PedAM

Pediatric Disease Annotations & Medicines


	wernicke encephalopathy

Disease ID	1133
Disease	wernicke encephalopathy
Definition	An acute neurological disorder characterized by the triad of ophthalmoplegia, ataxia, and disturbances of mental activity or consciousness. Eye movement abnormalities include nystagmus, external rectus palsies, and reduced conjugate gaze. THIAMINE DEFICIENCY and chronic ALCOHOLISM are associated conditions. Pathologic features include periventricular petechial hemorrhages and neuropil breakdown in the diencephalon and brainstem. Chronic thiamine deficiency may lead to KORSAKOFF SYNDROME. (Adams et al., Principles of Neurology, 6th ed, pp1139-42; Davis & Robertson, Textbook of Neuropathology, 2nd ed, pp452-3)
Synonym	beriberi, cerebral cerebral beriberi disease wernickes enceph gayet wernicke enceph wernicke enceph wernickes encephalopathies, wernicke encephalopathy wernicke's encephalopathy wernickes encephalopathy, gayet wernicke encephalopathy, gayet-wernicke encephalopathy, wernicke encephalopathy, wernicke's encephalopathy, wernickes gayet wernicke enceph gayet wernicke encephalopathy gayet-wernicke encephalopathy gayet-wernicke syndrome wernicke wernicke dis wernicke disease wernicke enceph wernicke encephalopathies wernicke encephalopathy (disorder) wernicke encephalopathy [disease/finding] wernicke encephalopathy syndrome wernicke polioenceph superior hemorrhagic wernicke polioencephalitis, superior hemorrhagic wernicke superior hemorrhagic polioenceph wernicke superior hemorrhagic polioencephalitis wernicke syndrome wernicke's disease wernicke's disease (disorder) wernicke's encephalopathy wernicke's polioencephalitis, superior hemorrhagic wernicke's superior hemorrhagic polioencephalitis wernicke's syndrome wernickes wernickes dis wernickes enceph wernickes encephalopathy wernickes superior hemorrhagic polioenceph wernickes syndrome
DOID	DOID:2384
ICD10	ICD10CM:E51.2
UMLS	C0043121
MeSH	D014899
SNOMED-CT	SNOMEDCT_US_2016_09_01:21007002
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:12) C0001339 \| acute pancreatitis \| 2 C0024623 \| gastric cancer \| 1 C0162429 \| nutritional deficiency \| 1 C0162429 \| malnutrition \| 1 C0235250 \| hyperemesis \| 1 C0023890 \| liver cirrhosis \| 1 C0020450 \| hyperemesis gravidarum \| 1 C0442874 \| neuropathy \| 1 C0039841 \| thiamine deficiency \| 1 C0029132 \| optic neuropathy \| 1 C0003125 \| anorexia nervosa \| 1 C0349464 \| korsakoff syndrome \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) TKT \| 7086 \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:58) 84245 \| MRI1 \| DISEASES 266 \| AMELY \| DISEASES 7494 \| XBP1 \| DISEASES 3162 \| HMOX1 \| DISEASES 5816 \| PVALB \| DISEASES 10560 \| SLC19A2 \| DISEASES 80218 \| NAA50 \| DISEASES 968 \| CD68 \| DISEASES 55902 \| ACSS2 \| DISEASES 2670 \| GFAP \| DISEASES 6538 \| SLC6A11 \| DISEASES 2694 \| GIF \| DISEASES 80704 \| SLC19A3 \| DISEASES 9739 \| SETD1A \| DISEASES 443 \| ASPA \| DISEASES 6855 \| SYP \| DISEASES 8273 \| SLC10A3 \| DISEASES 492 \| ATP2B3 \| DISEASES 80321 \| CEP70 \| DISEASES 6507 \| SLC1A3 \| DISEASES 6506 \| SLC1A2 \| DISEASES 7082 \| TJP1 \| DISEASES 4846 \| NOS3 \| DISEASES 171558 \| PTCRA \| DISEASES 375611 \| SLC26A5 \| DISEASES 10815 \| CPLX1 \| DISEASES 2353 \| FOS \| DISEASES 794 \| CALB2 \| DISEASES 2752 \| GLUL \| DISEASES 660 \| BMX \| DISEASES 63951 \| DMRTA1 \| DISEASES 706 \| TSPO \| DISEASES 5155 \| PDGFB \| DISEASES 2042 \| EPHA3 \| DISEASES 1641 \| DCX \| DISEASES 6540 \| SLC6A13 \| DISEASES 4137 \| MAPT \| DISEASES 3716 \| JAK1 \| DISEASES 100506658 \| OCLN \| DISEASES 3177 \| SLC29A2 \| DISEASES 10814 \| CPLX2 \| DISEASES 5743 \| PTGS2 \| DISEASES 22926 \| ATF6 \| DISEASES 5654 \| HTRA1 \| DISEASES 9118 \| INA \| DISEASES 2030 \| SLC29A1 \| DISEASES 4318 \| MMP9 \| DISEASES 1025 \| CDK9 \| DISEASES 1896 \| EDA \| DISEASES 3717 \| JAK2 \| DISEASES 7436 \| VLDLR \| DISEASES 5888 \| RAD51 \| DISEASES 361 \| AQP4 \| DISEASES 51520 \| LARS \| DISEASES 7086 \| TKT \| DISEASES 100506742 \| CASP12 \| DISEASES 9414 \| TJP2 \| DISEASES 3684 \| ITGAM \| DISEASES
Locus	(Waiting for update.)

Disease ID	1133
Disease	wernicke encephalopathy
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:7) HP:0001735 \| Acute pancreatitis \| 2 HP:0004395 \| Malnutrition \| 1 HP:0012126 \| Gastric cancer \| 1 HP:0001138 \| Damaged optic nerve \| 1 HP:0001259 \| Coma \| 1 HP:0001410 \| Decreased liver function \| 1 HP:0012188 \| Hyperemesis gravidarum \| 1

Disease ID	1133
Disease	wernicke encephalopathy
Manually Symptom	(Waiting for update.)
Text Mined Symptom	(Waiting for update.)

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:2)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0043121	thiamine	D013831	59-43-8	wernicke encephalopathy	MESH:D014899	therapeutic	14644703
C0043121	zidovudine	D015215	30516-87-1	wernicke encephalopathy	MESH:D014899	marker/mechanism	2882316

FDA approved drug and dosage information(Total Drugs:6)
DiseaseID	Drug_name	active_ingredients	strength	Dosage Form/Route	Marketing Status	TE code	RLD	RS
MESH:D014899	retrovir	zidovudine	100MG	CAPSULE;ORAL	Prescription	AB	Yes	Yes
MESH:D014899	retrovir	zidovudine	50MG/5ML	SYRUP;ORAL	Prescription	AA	Yes	Yes
MESH:D014899	retrovir	zidovudine	10MG/ML	INJECTABLE;INJECTION	Prescription	AP	Yes	Yes
MESH:D014899	retrovir	zidovudine	200MG	TABLET;ORAL	Discontinued	None	No	No
MESH:D014899	zidovudine	zidovudine	60MG	TABLET;ORAL	Discontinued	None	No	No
MESH:D014899	zidovudine	zidovudine	60MG	TABLET;ORAL	Discontinued	None	No	No

FDA labeling changes(Total Drugs:6)
DiseaseID	Pediatric_Labeling_Date	Trade_Name	Generic_Name_or_Proper_Name	Indications Studied	Label Changes Summary	Product Labeling	BPCA(B)	PREA(P)	BPCA(B) and PREA(P)	Pediatric Rule (R)	Sponsor	Pediatric Exclusivity Granted Date	NNPS
MESH:D014899	6/11/2009	retrovir	zidovudine	Treatment of HIV-1 infection in combination with other antiretroviral agents	Provided dosing recommendations for patients 4 weeks to < 6 weeks of age and weighing 4 kg to < 9 kg	Labeling	-	P	-	-	GlaxoSmithKline	-	TRUE'
MESH:D014899	6/11/2009	retrovir	zidovudine	Treatment of HIV-1 infection in combination with other antiretroviral agents	Provided dosing recommendations for patients 4 weeks to < 6 weeks of age and weighing 4 kg to < 9 kg	Labeling	-	P	-	-	GlaxoSmithKline	-	TRUE'
MESH:D014899	6/11/2009	retrovir	zidovudine	Treatment of HIV-1 infection in combination with other antiretroviral agents	Provided dosing recommendations for patients 4 weeks to < 6 weeks of age and weighing 4 kg to < 9 kg	Labeling	-	P	-	-	GlaxoSmithKline	-	TRUE'
MESH:D014899	6/11/2009	retrovir	zidovudine	Treatment of HIV-1 infection in combination with other antiretroviral agents	Provided dosing recommendations for patients 4 weeks to < 6 weeks of age and weighing 4 kg to < 9 kg	Labeling	-	P	-	-	GlaxoSmithKline	-	TRUE'
MESH:D014899	09/19/2008	retrovir syrup, capsules and tablets	zidovudine	Used in combination with 18 other antiretroviral agents for the treatment of HIV-1 infection	Dosing and administration information provided to children 6 weeks to less than 18 years of age Macrocytosis was reported in the majority of pediatric patients receiving Retrovir 180 mg/m2 every 6 hours in open-label studies New dosing regimen	Labeling	-	P	-	-	GlaxoSmithKline	-	TRUE'
MESH:D014899	6/11/2009	retrovir	zidovudine	Treatment of HIV-1 infection in combination with other antiretroviral agents	Provided dosing recommendations for patients 4 weeks to < 6 weeks of age and weighing 4 kg to < 9 kg	Labeling	-	P	-	-	GlaxoSmithKline	-	TRUE'

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