PedAM

Pediatric Disease Annotations & Medicines


	xerophthalmia

Disease ID	1550
Disease	xerophthalmia
Definition	Dryness of the eye surfaces caused by deficiency of tears or conjunctival secretions. It may be associated with vitamin A deficiency, trauma, or any condition in which the eyelids do not close completely.
Synonym	conjunctival xerosis conjunctival xerosis (& [xerophthalmia]) conjunctival xerosis (& [xerophthalmia]) (disorder) ophthalmoxerosis tear film insuffic nos tear film insufficiency tear film insufficiency (disorder) tear film insufficiency, nos tear film insufficiency, unspecified xeroma xerophthalmia (disorder) xerophthalmia [disease/finding] xerophthalmias xerophthalmus
DOID	DOID:10138 DOID:10140
UMLS	C0043349
MeSH	D014985
SNOMED-CT	SNOMEDCT_US_2016_09_01:46152009;SNOMEDCT_US_2016_09_01:363677007
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:10) C0456909 \| blindness \| 2 C0003873 \| rheumatoid arthritis \| 1 C0003864 \| arthritis \| 1 C0011334 \| cavities \| 1 C0022575 \| keratoconjunctivitis sicca \| 1 C0009782 \| connective tissue disorder \| 1 C0022568 \| keratitis \| 1 C0021053 \| immune disease \| 1 C0870082 \| hyperkeratosis \| 1 C0022573 \| keratoconjunctivitis \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:55) 1774 \| DNASE1L1 \| DISEASES 1472 \| CST4 \| DISEASES 973 \| CD79A \| DISEASES 3565 \| IL4 \| DISEASES 5917 \| RARS \| DISEASES 5947 \| RBP1 \| DISEASES 7276 \| TTR \| DISEASES 59272 \| ACE2 \| DISEASES 140683 \| BPIFA2 \| DISEASES 50617 \| ATP6V0A4 \| DISEASES 6737 \| TRIM21 \| DISEASES 1401 \| CRP \| DISEASES 4836 \| NMT1 \| DISEASES 6496 \| SIX3 \| DISEASES 6741 \| SSB \| DISEASES 54957 \| TXNL4B \| DISEASES 654 \| BMP6 \| DISEASES 4041 \| LRP5 \| DISEASES 7412 \| VCAM1 \| DISEASES 6010 \| RHO \| DISEASES 6778 \| STAT6 \| DISEASES 3268 \| AGFG2 \| DISEASES 7156 \| TOP3A \| DISEASES 6014 \| RIT2 \| DISEASES 6906 \| SERPINA7 \| DISEASES 340075 \| ARSI \| DISEASES 8835 \| SOCS2 \| DISEASES 80320 \| SP6 \| DISEASES 26578 \| OSTF1 \| DISEASES 9588 \| PRDX6 \| DISEASES 4948 \| OCA2 \| DISEASES 3663 \| IRF5 \| DISEASES 6775 \| STAT4 \| DISEASES 26047 \| CNTNAP2 \| DISEASES 6738 \| TROVE2 \| DISEASES 4720 \| NDUFS2 \| DISEASES 8349 \| HIST2H2BE \| DISEASES 959 \| CD40LG \| DISEASES 6709 \| SPTAN1 \| DISEASES 3339 \| HSPG2 \| DISEASES 3376 \| IARS \| DISEASES 1041 \| CDSN \| DISEASES 2550 \| GABBR1 \| DISEASES 765 \| CA6 \| DISEASES 1059 \| CENPB \| DISEASES 100463285 \| MTRNR2L4 \| DISEASES 7018 \| TF \| DISEASES 3718 \| JAK3 \| DISEASES 23705 \| CADM1 \| DISEASES 5795 \| PTPRJ \| DISEASES 54900 \| LAX1 \| DISEASES 100463289 \| MTRNR2L5 \| DISEASES 6510 \| SLC1A5 \| DISEASES 5125 \| PCSK5 \| DISEASES 6625 \| SNRNP70 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1550
Disease	xerophthalmia
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:10) HP:0004905 \| Vitamin A deficiency \| 4 HP:0000618 \| Blindness \| 2 HP:0000962 \| Hyperkeratosis \| 1 HP:0001096 \| Keratoconjunctivitis \| 1 HP:0000491 \| Corneal inflammation \| 1 HP:0001097 \| Keratoconjunctivitis sicca \| 1 HP:0001370 \| Rheumatoid arthritis \| 1 HP:0001369 \| Arthritis \| 1 HP:0007502 \| Hyperkeratosis follicularis \| 1 HP:0002960 \| Autoimmune condition \| 1

Disease ID	1550
Disease	xerophthalmia
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:1) C0456909 \| blindness \| 2

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:2)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0043349	cyclosporine	D016572	59865-13-3	xerophthalmia	MESH:D014985	therapeutic	17120751
C0043349	tacrolimus	D016559	109581-93-3	xerophthalmia	MESH:D014985	marker/mechanism	20233105

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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