PedAM
Pediatric Disease Annotations & Medicines
| Disease | constipation |
| Symptom | |irritable bowel syndrome |
| Sentences | 56 |
| PubMedID- 21446888 | Introduction: linaclotide is a novel intestinal secretagogue that is in the advanced stages of development for the treatment of irritable bowel syndrome with constipation (ibs-c) and chronic constipation. |
| PubMedID- PMC4350137 | We conclude that visceral hypersensitivity is likely to be a primary cause of constipation in rats with irritable bowel syndrome with constipation. |
| PubMedID- 23464519 | irritable bowel syndrome with constipation (ibs-c) and chronic idiopathic constipation (cic) are highly prevalent gastrointestinal disorders associated with health, economical and social problems. |
| PubMedID- 23198977 | Objectives: the aims were: firstly, to review the definition and diagnosis of irritable bowel syndrome with constipation (ibs-c, a subtype of ibs); secondly, to critically assess current therapies for ibs-c with a focus on effectiveness for abdominal pain; and thirdly, to review clinical studies evaluating the efficacy of linaclotide, a therapy recently approved by the us food and drug administration for the treatment of adults with ibs-c and chronic idiopathic constipation and the european medicines agency for the symptomatic treatment of moderate to severe ibs-c in adults, and in development for treatment of ibs-c worldwide. |
| PubMedID- 24351035 | Effect of linaclotide in irritable bowel syndrome with constipation (ibs-c): a systematic review and meta-analysis. |
| PubMedID- 21303430 | The aim of this work was to perform a dose-finding study for lubiprostone for the treatment of constipation with or without irritable bowel syndrome (ibs) in japan. |
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