PedAM
Pediatric Disease Annotations & Medicines
| vesicoureteral reflux | ||||
| Disease ID | 217 |
|---|---|
| Disease | vesicoureteral reflux |
| Manually Symptom | UMLS | Name(Total Manually Symptoms:19) C2632116 | stenosis C1963154 | renal failure C1963087 | constipation C1567741 | hereditary nephritis C0403477 | medullary nephrocalcinosis C0403447 | chronic kidney disease C0403389 | chronic obstructive pyelonephritis C0282488 | interstitial cystitis C0262655 | recurrent urinary tract infection C0232495 | lower abdominal pain C0151465 | renal abscess C0085697 | chronic pyelonephritis C0042029 | urinary tract infections C0042029 | urinary tract infection C0034186 | pyelonephritis C0022661 | end-stage renal disease C0022661 | end stage renal disease C0022658 | renal disease C0000737 | abdominal pain |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:9) C0042029 | urinary tract infection | 15 C0042029 | urinary tract infections | 4 C0262655 | recurrent urinary tract infection | 3 C0034186 | pyelonephritis | 2 C0022658 | renal disease | 1 C0022661 | end-stage renal disease | 1 C0282488 | interstitial cystitis | 1 C0022661 | chronic kidney disease | 1 C0035078 | renal failure | 1 |
Manually Genotype(Total Text Mining Genotypes:0) |
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| (Waiting for update.) |
All Snps(Total Genotypes:4) | |||||||||||||
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| snpId | pubmedId | geneId | geneSymbol | diseaseId | sourceId | sentence | score | Year | geneSymbol_dbSNP | CHROMOSOME | POS | REF | ALT |
| rs3804099 | 23484049 | 7097 | TLR2 | umls:C0042580 | BeFree | Further genotype pattern frequency analysis in TLR-2 SNPs (rs3804099 and rs3804100) showed significantly reduced occurrence of the rare allele homozygote (CC+CC) in the no-VUR subgroup of APN and ALN cases. | 0.000271442 | 2013 | TLR2 | 4 | 153703504 | T | C |
| rs3804100 | 23484049 | 7097 | TLR2 | umls:C0042580 | BeFree | Further genotype pattern frequency analysis in TLR-2 SNPs (rs3804099 and rs3804100) showed significantly reduced occurrence of the rare allele homozygote (CC+CC) in the no-VUR subgroup of APN and ALN cases. | 0.000271442 | 2013 | TLR2 | 4 | 153704257 | T | C |
| rs4073 | 21042230 | 3576 | CXCL8 | umls:C0042580 | BeFree | Following the elimination of vesicoureteral reflux, which is a significant risk factor for severe parenchymal infection, a single SNP in IL-8 (rs4073) was found to be associated with clinically severe ALN. | 0.000814326 | 2011 | CXCL8 | 4 | 73740307 | A | T |
| rs5443 | 15337465 | 2784 | GNB3 | umls:C0042580 | BeFree | This result suggests that the C825T polymorphism of the GNB3 gene might be associated with the development of VUR. | 0.005634266 | 2004 | GNB3;CDCA3 | 12 | 6845711 | C | T |
GWASdb Annotation(Total Genotypes:0) | |
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| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
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| (Waiting for update.) | |
Mapped by lexical matching(Total Items:0) |
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| (Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
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| (Waiting for update.) |
Chemical(Total Drugs:1) | |||||||||
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| CUI | ChemicalName | ChemicalID | CasRN | DiseaseName | DiseaseID | DirectEvidence | PubMedIDs | ||
| C0042580 | cyclophosphamide | D003520 | 50-18-0 | vesico-ureteral reflux | MESH:D014718 | marker/mechanism | 6887415 | ||
FDA approved drug and dosage information(Total Drugs:0) | |
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| (Waiting for update.) | |
FDA labeling changes(Total Drugs:0) | |
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| (Waiting for update.) | |