PedAM
Pediatric Disease Annotations & Medicines
| Disease | schizophrenia |
| Symptom | |cognitive deficits |
| Sentences | 145 |
| PubMedID- 24047425 | Objective: the course of neurocognitive deficits in schizophrenia has not yet been established. |
| PubMedID- 22982201 | Mood congruent psychotic symptoms and specific cognitive deficits in carriers of the novel schizophrenia risk variant at mir-137. |
| PubMedID- 24391807 | The temporal gray matter volume abnormalities found in our study likely contributes to cognitive deficits in patients with untreated schizophrenia as reported in the literature. |
| PubMedID- 22669170 | Among the cognitive deficits observed in patients with schizophrenia, recent work has indicated abnormalities in multisensory integration, a process that is important for the formation of comprehensive environmental percepts and for the appropriate guidance of behavior. |
| PubMedID- 24288608 | cognitive deficits in schizophrenia can massively impact functionality and quality of life, furthering the importance of cognitive training. |
| PubMedID- 23847557 | An impressive number of studies have actually shown that the development of schizophrenia may be associated with these cognitive deficits and that these cognitive deficits could be stage-specific (heaton et al., 1994; niendam et al., 2006; fusar-poli et al., 2007; lysaker et al., 2007; langdon and ward, 2008; picard et al., 2009; barlati et al., 2012). |
| PubMedID- 21808609 | The cognitive deficits associated with schizophrenia are commonly believed to arise from the abnormal temporal integration of information, however a quantitative approach to assess network coordination is lacking. |
| PubMedID- 22666197 | Recent research suggests that the cerebral correlates of cognitive deficits in schizophrenia are nested in the activity of widespread, inter-regional networks rather than being restricted to any specific brain location. |
| PubMedID- 24583905 | To date, many studies have suggested that cognitive deficits in patients with schizophrenia are stable over time, regardless of symptomatic fluctuations.34 a meta-analysis of 53 longitudinal studies found that patients with schizophrenia show significant improvements in most cognitive tasks,35 although they may not improve with time as much as controls.36 however, previous studies tend not to focus on general population samples and usually do not follow up patients over periods as long as the 9-year follow-up employed in our study. |
| PubMedID- 24396009 | Results suggest that vulnerability for schizophrenia is associated with neurocognitive deficits in tom and the degree of deficit is related to day-to-day social functioning. |
| PubMedID- 23591167 | Swm may be an important neurobiological substrate of cognitive performance and a novel cortical treatment target for cognitive deficits in schizophrenia patients. |
| PubMedID- 26233432 | Smaller than expected cognitive deficits in schizophrenia patients from the population-representative abc catchment cohort. |
| PubMedID- 23034345 | Conclusions: our results support the use of a six-factor model and suggest that the cognitive factor could be a valid measure of cognitive deficits in schizophrenia, although the use of a standard neuropsychological battery is advisable. |
| PubMedID- 24747179 | cognitive deficits in schizophrenia (sz) reflect maturational disruptions within a neural system that includes the ventral hippocampus (vh), nucleus accumbens (nac), basal forebrain, and prefrontal cortex (pfc). |
| PubMedID- 22355184 | Because gamma-band synchrony is thought to be crucial for cognition, cognitive deficits in schizophrenia may reflect pv neuron dysfunction in cortical neural circuits. |
| PubMedID- 23115554 | Cannabis use characterizes a subgroup of schizophrenia patients with less cognitive deficits. |
| PubMedID- 21798517 | Although animal models have captured negative symptoms and cognitive deficits associated with schizophrenia, none have addressed these defining, positive symptoms. |
| PubMedID- 26106146 | Dysregulation of d1r has been related to cognitive deficits in schizophrenia, and there is a need for new, lower-affinity d1r agonists that may better mimic endogenous da to enhance mental representations and improve cognition. |
| PubMedID- 25379239 | Finally, the literature has supported the notion that the cognitive deficits associated with schizophrenia are not accounted for by clinical symptomatology, such as psychosis , and are stable characteristics of individuals affected by the disorder or who carry substantial genetic liability for the condition. |
| PubMedID- 21833224 | Furthermore, heinrichs (2007) concludes that cognitive deficits in patients with schizophrenia appear for the most part unresponsive to antipsychotic medication and this regardless of the type of drug. |
| PubMedID- 21779401 | A behavioural procedure to potentially model cognitive deficits associated with schizophrenia concerns the use of mk-801 during extinction of a learned response. |
| PubMedID- 24050963 | The importance of cognitive deficits in schizophrenia is emphasized by reports indicating that the severity of cognitive deficits is predictive of treatment compliance, adherence, and risk of relapse among first-episode individuals. |
| PubMedID- 22745912 | Due to cognitive deficits, individuals with schizophrenia often struggle to transport skills and lessons from the treatment environment to their day-to-day lives . |
| PubMedID- 24365456 | While an association has been reported between metabolic disturbance and cognitive deficits, including speed of processing deficits, in schizophrenia (meyer et al.2005; lindenmayer et al.2012), further investigation of possible bidirectionality is warranted in psychotic illness where cognitive impairment antedates the onset of metabolic disorders. |
| PubMedID- 24391602 | Furthermore, chronic cannabis use has been associated with gray matter volume changes and cognitive deficits reminiscent of those in schizophrenia (144–147). |
| PubMedID- 21904685 | Therefore, cognitive deficits in schizophrenia may result from a gaba synapse dysfunction that disturbs neural synchrony. |
| PubMedID- 20701825 | Classical antipsychotic drugs to treat negative symptoms and cognitive deficits in schizophrenia appears related to their ability to enhance mesocortical dopamine (da) function. |
| PubMedID- 23995185 | Background: cognitive deficits in schizophrenia are regarded by many psychiatrist as an important symptom, which requires appropriate treatment and rehabilitation. |
| PubMedID- 20889653 | Objective: certain cognitive deficits in individuals with schizophrenia have been linked to disturbed gamma-aminobutyric acid (gaba) and glutamate neurotrans-mission in the prefrontal cortex. |
| PubMedID- 20544314 | Thus, modeling cognitive deficits associated with schizophrenia in animals is generally believed to be a very useful strategy, and substantial effort is being expended to refine existing animal tests and develop novel ones that have validity for domains of cognitive performance identified by matrics . |
| PubMedID- 21555247 | This article focuses on cognitive deficits associated with schizophrenia to illustrate: a) how non-invasive eeg biomarkers of cognitive function constitute such a 'higher level correlate' of underlying pathologies. |
| PubMedID- 20048021 | Objective: premorbid cognitive deficits in schizophrenia are well documented and have been interpreted as supporting a neurodevelopmental etiological model. |
| PubMedID- 23847468 | cognitive deficits in individuals with schizophrenia (scz) are considered core symptoms of this disorder, and can manifest at the prodromal stage. |
| PubMedID- 25774979 | Symptoms of anxiety in schizophrenia are associated with cognitive deficits, a greater risk of relapse, poorer quality of life, and an increased risk of suicide 6. |
| PubMedID- 24919170 | cognitive deficits in schizophrenia are important predictors of impairment in most functional domains and are a critical therapeutic target. |
| PubMedID- 21669462 | schizophrenia is associated with many neurocognitive deficits, some of which are improved by nicotine and cigarette smoking. |
| PubMedID- 20195566 | Standards for the reliable evaluation of neurocognitive deficits in schizophrenia have been put forward by the matrics initiative (measurement and treatment research to improve cognition in schizophrenia). |
| PubMedID- 24726270 | Social cognitive deficits in schizophrenia are well documented and related to functional outcome. |
| PubMedID- 20195567 | cognitive deficits in schizophrenia are a clinically relevant symptom dimension and one of the best predictors for functional outcome. |
| PubMedID- 23769891 | Furthermore, cognitive deficits in schizophrenia appear well before the onset of psychosis and have been reported to be present during early childhood and even during the first year of life. |
| PubMedID- 19732482 | Background: cognitive deficits in schizophrenia are well established and are known to be present during the first episode of a psychotic disorder. |
| PubMedID- 24847231 | Among the core cognitive deficits observed in patients with schizophrenia are disruptions in behavioral flexibility (pantelis et al., 1999; brown et al., 2009; leeson et al., 2009) which are also seen after mia in the male, but not female, offspring of rats (zuckerman and weiner, 2005; zhang et al., 2012; savanthrapadian et al., 2013). |
| PubMedID- 22708598 | Cortical circuit dysfunction and cognitive deficits in schizophrenia--implications for preemptive interventions. |
| PubMedID- 25679135 | To test the veracity of the ketamine model further, research is attempting to replicate a range of cognitive deficits associated with schizophrenia in healthy controls under the influence of ketamine. |
| PubMedID- 26121151 | Studies are detailed that find greater levels of these impairments, defined as metacognitive deficits, in persons with schizophrenia in both early and later phases of illness as compared with other clinical and community groups. |
| PubMedID- 25103208 | It is not clear whether cognitive deficits associated with schizophrenia remain as strong predictors of function in older and younger individuals. |
| PubMedID- 26169626 | Background: although cognitive deficits in patients with schizophrenia are rooted early in development, the impact of psychosis on the course of cognitive functioning remains unclear. |
| PubMedID- 23818944 | Deficits in executive function and sustained attention are two well-studied neurocognitive deficits in patients with schizophrenia, which are robustly linked to the genetic predisposition for schizophrenia . |
| PubMedID- 24179753 | schizophrenia (sz) is associated with cognitive deficits that represent a core feature of the disorder and are primary predictors of impaired long-term functional outcome. |
| PubMedID- 23322976 | The pathophysiology underlying the cognitive deficits often associated with schizophrenia may be distinct from that causing some of the core clinical features (3). |