PedAM
Pediatric Disease Annotations & Medicines
| Disease | arthritis |
| Symptom | C0238790|bone destruction |
| Sentences | 11 |
| PubMedID- 25770819 | For example, the absence of tnf or il-6 signaling has been found to impair fracture healing (gerstenfeld et al, 2003a; yang et al, 2007), whereas persistent and elevated levels of tnf in rheumatoid arthritis are associated with bone destruction (binder et al, 2013) and systemic daily administration of high-dose tnf in a rat rib fracture model also resulted in impaired healing (hashimoto et al, 1989). |
| PubMedID- PMC4033988 | Thus, controlling il-23 production and function could be a strategy for preventing inflammation and bone destruction in patients with rheumatoid arthritis . |
| PubMedID- 24556956 | Studies of bone destruction associated with rheumatoid arthritis have highlighted the importance of the interaction between the immune and skeletal systems. |
| PubMedID- 20973954 | Joint damage in arthritis, with cartilage and bone destruction, is believed to be mediated (at least in part) through proteases, such as mmps and plasmin 8. |
| PubMedID- 24674692 | Thus, reduction of m-csf with the anti-il-17a antibody treatment supports the hypothesis that bone destruction due to arthritis creates a supportive milieu for bc cells to metastasize. |
| PubMedID- 21635718 | Accumulating evidence lends support to the theory that bone destruction associated with rheumatoid arthritis is caused by the enhanced activity of osteoclasts, resulting from the activation of a unique helper t cell subset, 'th17 cells'. |
| PubMedID- 21081190 | bone destruction associated with rheumatoid arthritis (ra) is mainly attributed to the abnormal activation of osteoclasts, which are terminally differentiated cells of monocyte/macrophage lineage that resorb bone matrix. |
| PubMedID- 24395111 | In this report, we investigated the regulatory function of mscs in the development of inflammatory bone destruction in rats with adjuvant-induced arthritis (aa rats). |
| PubMedID- 23476804 | These rats develop a chronic and severe form of autoimmune arthritis, which leads to permanent bone destruction and ankylosis of affected joints. |
| PubMedID- 22172512 | Rheumatoid arthritis (ra) is associated with pathological bone destruction mediated by osteoclasts. |
| PubMedID- 26065006 | Overexpression of il-1α or il-1β or deletion of the il-1 receptor antagonist (il-1ra) leads to the development of arthritis with cartilage and bone destruction . |
Page: 1