulmonary symptoms.
PubMedID- 25936567	This suggests that ccl26 production by becs might be involved in persistent eosinophilia in patients with severe asthma despite treatment with high corticosteroid doses.
PubMedID- 26194544	Conclusions: our findings suggest that ilc2s can promote the persistence of airway eosinophilia in patients with severe asthma through uncontrolled localized production of the type 2 cytokines il-5 and il-13, despite high-dose oral corticosteroid therapy.
PubMedID- 23593249	Β5i-deficient mice showed reduced ova/alum- and subcutaneous/ova-induced acute asthma with decreased eosinophilia in the bronchoalveolar lavage (bal), low ova-specific igg1 and reduced local and systemic th2 cytokines.
PubMedID- 23091327	Moreover, anti-ige therapy has profound and significant reducing effects on airway and tissue eosinophilia in patients with mild allergic asthma and on allergen-induced seasonal increases in circulating and tissue eosinophils in subjects with allergic rhinitis (4, 7).
PubMedID- 22541618	In patients with severe, refractory asthma associated with eosinophilia, however, clinical trials have demonstrated significant reductions in asthma exacerbations.
PubMedID- 22187177	The presence of asthma, sinusitis associated with peripheral eosinophilia and organ symptoms suggesting a vasculitis could support the diagnosis, without histologic evidence.
PubMedID- 24991461	Moreover, anti-ige therapy exerts profound and significant reductions in airway and tissue eosinophilia in patients with mild allergic asthma and on allergen-induced seasonal increases in circulating and tissue eosinophils in subjects with allergic rhinitis.28 these findings suggest that anti-ige therapy can be considered a steroid-sparing option for eae.
PubMedID- 23592945	Churg-strauss syndrome was diagnosed based on the patient's history of asthma, sinusitis, eosinophilia, nasal polyps, transient radiological pulmonary infiltrations and transient paresthesia over the left tibia, and eosinophilic pericardial effusion and eosinophilic infiltrations revealed in a myocardial biopsy.
PubMedID- 21387750	Introduction: churg-strauss syndrome (css) is a rare, systemic, necrotizing, small- and middle-sized vessel vasculitis which is accompanied by blood eosinophilia, eosinophil infiltration of various tissues and bronchial asthma.
PubMedID- 22090223	Background: churg-strauss syndrome (css) is a rare, systemic necrotising small and middle-sized vessel vasculitis, accompanied by blood eosinophilia, eosinophil infiltration of various tissues and bronchial asthma.
PubMedID- 23184213	Sputum eosinophilia is associated with difficult-to-control asthma (68), and the normalization of this condition after treatment was correlated with a decrease in the number of exacerbations and hospitalizations.
PubMedID- 22419386	asthma was not associated with high tissue eosinophilia (p = 0.60), with 43% of nonasthmatics demonstrating high tissue eosinophilia.
PubMedID- 22029856	Furthermore, severe asthma exacerbations are associated with bronchial mucosal eosinophilia and neutrophilia, as well as upregulation of cxc chemoattractants and their receptors 3.
PubMedID- 22921086	asthma is sever, associated with eosinophilia and extrapulmonary symptoms.
PubMedID- 22880030	An ovine orthologue, galectin-14, has been shown to be secreted in the airway mucus of a sheep asthma model closely associated with lung eosinophilia , .
PubMedID- 23738037	Tarc is a pivotal chemokine for the development of th2-dominated experimental allergen-induced asthma with eosinophilia and airway hyperresponsiveness .
PubMedID- 25954267	However, this effect may be overcome by allergic sensitization, as dectin-1 deficient mice did not exhibit increased lung eosinophilia in a model of fungal asthma (lilly et al., 2012).

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