PedAM
Pediatric Disease Annotations & Medicines
| Disease | schizophrenia |
| Symptom | |cognitive deficits |
| Sentences | 145 |
| PubMedID- 22957138 | The initial two-way ancova controlling for age and gender showed that the main effect of diagnosis was significant for all the seven cognitive factors (all p-values < 0.001), confirming the association of schizophrenia with pervasive neurocognitive deficits. |
| PubMedID- 24703529 | cognitive deficits in schizophrenia underlie more functional disability than any other symptom of the illness and existing treatments are largely inadequate. |
| PubMedID- 25139002 | Conclusion: altogether, these findings point to deficits in a specific thalamo-cortical circuitry in schizophrenia, which is associated with some cognitive deficits commonly reported in those patients. |
| PubMedID- 23637704 | In addition, this snp was also shown to have a potential association with the p300 endophenotype (decoster et al., 2012) and a significant association with cognitive deficits in patients with schizophrenia using a variety of tasks (green et al., 2012; cummings et al., 2013). |
| PubMedID- 23346419 | Npas, a bhlh transcription factor that is broadly expressed in the developing neuroepithelium, was identified as a risk factor for schizophrenia and associated with cognitive deficits in an affected mother and her daughter . |
| PubMedID- 26359226 | Rationale: new pharmacological treatments for the cognitive deficits in schizophrenia are needed. |
| PubMedID- 21167848 | Furthermore, these results may have implications for developing effective therapeutics for the cognitive deficits associated with schizophrenia because a large subset of patients with schizophrenia exhibit cognitive deficits that may be related to nmdar dysfunction and smoke at much higher rates than the healthy population, which may be an attempt to ameliorate cognitive deficits. |
| PubMedID- 20573264 | Background: cognitive deficits in schizophrenia are associated with psychosocial deficits that are primarily responsible for the poor long-term outcome of this disease. |
| PubMedID- 24885177 | Conclusions: these findings suggest that neurocognitive deficits predispose people with schizophrenia to worse psychiatric symptoms through the impairment of social cognition. |
| PubMedID- 22705396 | cognitive deficits in schizophrenia are critically important predictors of long-term psychosocial outcome and are not significantly ameliorated by currently available medications. |
| PubMedID- 20488434 | Translational animal models of cognitive deficits with relevance to schizophrenia are critical for gaining insights into the mechanisms underlying these impairments and developing more effective treatments. |
| PubMedID- 25510904 | Previous research has suggested that the pattern and severity of cognitive deficits in people with severe chronic schizophrenia is similar to that observed in behavioural variant frontotemporal dementia (bvftd). |
| PubMedID- 23027611 | cognitive deficits in schizophrenia severely compromise quality of life and are poorly controlled by current antipsychotics. |
| PubMedID- 20083164 | Based on nmda hypofunction hypothesis for negative symptoms and cognitive deficits in schizophrenia, mk-801-induced animal models of schizophrenia may help us understand the different effects between typical and atypical antipsychotics. |
| PubMedID- 21924537 | In this study, we examined antisaccade performance in patients and relatives, and sought to establish whether antisaccade measures could differentiate between two patients clusters identified in the western australian family study of schizophrenia with either pervasive cognitive deficits (cd) or cognitively spared (cs). |
| PubMedID- 21632647 | Objective: cognitive deficits in schizophrenia are associated with altered activity of the dorsolateral prefrontal cortex, which has been attributed to lower expression of the 67 kda isoform of glutamic acid decarboxylase (gad67), the major gamma-aminobutyric acid (gaba)-synthesizing enzyme. |
| PubMedID- 23251669 | Additionally, previous studies have demonstrated that structural and functional abnormalities in broca's area were associated with clinical symptoms and cognitive deficits in patients with schizophrenia, suggesting that deficits in this area may reflect the core pathology of schizophrenia. |
| PubMedID- 24345263 | Much of this literature has focused on animal models of neuropathology and cognitive deficits associated with schizophrenia and other human conditions. |
| PubMedID- 20571978 | Its activity against the cognitive deficits associated with schizophrenia has to be carefully investigated. |
| PubMedID- 25566009 | cognitive deficits in schizophrenia and other neuropsychiatric disorders: convergence of preclinical and clinical evidence. |
| PubMedID- 25827398 | Alpha7 nicotinic acetylcholine receptors (nachrs) have implications in the regulation of cognitive processes such as memory and attention and have been identified as a promising therapeutic target for the treatment of the cognitive deficits associated with schizophrenia and alzheimer's disease (ad). |
| PubMedID- 23161113 | cognitive deficits are prevalent in patients with schizophrenia (scz) and worsen with old age. |
| PubMedID- 24526625 | The etiologic and phenomenological complexity of neurocognitive deficits in schizophrenia may be better served by psychopharmacological agents that (i) target neurotransmitter systems proximal in the causal chain to neurocognitive deficits; (ii) enhance distal survival processes in the central nervous system-neurogenesis, neuronal growth, synaptogenesis, and connectivity; and (iii) counteract the negative effects of aberrant neurodevelopment in schizophrenia, such as neuroinflammation and oxidative stress. |
| PubMedID- 25804359 | These results suggest that tandospirone is a promising candidate for the treatment of cognitive deficits associated with schizophrenia and that adjunctive treatment with tandospirone and blonanserin is more appropriate for cognitive deficits than combination therapy with tandospirone and risperidone or haloperidol. |
| PubMedID- 20970118 | Background: cognitive deficits in schizophrenia may be related to glutamatergic dysfunction, but in vivo measurement of glutamate metabolism has been challenging. |
| PubMedID- 26159728 | None of the studies reviewed assessed the range of neurocognitive deficits associated with schizophrenia as outlined in the matrics consensus battery. |
| PubMedID- 26089815 | Oxt is likely to also contribute to the cognitive deficits associated with schizophrenia, such as impaired spatial memory and cognitive flexibility (3, 174). |
| PubMedID- 25432636 | Background: neurocognitive deficits in schizophrenia (sz) are established and the consortium on the genetics of schizophrenia (cogs) investigated such measures as endophenotypes in family-based (cogs-1) and case-control (cogs-2) studies. |
| PubMedID- 22565235 | cognitive deficits in schizophrenia have been hypothesized to be caused by altered synaptic transmission in circuits of the prefrontal cortex. |
| PubMedID- 21084390 | The alpha(7) nicotinic acetylcholine receptor (nachr) is a potential therapeutic target for the treatment of cognitive deficits associated with schizophrenia, alzheimer's disease, parkinson's disease, and attention-deficit/hyperactivity disorder. |
| PubMedID- 23785309 | To date, however, there has been limited success in clinical trials of treatments aiming to reverse cognitive deficits in patients with schizophrenia (javitt et al., 2012; keefe et al., 2013). |
| PubMedID- 24656901 | Cognitive remediation is the best available tool to treat cognitive deficits in schizophrenia and has evidence of biological validity; however results are still heterogeneous and significant predictors are lacking. |
| PubMedID- 20584553 | This study investigates whether social cognitive deficits found in patients with schizophrenia are specific to social threat stimuli, and whether the deficits increase across the delusion spectrum from a subclinical sample to clinical manifestation. |
| PubMedID- 25324619 | Background: cognitive remediation therapy (crt) is one of the promising new non-drug approaches to reducing cognitive deficits of patients with schizophrenia that has not yet been fully evaluated in china. |
| PubMedID- 19751542 | Background: it has become widely accepted that cognitive deficits in schizophrenia are related to functional outcome. |
| PubMedID- 24179465 | This compound is still under development for the treatment of ad and cognitive deficits associated with schizophrenia, but preliminary results in pharmacokinetic, safety, and tolerability profiles of abt-107 suggest that it is a good candidate for further development . |
| PubMedID- 23017655 | Social cognitive deficits in schizophrenia and their relationship to clinical and functional status. |
| PubMedID- 22038534 | The efficacy but not the motoric side effects of antipsychotics was enhanced, suggesting that adjunctive therapy of alpha7 nachr agonists not only could be useful for the treatment of cognitive deficits associated with schizophrenia but also could enhance the efficacy against positive symptoms. |
| PubMedID- 22654380 | This also holds true for mirtazapine which, in addition, showed favorable effects on cognitive deficits usually associated with schizophrenia in several rcts (stenberg et al., 2011). |
| PubMedID- 23430145 | cognitive deficits in schizophrenia are pervasive, severe, and largely independent of the positive and negative symptoms of the illness. |
| PubMedID- 23914162 | Based on the core cognitive deficits found in patients with schizophrenia seven cognitive domains were identified including working memory and attention/vigilance (green et al., 2004). |
| PubMedID- 22701481 | schizophrenia is associated with cognitive deficits . |
| PubMedID- 20705091 | cognitive deficits in schizophrenia remain an unmet clinical need. |
| PubMedID- 25109501 | Purpose: cognitive deficits in schizophrenia mainly affect memory, attention and executive functions. |
| PubMedID- 23623456 | We tested the hypothesis that right anterior insula modulation of central executive and default mode networks is disrupted in schizophrenia and associated with cognitive deficits. |