PedAM

Pediatric Disease Annotations & Medicines


	wilms tumor

Disease ID	169
Disease	wilms tumor
Definition	pediatric nephroblastoma originating from embryonic kidney stem cells; usually affects children before the fifth year, but may occur in the fetus or rarely in later life; caused by defects in one or more tumor suppressor genes.
Synonym	[m]nephroblastoma nos embryonal adenosarcoma embryonal nephroma kidney wilms tumor kidney, adenomyosarcoma, embryonal kidney, carcinosarcoma, embryonal kidney, embryoma kidney, embryonal mixed tumor nephroblastoma nephroblastoma (disorder) nephroblastoma (m-89603) nephroblastoma (morphologic abnormality) nephroblastoma (wilms tumor) nephroblastoma, malignant nephroblastoma, nos nephroblastomas nephroma nephroma, nos nephromas perlman syndrome renal adenosarcoma renal cancer, wilms renal wilms tumor renal wilms' tumor tumor wilm's tumor wilms tumor wilms' tumor wilms's tumor, wilms tumor, wilms' tumors wilm's tumors wilms wilm tumor wilm's tumor wilms tumor (nephroblastoma) wilms tumor 1 wilms tumor [disease/finding] wilms tumor of the kidney wilms tumour wilms' tumor wilms' tumor and other childhood kidney tumors wilms' tumor of the kidney wilms' tumour wt1
Orphanet	ORPHANET:654 ORPHANET:2849
OMIM	OMIM:194070 OMIM:267000 OMIM:607102
DOID	DOID:2154 DOID:0060476 DOID:5183 DOID:5176
UMLS	C0027708
MeSH	D009396
SNOMED-CT	SNOMEDCT_US_2016_09_01:302849000
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:34) C0040053 \| thrombus \| 2 C0153676 \| lung metastasis \| 2 C0022972 \| lambert-eaton myasthenic syndrome \| 1 C0950121 \| denys-drash syndrome \| 1 C0555198 \| malignant gliomas \| 1 C0153676 \| pulmonary metastases \| 1 C0677886 \| epithelial ovarian cancer \| 1 C0039446 \| telangiectasia \| 1 C0152096 \| trisomy 18 \| 1 C0022658 \| renal disease \| 1 C0153676 \| lung metastases \| 1 C0027819 \| neuroblastoma \| 1 C1370740 \| adrenal carcinoma \| 1 C0006142 \| breast cancer \| 1 C0007134 \| renal carcinoma \| 1 C1140680 \| ovarian ca \| 1 C0023418 \| leukemia \| 1 C0020598 \| hypoglycaemia \| 1 C0392784 \| dermatofibrosarcoma protuberans \| 1 C0041341 \| tuberous sclerosis complex \| 1 C1140680 \| ovarian cancer \| 1 C0950121 \| drash syndrome \| 1 C0004134 \| ataxia \| 1 C0555198 \| malignant glioma \| 1 C0740394 \| hyperuricemia \| 1 C0024115 \| lung disease \| 1 C0022972 \| myasthenic syndrome \| 1 C0004779 \| gorlin syndrome \| 1 C0041341 \| tuberous sclerosis \| 1 C0022661 \| end stage renal disease \| 1 C0015625 \| fanconi anemia \| 1 C0002871 \| anemia \| 1 C0010481 \| cushing syndrome \| 1 C0008479 \| chondrosarcoma \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:16) BRCA2 \| 675 \| CTD_human IGF2 \| 3481 \| CTD_human WT1 \| 7490 \| CTD_human;OMIM;ORPHANET;UNIPROT NHS \| 4810 \| GWASCAT TCN2 \| 6948 \| GWASCAT PCSK9 \| 255738 \| GWASCAT GPC3 \| 2719 \| CTD_human CTNNB1 \| 1499 \| CTD_human DDX1 \| 1653 \| GWASCAT GLIPR1 \| 11010 \| CTD_human VHL \| 7428 \| CTD_human H19 \| 283120 \| ORPHANET POU6F2 \| 11281 \| ORPHANET DIS3L2 \| 129563 \| ORPHANET REST \| 5978 \| CTD_human;ORPHANET DLG2 \| 1740 \| GWASCAT
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) 7490 \| WT1 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:409) 618 \| BCYRN1 \| DISEASES 928 \| CD9 \| DISEASES 4826 \| NNAT \| DISEASES 54432 \| YIPF1 \| DISEASES 3784 \| KCNQ1 \| DISEASES 9319 \| TRIP13 \| DISEASES 54474 \| KRT20 \| DISEASES 2099 \| ESR1 \| DISEASES 25776 \| CBY1 \| DISEASES 10914 \| PAPOLA \| DISEASES 57167 \| SALL4 \| DISEASES 6725 \| SRMS \| DISEASES 58189 \| WFDC1 \| DISEASES 56915 \| EXOSC5 \| DISEASES 268 \| AMH \| DISEASES 7040 \| TGFB1 \| DISEASES 1048 \| CEACAM5 \| DISEASES 199731 \| CADM4 \| DISEASES 2645 \| GCK \| DISEASES 733 \| C8G \| DISEASES 1440 \| CSF3 \| DISEASES 10014 \| HDAC5 \| DISEASES 8929 \| PHOX2B \| DISEASES 3558 \| IL2 \| DISEASES 1410 \| CRYAB \| DISEASES 595 \| CCND1 \| DISEASES 1027 \| CDKN1B \| DISEASES 3458 \| IFNG \| DISEASES 2597 \| GAPDH \| DISEASES 2026 \| ENO2 \| DISEASES 26271 \| FBXO5 \| DISEASES 1653 \| DDX1 \| DISEASES 5657 \| PRTN3 \| DISEASES 7799 \| PRDM2 \| DISEASES 6943 \| TCF21 \| DISEASES 5918 \| RARRES1 \| DISEASES 9525 \| VPS4B \| DISEASES 84272 \| YIPF4 \| DISEASES 1958 \| EGR1 \| DISEASES 847 \| CAT \| DISEASES 2322 \| FLT3 \| DISEASES 4656 \| MYOG \| DISEASES 1959 \| EGR2 \| DISEASES 1026 \| CDKN1A \| DISEASES 6662 \| SOX9 \| DISEASES 7389 \| UROD \| DISEASES 6495 \| SIX1 \| DISEASES 3976 \| LIF \| DISEASES 8854 \| ALDH1A2 \| DISEASES 4654 \| MYOD1 \| DISEASES 6299 \| SALL1 \| DISEASES 56097 \| PCDHGC5 \| DISEASES 3852 \| KRT5 \| DISEASES 81 \| ACTN4 \| DISEASES 9253 \| NUMBL \| DISEASES 78992 \| YIPF2 \| DISEASES 10343 \| PKDREJ \| DISEASES 10343 \| PKDREJ \| DISEASES 5914 \| RARA \| DISEASES 2488 \| FSHB \| DISEASES 79727 \| LIN28A \| DISEASES 79727 \| LIN28A \| DISEASES 3975 \| LHX1 \| DISEASES 8900 \| CCNA1 \| DISEASES 5920 \| RARRES3 \| DISEASES 10752 \| CHL1 \| DISEASES 23318 \| ZCCHC11 \| DISEASES 5156 \| PDGFRA \| DISEASES 9883 \| POM121 \| DISEASES 79056 \| PRRG4 \| DISEASES 3569 \| IL6 \| DISEASES 28969 \| BZW2 \| DISEASES 4856 \| NOV \| DISEASES 5460 \| POU5F1 \| DISEASES 23213 \| SULF1 \| DISEASES 7057 \| THBS1 \| DISEASES 1588 \| CYP19A1 \| DISEASES 9585 \| KIF20B \| DISEASES 894 \| CCND2 \| DISEASES 79728 \| PALB2 \| DISEASES 1800 \| DPEP1 \| DISEASES 999 \| CDH1 \| DISEASES 945 \| CD33 \| DISEASES 29855 \| UBN1 \| DISEASES 26001 \| RNF167 \| DISEASES 23361 \| ZNF629 \| DISEASES 57531 \| HACE1 \| DISEASES 1871 \| E2F3 \| DISEASES 6598 \| SMARCB1 \| DISEASES 8424 \| BBOX1 \| DISEASES 54487 \| DGCR8 \| DISEASES 6855 \| SYP \| DISEASES 975 \| CD81 \| DISEASES 4072 \| EPCAM \| DISEASES 55850 \| USE1 \| DISEASES 10664 \| CTCF \| DISEASES 2817 \| GPC1 \| DISEASES 60482 \| SLC5A7 \| DISEASES 374 \| AREG \| DISEASES 6774 \| STAT3 \| DISEASES 10923 \| SUB1 \| DISEASES 51176 \| LEF1 \| DISEASES 7472 \| WNT2 \| DISEASES 5395 \| PMS2 \| DISEASES 11010 \| GLIPR1 \| DISEASES 22822 \| PHLDA1 \| DISEASES 3480 \| IGF1R \| DISEASES 7727 \| ZNF174 \| DISEASES 7157 \| TP53 \| DISEASES 2064 \| ERBB2 \| DISEASES 207 \| AKT1 \| DISEASES 126374 \| WTIP \| DISEASES 83540 \| NUF2 \| DISEASES 5546 \| PRCC \| DISEASES 5972 \| REN \| DISEASES 890 \| CCNA2 \| DISEASES 1956 \| EGFR \| DISEASES 4915 \| NTRK2 \| DISEASES 2620 \| GAS2 \| DISEASES 22948 \| CCT5 \| DISEASES 4613 \| MYCN \| DISEASES 5800 \| PTPRO \| DISEASES 5458 \| POU4F2 \| DISEASES 55294 \| FBXW7 \| DISEASES 23091 \| ZC3H13 \| DISEASES 7070 \| THY1 \| DISEASES 7071 \| KLF10 \| DISEASES 8324 \| FZD7 \| DISEASES 9246 \| UBE2L6 \| DISEASES 701 \| BUB1B \| DISEASES 8321 \| FZD1 \| DISEASES 3815 \| KIT \| DISEASES 54361 \| WNT4 \| DISEASES 3856 \| KRT8 \| DISEASES 213 \| ALB \| DISEASES 25976 \| TIPARP \| DISEASES 134288 \| TMEM174 \| DISEASES 4869 \| NPM1 \| DISEASES 168667 \| BMPER \| DISEASES 116039 \| OSR2 \| DISEASES 11244 \| ZHX1 \| DISEASES 56339 \| METTL3 \| DISEASES 26610 \| ELP4 \| DISEASES 9317 \| PTER \| DISEASES 54765 \| TRIM44 \| DISEASES 861 \| RUNX1 \| DISEASES 6786 \| STIM1 \| DISEASES 353514 \| LILRA5 \| DISEASES 3960 \| LGALS4 \| DISEASES 3233 \| HOXD4 \| DISEASES 598 \| BCL2L1 \| DISEASES 8796 \| SCEL \| DISEASES 3479 \| IGF1 \| DISEASES 7324 \| UBE2E1 \| DISEASES 90075 \| ZNF30 \| DISEASES 10736 \| SIX2 \| DISEASES 1495 \| CTNNA1 \| DISEASES 25928 \| SOSTDC1 \| DISEASES 2353 \| FOS \| DISEASES 794 \| CALB2 \| DISEASES 51068 \| NMD3 \| DISEASES 5002 \| SLC22A18 \| DISEASES 11338 \| U2AF2 \| DISEASES 27087 \| B3GAT1 \| DISEASES 64852 \| TUT1 \| DISEASES 7015 \| TERT \| DISEASES 3265 \| HRAS \| DISEASES 947 \| CD34 \| DISEASES 9610 \| RIN1 \| DISEASES 5098 \| PCDHGC3 \| DISEASES 79870 \| BAALC \| DISEASES 3172 \| HNF4A \| DISEASES 80818 \| ZNF436 \| DISEASES 7030 \| TFE3 \| DISEASES 129563 \| DIS3L2 \| DISEASES 129563 \| DIS3L2 \| DISEASES 23541 \| SEC14L2 \| DISEASES 4302 \| MLLT6 \| DISEASES 50649 \| ARHGEF4 \| DISEASES 4233 \| MET \| DISEASES 9702 \| CEP57 \| DISEASES 1960 \| EGR3 \| DISEASES 4684 \| NCAM1 \| DISEASES 7262 \| PHLDA2 \| DISEASES 10409 \| BASP1 \| DISEASES 2146 \| EZH2 \| DISEASES 10782 \| ZNF274 \| DISEASES 4222 \| MEOX1 \| DISEASES 115752 \| DIS3L \| DISEASES 115752 \| DIS3L \| DISEASES 10611 \| PDLIM5 \| DISEASES 387758 \| FIBIN \| DISEASES 8938 \| BAIAP3 \| DISEASES 148266 \| ZNF569 \| DISEASES 5241 \| PGR \| DISEASES 7481 \| WNT11 \| DISEASES 58531 \| PRM3 \| DISEASES 2863 \| GPR39 \| DISEASES 5074 \| PAWR \| DISEASES 3855 \| KRT7 \| DISEASES 83999 \| KREMEN1 \| DISEASES 7490 \| WT1 \| DISEASES 7490 \| WT1 \| DISEASES 942 \| CD86 \| DISEASES 430 \| ASCL2 \| DISEASES 5727 \| PTCH1 \| DISEASES 60529 \| ALX4 \| DISEASES 3916 \| LAMP1 \| DISEASES 266740 \| MAGEA2B \| DISEASES 6297 \| SALL2 \| DISEASES 148103 \| ZNF599 \| DISEASES 3043 \| HBB \| DISEASES 2626 \| GATA4 \| DISEASES 338645 \| LUZP2 \| DISEASES 4664 \| NAB1 \| DISEASES 6940 \| ZNF354A \| DISEASES 7767 \| ZNF224 \| DISEASES 7016 \| TESK1 \| DISEASES 29102 \| DROSHA \| DISEASES 4602 \| MYB \| DISEASES 966 \| CD59 \| DISEASES 57175 \| CORO1B \| DISEASES 8788 \| DLK1 \| DISEASES 3167 \| HMX2 \| DISEASES 5764 \| PTN \| DISEASES 2138 \| EYA1 \| DISEASES 23405 \| DICER1 \| DISEASES 23405 \| DICER1 \| DISEASES 389421 \| LIN28B \| DISEASES 1499 \| CTNNB1 \| DISEASES 9158 \| FIBP \| DISEASES 3767 \| KCNJ11 \| DISEASES 797 \| CALCB \| DISEASES 2109 \| ETFB \| DISEASES 6275 \| S100A4 \| DISEASES 5154 \| PDGFA \| DISEASES 9967 \| THRAP3 \| DISEASES 7080 \| NKX2-1 \| DISEASES 6666 \| SOX12 \| DISEASES 4010 \| LMX1B \| DISEASES 51710 \| ZNF44 \| DISEASES 8736 \| MYOM1 \| DISEASES 11186 \| RASSF1 \| DISEASES 60 \| ACTB \| DISEASES 9961 \| MVP \| DISEASES 744 \| MPPED2 \| DISEASES 23567 \| ZNF346 \| DISEASES 4763 \| NF1 \| DISEASES 9589 \| WTAP \| DISEASES 2526 \| FUT4 \| DISEASES 55243 \| KIRREL \| DISEASES 23607 \| CD2AP \| DISEASES 4151 \| MB \| DISEASES 4192 \| MDK \| DISEASES 4311 \| MME \| DISEASES 6533 \| SLC6A6 \| DISEASES 51222 \| ZNF219 \| DISEASES 4916 \| NTRK3 \| DISEASES 10256 \| CNKSR1 \| DISEASES 6665 \| SOX15 \| DISEASES 57829 \| ZP4 \| DISEASES 7107 \| GPR137B \| DISEASES 148811 \| PM20D1 \| DISEASES 89796 \| NAV1 \| DISEASES 2494 \| NR5A2 \| DISEASES 5788 \| PTPRC \| DISEASES 56956 \| LHX9 \| DISEASES 79577 \| CDC73 \| DISEASES 10625 \| IVNS1ABP \| DISEASES 54823 \| SWT1 \| DISEASES 777 \| CACNA1E \| DISEASES 7827 \| NPHS2 \| DISEASES 1490 \| CTGF \| DISEASES 93183 \| PIGM \| DISEASES 1382 \| CRABP2 \| DISEASES 10763 \| NES \| DISEASES 10654 \| PMVK \| DISEASES 256536 \| TCERG1L \| DISEASES 126961 \| HIST2H3C \| DISEASES 3283 \| HSD3B1 \| DISEASES 474384 \| F8A3 \| DISEASES 474383 \| F8A2 \| DISEASES 4803 \| NGF \| DISEASES 4893 \| NRAS \| DISEASES 64858 \| DCLRE1B \| DISEASES 10745 \| PHTF1 \| DISEASES 9096 \| TBX18 \| DISEASES 9748 \| SLK \| DISEASES 4102 \| MAGEA3 \| DISEASES 4101 \| MAGEA2 \| DISEASES 2239 \| GPC4 \| DISEASES 2239 \| GPC4 \| DISEASES 84612 \| PARD6B \| DISEASES 7422 \| VEGFA \| DISEASES 25 \| ABL1 \| DISEASES 25844 \| YIPF3 \| DISEASES 10953 \| TOMM34 \| DISEASES 60598 \| KCNK15 \| DISEASES 10904 \| BLCAP \| DISEASES 3065 \| HDAC1 \| DISEASES 2516 \| NR5A1 \| DISEASES 29119 \| CTNNA3 \| DISEASES 164091 \| PAQR7 \| DISEASES 10471 \| PFDN6 \| DISEASES 367 \| AR \| DISEASES 5081 \| PAX7 \| DISEASES 727837 \| SSX2B \| DISEASES 79670 \| ZCCHC6 \| DISEASES 7091 \| TLE4 \| DISEASES 2623 \| GATA1 \| DISEASES 3105 \| HLA-A \| DISEASES 1471 \| CST3 \| DISEASES 56998 \| CTNNBIP1 \| DISEASES 2512 \| FTL \| DISEASES 3604 \| TNFRSF9 \| DISEASES 22894 \| DIS3 \| DISEASES 22894 \| DIS3 \| DISEASES 4609 \| MYC \| DISEASES 8516 \| ITGA8 \| DISEASES 5420 \| PODXL \| DISEASES 4868 \| NPHS1 \| DISEASES 190 \| NR0B1 \| DISEASES 5080 \| PAX6 \| DISEASES 9308 \| CD83 \| DISEASES 2308 \| FOXO1 \| DISEASES 10346 \| TRIM22 \| DISEASES 54790 \| TET2 \| DISEASES 5931 \| RBBP7 \| DISEASES 675 \| BRCA2 \| DISEASES 284390 \| ZNF763 \| DISEASES 4676 \| NAP1L4 \| DISEASES 2296 \| FOXC1 \| DISEASES 1045 \| CDX2 \| DISEASES 2971 \| GTF3A \| DISEASES 4267 \| CD99 \| DISEASES 2315 \| MLANA \| DISEASES 6150 \| MRPL23 \| DISEASES 23600 \| AMACR \| DISEASES 7260 \| TSSC1 \| DISEASES 2254 \| FGF9 \| DISEASES 10232 \| MSLN \| DISEASES 6736 \| SRY \| DISEASES 57721 \| METTL14 \| DISEASES 6833 \| ABCC8 \| DISEASES 5077 \| PAX3 \| DISEASES 5973 \| RENBP \| DISEASES 3161 \| HMMR \| DISEASES 11346 \| SYNPO \| DISEASES 2719 \| GPC3 \| DISEASES 2719 \| GPC3 \| DISEASES 10575 \| CCT4 \| DISEASES 10265 \| IRX5 \| DISEASES 5532 \| PPP3CB \| DISEASES 23475 \| QPRT \| DISEASES 174 \| AFP \| DISEASES 115560 \| ZNF501 \| DISEASES 4629 \| MYH11 \| DISEASES 2120 \| ETV6 \| DISEASES 1781 \| DYNC1I2 \| DISEASES 23532 \| PRAME \| DISEASES 1607 \| DGKB \| DISEASES 11281 \| POU6F2 \| DISEASES 22976 \| PAXIP1 \| DISEASES 23414 \| ZFPM2 \| DISEASES 56903 \| PAPOLB \| DISEASES 333932 \| HIST2H3A \| DISEASES 758 \| MPPED1 \| DISEASES 4435 \| CITED1 \| DISEASES 131578 \| LRRC15 \| DISEASES 55900 \| ZNF302 \| DISEASES 3481 \| IGF2 \| DISEASES 3481 \| IGF2 \| DISEASES 2674 \| GFRA1 \| DISEASES 7849 \| PAX8 \| DISEASES 5076 \| PAX2 \| DISEASES 960 \| CD44 \| DISEASES 3491 \| CYR61 \| DISEASES 23161 \| SNX13 \| DISEASES 2130 \| EWSR1 \| DISEASES 79872 \| CBLL1 \| DISEASES 862 \| RUNX1T1 \| DISEASES 5087 \| PBX1 \| DISEASES 57862 \| ZNF410 \| DISEASES 2668 \| GDNF \| DISEASES 1028 \| CDKN1C \| DISEASES 1028 \| CDKN1C \| DISEASES 80319 \| CXXC4 \| DISEASES 55635 \| DEPDC1 \| DISEASES 627 \| BDNF \| DISEASES 9391 \| CIAO1 \| DISEASES 5447 \| POR \| DISEASES 339318 \| ZNF181 \| DISEASES 4750 \| NEK1 \| DISEASES 3347 \| HTN3 \| DISEASES 92312 \| MEX3A \| DISEASES 5003 \| SLC22A18AS \| DISEASES 3939 \| LDHA \| DISEASES 1961 \| EGR4 \| DISEASES 567 \| B2M \| DISEASES 2297 \| FOXD1 \| DISEASES 9294 \| S1PR2 \| DISEASES 283120 \| H19 \| DISEASES 51214 \| IGF2-AS \| DISEASES 10984 \| KCNQ1OT1 \| DISEASES 10408 \| MYCNOS \| DISEASES 6023 \| RMRP \| DISEASES 6029 \| RN7SL1 \| DISEASES 6029 \| RN7SL1 \| DISEASES 51352 \| WT1-AS \| DISEASES
Locus	(Waiting for update.)

Disease ID	169
Disease	wilms tumor
Integrated Phenotype	HPO \| Name(Total Integrated Phenotypes:1) HP:0002667 \| Wilms tumor
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:24) HP:0002664 \| Neoplasia \| 6 HP:0000110 \| Renal dysplasia \| 1 HP:0001399 \| Liver failure \| 1 HP:0001009 \| Telangiectases \| 1 HP:0005584 \| Renal cell carcinoma \| 1 HP:0003002 \| Breast carcinoma \| 1 HP:0009733 \| Glioma \| 1 HP:0004448 \| Fulminant hepatic failure \| 1 HP:0030731 \| Carcinoma \| 1 HP:0007281 \| Developmental stagnation \| 1 HP:0006254 \| Increased serum alpha-fetoprotein \| 1 HP:0001520 \| Birthweight > 90th percentile \| 1 HP:0001959 \| Polydipsia \| 1 HP:0001251 \| Ataxia \| 1 HP:0006744 \| Adrenal carcinoma \| 1 HP:0100880 \| Nephrogenic rest \| 1 HP:0003006 \| Neuroblastoma \| 1 HP:0001578 \| Hypercortisolism \| 1 HP:0003774 \| End-stage renal failure \| 1 HP:0001943 \| Hypoglycemia \| 1 HP:0006765 \| Chondrosarcoma \| 1 HP:0001909 \| Leukemia \| 1 HP:0000103 \| Polyuria \| 1 HP:0001903 \| Anemia \| 1

Disease ID	169
Disease	wilms tumor
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:4) C0002793 \| anaplasia \| 4 C0950121 \| drash syndrome \| 1 C0022661 \| end stage renal disease \| 1 C0085602 \| polydipsia \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:14)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1051266	25536437	4524	MTHFR	umls:C0027708	BeFree	The aim of this study was to investigate the association between MTHFR rs1801133 (C677T) and RFC-1 rs1051266 (G80A) genotypes with the risk of developing nephroblastoma and neuroblastoma.	0.002909916	2015	SLC19A1	21	45537880	T	C
rs16754	21189390	7490	WT1	umls:C0027708	BeFree	To analyze the prevalence and clinical implications of Wilms' tumor 1 (WT1) single nucleotide polymorphism (SNP) rs16754 in the context of other prognostic markers in pediatric acute myeloid leukemia (AML).	0.444098287	2011	WT1	11	32396399	T	C
rs16754	21659357	7490	WT1	umls:C0027708	BeFree	Clinical outcome and gene- and microRNA-expression profiling according to the Wilms tumor 1 (WT1) single nucleotide polymorphism rs16754 in adult de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study.	0.444098287	2011	WT1	11	32396399	T	C
rs1801133	25536437	4524	MTHFR	umls:C0027708	BeFree	The aim of this study was to investigate the association between MTHFR rs1801133 (C677T) and RFC-1 rs1051266 (G80A) genotypes with the risk of developing nephroblastoma and neuroblastoma.	0.002909916	2015	MTHFR	1	11796321	G	A
rs2234584	15150775	7490	WT1	umls:C0027708	UNIPROT	Twenty-four new cases of WT1 germline mutations and review of the literature: genotype/phenotype correlations for Wilms tumor development.	0.444098287	2004	WT1	11	32428521	G	T,A
rs2283873	22544364	6948	TCN2	umls:C0027708	GWASCAT	A genome-wide association study identifies susceptibility loci for Wilms tumor.	0.12	2012	TCN2	22	30617309	G	A
rs2495478	22544364	255738	PCSK9	umls:C0027708	GWASCAT	A genome-wide association study identifies susceptibility loci for Wilms tumor.	0.12	2012	PCSK9	1	55047322	G	A
rs2857461	21793187	2130	EWSR1	umls:C0027708	BeFree	One SNP in EWSR1 (rs2857461) showed a low level of statistical association with the diagnosis of Ewing sarcoma compared to Wilms tumor.	0.002442977	2012	EWSR1	22	29272015	C	T
rs368087026	25536437	4524	MTHFR	umls:C0027708	BeFree	The aim of this study was to investigate the association between MTHFR rs1801133 (C677T) and RFC-1 rs1051266 (G80A) genotypes with the risk of developing nephroblastoma and neuroblastoma.	0.002909916	2015	SLC19A1	21	45530890	G	A
rs3755132	22544364	1653	DDX1	umls:C0027708	GWASCAT	A genome-wide association study identifies susceptibility loci for Wilms tumor.	0.12	2012	DDX1	2	15589696	T	G
rs386514057	25536437	4524	MTHFR	umls:C0027708	BeFree	The aim of this study was to investigate the association between MTHFR rs1801133 (C677T) and RFC-1 rs1051266 (G80A) genotypes with the risk of developing nephroblastoma and neuroblastoma.	0.002909916	2015	NA	NA	NA	NA	NA
rs5955543	22544364	4810	NHS	umls:C0027708	GWASCAT	A genome-wide association study identifies susceptibility loci for Wilms tumor.	0.12	2012	NHS	X	17680277	A	G
rs662	24972570	5444	PON1	umls:C0027708	BeFree	The presence of at least one variant PON1 rs662 R allele increased the risk of developing Wilms´ Tumor although without statistical power.	0.000271442	2014	PON1	7	95308134	T	C
rs790356	22544364	1740	DLG2	umls:C0027708	GWASCAT	A genome-wide association study identifies susceptibility loci for Wilms tumor.	0.12	2012	DLG2;LOC105369418	11	83909744	A	G

GWASdb Annotation(Total Genotypes:8)
Chr	Pos	SNP_Id	RefGene	EnsemblGene	ENCODE_Factor	ENCODE_TFBS	Chromosome_interaction	GTEx_eQTL	SNP_TFBS_affinity_GWAS3D	SNP_miRNA_target_affinity_PolymiRTS	SNP_splicing_effect_Skippy	SNP_splicing_effect_MutPred_Splice	SNP_ns_protein_effect_dbNSFP	SNP_syn_effect_Silva	SNP_phosphorylation_effect_PhosSNP	PhastCons_score	PhyloP_score	GERP++_RS	Segway_state	Ancestral_allele	ESP_AF	ESP_AFR	ESP_AFR	ESP_EUR	TG_ASN	TG_AMR	TG_AFR	TG_EUR	Type	Consequence	bStatistic	EncH3K27Ac	EncH3K4Me1	EncH3K4Me3	EncNucleo	OMIM	Clinvar
11	32410380	rs5030316	NM_001198551,WT1	NM_001198552,WT1	NM_000378,WT1	NM_024424,WT1	NM_024426,WT1	ENST00000448076,ENSG00000184937	ENST00000332351,ENSG00000184937	ENST00000379077,ENSG00000184937	ENST00000379079,ENSG00000184937	ENST00000530998,ENSG00000184937	ENST00000452863,ENSG00000184937	ENST00000527882,ENSG00000184937	ENST00000527201,ENSG00000254922	ENST00000524721,ENSG00000254611	ENST00000526998,ENSG00000254439	TFP.EBF1	NA	chr11,32410001,32420000,chr11,32430001,32440000,25,Hi-C	chr11,32410001,32420000,chr11,30250001,30260000,4,Hi-C	NA	LM7,1.3875	LM9,1.6073	LM19,1.3438	LM23,1.543	LM64,4.5093	hsa-miR-6746-3p,-0.276000	NA	NA	NA	NA	NA	0.008	0.317	2.02	GM0
11	32411240	rs5030310	NM_001198551,WT1	NM_001198552,WT1	NM_000378,WT1	NM_024424,WT1	NM_024426,WT1	ENST00000448076,ENSG00000184937	ENST00000332351,ENSG00000184937	ENST00000379077,ENSG00000184937	ENST00000379079,ENSG00000184937	ENST00000530998,ENSG00000184937	ENST00000452863,ENSG00000184937	ENST00000527882,ENSG00000184937	ENST00000527201,ENSG00000254922	ENST00000524721,ENSG00000254611	ENST00000526998,ENSG00000254439	TFP.EBF1	NA	chr11,32410001,32420000,chr11,32430001,32440000,25,Hi-C	chr11,32410001,32420000,chr11,30250001,30260000,4,Hi-C	NA	LM12,1.9437	LM96,1.6012	LM175,4.4172	LM180,2.5323	LM203,2.1185	NA	NA	NA	NA	NA	NA	0.004	0.731	2.25	GE1
11	32416875	rs5030281	NM_001198551,WT1	NM_001198552,WT1	NM_000378,WT1	NM_024424,WT1	NM_024426,WT1	ENST00000448076,ENSG00000184937	ENST00000332351,ENSG00000184937	ENST00000379077,ENSG00000184937	ENST00000379079,ENSG00000184937	ENST00000530998,ENSG00000184937	ENST00000452863,ENSG00000184937	ENST00000527882,ENSG00000184937	ENST00000527201,ENSG00000254922	ENST00000524721,ENSG00000254611	ENST00000526998,ENSG00000254439	ENST00000526685,ENSG00000184937	TFP.CTCF	TFP.RAD21	MCV-4	NA	chr11,32410001,32420000,chr11,32430001,32440000,25,Hi-C	chr11,32410001,32420000,chr11,30250001,30260000,4,Hi-C	NA	LM203,1.3929	FOXF2,45.4838	Foxd3,3.791	Foxa2,10.0622	PPARG-RXRA,1.2759	NA	NA	NA	NA	NA	NA	0.000
11	32423752	rs5030244	NM_001198551,WT1	NM_001198552,WT1	NM_000378,WT1	NM_024424,WT1	NM_024426,WT1	ENST00000448076,ENSG00000184937	ENST00000332351,ENSG00000184937	ENST00000379077,ENSG00000184937	ENST00000379079,ENSG00000184937	ENST00000530998,ENSG00000184937	ENST00000452863,ENSG00000184937	ENST00000527882,ENSG00000184937	ENST00000527201,ENSG00000254922	ENST00000524721,ENSG00000254611	ENST00000526998,ENSG00000254439	ENST00000527775,ENSG00000184937	NA	NA	NA	NA	Barx1_2877,2.7215	Barx2_3447,1.3938	Cdx2_4272,1.3316	Hmx1_3423,10.0742	Hmx2_3424,10.7379	NA	NA	NA	NA	NA	NA	0.013	2.025	3.78	GE0
11	32435529	rs2900740	NM_001198551,WT1	NM_001198552,WT1	NM_000378,WT1	NM_024424,WT1	NM_024426,WT1	ENST00000448076,ENSG00000184937	ENST00000332351,ENSG00000184937	ENST00000379077,ENSG00000184937	ENST00000379079,ENSG00000184937	ENST00000530998,ENSG00000184937	ENST00000452863,ENSG00000184937	ENST00000527882,ENSG00000184937	ENST00000527201,ENSG00000254922	ENST00000524721,ENSG00000254611	ENST00000526998,ENSG00000254439	ENST00000527775,ENSG00000184937	MCV-1	NA	chr11,32430001,32440000,chr11,32410001,32420000,25,Hi-C	NA	NA	NA	NA	NA	NA	NA	NA	0.000	-1.153	-4.98	GE1	G	NA	NA	NA
11	32446985	rs12293750	NM_001198551,WT1	NM_001198552,WT1	NM_000378,WT1	NM_024424,WT1	NM_024426,WT1	ENST00000448076,ENSG00000184937	ENST00000332351,ENSG00000184937	ENST00000379077,ENSG00000184937	ENST00000379079,ENSG00000184937	ENST00000530998,ENSG00000184937	ENST00000452863,ENSG00000184937	ENST00000527201,ENSG00000254922	ENST00000524721,ENSG00000254611	ENST00000526998,ENSG00000254439	ENST00000527775,ENSG00000184937	MCV-11	NA	chr11,32440001,32450000,chr22,17040001,17050000,25,Hi-C	NA	LM11,2.9255	LM51,1.7867	LM60,1.7067	LM72,1.7266	LM81,13.0445	NA	NA	NA	NA	NA	NA	0.005	0.456	1.61	R4	C
11	32447347	rs7110547	NM_001198551,WT1	NM_001198552,WT1	NM_000378,WT1	NM_024424,WT1	NM_024426,WT1	ENST00000448076,ENSG00000184937	ENST00000332351,ENSG00000184937	ENST00000379077,ENSG00000184937	ENST00000379079,ENSG00000184937	ENST00000530998,ENSG00000184937	ENST00000452863,ENSG00000184937	ENST00000527201,ENSG00000254922	ENST00000524721,ENSG00000254611	ENST00000526998,ENSG00000254439	ENST00000527775,ENSG00000184937	MCV-6	NA	chr11,32440001,32450000,chr22,17040001,17050000,25,Hi-C	NA	LM12,4.2671	LM25,1.3006	LM25,1.3006	LM162,3.3264	LM170,2.1769	NA	NA	NA	NA	NA	NA	0.002	0.509	1.35	GE0	G
11	32455527	rs3930513	NM_000378,WT1	NM_024424,WT1	NM_024426,WT1	ENST00000448076,ENSG00000184937	ENST00000332351,ENSG00000184937	ENST00000379077,ENSG00000184937	ENST00000452863,ENSG00000184937	ENST00000527201,ENSG00000254922	ENST00000524721,ENSG00000254611	ENST00000526998,ENSG00000254439	TFP.SUZ12	TFP.TAF1	TFP.TBP	TFP.E2F6	TFP.MYC	TFP.YY1	TFP.MAX	TFP.SIN3A	TFP.CTBP2	TFP.EGR1	TFP.SPI1	TFP.ZBTB7A	TFP.HDAC2	MCV-10	NA	chr11,32450001,32460000,chr3,145640001,145650000,25,Hi-C	chr11,32450001,32460000,chr7,101970001,101980000,29,Hi-C	NA	LM231,2.1728	Pax5,1.4414	GATA-1,2.2919	AhR,3.8792	LUN-1,2.4693	NA	NA

GWASdb Snp Trait(Total Genotypes:51)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
1	55512995	rs2495478	G	A	rs2495478	22544364	1.00E-07	NA	1.4	[1.15-1.72]	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	rs2495478-T	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C	PCSK9
2	15729820	rs3755132	T	G	rs3755132	22544364	1.00E-14	NA	1.45	[1.29-1.64]	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	rs3755132-G	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G	NA
2	15737343	rs2302930	A	G	rs2302930	22544364	3.10E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A	DDX1
2	15737480	rs2302931	C	A	rs2302931	22544364	3.10E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C	DDX1
2	15750443	rs4668942	T	C	rs4668942	22544364	3.10E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T	DDX1
2	15750640	rs7594193	A	G	rs7594193	22544364	3.10E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G	DDX1
2	15758293	rs3770466	T	C	rs3770466	22544364	3.10E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C	DDX1
2	15762935	rs3770467	G	A	rs3770467	22544364	3.14E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G	DDX1
2	15763788	rs41264163	C	T	rs41264163	22544364	3.14E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T	DDX1
2	15764078	rs4668945	G	C	rs4668945	22544364	3.34E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G	DDX1
2	15765425	rs6734471	C	T	rs6734471	22544364	3.34E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C	DDX1
2	15767761	rs6743036	G	A	rs6743036	22544364	3.34E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	NA	DDX1
2	15768256	rs6743630	G	A	rs6743630	22544364	3.34E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A	DDX1
2	15770507	rs3770470	G	T	rs3770470	22544364	3.34E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T	DDX1
2	15770775	rs3770471	C	T	rs3770471	22544364	3.34E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C	DDX1
2	15771586	rs4668948	A	C	rs4668948	22544364	2.55E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A	NA
2	15771615	rs4668949	C	T	rs4668949	22544364	1.51E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T	NA
2	15772546	rs976015	C	G	rs976015	22544364	3.14E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C	NA
2	15772958	rs16862822	G	A	rs16862822	22544364	3.34E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G	NA
2	15774115	rs976233	C	T	rs976233	22544364	3.34E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C	NA
2	15775210	rs16862823	T	C	rs16862823	22544364	3.14E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T	NA
2	15782471	rs807624	G	T	rs807624	22544364	1.00E-14	NA	1.33	[1.22-1.45]	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	rs807624-A	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A	NA
2	15786243	rs6724800	A	G	rs6724800	22544364	1.86E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A	NA
2	15788191	rs16862838	C	T	rs16862838	22544364	1.71E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C	NA
2	15789441	rs4668458	G	A	rs4668458	22544364	2.22E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G	NA
2	15791937	rs6431721	C	T	rs6431721	22544364	2.66E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C	NA
5	91845809	rs6887553	A	G	rs6887553	22544364	5.35E-10	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G	NA
5	91859029	rs10060683	T	C	rs10060683	22544364	2.41E-10	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C	NA
5	91893792	rs1027643	C	T	rs1027643	22544364	5.00E-10	NA	1.43	[1.18-1.73]	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	rs1027643-T	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T	NA
5	91904447	rs61344503	G	T	rs61344503	22544364	2.40E-10	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T	NA
5	91907006	rs2221269	A	G	rs2221269	22544364	1.45E-10	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A	NA
11	83620787	rs790356	A	G	rs790356	22544364	4.00E-15	NA	1.28	[1.17-1.39]	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	rs790356-G	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A	DLG2
22	31009839	rs11913239	C	T	rs11913239	22544364	6.49E-09	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C	TCN2
22	31010997	rs2267162	C	T	rs2267162	22544364	1.12E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C	TCN2
22	31011280	rs7290898	A	C,G,T	rs7290898	22544364	2.97E-09	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C	TCN2
22	31011923	rs16988855	T	C	rs16988855	22544364	5.40E-09	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C	TCN2
22	31013296	rs2283873	G	A	rs2283873	22544364	5.00E-12	NA	2.05	[1.57-2.69]	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	rs2283873-A	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C	TCN2
22	31014377	rs2009857	C	T	rs2009857	22544364	5.40E-09	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G	TCN2
22	31015562	rs7288627	G	A	rs7288627	22544364	5.40E-09	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G	TCN2
22	31015573	rs7288385	C	A	rs7288385	22544364	5.40E-09	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C	TCN2
22	31018072	rs8141515	T	C	rs8141515	22544364	1.17E-08	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T	TCN2
22	31018078	rs2267166	G	A	rs2267166	22544364	1.17E-08	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G	TCN2
22	31022733	rs2072195	A	T	rs2072195	22544364	1.13E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A	TCN2
X	17669042	rs4825280	T	A	rs4825280	22544364	2.54E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T	NHS
X	17677803	rs978158	A	T	rs978158	22544364	2.54E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A	NHS
X	17692151	rs6633014	C	T	rs6633014	22544364	2.54E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T	NHS
X	17693746	rs5955717	C	T	rs5955717	22544364	2.54E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T	NHS
X	17695190	rs5955731	C	A	rs5955731	22544364	2.54E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C	NHS
X	17698397	rs5955543	A	G	rs5955543	22544364	1.00E-09	NA	2.64	[1.74-4.01]	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	rs5955543-G	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A	NHS
X	17699505	rs12392874	C	A	rs12392874	22544364	2.54E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C	NHS
X	17699834	rs4825243	C	A	rs4825243	22544364	2.54E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A	NHS

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:8)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0027708	carbamazepine	D002220	298-46-4	wilms tumor	MESH:D009396	marker/mechanism	6106127
C0027708	cisplatin	D002945	15663-27-1	wilms tumor	MESH:D009396	therapeutic	2206854
C0027708	ifosfamide	D007069	3778-73-2	wilms tumor	MESH:D009396	therapeutic	2166154
C0027708	melphalan	D008558	148-82-3	wilms tumor	MESH:D009396	therapeutic	15591903
C0027708	phenytoin	D010672	57-41-0	wilms tumor	MESH:D009396	marker/mechanism	6106127
C0027708	tretinoin	D014212	302-79-4	wilms tumor	MESH:D009396	therapeutic	16287080
C0027708	vincristine	D014750	-	wilms tumor	MESH:D009396	therapeutic	15838404
C0027708	vindesine	D014751	53643-48-4	wilms tumor	MESH:D009396	therapeutic	455587

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)