PedAM
Pediatric Disease Annotations & Medicines
| Disease | prostate cancer |
| Symptom | |bone metastasis |
| Sentences | 83 |
| PubMedID- 20360964 | Because of the low levels of bone metastasis with prostate cancer models , techniques for direct injection into bone have been established –. |
| PubMedID- 21502970 | The purpose of this study was to identify the early predictor of survival for prostate cancer patients with bone metastasis. |
| PubMedID- 21350583 | It also exhibits efficacy in inhibiting bone metastasis of prostate cancer . |
| PubMedID- 24115186 | Increased expression of putative cancer stem cell markers in the bone marrow of prostate cancer patients is associated with bone metastasis progression. |
| PubMedID- 23951432 | Denosumab delays bone metastasis in prostate cancer. |
| PubMedID- 24435407 | Background and objective: advanced prostate cancer patients with bone metastasis are predisposed to skeletal complications termed skeletal-related events (sres). |
| PubMedID- 25469306 | Palliative effects and adverse events of strontium-89 for prostate cancer patients with bone metastasis. |
| PubMedID- 21083514 | Zoledronic acid therapy impacts risk and frequency of skeletal complications and follow-up duration in prostate cancer patients with bone metastasis. |
| PubMedID- 26103516 | Furthermore, considering that a reduced bone matrix is found in patients suffering from breast and prostate cancers treated with hormonal therapies, bone metastasis grows into a compartment bone that is itself already weakened . |
| PubMedID- 22025955 | This antibody was also found to restrict lung metastasis in murine b16 melanoma and bone metastasis of human prostate cancer in the murine model . |
| PubMedID- 23912936 | We conducted a phase ii study to investigate the benefits of combined zoledronic acid and androgen deprivation therapy in treatment-naive prostate cancer with bone metastasis. |
| PubMedID- 22190971 | In the context of tumor immunology, expression of etar has been reported in prostate cancer patients with bone metastasis and hpv-induced neoplasia , whereas etbr expression was associated with the absence of tumor infiltrating lymphocytes and decreased survival time of ovarian cancer patients . |
| PubMedID- 23476138 | However, prolonged androgen ablation therapy results in relapse and androgen independent prostate cancer progression with bone metastasis. |
| PubMedID- 20616956 | The endothelins bind to two receptors, endothelin-a and endothelin-b, and play a major role in tumor growth, proliferation, apoptosis, angiogenesis, and bone metastasis.67 patients with metastatic prostate cancer have elevated levels of plasma endothelin-1 compared with patients with organ-confined cancer. |
| PubMedID- 23478119 | Background: there is no general consensus on the optimal criteria for the application of bone scintigraphy in screening of bone metastasis in patients with prostate cancer. |
| PubMedID- 23327798 | Approximately 20% of prostate cancer patients with bone metastasis are treated for pathologic fractures. |
| PubMedID- 26328198 | Due to their efficient osteoclastic inhibitor effect in bone metabolism and antiangiogenic activity, bisphosphonates are widely used in many cancer diseases particularly in prostate cancers with bone metastasis, lung cancer, breast cancer and multiple myeloma, as well as in systemic diseases such as osteoporosis, osteopenia, paget disease and osteogenesis imperfect for the last 13 years. |
| PubMedID- 26157761 | Predictors of survival in prostate cancer patients with bone metastasis and extremely high prostate-specific antigen levels. |
| PubMedID- 26451085 | Comparative efficacy, tolerability, and survival outcomes of various radiopharmaceuticals in castration-resistant prostate cancer with bone metastasis: a meta-analysis of randomized controlled trials. |
| PubMedID- 20493451 | How to manage bone metastasis in prostate cancer. |
| PubMedID- 22093187 | Interpretation: this large randomised study shows that targeting of the bone microenvironment can delay bone metastasis in men with prostate cancer. |
| PubMedID- 23359820 | Using a cell line from bone metastasis of prostate cancer (pc3), we analyzed how prostate cancer cells migrate in a physiologically relevant 3d matrigel. |
| PubMedID- 25071888 | Various single or multi-modality therapeutic options are available to treat pain of bone metastasis in patients with prostate cancer. |
| PubMedID- 23530598 | In this retrospective study, we aimed to evaluate the association of four polymorphisms in three ld blocks of the igf-1 on the survival of prostate cancer patients with bone metastasis at initial diagnosis. |
| PubMedID- 25609920 | Pc3 cells were obtained from a patient with a bone metastasis of grade iv prostate cancer and showed a higher metastatic potential compared to du145 cells, and did not respond to androgens, glucocorticoids, or epidermal or fibroblast growth factors.71 the significantly different cytogenetic characteristics of pc-3 and du145 cells may be another contributing factor.72,73 pc-3 cells have a unique karyotype in the absence of chromosomes 2, 3, 5, 15, and y.74 the centromere 8 copy number was substantially different between pc-3 and du145 cells.75 the copy number of centromere 8 with the highest observed frequency was two (79.4%) in pc-3 cells and three (70.%) in du145 cells.75 a recent study indicated that du145 cells have no detectable autophagy upon treatment with a known autophagic inducer, valproic acid, indicating a defect of autophagy in this cell line.76 in addition, the different batches and passages of cells used for separate experiments might also contribute to the different responses to plb treatment as well. |
| PubMedID- 24127064 | In this study, we examined the tumoricidal and pain-relief effects of sr-89 on prostate cancer with bone metastasis as well as survival. |
| PubMedID- 24626126 | Recent findings: trial data indicate that sres occur in half of prostate cancer patients with bone metastasis in the absence of treatment, and 30-45% among those who receive bone-modifying agents. |
| PubMedID- 22037741 | The levels of these markers were higher in prostate cancer patients with bone metastasis. |
| PubMedID- 23951518 | Cyclophosphamide promotes bone metastasis in prostate cancer. |
| PubMedID- 22405133 | The chemokine cxcl12 and c-x-c chemokine receptor 4 (cxcr4), to which it binds, form an axis that is a key molecular interaction between hscs and the bone niche , and is also engaged in bone metastasis of prostate cancer . |
| PubMedID- 23536580 | bone metastasis in patient with advanced-stage prostate cancer, the most commonly diagnosed malignancy in western countries, increases the risk of intractable bone pain. |
| PubMedID- 22194926 | To evaluate whether this happens only in lncap or lncap-derived cell lines, we similarly treated vcap cells, which are derived from a xenograft bone metastasis of human prostate cancer. |
| PubMedID- 21403668 | bone metastasis was associated with mortality among prostate cancer patients. |
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