PedAM
Pediatric Disease Annotations & Medicines
| Disease | breast cancer |
| Symptom | |bone metastasis |
| Sentences | 98 |
| PubMedID- 23516466 | Similar results have been reported in breast cancer with osteolytic bone metastasis. |
| PubMedID- 23045282 | The skeleton is the most common metastatic site for breast cancer, with bone metastasis causing pain as well as risk of pathological fractures. |
| PubMedID- 25289111 | A previous study has shown that anxa9 expression is associated with bone metastasis in breast cancer, whereas its significance in colorectal cancer (crc) is unknown. |
| PubMedID- 22479425 | This phosphorylation is also required for inducing bone metastasis of breast cancer cells in nude mice , and it appears to be involved in bacterial invasion of cells, such as for the adhesion of enteropathogenic escherichia coli (epec) . |
| PubMedID- 19921245 | Importance of the development time of isolated bone metastasis in breast cancer. |
| PubMedID- 23411961 | A case of recurrent breast cancer with multiple bone metastasis successfully treated with s-1 and zoledronic acid therapy. |
| PubMedID- 23822995 | Contrary to this, a larger clinical study that examined the relationship between pthrp production and bone metastasis in patients with operable breast cancer revealed that patients with pthrp positive tumours had significantly improved survival rate with less metastases to bone than patients with pthrp-negative tumours . |
| PubMedID- 21672271 | Sethi and colleagues observed that the expression of jagged1, but not that of notch receptors, is higher in high-metastatic cell lines than in their low-metastatic counterparts and that it positively correlated with the incidence of bone metastasis in patients with breast cancer. |
| PubMedID- 22740793 | bone metastasis in breast cancer. |
| PubMedID- 22439092 | According to recent studies on bone metastasis of multiple myeloma, breast cancer, prostate cancer, continuous administration of zoledronic acid and the 3rd generation amino-bisphosphonate resulted in reduced skeletal complications . |
| PubMedID- 21892536 | Vertebral bone metastasis in breast cancer: a case report. |
| PubMedID- 23813018 | To evaluate the relationship between il-11 and bone metastasis in patients with breast cancer and explore the potential molecular mechanism, total serum samples were collected from 180 breast cancer patients and 20 women without breast cancer. |
| PubMedID- 21683530 | Eligibility criteria were the following: (1) the trial must include at least 10 breast cancer patients with painful bone metastasis, (2) the radionuclide has been approved by regulatory authorities in europe or the united states and is commercially available (sr-89, sm-153, and re-186), (3) the dose of radionuclides must be clinically effective, (4) the primary endpoint must be pain, performance status or quality of life, and (5) separate reporting of efficacy should be available for breast cancer patients provided the trial included patients with various types of cancer. |
| PubMedID- 24625091 | One recent study also suggested that smad4 is required for tgf-β-induced emt to mediate bone metastasis of breast cancer cells . |
| PubMedID- 23368410 | For example, bone metastasis of breast cancer is often osteoblastic and osteoblastic bone metastatic foci usually show low fdg uptake, regardless of biologic behavior of tumor cells. |
| PubMedID- 22767217 | Thus, aav-hgfk1 treatment represents a potential therapy for bone metastasis in breast cancer. |
| PubMedID- 25800315 | " methods: between 1993-2006, 139 breast cancer patients with isolated bone metastasis were examined. |
| PubMedID- 22279421 | Rank–rankl signaling has been documented to play an important role in bone metastasis of breast cancer. |
| PubMedID- 20234370 | Silencing lpa1 expression by sirna or inhibiting lpa function with small molecule inhibitors effectively suppressed cytokine production and bone metastasis of breast cancer cell lines (boucharaba et al, 2006). |
| PubMedID- 26000310 | Despite reducing tumor-associated bone complications, recent meta-analysis studies show controversial results on the antitumor effects of oc blockade in breast cancer patients with bone metastasis . |
| PubMedID- 22037741 | In addition, patients with bone metastasis of breast cancer had longer survival time. |
| PubMedID- 22500564 | Expert opinion: in breast cancer patients with bone metastasis, several bisphosphonates and denosumab demonstrated clinical efficacy. |
| PubMedID- 26343739 | In addition, pthrp expression has been determined to be a risk factor for predicting bone metastasis in patients with breast cancer 2. |
| PubMedID- 26161302 | They did not find differences between nuclear and cytoplasmic cxcr4 expressions in primary and bone metastasis of breast cancer, and nearly all tumours showed strong immunoreactivity. |
| PubMedID- 25163697 | A computational model to predict bone metastasis in breast cancer by integrating the dysregulated pathways. |
| PubMedID- 22532777 | Fractures are the most commonly reported skeletal-related events and occur in up to 60% of untreated breast cancer patients with bone metastasis.7 bone metastases cause pain, limited mobility, fears of future fracture, and loss of function, significantly decreasing quality of life. |
| PubMedID- 21352696 | Our results further support important roles for a tumor-osteoblast axis during bone metastasis of breast cancer, which have been underappreciated in the context of well-established and well-studied tumor cell-osteoclast activation. |
| PubMedID- 24799764 | Mir-379 was studied by kallioniemi group in bone metastasis of breast cancer. |
| PubMedID- 25952319 | Mirnas affect tumor metastasis, such as the lung and bone metastasis of human breast cancer . |
| PubMedID- 24744802 | The diagnosis of bone metastasis in patients with early breast cancer is very important because it has a significant impact on treatment planning. |
| PubMedID- 24340030 | Osteoclast (oc)-mediated bone resorption is crucial for normal bone homeostasis, and also plays a causative role in osteoporosis, rheumatoid arthritis, paget disease, multiple myeloma (mm), and bone metastasis of breast cancers. |
| PubMedID- 21111244 | In this review, clinical evidence regarding the efficacy and safety of currently available bone-targeted therapies including bisphosphonates and anti-rankl monoclonal antibody in the treatment of bone metastasis due to breast cancer, prostate cancer, lung cancer, and multiple myeloma bone disease will be summarized. |
| PubMedID- 22740796 | Radiotherapy of bone metastasis in breast cancer patients - current approaches. |
| PubMedID- 23773523 | It is worth noting that a polymorphism in the gene encoding gβ3 subunit is associated with oncogenesis and risk of bone metastasis in patients with breast cancer, while the homozygous gβ3 genotype conferred protection against disease progression . |
| PubMedID- 20978950 | Significance of survivin and bcl-2 homologous antagonist/killer mrna in detection of bone metastasis in patients with breast cancer. |
| PubMedID- 24432249 | High rank and low opg expression in primary breast cancer tumors correlated with accelerated bone metastasis and shortened skeletal-disease-free survival (60). |
| PubMedID- 22315972 | Knockdown studies showed that smad4 is required for bone metastasis of breast cancer cells but mainly for the initial establishment and less for metastasis maintenance or progression of already-established macrometastases . |
| PubMedID- 21913222 | These results suggest that ha oligosaccharides suppressed progression of bone metastasis in breast cancer via interruption of endogenous ha-cd44 interaction, and as such, can be a novel therapeutic candidate to limit bone metastasis of breast cancer. |
| PubMedID- 22200658 | We have shown that lpa-derived from platelets controls bone metastasis formation of breast cancer cells (14). |
| PubMedID- 25980494 | Then, we cannot discard its contribution to lung and bone metastasis of breast cancer cells. |
| PubMedID- 23905676 | Previous studies showed that brucine inhibited vegf expression and decreased microvessel density in a nude mouse model of bone metastasis because of breast cancer , and brucine could inhibit cell proliferation, chemotactic motility and down-regulate levels of vegf, no, il-6, il-8, tnf-α and ifn-γ in huvecs . |
| PubMedID- 26244975 | The frequency rate for the occurrence bone pain has been found to be approximately 40% in breast cancer patients with bone metastasis 3. |
| PubMedID- 25867965 | Further, hur levels were also found to be downregulated in breast cancer patients with bone metastasis62. |
| PubMedID- 20414026 | The patient had a medical history of breast cancer with bone metastasis that was treated by chemotherapy with 45 mg pamidronate in 2 weekly courses for 16 months. |
| PubMedID- 20967488 | The 5b isoform is secreted by osteoclasts and has recently been advocated as a serum marker for bone metastasis in breast cancer patients. |
| PubMedID- 26037335 | Diagnostic performance of f-fluorodeoxyglucose pet/ct and bone scintigraphy in breast cancer patients with suspected bone metastasis. |
| PubMedID- 23667544 | Most importantly, bsp silencing significantly inhibits bone metastasis of breast cancer cells in nude mice. |
| PubMedID- 25773070 | Therefore, it is important to define mechanisms underlying bone metastasis of breast cancer cells. |
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