PedAM
Pediatric Disease Annotations & Medicines
| Disease | vascular disease |
| Symptom | |endothelial dysfunction |
| Sentences | 96 |
| PubMedID- 24880668 | Therefore, the present findings support the importance of early correction or prevention of high cholesterol levels to disrupt the endothelial dysfunction process that leads to cardiovascular disease. |
| PubMedID- 25864450 | Additionally, the et-1 plasma levels might be related to a particular clinical course of ms. however, we did not find any statistically significant differences in the et-1 plasma levels between rrms patients and those with the other forms of ms. it could be speculated that, compared to other studies, lower disease activity and shorter duration of ms, and exclusion of patients with cardiovascular disease associated with endothelial dysfunction, including clinically ‘silent’ dyslipidemia, may have accounted for the plasma levels of et-1 found in this study. |
| PubMedID- 21196259 | Oxidative stress and endothelial dysfunction in cerebrovascular disease. |
| PubMedID- 25005182 | endothelial dysfunctions are associated with various cardiovascular diseases, including atherosclerosis, hypertension, myocardial infarction, and cardiovascular complications of diabetes. |
| PubMedID- 21625725 | Besides the important fact of releasing no mainly at the nos-side of action, noha also represents a potent inhibitor of arginases, making it an ideal therapeutic tool to treat cardiovascular diseases that are associated with endothelial dysfunction. |
| PubMedID- 20832948 | The cyclosporine a (csa) caused ccn and the ar caused renal injury after renal transplantation are both vascular diseases related with endothelial dysfunction, and up to now, there is still no effective method to distinguish the two kinds of diseases. |
| PubMedID- 21445895 | Background: inflammation is an independent risk factor of cardiovascular diseases and is associated with endothelial dysfunction. |
| PubMedID- 22548049 | Dm increases 2-3-fold the risk of cardiovascular disease (cvd), owing to the widespread endothelial dysfunction, which is considered the first step in the atherogenetic process . |
| PubMedID- 24842914 | endothelial dysfunction, the earliest indicator of the development of cardiovascular disease, is present in lupus. |
| PubMedID- 24475175 | Increased adiposity and obesity are the leading causes of arterial hypertension and atherosclerosis, the most prevalent cardiovascular diseases associated with endothelial dysfunction . |
| PubMedID- 25913171 | It has been suggested that olmesartan can improve neovascularization in myocardial ischemia , improve endothelial dysfunction in patients with various cardiovascular disease, promote the endothelium-dependent relaxation in hypertension patients , improve circulating endothelial progenitor cell number in type 2 diabetic patients , and even improve the vascular morphology of hypertension patients in stage i (the vios study) . |
| PubMedID- 20831049 | Value of endothelial dysfunction in cardiovascular diseases and methods of its correction with drugs. |
| PubMedID- 22145651 | Here we discuss whether epac1 represents an attractive therapeutic target for limiting endothelial dysfunction associated with cardiovascular diseases like atherosclerosis. |
| PubMedID- 21860794 | The aim of this study was to assess the relationship between fgf-23 and lvh using cmri in patients with ckd stages 3 and 4. we also assessed the effects of phosphate, fgf-23 and klotho on the expression of e-selectin and vcam in human endothelial umbilical vein cells (huvecs), as markers of endothelial dysfunction associated with accelerated cardiovascular disease in ckd . |
| PubMedID- 22689561 | endothelial dysfunction is tightly associated with cardiovascular disease, and improved understanding of ca(2+) entry pathways in these cells will have a significant impact on human health. |
| PubMedID- 22442118 | Taken together, we suggest that sal b may represent a potent candidate therapeutic for the treatment of cardiovascular diseases associated with endothelial dysfunction. |
| PubMedID- 24125483 | Aim: obese individuals have high aldosterone levels that may contribute to insulin resistance (ir) and endothelial dysfunction leading to obesity-induced cardiovascular disease. |
| PubMedID- 22978405 | Even in the absence of any detectable underlying condition or risk factor, an organic aetiology cannot be refuted as ed is known to share common endothelial dysfunction pathways with many vascular diseases and manifests 2–3 years beforehand to serve as an early warning of such diseases, particularly in men 45 years or younger . |
| PubMedID- 25463089 | The oxidative stress generated by these enzymes may induce endothelial dysfunction, leading to atherosclerosis, cardiovascular diseases and metabolic syndrome. |
| PubMedID- 20410832 | Furthermore, iptakalim has exerted protective effects against hypertensive damage to target organs in rats and improves endothelial dysfunction associated with cardiovascular diseases by selective activation of the sur2b/kir6.1 subtype of k(atp) channels expressed in the endothelium. |
| PubMedID- 23056429 | Background: in rat middle cerebral and mesenteric arteries the k(ca)2.3 component of endothelium-dependent hyperpolarization (edh) is lost following stimulation of thromboxane (tp) receptors, an effect that may contribute to the endothelial dysfunction associated with cardiovascular disease. |
| PubMedID- 26539255 | Recent studies have shown that hyperuricemia characterized by high serum uric acid level was associated with hypertension, gout, systemic inflammation, and cardiovascular disease mediated because of endothelial dysfunction and pathologic vascular remodeling . |
| PubMedID- 25108154 | Adipose and endothelial dysfunction is tightly associated with cardiovascular diseases in obesity and insulin resistance. |
| PubMedID- 25895347 | endothelial dysfunction underlies the development of many cardiovascular diseases. |
| PubMedID- 25728053 | Background: endothelial dysfunction is a marker of future cardiovascular disease (cvd) risk, yet epidemiological studies have yielded inconsistent results. |
| PubMedID- 22648973 | Therefore, administration of bh4 is considered a promising therapy for cardiovascular diseases associated with endothelial dysfunction and oxidative stress. |
| PubMedID- 24634835 | Uncoupling of enos has been related to different cardiovascular diseases that concur with endothelial dysfunction such as atherosclerosis, hypertension, hypercholesterolemia or diabetes . |
| PubMedID- 21860589 | These results indicate that cle augments no production on endothelium through inhibition of arginase activity, and may imply their usefulness for the treatment of cardiovascular diseases associated with endothelial dysfunction. |
| PubMedID- 26367737 | Objective: endothelial dysfunction associated with many cardiovascular diseases is largely due to reduced nitric oxide (no) derived from endothelial no synthase (enos). |
| PubMedID- 20169119 | endothelial dysfunction increases cardiovascular disease risk in chronic kidney disease (ckd). |
| PubMedID- 23863812 | The endothelial dysfunction associated with cardiovascular diseases may contribute to insulin resistance and the pathophysiology of diabetes and its vascular complications (3). |
| PubMedID- 23984350 | A relation between cardiovascular diseases which are associated with endothelial dysfunction and migraine has been found . |
| PubMedID- 23856194 | The findings might be of clinical significance, as endothelial dysfunction that could lead to cardiovascular disease is preventable, and quercetin is a natural compound found in various plants and fruits. |
| PubMedID- 24491900 | It is widely accepted that endothelial dysfunction is the basis of the development of cardiovascular diseases, including hypertension. |
| PubMedID- 22287576 | Aims: vascular disease states are associated with endothelial dysfunction and increased production of reactive oxygen species derived from nadph oxidases. |
| PubMedID- 25890359 | Moreover, aa appears to increase the no bioavailability and alleviate endothelial dysfunction in patients with cardiovascular disease . |
| PubMedID- 23059132 | Oxidative reactions catalyzed by subendothelial-localized mpo are implicated as a cause of endothelial dysfunction in vascular disease. |
| PubMedID- 25247304 | The present study may provide a new insight into the protective properties of let-7a and let-7b in preventing the endothelial dysfunction associated with cardiovascular disease, such as atherosclerosis. |
| PubMedID- 19962451 | Asymmetric dimethylarginine (adma), a known cardiovascular risk factor, has been linked to endothelial dysfunction and the pathogenesis of a number of cardiovascular diseases. |
| PubMedID- 21117311 | endothelial dysfunction associated with different cardiovascular diseases is related to the local formation of reactive oxygen/nitrogen species, mainly peroxynitrite that is produced in a rapid reaction between nitric oxide and superoxide anion. |
| PubMedID- 24091673 | Adma is an endogenous inhibitor of nitric oxide synthase, which is elevated in cardiovascular diseases and associated with endothelial dysfunction.24 adma has been reported to induce apoptosis in human umbilical vein endothelial cells (huvecs),25 and elicit significant changes in coronary artery endothelial cell gene expression.12 adma is also a structural analog of metformin, and they have opposite functions in multiple metabolic and signaling pathways that coordinate energy metabolism, cell growth, and molecule synthesis.26 metformin treatment was reported to lower adma levels in patients with type 2 diabetes.27 given the preventive effect of metformin against various cancers,28, 29, 30, 31 adma may also play important roles in cancer development. |
| PubMedID- 20482882 | This finding seems to be related only to the apoe-deficient mouse because it is well known that in other models of cardiovascular diseases estrogen deficiency leads to endothelial dysfunction . |
| PubMedID- 26293469 | Conclusions: these results indicate that ptb1 is essential for regulating enos expression at post-transcriptional levels and suggest a novel therapeutic target for treatment of vascular diseases associated with inflammatory endothelial dysfunction. |
| PubMedID- 26265320 | Thus, arginase inhibitors may help treat vascular diseases associated with endothelial dysfunction. |
| PubMedID- 26221610 | It is interesting to determine whether the endothelial dysfunction associated with cardiovascular disease is also associated with altered endothelial mir-223 levels. |
| PubMedID- 21933910 | Aims: hyperhomocysteinaemia is an independent risk factor for atherosclerotic vascular disease and is associated with vascular endothelial dysfunction. |
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