PedAM
Pediatric Disease Annotations & Medicines
| Disease | temporal lobe epilepsy |
| Symptom | |hippocampal sclerosis |
| Sentences | 142 |
| PubMedID- 22738717 | Grey-white matter abnormalities in temporal lobe epilepsy associated with hippocampal sclerosis: inter-observer analysis, histopathological findings, and correlation with clinical variables. |
| PubMedID- 23674488 | Both right and left temporal lobe epilepsy owing to hippocampal sclerosis have altered memory networks with a predominantly ipsilesional hemisphere reduction in activations during encoding. |
| PubMedID- 22340380 | Univariate analysis showed that medial temporal lobe epilepsy with hippocampal sclerosis, mri with visible focal lesions concordant with eeg, and regional ictal eeg and electrocorticography patterns were associated with a favorable surgical outcome. |
| PubMedID- 26552570 | Temporal pole abnormalities in temporal lobe epilepsy with hippocampal sclerosis: clinical significance and seizure outcome after surgery. |
| PubMedID- 22336897 | Antiepileptic drugs management and long-term seizure outcome in post surgical mesial temporal lobe epilepsy with hippocampal sclerosis. |
| PubMedID- 22220564 | Of 21 affected first-degree relatives: 8 of 21 had febrile seizures (fs), 4 had bects, 2 had epilepsy-aphasia spectrum disorder, one had temporal lobe epilepsy with hippocampal sclerosis, 2 had focal epilepsy of unknown cause, 2 had genetic generalized epilepsies, and 3 had miscellaneous. |
| PubMedID- 22535546 | Emerging evidence points to monocarboxylates as key players in the pathophysiology of temporal lobe epilepsy (tle) with hippocampal sclerosis (mesial temporal lobe epilepsy, mtle). |
| PubMedID- 23220462 | This study analyzes the hippocampal formation (hf) morphology of asymptomatic individuals (n = 30) and of patients with mesial temporal lobe epilepsy associated with hippocampal sclerosis (mtle-hs) (n = 68), patients with malformations of cortical development (mcd) (n = 34), or patients with pure morphological variations of hippocampal formation (pure mvhf) (n = 12). |
| PubMedID- 24095794 | Inflammation influences the pathogenesis of seizures by boosting neuronal degeneration of temporal lobe epilepsy with hippocampal sclerosis (tle-hs). |
| PubMedID- 21986136 | Selective upregulation of brain-derived neurotrophic factor (bdnf) transcripts and bdnf direct induction of activity independent n-methyl-d-aspartate currents in temporal lobe epilepsy patients with hippocampal sclerosis. |
| PubMedID- 25746582 | The aim of this article is to review and evaluate the published literature related to the outcome of the surgical treatment of mesial temporal lobe epilepsy (mtle) associated with hippocampal sclerosis (hs) and to describe the future prospects in this field. |
| PubMedID- 25752305 | Therefore, using a mouse model of temporal lobe epilepsy with hippocampal sclerosis, a closed-loop system and selective optogenetic manipulation of granule cells during seizures, we directly tested the dentate 'gate' hypothesis in vivo. |
| PubMedID- 22916181 | Although fs does not generally induce long-term brain damage or cognitive deficits, a relationship between a history of complex fs, especially prolonged fs, during early childhood and temporal lobe epilepsy with hippocampal sclerosis has been reported . |
| PubMedID- 22875126 | The best results after epilepsy surgery are seen in patients with a morphological substrate, particularly temporal lobe epilepsy associated with hippocampal sclerosis. |
| PubMedID- 20965234 | Cumulative evidence suggests that programmed cell death (apoptosis) may contribute to the progressive hippocampal sclerosis seen in patients with refractory mesial temporal lobe epilepsy (mtle). |
| PubMedID- 22925605 | Altered hemispheric symmetry found in left-sided mesial temporal lobe epilepsy with hippocampal sclerosis (mtle/hs) but not found in right-sided mtle/hs. |
| PubMedID- 25847342 | Temporopolar blurring in temporal lobe epilepsy with hippocampal sclerosis and long-term prognosis after epilepsy surgery. |
| PubMedID- 23150823 | Mesial temporal lobe epilepsy (mtle) associated with hippocampal sclerosis is highly refractory to clinical treatment. |
| PubMedID- 22794520 | Mesial temporal lobe epilepsy with hippocampal sclerosis in two pairs of identical twins. |
| PubMedID- 22957234 | The classification released by the ilae in 2010 recognizes some diagnostically meaningful forms of epilepsy such as mesial temporal lobe epilepsy (mtle) with hippocampal sclerosis (hs) that was not included in the previous classifications . |
| PubMedID- 23751308 | Major vault protein (mvp) gene polymorphisms and drug resistance in mesial temporal lobe epilepsy with hippocampal sclerosis. |
| PubMedID- 21112221 | Mesial temporal lobe epilepsy with hippocampal sclerosis: study of 42 children. |
| PubMedID- 20977472 | How frequent is the association of neurocysticercosis and mesial temporal lobe epilepsy with hippocampal sclerosis. |
| PubMedID- 25325201 | One of the most common and difficult to treat types of epilepsy is temporal lobe epilepsy (tle) which results from hippocampal sclerosis. |
| PubMedID- 22197033 | Purpose: applying a cross-sectional design, we set out to further characterize the significance of extrahippocampal brain atrophy in a large sample of 'sporadic' mesial temporal lobe epilepsy with hippocampal sclerosis (mtle+hs). |
| PubMedID- 25864570 | Objective: to examine antioxidative system in hippocampi of patients with mesial temporal lobe epilepsy associated with hippocampal sclerosis (mtle-hs). |
| PubMedID- 23955266 | Interestingly, both nfkb 1 and tnfalpha are strongly upregulated in the hippocampus of patients affected by temporal lobe epilepsy associated with hippocampal sclerosis, supporting the role of neuroinflammation in human epilepsy and the translational value of the molecular mechanisms activated by tmt in rodent hippocampus. |
| PubMedID- 21719429 | Previous studies have suggested that the upregulation of cx43 in medial temporal lobe epilepsy with hippocampal sclerosis may facilitate seizure propagation (fonseca et al., 2002; kielian, 2008). |
| PubMedID- 19948825 | Experimental neonatal status epilepticus and the development of temporal lobe epilepsy with unilateral hippocampal sclerosis. |
| PubMedID- 24977123 | The syndrome of medial temporal lobe epilepsy with hippocampal sclerosis (mtle with hs) is often resistant to aeds, and surgically remediable. |
| PubMedID- 26362370 | Genetic association study of the hla class ii alleles drb1, dqa1, and dqb1 in patients with pharmacoresistant temporal lobe epilepsy associated with mesial hippocampal sclerosis. |
| PubMedID- 19845729 | This model is a potential infection-driven model of mesial temporal lobe epilepsy with hippocampal sclerosis. |
| PubMedID- 25891932 | Purpose: granule cells pathology in dentate gyrus, have received considerable attention in terms of understanding the pathophysiology of temporal lobe epilepsy with hippocampal sclerosis. |
| PubMedID- 25809843 | Mesial temporal lobe epilepsy with hippocampal sclerosis is a network disorder with altered cortical hubs. |
| PubMedID- 22330313 | temporal lobe epilepsy (tle) with unilateral hippocampal sclerosis (hs) is associated with significant impairment of the formation and storage of long-term memories (squire, 1992). |
| PubMedID- 26119622 | Purpose: this study aimed to evaluate the diagnostic accuracy of the hamilton rating scale for depression (hrsd), the beck depression inventory (bdi), the hospital anxiety and depression scale (hads), and the hospital anxiety and depression scale-depression subscale (hads-d) as diagnostic tests for depressive disorder in drug-resistant mesial temporal lobe epilepsy with hippocampal sclerosis (mtle-hs). |
| PubMedID- 22953059 | Mesial temporal lobe epilepsy (mtle) associated with hippocampal sclerosis (mtle-hs), a condition that can be detected by modern magnetic resonance imaging (mri) techniques with a high sensitivity and specificity, is now the most common indication for epilepsy surgery. |
| PubMedID- 20012068 | In mesial temporal lobe epilepsy with hippocampal sclerosis, neuropathological ultrastructural evaluations suggest that reduced levels of aqp4 and dystrophin in perivascular foot-processes of astrocytes and reactive astrocytes may lead to perturbed water flux through astrocytes with impaired buffering of k+ and an increased propensity for seizures . |
| PubMedID- 24005737 | Mesial temporal lobe epilepsy with hippocampal sclerosis preceded by eclampsia: a rare association. |
| PubMedID- 22408626 | In human temporal lobe epilepsy with hippocampal sclerosis, the complements factors are expressed in both astrocytes, mature neurons and microglia, but particularly in microglia (aronica et al., 2007). |
| PubMedID- 21479101 | Less is known about whether neurogenesis and markers thereof are aberrantly expressed in human temporal lobe epilepsy (tle) with hippocampal sclerosis. |
| PubMedID- 21216629 | Thus, while surgical treatment of temporal lobe epilepsy with unilateral hippocampal sclerosis is still beneficial in older patients who are refractory to medical therapy, surgical treatment should be considered at as early an age as possible, to maximize the chance for a better outcome with fewer complications. |