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PedAM

Pediatric Disease Annotations & Medicines




Disease arteriosclerosis
Symptom C0856169|endothelial dysfunction
Sentences 54
PubMedID- 25460725 The pathogenesis of atherosclerosis also begins with endothelial dysfunction.
PubMedID- 22935960 Oxidative stress is also implicit in endothelial dysfunction associated with atherosclerosis and subsequent thrombotic complications 9.
PubMedID- 25650072 Leptin has been documented to influence a multitude of organ systems, that is, central nervous system (appetite regulation, satiety factor) and cardiovascular system (endothelial dysfunction leading to atherosclerosis).
PubMedID- 23739294 suggested that hyperhomocysteinemia is a risk factor for atherosclerosis, and is associated with endothelial dysfunction.
PubMedID- 22642467 Background: ykl-40, a proposed marker of inflammation and endothelial dysfunction, is associated with atherosclerosis and an increased cardiovascular mortality in the general population.
PubMedID- 24139427 In this regard, given the theory of the pathogenesis of atherosclerosis , with detection of endothelial dysfunction predicting an early functional disturbance of the vessel wall and measurement of imt functioning as an early morphological sign , our findings emphasize the likelihood that scd146 is a more sensitive and earlier predictor of subclinical endothelial dysfunction than cimt.
PubMedID- 23307875 Objective: endothelial dysfunction is associated with atherosclerosis in mice, but it is difficult to reduce cholesterol levels enough to study regression of atherosclerosis in genetically modified mice.
PubMedID- 22536426 Type 2 diabetes is well known to accelerate the course of atherosclerosis, a condition associated with arterial endothelial dysfunction, macrophage foam cell formation, and vascular smooth muscle cell (vsmc) proliferation.
PubMedID- 22086659 One of the earliest manifestations of hypertension and associated atherosclerosis includes endothelial dysfunction in the vascular tree (krieglstein and granger 2001).
PubMedID- 24959009 The pathogenesis of atherosclerosis also begins with endothelial dysfunction.
PubMedID- 25705139 Indeed, decreased numbers and/or impaired function of epcs in adult ra patients were associated with significant endothelial dysfunction leading to accelerated atherosclerosis and development of cvd .
PubMedID- 20361006 Like native glp-1, liraglutide inhibits tumor necrosis factor alpha (tnf) mediated plasminogen activator inhibitor type-1 (pai-1) activation in human vascular endothelial cells.33 these observations suggest that a beneficial effect of liraglutide on endothelial dysfunction associated with premature atherosclerosis observed in t2dm.
PubMedID- 24288612 The authors identified that t-cadherin levels in plasma are increased in early atherosclerosis and correlate with endothelial dysfunction, which may lead to increased release of emps from ecs .
PubMedID- 21600014 Oxidative stress also results in endothelial dysfunction associated with atherosclerosis and subsequent thrombotic complications 6, compounded in type-2 diabetes by a sustained hypercoagulable state and alterations in the fibrinolytic pathway.
PubMedID- 23497719 Dyslipidemia and atherosclerosis are disorders with endothelial dysfunction that are associated with an increased production of superoxide anion, and early deficit of nitric oxide (no) production.
PubMedID- 21615722 The present study provides a new mechanism for endothelial dysfunction in atherosclerosis and may represent a novel target to elaborate the therapeutic strategy for vascular atherosclerosis.
PubMedID- 25463089 The oxidative stress generated by these enzymes may induce endothelial dysfunction, leading to atherosclerosis, cardiovascular diseases and metabolic syndrome.
PubMedID- 20712865 endothelial dysfunction, a sign of very early atherosclerosis, can be assessed by impaired endothelial dependent flow-mediated vascular dilation (ed-fmd) of peripheral arteries, measured by ultrasonography .
PubMedID- 22050954 Oxidative stress triggers numerous deleterious processes in atherosclerosis, leading to endothelial dysfunction and platelet activation.
PubMedID- 26516419 endothelial dysfunction leads to atherosclerosis, characterized by chronic inflammation of the arterial wall and stepwise narrowing of the vessel lumen.
PubMedID- 23446035 There is a strong association between cardiovascular diseases, thromboembolism, and atherosclerosis with endothelial dysfunction.
PubMedID- 25109946 Glucose spikes after meals induce endothelial dysfunction, which may lead to progression of atherosclerosis and cardiovascular events.
PubMedID- 22254061 Further, nadh/nadph oxidase is the most important source of reactive oxygen species in the vasculature and inactivation of nadh/nadph oxidase may contribute to the improvement in endothelial dysfunction in patients with atherosclerosis .
PubMedID- 23698028 Pet mbf measurements can be used in evaluating early-stage atherosclerosis with endothelial dysfunction right through to diagnosing cad.
PubMedID- 22754320 Vascular inflammation induced by cytokine occurs early in the development of atherosclerosis, and leads to endothelial dysfunction.
PubMedID- 22872323 Conclusions: improvement in endothelial dysfunction in patients with early atherosclerosis in association with significant reduction in leukocytes may suggest an important role of early cellular inflammatory mediators on endothelial function.
PubMedID- 24383040 It is known that chemokines/cytokines including il-6 and the opg/rank/rankl system are involved in endothelial dysfunction leading to atherosclerosis development and progression.
PubMedID- 22359630 Convincing evidence indicates that atherosclerosis is associated with endothelial dysfunction at the early stage of the disease process .
PubMedID- 25705646 Accumulating evidence supports the idea that atherosclerosis is associated with endothelial dysfunction, hypertension, hyperlipidemia, and elevated concentrations of reactive oxygen species (ros).
PubMedID- 24528626 Vascular complications in diabetes start with impaired angiogenesis and endothelial dysfunction which lead to atherosclerosis at later stage.
PubMedID- 21247546 Peripheral endothelial dysfunction, an inherent feature of early atherosclerosis, has been suggested as a surrogate marker of cardiovascular risk.
PubMedID- 23984434 Alterations in the control of these processes, a feature of endothelial dysfunction, often leads to atherosclerosis and other vascular disorders .
PubMedID- 24028208 Such size-selective defects are likely to be caused by endothelial dysfunction (due to atherosclerosis), acute systemic inflammation and/or ischemic (or hf-induced) release of anp .
PubMedID- 23422724 It is well known that the endothelial dysfunction is associated with aging, hypertension, atherosclerosis, and numerous other physiological and pathophysiological processes 2.
PubMedID- 23776901 Considering the role of endothelium in vascular integrity and the association of endothelial dysfunction with atherosclerosis, one can speculate that there is link between sch and atherosclerosis.
PubMedID- 23684441 endothelial dysfunction is associated with hypertension, atherosclerosis, and metabolic syndrome.
PubMedID- 22673743 endothelial dysfunction leads to accelerated atherosclerosis in rheumatoid arthritis, systemic lupus erythematosus and spondyloarthropaties whereas obliterative vasculopathy is associated with systemic sclerosis.
PubMedID- 20584775 We identify t-cad as an endothelial mp antigen in vivo and demonstrate that its level in plasma is increased in early atherosclerosis and correlates with endothelial dysfunction.
PubMedID- 23825152 The development of cardiovascular diseases, particularly atherosclerosis, is associated with endothelial dysfunction.
PubMedID- 21786155 Type 2 diabetes is well known to accelerate the clinical course of atherosclerosis, a condition associated with arterial endothelial dysfunction and several metabolic abnormalities.
PubMedID- 24386401 In contrast, data on its relation with endothelial dysfunction as a marker of early subclinical atherosclerosis is inconclusive and limited to patient-cohort studies.
PubMedID- 26091235 As mentioned above, insulin resistance always accompanies metabolic and endothelial dysfunction, which lead to hypertension and atherosclerosis .
PubMedID- 25478508 Previous studies indicate that the blood pressure elevation and endothelial dysfunction are associated with atherosclerosis on ras signaling pathway.
PubMedID- 22428603 A potential explanation is that, at hyperglycaemia and with higher triglyceride concentrations, atherosclerosis leads to endothelial dysfunction and, subsequently, to decreased production and increased degradation of no.
PubMedID- 24734153 Eventually endothelial dysfunction leads to atherosclerosis, a condition where artery walls become narrow due to the buildup of fatty materials, cholesterol, macrophages, cellular debris, and other substances.
PubMedID- 24607773 Aims: endothelin-1 contributes to endothelial dysfunction in patients with atherosclerosis and type 2 diabetes.
PubMedID- 20361178 endothelial dysfunction is associated with accelerated atherosclerosis and insulin resistance , providing another mechanism via which nefa promote cvd in type 2 diabetes mellitus.
PubMedID- 25464433 endothelial dysfunction is associated with atherosclerosis and independently predicts cve.
PubMedID- 21525484 Several alterations that are linked with the pathogenesis of atherosclerosis were reported in patients with nafld, including endothelial dysfunction, alterations of the coronary and carotid arteries, abnormal cardiac energy metabolism, and low-grade inflammation.
PubMedID- 22111033 These observations suggest that glp-1 might potentially improve endothelial dysfunction associated with atherosclerosis but not insulin resistance in patients with t2dm .

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