PedAM

Pediatric Disease Annotations & Medicines


	vestibular disease

Disease ID	1583
Disease	vestibular disease
Definition	Pathological processes of the VESTIBULAR LABYRINTH which contains part of the balancing apparatus. Patients with vestibular diseases show instability and are at risk of frequent falls.
Synonym	[x]disorder of vestibular function, unspecified [x]disorder of vestibular function, unspecified (disorder) disease, vestibular diseases, vestibular disorder vestibular disorders system vestibular disorders vestibular problems vestibular vertigo, vestibular disorders vestibular dis vestibular diseases vestibular diseases [disease/finding] vestibular disorder vestibular disorder, nos vestibular disorders vestibular problem vestibular syndromes/disorders vestibular system disorder
DOID	DOID:3426
UMLS	C0042594
MeSH	D015837
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:3) C0003467 \| anxiety \| 1 C0011570 \| depression \| 1 C0029882 \| otitis media \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:6) NOS3 \| 4846 \| CTD_human ESPN \| 83715 \| CTD_human GSTZ1 \| 2954 \| CTD_human ATP1A1 \| 476 \| CTD_human GSTP1 \| 2950 \| CTD_human OC90 \| 729330 \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:206) 64132 \| XYLT2 \| DISEASES 84908 \| FAM136A \| DISEASES 84245 \| MRI1 \| DISEASES 5010 \| CLDN11 \| DISEASES 359 \| AQP2 \| DISEASES 3049 \| HBQ1 \| DISEASES 343641 \| TGM6 \| DISEASES 51168 \| MYO15A \| DISEASES 1690 \| COCH \| DISEASES 10857 \| PGRMC1 \| DISEASES 869 \| CBLN1 \| DISEASES 9333 \| TGM5 \| DISEASES 7038 \| TG \| DISEASES 3191 \| HNRNPL \| DISEASES 973 \| CD79A \| DISEASES 5445 \| PON2 \| DISEASES 5459 \| POU4F3 \| DISEASES 6500 \| SKP1 \| DISEASES 3769 \| KCNJ13 \| DISEASES 6549 \| SLC9A2 \| DISEASES 525 \| ATP6V1B1 \| DISEASES 3764 \| KCNJ8 \| DISEASES 10804 \| GJB6 \| DISEASES 654231 \| OCM \| DISEASES 4974 \| OMG \| DISEASES 22879 \| MON1B \| DISEASES 27352 \| SGSM3 \| DISEASES 6299 \| SALL1 \| DISEASES 47 \| ACLY \| DISEASES 50617 \| ATP6V0A4 \| DISEASES 729330 \| OC90 \| DISEASES 4677 \| NARS \| DISEASES 4544 \| MTNR1B \| DISEASES 3290 \| HSD11B1 \| DISEASES 55813 \| UTP6 \| DISEASES 6558 \| SLC12A2 \| DISEASES 3249 \| HPN \| DISEASES 27033 \| ZBTB32 \| DISEASES 9132 \| KCNQ4 \| DISEASES 7007 \| TECTA \| DISEASES 4811 \| NID1 \| DISEASES 119 \| ADD2 \| DISEASES 118 \| ADD1 \| DISEASES 8622 \| PDE8B \| DISEASES 644 \| BLVRA \| DISEASES 5172 \| SLC26A4 \| DISEASES 8034 \| SLC25A16 \| DISEASES 51411 \| BIN2 \| DISEASES 597 \| BCL2A1 \| DISEASES 150094 \| SIK1 \| DISEASES 5141 \| PDE4A \| DISEASES 9381 \| OTOF \| DISEASES 4715 \| NDUFB9 \| DISEASES 4863 \| NPAT \| DISEASES 79731 \| NARS2 \| DISEASES 5140 \| PDE3B \| DISEASES 3773 \| KCNJ16 \| DISEASES 223117 \| SEMA3D \| DISEASES 57630 \| SH3RF1 \| DISEASES 1836 \| SLC26A2 \| DISEASES 3763 \| KCNJ6 \| DISEASES 22808 \| MRAS \| DISEASES 55687 \| TRMU \| DISEASES 5152 \| PDE9A \| DISEASES 55129 \| ANO10 \| DISEASES 85451 \| UNK \| DISEASES 362 \| AQP5 \| DISEASES 10158 \| PDZK1IP1 \| DISEASES 3760 \| KCNJ3 \| DISEASES 2019 \| EN1 \| DISEASES 213 \| ALB \| DISEASES 7349 \| UCN \| DISEASES 7123 \| CLEC3B \| DISEASES 133060 \| OTOP1 \| DISEASES 22824 \| HSPA4L \| DISEASES 117531 \| TMC1 \| DISEASES 364 \| AQP7 \| DISEASES 360 \| AQP3 \| DISEASES 115825 \| WDFY2 \| DISEASES 124935 \| SLC43A2 \| DISEASES 79058 \| ASPSCR1 \| DISEASES 3308 \| HSPA4 \| DISEASES 2299 \| FOXI1 \| DISEASES 25928 \| SOSTDC1 \| DISEASES 5579 \| PRKCB \| DISEASES 2243 \| FGA \| DISEASES 3761 \| KCNJ4 \| DISEASES 285335 \| SLC9C1 \| DISEASES 1241 \| LTB4R \| DISEASES 81793 \| TLR10 \| DISEASES 6670 \| SP3 \| DISEASES 5029 \| P2RY2 \| DISEASES 10008 \| KCNE3 \| DISEASES 358 \| AQP1 \| DISEASES 5151 \| PDE8A \| DISEASES 246777 \| SPESP1 \| DISEASES 85406 \| DNAJC14 \| DISEASES 147912 \| SIX5 \| DISEASES 10318 \| TNIP1 \| DISEASES 8490 \| RGS5 \| DISEASES 26526 \| TSPAN16 \| DISEASES 363 \| AQP6 \| DISEASES 2193 \| FARSA \| DISEASES 8289 \| ARID1A \| DISEASES 150677 \| OTOS \| DISEASES 83903 \| GSG2 \| DISEASES 347741 \| OTOP3 \| DISEASES 3768 \| KCNJ12 \| DISEASES 10871 \| CD300C \| DISEASES 131149 \| OTOL1 \| DISEASES 71 \| ACTG1 \| DISEASES 3772 \| KCNJ15 \| DISEASES 92736 \| OTOP2 \| DISEASES 10227 \| MFSD10 \| DISEASES 6546 \| SLC8A1 \| DISEASES 3751 \| KCND2 \| DISEASES 10732 \| TCFL5 \| DISEASES 27445 \| PCLO \| DISEASES 57153 \| SLC44A2 \| DISEASES 3753 \| KCNE1 \| DISEASES 9138 \| ARHGEF1 \| DISEASES 554 \| AVPR2 \| DISEASES 1687 \| DFNA5 \| DISEASES 4882 \| NPR2 \| DISEASES 3770 \| KCNJ14 \| DISEASES 11255 \| HRH3 \| DISEASES 2138 \| EYA1 \| DISEASES 92399 \| MRRF \| DISEASES 10950 \| BTG3 \| DISEASES 5144 \| PDE4D \| DISEASES 26232 \| FBXO2 \| DISEASES 133584 \| EGFLAM \| DISEASES 120 \| ADD3 \| DISEASES 60 \| ACTB \| DISEASES 1510 \| CTSE \| DISEASES 23607 \| CD2AP \| DISEASES 1735 \| DIO3 \| DISEASES 3123 \| HLA-DRB1 \| DISEASES 6337 \| SCNN1A \| DISEASES 773 \| CACNA1A \| DISEASES 1366 \| CLDN7 \| DISEASES 6238 \| RRBP1 \| DISEASES 65217 \| PCDH15 \| DISEASES 8564 \| KMO \| DISEASES 9804 \| TOMM20 \| DISEASES 51106 \| TFB1M \| DISEASES 117157 \| SH2D1B \| DISEASES 3765 \| KCNJ9 \| DISEASES 3766 \| KCNJ10 \| DISEASES 55974 \| SLC50A1 \| DISEASES 103 \| ADAR \| DISEASES 3713 \| IVL \| DISEASES 6975 \| TECTB \| DISEASES 51750 \| RTEL1 \| DISEASES 23443 \| SLC35A3 \| DISEASES 1069 \| CETN2 \| DISEASES 959 \| CD40LG \| DISEASES 26036 \| ZNF451 \| DISEASES 51013 \| EXOSC1 \| DISEASES 23413 \| NCS1 \| DISEASES 5456 \| POU3F4 \| DISEASES 2707 \| GJB3 \| DISEASES 26190 \| FBXW2 \| DISEASES 57134 \| MAN1C1 \| DISEASES 3376 \| IARS \| DISEASES 3107 \| HLA-C \| DISEASES 778 \| CACNA1F \| DISEASES 3105 \| HLA-A \| DISEASES 8516 \| ITGA8 \| DISEASES 57704 \| GBA2 \| DISEASES 1677 \| DFFB \| DISEASES 5251 \| PHEX \| DISEASES 551 \| AVP \| DISEASES 4300 \| MLLT3 \| DISEASES 10568 \| SLC34A2 \| DISEASES 3736 \| KCNA1 \| DISEASES 2706 \| GJB2 \| DISEASES 361 \| AQP4 \| DISEASES 9244 \| CRLF1 \| DISEASES 4668 \| NAGA \| DISEASES 3269 \| HRH1 \| DISEASES 94025 \| MUC16 \| DISEASES 64072 \| CDH23 \| DISEASES 1837 \| DTNA \| DISEASES 340990 \| OTOG \| DISEASES 23327 \| NEDD4L \| DISEASES 51270 \| TFDP3 \| DISEASES 4647 \| MYO7A \| DISEASES 255928 \| SYT14 \| DISEASES 6559 \| SLC12A3 \| DISEASES 862 \| RUNX1T1 \| DISEASES 6522 \| SLC4A2 \| DISEASES 56649 \| TMPRSS4 \| DISEASES 6949 \| TCOF1 \| DISEASES 134430 \| WDR36 \| DISEASES 57451 \| TENM2 \| DISEASES 4359 \| MPZ \| DISEASES 56 \| ACRV1 \| DISEASES 10846 \| PDE10A \| DISEASES 83695 \| RHNO1 \| DISEASES 100288485 \| MTRNR2L7 \| DISEASES 1734 \| DIO2 \| DISEASES 63895 \| PIEZO2 \| DISEASES 102723508 \| KANTR \| DISEASES 79104 \| MEG8 \| DISEASES 4549 \| MT-RNR1 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1583
Disease	vestibular disease
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:3) HP:0000739 \| Anxiety \| 1 HP:0000388 \| Otitis media \| 1 HP:0000716 \| Depression \| 1

Disease ID	1583
Disease	vestibular disease
Manually Symptom	(Waiting for update.)
Text Mined Symptom	(Waiting for update.)

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:3)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1695	18776599	2950	GSTP1	umls:C0042594	GAD	[Susceptibility genes for gentamicin-induced vestibular dysfunction.]	0.122367032	2008	GSTP1	11	67585218	A	G
rs1799983	18776599	4846	NOS3	umls:C0042594	GAD	[Susceptibility genes for gentamicin-induced vestibular dysfunction.]	0.122367032	2008	NOS3	7	150999023	T	G
rs3177427	18776599	2954	GSTZ1	umls:C0042594	GAD	[Susceptibility genes for gentamicin-induced vestibular dysfunction.]	0.122367032	2008	NA	NA	NA	NA	NA

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:6)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0042594	amikacin	D000583	37517-28-5	vestibular diseases	MESH:D015837	marker/mechanism	3485932
C0042594	ampicillin	D000667	69-53-4	vestibular diseases	MESH:D015837	marker/mechanism	306816
C0042594	cinnarizine	D002936	298-57-7	vestibular diseases	MESH:D015837	therapeutic	15262457
C0042594	methoxsalen	D008730	298-81-7	vestibular diseases	MESH:D015837	therapeutic	18990727
C0042594	phenytoin	D010672	57-41-0	vestibular diseases	MESH:D015837	marker/mechanism	11433844
C0042594	vancomycin	D014640	1404-90-6	vestibular diseases	MESH:D015837	marker/mechanism	6805786

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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