PedAM
Pediatric Disease Annotations & Medicines
| Disease | epilepsy |
| Symptom | |hippocampal sclerosis |
| Sentences | 147 |
| PubMedID- 20012068 | In mesial temporal lobe epilepsy with hippocampal sclerosis, neuropathological ultrastructural evaluations suggest that reduced levels of aqp4 and dystrophin in perivascular foot-processes of astrocytes and reactive astrocytes may lead to perturbed water flux through astrocytes with impaired buffering of k+ and an increased propensity for seizures . |
| PubMedID- 26464976 | Nevertheless, inflammation has been strongly implicated in prior studies of epilepsy associated with hippocampal sclerosis (ravizza et al., 2008), which is not considered to be an immune-mediated injury. |
| PubMedID- 23055516 | The largest presurgical/surgical group was mediotemporal lobe epilepsy with hippocampal sclerosis (29.5%/35.4%). |
| PubMedID- 24977123 | The syndrome of medial temporal lobe epilepsy with hippocampal sclerosis (mtle with hs) is often resistant to aeds, and surgically remediable. |
| PubMedID- 24358235 | In relation to the use of vpa as an anti-epileptic drug, the finding that dicer protein is reduced in temporal lobe epilepsy (tle) with hippocampal sclerosis is most interesting . |
| PubMedID- 22953059 | Mesial temporal lobe epilepsy (mtle) associated with hippocampal sclerosis (mtle-hs), a condition that can be detected by modern magnetic resonance imaging (mri) techniques with a high sensitivity and specificity, is now the most common indication for epilepsy surgery. |
| PubMedID- 24440288 | Mitochondrial dna profiling via genomic analysis in mesial temporal lobe epilepsy patients with hippocampal sclerosis. |
| PubMedID- 21719429 | Previous studies have suggested that the upregulation of cx43 in medial temporal lobe epilepsy with hippocampal sclerosis may facilitate seizure propagation (fonseca et al., 2002; kielian, 2008). |
| PubMedID- 23991095 | Mesial temporal lobe epilepsy (mtle) with hippocampal sclerosis is one of the most common forms of drug-resistant partial epilepsy in humans 1. |
| PubMedID- 25864570 | Objective: to examine antioxidative system in hippocampi of patients with mesial temporal lobe epilepsy associated with hippocampal sclerosis (mtle-hs). |
| PubMedID- 21099715 | Analysis of reoperation in mesial temporal lobe epilepsy with hippocampal sclerosis. |
| PubMedID- 24095794 | Inflammation influences the pathogenesis of seizures by boosting neuronal degeneration of temporal lobe epilepsy with hippocampal sclerosis (tle-hs). |
| PubMedID- 25752305 | Therefore, using a mouse model of temporal lobe epilepsy with hippocampal sclerosis, a closed-loop system and selective optogenetic manipulation of granule cells during seizures, we directly tested the dentate 'gate' hypothesis in vivo. |
| PubMedID- 25552301 | Here, through methylation analysis of all annotated c-phosphate-g islands and promoter regions in the human genome, we report a pilot study of the methylation profiles of temporal lobe epilepsy with or without hippocampal sclerosis. |
| PubMedID- 25809843 | Mesial temporal lobe epilepsy with hippocampal sclerosis is a network disorder with altered cortical hubs. |
| PubMedID- 20888264 | Doublecortin (dcx) immunoreactivity in hippocampus of chronic refractory temporal lobe epilepsy patients with hippocampal sclerosis. |
| PubMedID- 26277098 | Mesial temporal lobe epilepsy (mtle) with hippocampal sclerosis (hs) is the most common epilepsy syndrome in adults and is often associated with pharmacoresistance . |
| PubMedID- 23955266 | Interestingly, both nfkb 1 and tnfalpha are strongly upregulated in the hippocampus of patients affected by temporal lobe epilepsy associated with hippocampal sclerosis, supporting the role of neuroinflammation in human epilepsy and the translational value of the molecular mechanisms activated by tmt in rodent hippocampus. |
| PubMedID- 21986136 | Selective upregulation of brain-derived neurotrophic factor (bdnf) transcripts and bdnf direct induction of activity independent n-methyl-d-aspartate currents in temporal lobe epilepsy patients with hippocampal sclerosis. |
| PubMedID- 19845729 | This model is a potential infection-driven model of mesial temporal lobe epilepsy with hippocampal sclerosis. |
| PubMedID- 22925605 | Altered hemispheric symmetry found in left-sided mesial temporal lobe epilepsy with hippocampal sclerosis (mtle/hs) but not found in right-sided mtle/hs. |
| PubMedID- 23150823 | Mesial temporal lobe epilepsy (mtle) associated with hippocampal sclerosis is highly refractory to clinical treatment. |
| PubMedID- 23323167 | However, the postoperative seizure outcome is relatively limited when compared outcome with epilepsy associated with hippocampal sclerosis or tumor4,7,18). |
| PubMedID- 23751308 | Major vault protein (mvp) gene polymorphisms and drug resistance in mesial temporal lobe epilepsy with hippocampal sclerosis. |
| PubMedID- 23789488 | This patient experienced prolonged, repeated febrile seizures in infancy suggesting the epilepsy was linked with a hippocampal sclerosis. |
| PubMedID- 26256064 | The present study examined the relationship between residual discharges from the temporal neocortex postoperatively and seizure outcomes, in mesial temporal lobe epilepsy (mtle) patients with hippocampal sclerosis (hs) who were treated with selective amygdalohippocampectomy (selah). |
| PubMedID- 22794520 | Mesial temporal lobe epilepsy with hippocampal sclerosis in two pairs of identical twins. |
| PubMedID- 23220462 | This study analyzes the hippocampal formation (hf) morphology of asymptomatic individuals (n = 30) and of patients with mesial temporal lobe epilepsy associated with hippocampal sclerosis (mtle-hs) (n = 68), patients with malformations of cortical development (mcd) (n = 34), or patients with pure morphological variations of hippocampal formation (pure mvhf) (n = 12). |
| PubMedID- 21377331 | Introduction: diffusion tensor imaging (dti) techniques demonstrated diffuse bilateral temporal and extra-temporal abnormalities of white matter in patients presenting mesial temporal lobe epilepsy with hippocampal sclerosis (hs). |
| PubMedID- 21086221 | Heterotopia associated with hippocampal sclerosis: an under-recognized cause of early onset epilepsy in children operated on for temporal lobe epilepsy. |
| PubMedID- 23908665 | In genetic studies, homozygosity for the il-1β-511 allele 2, which is thought to be an inducer of il-1β, was overrepresented in temporal lobe epilepsy patients with hippocampal sclerosis when compared to control subjects18). |
| PubMedID- 22330313 | Temporal lobe epilepsy (tle) with unilateral hippocampal sclerosis (hs) is associated with significant impairment of the formation and storage of long-term memories (squire, 1992). |
| PubMedID- 21789691 | Those are (1) inflammatory processes which play an increasingly important role for the generation of temporal lobe epilepsy with hippocampal sclerosis (tle with hs), (2) disturbances of intrinsic properties of neuronal compartments, in particular acquired defects of ion channels of which those in dendrites are described here for tle with hs, (3) epigenetic effects, which affect for example the methylation of promoters and secondarily can change the expression of specific genes in tle with hs, and finally (4) the epileptogenesis of idiopathic epilepsies which are caused by inborn genetic alterations affecting mainly ion channels. |
| PubMedID- 22497612 | Defining clinico-neuropathological subtypes of mesial temporal lobe epilepsy with hippocampal sclerosis. |
| PubMedID- 25955498 | Interhemispheric microstructural connectivity in bitemporal lobe epilepsy with hippocampal sclerosis. |
| PubMedID- 24061200 | This was assessed in three cohorts of ethnically matched south indian ancestry: mesial temporal lobe epilepsy with hippocampal sclerosis (mtle-hs) (prototype of aed-resistant epilepsy syndrome), juvenile myoclonic epilepsy (prototype of aed-responsive epilepsy syndrome), and nonepilepsy controls. |
| PubMedID- 22520586 | Auras in temporal lobe epilepsy with hippocampal sclerosis: relation to seizure focus laterality and post surgical outcome. |
| PubMedID- 23674488 | Both right and left temporal lobe epilepsy owing to hippocampal sclerosis have altered memory networks with a predominantly ipsilesional hemisphere reduction in activations during encoding. |
| PubMedID- 24814212 | Our knowledge on temporal lobe epilepsy (tle) with hippocampal sclerosis has evolved towards the view that this syndrome affects widespread brain networks. |
| PubMedID- 23511251 | Enhanced sequential reaction time task performance in a rat model of mesial temporal lobe epilepsy with classic hippocampal sclerosis. |
| PubMedID- 22738717 | Grey-white matter abnormalities in temporal lobe epilepsy associated with hippocampal sclerosis: inter-observer analysis, histopathological findings, and correlation with clinical variables. |
| PubMedID- 23667120 | Early-onset right mesial temporal lobe epilepsy with hippocampal sclerosis is the key substrate determining a severe deficit in recognizing emotional facial expressions and decision-making. |
| PubMedID- 23875960 | Neuropsychological outcomes in epilepsy surgery patients with unilateral hippocampal sclerosis and good preoperative memory function. |
| PubMedID- 23153868 | Effect of patient sex on white matter alterations in unilateral medial temporal lobe epilepsy with hippocampal sclerosis assessed by diffusion tensor imaging. |
| PubMedID- 21245982 | In the present study, we investigated t lymphocyte infiltration in human hippocampi in four cases of epilepsy with hippocampal sclerosis, as well as in four control cases without neurological disease. |
| PubMedID- 21444904 | Objectives: the purpose of the study was to investigate the abnormalities of cortical lamination observed in temporal lobe specimens obtained during surgery for intractable temporal lobe epilepsy (tle) with hippocampal sclerosis. |
| PubMedID- 25934585 | Status epilepticus (se) is one of the recognized primary precipitating events that can lead to temporal lobe epilepsy (tle) associated with hippocampal sclerosis. |