PedAM

Pediatric Disease Annotations & Medicines


	whipple disease

Disease ID	306
Disease	whipple disease
Definition	A systemic infection caused by the Gram-positive bacterium Tropheryma whipplei. It affects the small intestine resulting in malabsorption. Other sites or systems affected by the infection are the joints, central nervous system, and the cardiovascular system.
Synonym	disease whipple disease whipple's disease, whipple disease, whipple's granulomatosis, lipophagic, intestinal intestinal lipodystrophy intestinal whipple's disease lipodystrophy, intestinal sprue, nontropical, secondary wd - whipple's disease whipple dis whipple disease [disease/finding] whipple's disease whipple's disease (disorder) whipples dis whipples disease
Orphanet	ORPHANET:3452
DOID	DOID:8476
ICD10	ICD10CM:K90.81
UMLS	C0023788
MeSH	D008061
SNOMED-CT	SNOMEDCT_US_2016_09_01:41545003
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:6) C0497327 \| dementia \| 1 C0235270 \| keratopathy \| 1 C0008526 \| choroiditis \| 1 C0020542 \| pulmonary hypertension \| 1 C0020538 \| hypertension \| 1 C0030343 \| panuveitis \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:2) 3119 \| HLA-DQB1 \| infer 3123 \| HLA-DRB1 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:49) 6362 \| CCL18 \| DISEASES 920 \| CD4 \| DISEASES 55586 \| MIOX \| DISEASES 973 \| CD79A \| DISEASES 3565 \| IL4 \| DISEASES 7128 \| TNFAIP3 \| DISEASES 7166 \| TPH1 \| DISEASES 968 \| CD68 \| DISEASES 1890 \| TYMP \| DISEASES 1401 \| CRP \| DISEASES 4069 \| LYZ \| DISEASES 492 \| ATP2B3 \| DISEASES 5443 \| POMC \| DISEASES 80273 \| GRPEL1 \| DISEASES 7879 \| RAB7A \| DISEASES 3613 \| IMPA2 \| DISEASES 5868 \| RAB5A \| DISEASES 925 \| CD8A \| DISEASES 3060 \| HCRT \| DISEASES 7471 \| WNT1 \| DISEASES 213 \| ALB \| DISEASES 4054 \| LTBP3 \| DISEASES 3603 \| IL16 \| DISEASES 56246 \| MRAP \| DISEASES 3661 \| IRF3 \| DISEASES 23166 \| STAB1 \| DISEASES 30835 \| CD209 \| DISEASES 10938 \| EHD1 \| DISEASES 153562 \| MARVELD2 \| DISEASES 706 \| TSPO \| DISEASES 8651 \| SOCS1 \| DISEASES 10215 \| OLIG2 \| DISEASES 3916 \| LAMP1 \| DISEASES 9075 \| CLDN2 \| DISEASES 51477 \| ISYNA1 \| DISEASES 23583 \| SMUG1 \| DISEASES 3329 \| HSPD1 \| DISEASES 5265 \| SERPINA1 \| DISEASES 965 \| CD58 \| DISEASES 959 \| CD40LG \| DISEASES 7133 \| TNFRSF1B \| DISEASES 9308 \| CD83 \| DISEASES 51429 \| SNX9 \| DISEASES 1365 \| CLDN3 \| DISEASES 7124 \| TNF \| DISEASES 3612 \| IMPA1 \| DISEASES 10687 \| PNMA2 \| DISEASES 3684 \| ITGAM \| DISEASES 11331 \| PHB2 \| DISEASES
Locus	(Waiting for update.)

Disease ID	306
Disease	whipple disease
Integrated Phenotype	HPO \| Name(Total Integrated Phenotypes:47) HP:0002102 \| Pleuritis HP:0100639 \| Erectile abnormalities HP:0012735 \| Cough HP:0002239 \| Gastrointestinal hemorrhage HP:0002829 \| Arthralgia HP:0004326 \| Cachexia HP:0010741 \| Edema of the lower limbs HP:0001324 \| Muscle weakness HP:0002014 \| Diarrhea HP:0009830 \| Peripheral neuropathy HP:0003326 \| Myalgia HP:0001945 \| Fever HP:0001251 \| Ataxia HP:0000520 \| Proptosis HP:0001744 \| Splenomegaly HP:0002902 \| Hyponatremia HP:0001250 \| Seizures HP:0100614 \| Myositis HP:0000238 \| Hydrocephalus HP:0002093 \| Respiratory insufficiency HP:0002376 \| Developmental regression HP:0007256 \| Abnormal pyramidal signs HP:0002240 \| Hepatomegaly HP:0100749 \| Chest pain HP:0100829 \| Galactorrhea HP:0002615 \| Hypotension HP:0000716 \| Depression HP:0012378 \| Fatigue HP:0000554 \| Uveitis HP:0000821 \| Hypothyroidism HP:0001369 \| Arthritis HP:0000855 \| Insulin resistance HP:0001701 \| Pericarditis HP:0002024 \| Malabsorption HP:0100721 \| Mediastinal lymphadenopathy HP:0002383 \| Encephalitis HP:0006824 \| Cranial nerve paralysis HP:0001903 \| Anemia HP:0012819 \| Myocarditis HP:0001658 \| Myocardial infarction HP:0002516 \| Increased intracranial pressure HP:0002360 \| Sleep disturbance HP:0002039 \| Anorexia HP:0002027 \| Abdominal pain HP:0001959 \| Polydipsia HP:0001336 \| Myoclonus HP:0007440 \| Generalized hyperpigmentation
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:9) HP:0012121 \| Panuveitis \| 1 HP:0000726 \| Dementia \| 1 HP:0012219 \| Erythema nodosum \| 1 HP:0011531 \| Hyalitis \| 1 HP:0000822 \| Hypertension \| 1 HP:0100543 \| Cognitive deficits \| 1 HP:0002092 \| Pulmonary artery hypertension \| 1 HP:0010783 \| Erythema \| 1 HP:0012123 \| Posterior uveitis \| 1

Disease ID	306
Disease	whipple disease
Manually Symptom	UMLS \| Name(Total Manually Symptoms:5) C1963266 \| uveitis C0917799 \| hypersomnia C0752303 \| urological manifestations C0268382 \| renal amyloidosis C0265072 \| inferior vena cava obstruction
Text Mined Symptom	(Waiting for update.)

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:1)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0000554	Uveitis	MP:0008260	abnormal autophagy;HP:0001917	Renal amyloidosis

Chemical(Total Drugs:0)
(Waiting for update.)

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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