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PedAM

Pediatric Disease Annotations & Medicines




Disease lymphocytic choriomeningitis
Symptom |infection
Sentences 84
PubMedID- 22496215 Mice deficient in stat1 but not stat2 or irf9 develop a lethal cd4+ t-cell-mediated disease following infection with lymphocytic choriomeningitis virus.
PubMedID- 26289159 Here, we show that low-dose infection with lymphocytic choriomeningitis virus (lcmv) caused rapid, transient inflammatory monocytosis that required type i interferon (ifn) and toll-like receptor (tlr) 7 signaling.
PubMedID- 24146739 In this study, we show that infection of mice with lymphocytic choriomeningitis virus we (lcmv we) leads to increased plasma levels of fgl2, which were detected as early as 2 days post-infection (pi) and persisted until day 50 pi.
PubMedID- 23190531 Stx11-deficient mice exhibited severely reduced degranulation and cytolytic activity of ctl and nk cells and developed all clinical symptoms of hemophagocytic lymphohistiocytosis (hlh) after infection with lymphocytic choriomeningitis virus (lcmv).
PubMedID- 26279441 Methods: we analyzed in a mouse model, whether pseudomonas aeruginosa control is influenced by co-infection with the lymphocytic choriomeningitis virus (lcmv).
PubMedID- 21533073 A recent study demonstrated that infection of mice with lymphocytic choriomeningitis virus reprogrammed otherwise stably committed th2 cells to adopt an il-4+ifnγ+ “th2+1” phenotype that was maintained in vivo for months .
PubMedID- 23232398 Rather than being solely expressed in their specific lineage, t-bet and gata3 are co-expressed in human th1 cells polarized in vitro11293031 and in mouse t cells after infection in vivo with lymphocytic choriomeningitis virus32.
PubMedID- 20507777 Human infection with lymphocytic choriomeningitis virus.
PubMedID- 22590468 Subsequent experiments showed that upon infection with lymphocytic choriomeningitis virus (lcmv), the generation of virus-specific ctl was reduced by 60–90% (kundig et al., 1993; cousens et al., 1995).
PubMedID- 24795715 The pearl mouse model of hps2, upon infection with lymphocytic choriomeningitis virus, developed all the key features of the disease, which yet was only transient (82).
PubMedID- 20485501 So far, this phenomenon has been only documented after infection with lymphocytic choriomeningitis viruses or dengue virus .
PubMedID- 22216280 The massive activation of cross-reactive b cells during acute secondary disease could result in a competition for t cell help at the expense of new neutralizing b cells, as has been shown in a mouse model of infection with lymphocytic choriomeningitis virus .
PubMedID- 20974245 We examined the effects of chronic social stress on virus-specific ctl responses in mice after infection with lymphocytic choriomeningitis virus (lcmv).
PubMedID- 24466045 To address this issue in a controlled study, we used a mouse model of viral hepatitis induced by infection with lymphocytic choriomeningitis virus (lcmv) of the strain we.
PubMedID- 24990517 Furthermore, infection with lymphocytic choriomeningitis virus strain we led to loss of tolerance suggesting that tolerance could be overcome by infection.
PubMedID- 21828218 The studies reported here evaluated nk cell responses following infections with lymphocytic choriomeningitis virus (lcmv) in the compartment handling the earliest events after infection, the peritoneal cavity.
PubMedID- 22305620 We have developed an in vivo model to study the various stages of wasting following infection of mice with lymphocytic choriomeningitis virus cl-13.
PubMedID- 23424063 Interestingly, during chronic infection with lymphocytic choriomeningitis virus (lcmv), so called exhausted t cells, lacking the capacity for prolonged proliferation in response to antigen, show increased eomes, and lower tbet expression than their proliferation competent predecessors (paley et al., 2012).
PubMedID- 23637417 Using il-21 receptor-deficient (il-21r(-/-)) mice, we found that virus-specific cd4 t cells were generated after infection with lymphocytic choriomeningitis virus (lcmv) and that these cd4 t cells differentiated into t follicular helper (tfh)-like cells in the absence of il-21 signaling.
PubMedID- 22648263 He demonstrated that chronic, but not acute, infection of mice with lymphocytic choriomeningitis virus results in a marked expansion of foxp3(+) t reg, which is dependent on retroviral superantigen (sag) genes encoded in the mouse genome.
PubMedID- 20457902 Here, we show that mice lacking t cell factor 1 (tcf-1), a nuclear effector of the canonical wingless/integration 1 (wnt) signaling pathway, mount normal effector and effector memory cd8 t cell responses to infection with lymphocytic choriomeningitis virus (lcmv).
PubMedID- 21321220 Here we show that chronic, but not acute, infection of mice with lymphocytic choriomeningitis virus results in a marked expansion of foxp3(+) treg that is dependent on retroviral superantigen (sag) genes encoded in the mouse genome.
PubMedID- 24586147 In addition, th1-derived production of the pro-inflammatory cytokine il-21 has also been shown to be a key regulator of the long-term maintenance and functionality of antigen-specific ctls important for protection against both acute and chronic infection with lymphocytic choriomeningitis virus (lcmv) –.
PubMedID- 23874808 Moreover, tnf has been shown to be critical in enhancing the cd8 t cell response to weak tumor antigens, but is less important in the cd8 t cell response in a more robust acute viral infection model with lymphocytic choriomeningitis virus (lcmv) armstrong 6.
PubMedID- 22363608 In this study, we show that pcd40l is present in th1 and follicular helper t cells developed during infection with lymphocytic choriomeningitis virus, th2 cells in the airway of asthmatic mice, and th17 cells from the cns of animals with experimental autoimmune encephalitis (eae).
PubMedID- 20370926 (2007) report down-regulation of egr1 and egr2 after infection with the lymphocytic choriomeningitis virus (lcmv) in a monkey model .
PubMedID- 20096607 After infection of mice with lymphocytic choriomeningitis virus, il-2ralpha-deficient effector cd8(+) t cells expressed more bcl6 but less perforin and granzyme b, formed fewer klrg-1(+) and t-bet-expressing ctl, and killed poorly.
PubMedID- 25017980 Background: infection with the lymphocytic choriomeningitis virus is a human zoonosis caused by a rodent-borne arenavirus and is often seen in autumn and winter when mice retreat into houses.
PubMedID- 25744061 Here, using a mouse model of chronic infection with lymphocytic choriomeningitis virus (lcmv), we found that vinegar-processed flowers (flos) of daphne genkwa (vp-genkwa), which was composed mainly of four index components, restored exhausted cd4(+) and cd8(+) t cells significantly, as corroborated by evidence that vp-genkwa treatment enhanced functional lcmv-specific cd4(+) and cd8(+) t cells, both quantitatively and qualitatively.
PubMedID- 23381109 After in vivo infection with the lymphocytic choriomeningitis virus (lcmv), which induces a potent cd8+ t cell response, nude bmt+pret recipients produced much more cd4+ t cells and cd8+ t cells than nude bmt alone controls.
PubMedID- 25066419 To accomplish this goal, we used in vivo staining of klrg-1, lamp-1 (cd107a) and lamp-2 (cd107b) proteins to distinguish between mpecs and slecs in vivo while simultaneously measuring their degranulation potential during murine infection with lymphocytic choriomeningitis virus (lcmv).
PubMedID- 25954270 I use allometric scaling theory to interpret observed quantitative differences in the infection dynamics of lymphocytic choriomeningitis virus (lcmv) in mice (mus musculus), simian immunodeficiency virus (siv) in rhesus macaques (macaca mulatta) and human immunodeficiency virus (hiv) in humans.
PubMedID- 20881186 We analyzed the immunoproteasome expression in the brain after an infection with lymphocytic choriomeningitis virus (lcmv) and could show that lcmv-infection of mice leads to the transcriptional induction of inducible proteasome subunits in the brain.
PubMedID- 25807057 In contrast, the levels of type i interferons (ifn) produced by plasmacytoid dc in the spleen upon infection with lymphocytic choriomeningitis virus were found to be diminished in cd45-/- mice .

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