PedAM

Pediatric Disease Annotations & Medicines


	vasculitis

Disease ID	37
Disease	vasculitis
Definition	Inflammation of any one of the blood vessels, including the ARTERIES; VEINS; and rest of the vasculature system in the body.
Synonym	angiitides angiitis angiitis, nos infection of the blood or lymph vessel infection of the blood vessel vascular inflammation or infection vasculitides vasculitis (disorder) vasculitis [disease/finding] vasculitis, nonspecific vasculitis, nos
Orphanet	ORPHANET:52759
DOID	DOID:865
UMLS	C0042384
MeSH	D014657
SNOMED-CT	SNOMEDCT_US_2016_09_01:31996006
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:306) C0024141 \| systemic lupus erythematosus \| 23 C0019158 \| hepatitis \| 21 C0034150 \| purpura \| 19 C0409974 \| lupus erythematosus \| 19 C0019196 \| hepatitis c \| 17 C0003873 \| rheumatoid arthritis \| 16 C0030326 \| panniculitis \| 14 C0022116 \| ischemia \| 14 C0040053 \| thrombosis \| 14 C0042164 \| uveitis \| 13 C0017658 \| glomerulonephritis \| 12 C0041296 \| tuberculosis \| 10 C0042769 \| virus infection \| 10 C0004096 \| asthma \| 10 C0010403 \| cryoglobulinemia \| 10 C0003864 \| arthritis \| 9 C0031036 \| polyarteritis nodosa \| 8 C0036421 \| systemic sclerosis \| 8 C0009324 \| ulcerative colitis \| 8 C0010346 \| crohn's disease \| 8 C0034152 \| henoch-schonlein purpura \| 8 C0043092 \| wegener's granulomatosis \| 7 C0011603 \| dermatitis \| 7 C0026691 \| kawasaki disease \| 6 C0009319 \| colitis \| 6 C0403416 \| crescentic glomerulonephritis \| 6 C0442874 \| neuropathy \| 6 C0008526 \| choroiditis \| 6 C0035078 \| renal failure \| 6 C0027051 \| myocardial infarction \| 5 C0027697 \| nephritis \| 5 C0022658 \| renal disease \| 5 C0027051 \| myocardial infarct \| 5 C0087086 \| thrombi \| 5 C0036202 \| sarcoidosis \| 5 C0032285 \| pneumonia \| 5 C0035435 \| rheumatic disease \| 5 C0025309 \| meningoencephalitis \| 5 C0008495 \| chorioamnionitis \| 5 C0151436 \| leukocytoclastic vasculitis \| 4 C0032533 \| polymyalgia rheumatica \| 4 C0021400 \| influenza \| 4 C0011633 \| dermatomyositis \| 4 C0027059 \| myocarditis \| 4 C0015397 \| ocular disease \| 4 C0004943 \| behcet's disease \| 4 C1527336 \| sjogren's syndrome \| 4 C0030343 \| panuveitis \| 4 C0009782 \| connective tissue disease \| 4 C0026769 \| multiple sclerosis \| 4 C0456909 \| blindness \| 3 C0085278 \| antiphospholipid syndrome \| 3 C0029882 \| otitis media \| 3 C0008728 \| churg-strauss syndrome \| 3 C0042167 \| posterior uveitis \| 3 C0031117 \| peripheral neuropathy \| 3 C0025289 \| meningitis \| 3 C0035435 \| rheumatic diseases \| 3 C0035302 \| retinal artery occlusion \| 3 C0010051 \| coronary artery aneurysms \| 3 C0040028 \| essential thrombocythaemia \| 3 C0019163 \| hepatitis b \| 3 C0035078 \| kidney failure \| 3 C0039483 \| giant cell arteritis \| 3 C0032285 \| pneumoniae \| 3 C0026986 \| myelodysplastic syndrome \| 3 C0035333 \| retinitis \| 3 C0021053 \| immune disease \| 3 C0015230 \| rash \| 3 C0006271 \| bronchiolitis \| 3 C0042109 \| urticaria \| 3 C0010051 \| coronary artery aneurysm \| 3 C0009782 \| connective tissue diseases \| 3 C0024143 \| lupus nephritis \| 2 C0014118 \| endocarditis \| 2 C0026764 \| multiple myeloma \| 2 C0002871 \| anemia \| 2 C0035328 \| retinal vein occlusion \| 2 C0010403 \| cryoglobulinaemia \| 2 C0007688 \| central retinal artery occlusion \| 2 C0014038 \| encephalitis \| 2 C0004153 \| atherosclerosis \| 2 C0002878 \| hemolytic anemia \| 2 C0023448 \| lymphocytic leukemia \| 2 C0031069 \| familial mediterranean fever \| 2 C0085652 \| pyoderma gangrenosum \| 2 C0026764 \| myeloma \| 2 C0039263 \| takayasu arteritis \| 2 C0024299 \| lymphoma \| 2 C0026934 \| mycoplasma \| 2 C0010051 \| coronary aneurysm \| 2 C0023418 \| leukemia \| 2 C0011303 \| demyelinating disease \| 2 C0398623 \| hypercoagulable state \| 2 C0003509 \| aortitis \| 2 C0042373 \| angiopathy \| 2 C0151744 \| myocardial ischemia \| 2 C0024623 \| gastric cancer \| 2 C0034212 \| pyoderma \| 2 C0376545 \| hematological malignancies \| 2 C0271051 \| macular edema \| 2 C0036202 \| sarcoid \| 2 C0036416 \| scleritis \| 2 C0006663 \| calcinosis \| 2 C0032302 \| mycoplasma pneumonia \| 2 C0040053 \| thrombus \| 2 C0271051 \| macular oedema \| 2 C0021390 \| inflammatory bowel disease \| 2 C0017665 \| membranous nephropathy \| 2 C0029134 \| optic neuritis \| 2 C0042166 \| intermediate uveitis \| 2 C0021845 \| intestinal perforation \| 2 C0008148 \| chlamydia \| 2 C0022661 \| end-stage renal disease \| 2 C0004623 \| bacterial infection \| 2 C0034065 \| pulmonary embolism \| 2 C0034069 \| pulmonary fibrosis \| 2 C0162293 \| papillitis \| 2 C0027707 \| interstitial nephritis \| 2 C0020542 \| pulmonary hypertension \| 2 C0041296 \| mycobacterium tuberculosis infection \| 1 C0155765 \| microangiopathy \| 1 C0302592 \| cervical ca \| 1 C0027813 \| neuritis \| 1 C0019061 \| hemolytic-uremic syndrome \| 1 C0001418 \| adenocarcinoma \| 1 C0002726 \| amyloidosis \| 1 C0033860 \| psoriasis \| 1 C0024314 \| lymphoproliferative disorder \| 1 C0042165 \| anterior uveitis \| 1 C0023530 \| leukopenia \| 1 C0043092 \| wegener granulomatosis \| 1 C0025290 \| aseptic meningitis \| 1 C0034152 \| schonlein-henoch purpura \| 1 C0014179 \| endometritis \| 1 C0024137 \| cutaneous lupus erythematosus \| 1 C0024305 \| non-hodgkin lymphoma \| 1 C0023448 \| lymphatic leukemia \| 1 C0029089 \| ophthalmoplegia \| 1 C0007785 \| cerebral infarct \| 1 C0023486 \| prolymphocytic leukemia \| 1 C0035319 \| acute retinal necrosis \| 1 C0398623 \| hypercoagulability \| 1 C0019360 \| zoster \| 1 C0027947 \| neutropenia \| 1 C0018784 \| sensorineural hearing loss \| 1 C0007113 \| rectal cancer \| 1 C0038013 \| ankylosing spondylitis \| 1 C0034372 \| quadriplegia \| 1 C0152253 \| posterior synechiae \| 1 C0042373 \| vascular disease \| 1 C0699790 \| colon carcinoma \| 1 C0036472 \| tsutsugamushi \| 1 C0007642 \| cellulitis \| 1 C0154874 \| neuroretinitis \| 1 C0023434 \| chronic lymphocytic leukemia \| 1 C0026975 \| myelitis \| 1 C0010674 \| cystic fibrosis \| 1 C0085278 \| antiphospholipid antibody syndrome \| 1 C0085642 \| livedo reticularis \| 1 C0026654 \| moyamoya \| 1 C0031117 \| peripheral neuropathies \| 1 C0017601 \| glaucoma \| 1 C0001363 \| acute mesenteric ischemia \| 1 C0021345 \| mononucleosis \| 1 C0020550 \| hyperthyroidism \| 1 C0004943 \| behcet syndrome \| 1 C0206138 \| crest syndrome \| 1 C0010051 \| coronary aneurysms \| 1 C0007847 \| cervical cancer \| 1 C0006309 \| brucellosis \| 1 C0026272 \| mixed connective tissue disease \| 1 C0008698 \| maxillary sinusitis \| 1 C0014544 \| epilepsia \| 1 C0206141 \| hypereosinophilic syndrome \| 1 C0034152 \| henoch purpura \| 1 C0271270 \| cogan's syndrome \| 1 C1258104 \| diffuse cutaneous systemic sclerosis \| 1 C0265965 \| dyskeratosis congenita \| 1 C0018801 \| heart failure \| 1 C0338106 \| adenocarcinoma of the colon \| 1 C0031099 \| periodontitis \| 1 C0039263 \| takayasu disease \| 1 C0021390 \| inflammatory bowel diseases \| 1 C0018418 \| gynecomastia \| 1 C0042384 \| angiitis \| 1 C0009782 \| connective tissue disorders \| 1 C0009171 \| cocaine abuse \| 1 C0039483 \| horton disease \| 1 C0002170 \| alopecia \| 1 C0022568 \| keratitis \| 1 C0008312 \| primary biliary cirrhosis \| 1 C0017665 \| membranous glomerulonephritis \| 1 C0021831 \| bowel disease \| 1 C0023434 \| chronic lymphatic leukemia \| 1 C0019829 \| hodgkin lymphoma \| 1 C0376545 \| hematologic malignancies \| 1 C0015464 \| facial palsy \| 1 C0242231 \| coronary stenosis \| 1 C0270922 \| demyelinating polyneuropathy \| 1 C0039128 \| syphilis \| 1 C0699790 \| carcinoma of the colon \| 1 C0701807 \| acute anterior uveitis \| 1 C0085220 \| cerebral amyloid angiopathy \| 1 C0349530 \| early gastric cancer \| 1 C1704437 \| respiratory distress syndrome \| 1 C0022658 \| kidney disease \| 1 C0006666 \| calciphylaxis \| 1 C0008513 \| retinochoroiditis \| 1 C0035222 \| adult respiratory distress syndrome \| 1 C0006625 \| cachexia \| 1 C0155626 \| acute myocardial infarction \| 1 C0004096 \| bronchial asthma \| 1 C0032461 \| polycythemia \| 1 C0017609 \| rubeotic glaucoma \| 1 C0021053 \| immune disorder \| 1 C0042373 \| vascular diseases \| 1 C0023895 \| liver diseases \| 1 C0035309 \| retinopathy \| 1 C0036319 \| schistosoma mansoni \| 1 C0221757 \| aat deficiency \| 1 C0494491 \| mononeuropathy \| 1 C0403529 \| pulmonary-renal syndrome \| 1 C1136085 \| monoclonal gammopathy \| 1 C0013080 \| trisomy 21 \| 1 C0242379 \| lung cancer \| 1 C0015230 \| exanthema \| 1 C0023281 \| leishmaniasis \| 1 C0042164 \| intraocular inflammation \| 1 C0154841 \| central retinal vein occlusion \| 1 C0011644 \| scleroderma \| 1 C0042900 \| vitiligo \| 1 C0033687 \| proteinuria \| 1 C0024314 \| lymphoproliferative disease \| 1 C0007134 \| renal cell carcinoma \| 1 C0162529 \| ischemic colitis \| 1 C0456909 \| vision loss \| 1 C0221390 \| marantic endocarditis \| 1 C0006272 \| obliterative bronchiolitis \| 1 C0836924 \| thrombocythaemia \| 1 C0004576 \| babesiosis \| 1 C0026946 \| fungus infection \| 1 C0079731 \| b-cell lymphoma \| 1 C0008728 \| churg-strauss vasculitis \| 1 C0023895 \| liver disease \| 1 C0085543 \| epilepsia partialis continua \| 1 C0004623 \| bacterial infections \| 1 C0042769 \| viral infection \| 1 C0032463 \| polycythemia vera \| 1 C0024904 \| mastoiditis \| 1 C0007786 \| brain ischemia \| 1 C0040034 \| thrombocytopenia \| 1 C0018213 \| graves' disease \| 1 C0151436 \| hypersensitivity vasculitis \| 1 C0023443 \| hairy cell leukemia \| 1 C0022661 \| chronic kidney disease \| 1 C0238309 \| ischemic neuropathy \| 1 C0023348 \| lepromatous leprosy \| 1 C0079731 \| b-cell non-hodgkin lymphoma \| 1 C0024440 \| cystoid macular edema \| 1 C0019348 \| herpes simplex \| 1 C1527336 \| sjogren syndrome \| 1 C0018202 \| granulomatous angiitis \| 1 C0206141 \| idiopathic hypereosinophilic syndrome \| 1 C0033838 \| kimura's disease \| 1 C0743039 \| progressive dementia \| 1 C0020538 \| hypertension \| 1 C0011303 \| demyelinating diseases \| 1 C0037198 \| sinus thrombosis \| 1 C0011615 \| atopic dermatitis \| 1 C0392041 \| testicular infarction \| 1 C0011881 \| diabetic nephropathy \| 1 C0019360 \| herpes zoster \| 1 C0008312 \| biliary cirrhosis \| 1 C0004771 \| bartonella infection \| 1 C0004943 \| behcet's syndrome \| 1 C0022658 \| nephropathy \| 1 C0013990 \| emphysema \| 1 C0037928 \| myelopathy \| 1 C0021345 \| infectious mononucleosis \| 1 C0024314 \| lymphoproliferative disorders \| 1 C0497327 \| dementia \| 1 C0031039 \| pericardial effusion \| 1 C0019204 \| hepatocellular carcinoma \| 1 C0021171 \| incontinentia pigmenti \| 1 C0149985 \| secondary syphilis \| 1 C0008049 \| chickenpox \| 1 C0006123 \| branch retinal artery occlusion \| 1 C0009782 \| connective tissue disorder \| 1 C0026654 \| moyamoya syndrome \| 1 C0022658 \| renal diseases \| 1 C0042345 \| varices \| 1 C0221239 \| rapidly progressive glomerulonephritis \| 1 C0392041 \| testicular infarct \| 1 C0031111 \| periostitis \| 1 C0017160 \| gastroenteritis \| 1 C0026986 \| myelodysplastic syndromes \| 1 C0282492 \| sneddon syndrome \| 1 C0003864 \| inflammatory arthritis \| 1 C0024205 \| lymphadenitis \| 1 C0042109 \| urticarial \| 1 C0151295 \| mononeuritis multiplex \| 1 C1333387 \| endocrine syndrome \| 1 C0007134 \| hypernephroma \| 1 C0156147 \| crohn's colitis \| 1 C0014121 \| infective endocarditis \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:3) HLA-B \| 3106 \| GHR CBL \| 867 \| CTD_human SERPINA1 \| 5265 \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:3) 1493 \| CTLA4 \| infer 5133 \| PDCD1 \| infer 12 \| SERPINA3 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:471) 10344 \| CCL26 \| DISEASES 6376 \| CX3CL1 \| DISEASES 933 \| CD22 \| DISEASES 3385 \| ICAM3 \| DISEASES 7132 \| TNFRSF1A \| DISEASES 30009 \| TBX21 \| DISEASES 1361 \| CPB2 \| DISEASES 350 \| APOH \| DISEASES 7049 \| TGFBR3 \| DISEASES 4282 \| MIF \| DISEASES 9567 \| GTPBP1 \| DISEASES 1511 \| CTSG \| DISEASES 3002 \| GZMB \| DISEASES 4792 \| NFKBIA \| DISEASES 10544 \| PROCR \| DISEASES 51311 \| TLR8 \| DISEASES 7076 \| TIMP1 \| DISEASES 479 \| ATP12A \| DISEASES 4313 \| MMP2 \| DISEASES 6361 \| CCL17 \| DISEASES 4210 \| MEFV \| DISEASES 51285 \| RASL12 \| DISEASES 7038 \| TG \| DISEASES 5327 \| PLAT \| DISEASES 8797 \| TNFRSF10A \| DISEASES 973 \| CD79A \| DISEASES 7392 \| USF2 \| DISEASES 5444 \| PON1 \| DISEASES 10392 \| NOD1 \| DISEASES 5054 \| SERPINE1 \| DISEASES 26157 \| GIMAP2 \| DISEASES 5949 \| RBP3 \| DISEASES 6348 \| CCL3 \| DISEASES 4353 \| MPO \| DISEASES 8288 \| EPX \| DISEASES 1440 \| CSF3 \| DISEASES 6347 \| CCL2 \| DISEASES 952 \| CD38 \| DISEASES 6372 \| CXCL6 \| DISEASES 4790 \| NFKB1 \| DISEASES 3558 \| IL2 \| DISEASES 969 \| CD69 \| DISEASES 4598 \| MVK \| DISEASES 51561 \| IL23A \| DISEASES 3458 \| IFNG \| DISEASES 55907 \| CMAS \| DISEASES 3111 \| HLA-DOA \| DISEASES 3565 \| IL4 \| DISEASES 3567 \| IL5 \| DISEASES 7035 \| TFPI \| DISEASES 29959 \| NRBP1 \| DISEASES 3554 \| IL1R1 \| DISEASES 566 \| AZU1 \| DISEASES 5657 \| PRTN3 \| DISEASES 2023 \| ENO1 \| DISEASES 6402 \| SELL \| DISEASES 7128 \| TNFAIP3 \| DISEASES 27230 \| SERP1 \| DISEASES 2946 \| GSTM2 \| DISEASES 6431 \| SRSF6 \| DISEASES 5184 \| PEPD \| DISEASES 3581 \| IL9R \| DISEASES 1088 \| CEACAM8 \| DISEASES 80352 \| RNF39 \| DISEASES 54210 \| TREM1 \| DISEASES 3659 \| IRF1 \| DISEASES 30833 \| NT5C \| DISEASES 11025 \| LILRB3 \| DISEASES 718 \| C3 \| DISEASES 10870 \| HCST \| DISEASES 1236 \| CCR7 \| DISEASES 5199 \| CFP \| DISEASES 58509 \| CACTIN \| DISEASES 11135 \| CDC42EP1 \| DISEASES 968 \| CD68 \| DISEASES 79148 \| MMP28 \| DISEASES 6351 \| CCL4 \| DISEASES 11027 \| LILRA2 \| DISEASES 11026 \| LILRA3 \| DISEASES 2006 \| ELN \| DISEASES 4277 \| MICB \| DISEASES 4298 \| MLLT1 \| DISEASES 59335 \| PRDM12 \| DISEASES 47 \| ACLY \| DISEASES 6737 \| TRIM21 \| DISEASES 60678 \| EEFSEC \| DISEASES 1401 \| CRP \| DISEASES 55303 \| GIMAP4 \| DISEASES 967 \| CD63 \| DISEASES 2799 \| GNS \| DISEASES 80210 \| ARMC9 \| DISEASES 3569 \| IL6 \| DISEASES 640 \| BLK \| DISEASES 3557 \| IL1RN \| DISEASES 26525 \| IL36RN \| DISEASES 27348 \| TOR1B \| DISEASES 6366 \| CCL21 \| DISEASES 3134 \| HLA-F \| DISEASES 7097 \| TLR2 \| DISEASES 1559 \| CYP2C9 \| DISEASES 6741 \| SSB \| DISEASES 9360 \| PPIG \| DISEASES 4069 \| LYZ \| DISEASES 7450 \| VWF \| DISEASES 10162 \| LPCAT3 \| DISEASES 7188 \| TRAF5 \| DISEASES 23531 \| MMD \| DISEASES 9172 \| MYOM2 \| DISEASES 3595 \| IL12RB2 \| DISEASES 51816 \| CECR1 \| DISEASES 495 \| ATP4A \| DISEASES 671 \| BPI \| DISEASES 25939 \| SAMHD1 \| DISEASES 5588 \| PRKCQ \| DISEASES 27178 \| IL37 \| DISEASES 3552 \| IL1A \| DISEASES 3553 \| IL1B \| DISEASES 80271 \| ITPKC \| DISEASES 55717 \| WDR11 \| DISEASES 1991 \| ELANE \| DISEASES 975 \| CD81 \| DISEASES 6403 \| SELP \| DISEASES 943 \| TNFRSF8 \| DISEASES 4162 \| MCAM \| DISEASES 4811 \| NID1 \| DISEASES 941 \| CD80 \| DISEASES 7294 \| TXK \| DISEASES 59067 \| IL21 \| DISEASES 2247 \| FGF2 \| DISEASES 1356 \| CP \| DISEASES 6774 \| STAT3 \| DISEASES 5443 \| POMC \| DISEASES 5496 \| PPM1G \| DISEASES 3383 \| ICAM1 \| DISEASES 3827 \| KNG1 \| DISEASES 54504 \| CPVL \| DISEASES 5286 \| PIK3C2A \| DISEASES 939 \| CD27 \| DISEASES 3687 \| ITGAX \| DISEASES 3394 \| IRF8 \| DISEASES 593 \| BCKDHA \| DISEASES 5141 \| PDE4A \| DISEASES 2212 \| FCGR2A \| DISEASES 5972 \| REN \| DISEASES 3439 \| IFNA1 \| DISEASES 3934 \| LCN2 \| DISEASES 133 \| ADM \| DISEASES 710 \| SERPING1 \| DISEASES 90952 \| ESAM \| DISEASES 10666 \| CD226 \| DISEASES 3606 \| IL18 \| DISEASES 5458 \| POU4F2 \| DISEASES 7292 \| TNFSF4 \| DISEASES 92935 \| MARS2 \| DISEASES 22925 \| PLA2R1 \| DISEASES 84959 \| UBASH3B \| DISEASES 83648 \| FAM167A \| DISEASES 10563 \| CXCL13 \| DISEASES 7079 \| TIMP4 \| DISEASES 909 \| CD1A \| DISEASES 715 \| C1R \| DISEASES 1636 \| ACE \| DISEASES 115650 \| TNFRSF13C \| DISEASES 115653 \| KIR3DL3 \| DISEASES 643 \| CXCR5 \| DISEASES 729230 \| CCR2 \| DISEASES 1234 \| CCR5 \| DISEASES 3046 \| HBE1 \| DISEASES 6352 \| CCL5 \| DISEASES 7412 \| VCAM1 \| DISEASES 2215 \| FCGR3B \| DISEASES 3577 \| CXCR1 \| DISEASES 50852 \| TRAT1 \| DISEASES 213 \| ALB \| DISEASES 5473 \| PPBP \| DISEASES 5196 \| PF4 \| DISEASES 1230 \| CCR1 \| DISEASES 5648 \| MASP1 \| DISEASES 308 \| ANXA5 \| DISEASES 3600 \| IL15 \| DISEASES 51752 \| ERAP1 \| DISEASES 7098 \| TLR3 \| DISEASES 3562 \| IL3 \| DISEASES 1437 \| CSF2 \| DISEASES 1669 \| DEFA4 \| DISEASES 4846 \| NOS3 \| DISEASES 5896 \| RAG1 \| DISEASES 26253 \| CLEC4E \| DISEASES 4314 \| MMP3 \| DISEASES 64127 \| NOD2 \| DISEASES 6356 \| CCL11 \| DISEASES 133418 \| EMB \| DISEASES 6037 \| RNASE3 \| DISEASES 170575 \| GIMAP1 \| DISEASES 6203 \| RPS9 \| DISEASES 3689 \| ITGB2 \| DISEASES 6036 \| RNASE2 \| DISEASES 3688 \| ITGB1 \| DISEASES 1493 \| CTLA4 \| DISEASES 929 \| CD14 \| DISEASES 171558 \| PTCRA \| DISEASES 375611 \| SLC26A5 \| DISEASES 3596 \| IL13 \| DISEASES 10815 \| CPLX1 \| DISEASES 3627 \| CXCL10 \| DISEASES 6504 \| SLAMF1 \| DISEASES 3669 \| ISG20 \| DISEASES 56246 \| MRAP \| DISEASES 6373 \| CXCL11 \| DISEASES 11280 \| SCN11A \| DISEASES 54205 \| CYCS \| DISEASES 2147 \| F2 \| DISEASES 6363 \| CCL19 \| DISEASES 5340 \| PLG \| DISEASES 947 \| CD34 \| DISEASES 8302 \| KLRC4 \| DISEASES 836 \| CASP3 \| DISEASES 137735 \| ABRA \| DISEASES 3952 \| LEP \| DISEASES 10294 \| DNAJA2 \| DISEASES 767 \| CA8 \| DISEASES 931 \| MS4A1 \| DISEASES 285 \| ANGPT2 \| DISEASES 1191 \| CLU \| DISEASES 30835 \| CD209 \| DISEASES 23075 \| SWAP70 \| DISEASES 1776 \| DNASE1L3 \| DISEASES 51268 \| PIPOX \| DISEASES 79932 \| KIAA0319L \| DISEASES 4684 \| NCAM1 \| DISEASES 387082 \| SUMO4 \| DISEASES 3579 \| CXCR2 \| DISEASES 80381 \| CD276 \| DISEASES 149233 \| IL23R \| DISEASES 5345 \| SERPINF2 \| DISEASES 3039 \| HBA1 \| DISEASES 4312 \| MMP1 \| DISEASES 2 \| A2M \| DISEASES 9235 \| IL32 \| DISEASES 3812 \| KIR3DL2 \| DISEASES 9622 \| KLK4 \| DISEASES 1237 \| CCR8 \| DISEASES 6097 \| RORC \| DISEASES 2318 \| FLNC \| DISEASES 3563 \| IL3RA \| DISEASES 716 \| C1S \| DISEASES 1668 \| DEFA3 \| DISEASES 3665 \| IRF7 \| DISEASES 9276 \| COPB2 \| DISEASES 340061 \| TMEM173 \| DISEASES 124783 \| SPATA32 \| DISEASES 6401 \| SELE \| DISEASES 2621 \| GAS6 \| DISEASES 942 \| CD86 \| DISEASES 10509 \| SEMA4B \| DISEASES 285525 \| YIPF7 \| DISEASES 8690 \| JRKL \| DISEASES 5332 \| PLCB4 \| DISEASES 2152 \| F3 \| DISEASES 503841 \| DEFB106B \| DISEASES 3320 \| HSP90AA1 \| DISEASES 245909 \| DEFB106A \| DISEASES 81608 \| FIP1L1 \| DISEASES 3802 \| KIR2DL1 \| DISEASES 114548 \| NLRP3 \| DISEASES 112744 \| IL17F \| DISEASES 50615 \| IL21R \| DISEASES 3824 \| KLRD1 \| DISEASES 23583 \| SMUG1 \| DISEASES 155051 \| CRYGN \| DISEASES 445329 \| SULT1A4 \| DISEASES 3117 \| HLA-DQA1 \| DISEASES 3329 \| HSPD1 \| DISEASES 7100 \| TLR5 \| DISEASES 3804 \| KIR2DL3 \| DISEASES 921 \| CD5 \| DISEASES 3146 \| HMGB1 \| DISEASES 3198 \| HOXA1 \| DISEASES 6818 \| SULT1A3 \| DISEASES 545 \| ATR \| DISEASES 3605 \| IL17A \| DISEASES 387837 \| CLEC12B \| DISEASES 5359 \| PLSCR1 \| DISEASES 57556 \| SEMA6A \| DISEASES 3767 \| KCNJ11 \| DISEASES 6133 \| RPL9 \| DISEASES 6189 \| RPS3A \| DISEASES 5154 \| PDGFA \| DISEASES 3181 \| HNRNPA2B1 \| DISEASES 728 \| C5AR1 \| DISEASES 160364 \| CLEC12A \| DISEASES 355 \| FAS \| DISEASES 5265 \| SERPINA1 \| DISEASES 3240 \| HP \| DISEASES 219844 \| HYLS1 \| DISEASES 6288 \| SAA1 \| DISEASES 3683 \| ITGAL \| DISEASES 246778 \| IL27 \| DISEASES 53916 \| RAB4B \| DISEASES 3663 \| IRF5 \| DISEASES 54437 \| SEMA5B \| DISEASES 23556 \| PIGN \| DISEASES 1524 \| CX3CR1 \| DISEASES 6775 \| STAT4 \| DISEASES 2213 \| FCGR2B \| DISEASES 3821 \| KLRC1 \| DISEASES 9332 \| CD163 \| DISEASES 23654 \| PLXNB2 \| DISEASES 26191 \| PTPN22 \| DISEASES 3123 \| HLA-DRB1 \| DISEASES 2157 \| F8 \| DISEASES 4478 \| MSN \| DISEASES 11177 \| BAZ1A \| DISEASES 3135 \| HLA-G \| DISEASES 5599 \| MAPK8 \| DISEASES 54106 \| TLR9 \| DISEASES 5646 \| PRSS3 \| DISEASES 4283 \| CXCL9 \| DISEASES 7096 \| TLR1 \| DISEASES 81706 \| PPP1R14C \| DISEASES 58 \| ACTA1 \| DISEASES 2853 \| GPR31 \| DISEASES 7042 \| TGFB2 \| DISEASES 1378 \| CR1 \| DISEASES 6993 \| DYNLT1 \| DISEASES 5788 \| PTPRC \| DISEASES 462 \| SERPINC1 \| DISEASES 356 \| FASLG \| DISEASES 2214 \| FCGR3A \| DISEASES 2205 \| FCER1A \| DISEASES 6283 \| S100A12 \| DISEASES 6280 \| S100A9 \| DISEASES 3713 \| IVL \| DISEASES 8349 \| HIST2H2BE \| DISEASES 2209 \| FCGR1A \| DISEASES 914 \| CD2 \| DISEASES 134701 \| RIPPLY2 \| DISEASES 8804 \| CREG1 \| DISEASES 959 \| CD40LG \| DISEASES 4068 \| SH2D1A \| DISEASES 1757 \| SARDH \| DISEASES 7422 \| VEGFA \| DISEASES 64405 \| CDH22 \| DISEASES 958 \| CD40 \| DISEASES 6441 \| SFTPD \| DISEASES 4318 \| MMP9 \| DISEASES 6709 \| SPTAN1 \| DISEASES 100 \| ADA \| DISEASES 1025 \| CDK9 \| DISEASES 139599 \| MAGEE2 \| DISEASES 23787 \| MTCH1 \| DISEASES 2833 \| CXCR3 \| DISEASES 4153 \| MBL2 \| DISEASES 7099 \| TLR4 \| DISEASES 1043 \| CD52 \| DISEASES 1896 \| EDA \| DISEASES 7923 \| HSD17B8 \| DISEASES 6257 \| RXRB \| DISEASES 3339 \| HSPG2 \| DISEASES 23569 \| PADI4 \| DISEASES 2155 \| F7 \| DISEASES 3305 \| HSPA1L \| DISEASES 10673 \| TNFSF13B \| DISEASES 50943 \| FOXP3 \| DISEASES 100507436 \| MICA \| DISEASES 3107 \| HLA-C \| DISEASES 7133 \| TNFRSF1B \| DISEASES 1041 \| CDSN \| DISEASES 4524 \| MTHFR \| DISEASES 2794 \| GNL1 \| DISEASES 3133 \| HLA-E \| DISEASES 56658 \| TRIM39 \| DISEASES 3105 \| HLA-A \| DISEASES 5394 \| EXOSC10 \| DISEASES 7056 \| THBD \| DISEASES 23130 \| ATG2A \| DISEASES 84210 \| ANKRD20A1 \| DISEASES 3604 \| TNFRSF9 \| DISEASES 8718 \| TNFRSF25 \| DISEASES 57126 \| CD177 \| DISEASES 9308 \| CD83 \| DISEASES 7293 \| TNFRSF4 \| DISEASES 2625 \| GATA3 \| DISEASES 1906 \| EDN1 \| DISEASES 3559 \| IL2RA \| DISEASES 54790 \| TET2 \| DISEASES 51374 \| ATRAID \| DISEASES 3440 \| IFNA2 \| DISEASES 3456 \| IFNB1 \| DISEASES 551 \| AVP \| DISEASES 158747 \| MOSPD2 \| DISEASES 51284 \| TLR7 \| DISEASES 1992 \| SERPINB1 \| DISEASES 51109 \| RDH11 \| DISEASES 90865 \| IL33 \| DISEASES 3822 \| KLRC2 \| DISEASES 3823 \| KLRC3 \| DISEASES 93978 \| CLEC6A \| DISEASES 4155 \| MBP \| DISEASES 361 \| AQP4 \| DISEASES 402682 \| UFSP1 \| DISEASES 339965 \| CCDC158 \| DISEASES 3811 \| KIR3DL1 \| DISEASES 2524 \| FUT2 \| DISEASES 4099 \| MAG \| DISEASES 12 \| SERPINA3 \| DISEASES 6696 \| SPP1 \| DISEASES 26091 \| HERC4 \| DISEASES 3895 \| KTN1 \| DISEASES 2919 \| CXCL1 \| DISEASES 79168 \| LILRA6 \| DISEASES 3676 \| ITGA4 \| DISEASES 1781 \| DYNC1I2 \| DISEASES 56138 \| PCDHA11 \| DISEASES 3119 \| HLA-DQB1 \| DISEASES 375704 \| ENHO \| DISEASES 7278 \| TUBA3C \| DISEASES 3803 \| KIR2DL2 \| DISEASES 10747 \| MASP2 \| DISEASES 337867 \| UBAC2 \| DISEASES 23308 \| ICOSLG \| DISEASES 6335 \| SCN9A \| DISEASES 6295 \| SAG \| DISEASES 6160 \| RPL31 \| DISEASES 6916 \| TBXAS1 \| DISEASES 3120 \| HLA-DQB2 \| DISEASES 11277 \| TREX1 \| DISEASES 23705 \| CADM1 \| DISEASES 720 \| C4A \| DISEASES 960 \| CD44 \| DISEASES 7124 \| TNF \| DISEASES 3106 \| HLA-B \| DISEASES 64167 \| ERAP2 \| DISEASES 4615 \| MYD88 \| DISEASES 3594 \| IL12RB1 \| DISEASES 4049 \| LTA \| DISEASES 254827 \| NAALADL2 \| DISEASES 9465 \| AKAP7 \| DISEASES 3115 \| HLA-DPB1 \| DISEASES 3920 \| LAMP2 \| DISEASES 81704 \| DOCK8 \| DISEASES 834 \| CASP1 \| DISEASES 3586 \| IL10 \| DISEASES 133396 \| IL31RA \| DISEASES 721 \| C4B \| DISEASES 27042 \| DIEXF \| DISEASES 30816 \| ERVW-1 \| DISEASES 23148 \| NACAD \| DISEASES 51428 \| DDX41 \| DISEASES 9555 \| H2AFY \| DISEASES 284 \| ANGPT1 \| DISEASES 56674 \| TMEM9B \| DISEASES 727897 \| MUC5B \| DISEASES 930 \| CD19 \| DISEASES 83695 \| RHNO1 \| DISEASES 1232 \| CCR3 \| DISEASES 3684 \| ITGAM \| DISEASES 51499 \| TRIAP1 \| DISEASES 8742 \| TNFSF12 \| DISEASES 567 \| B2M \| DISEASES 2585 \| GALK2 \| DISEASES 820 \| CAMP \| DISEASES 22861 \| NLRP1 \| DISEASES 124817 \| CNTD1 \| DISEASES 6625 \| SNRNP70 \| DISEASES 285830 \| HLA-F-AS1 \| DISEASES 101928376 \| IL12A-AS1 \| DISEASES 102723508 \| KANTR \| DISEASES 348120 \| LINC01193 \| DISEASES 79104 \| MEG8 \| DISEASES 102659353 \| THRIL \| DISEASES
Locus	(Waiting for update.)

Disease ID	37
Disease	vasculitis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:167) HP:0002725 \| Systemic lupus erythematosus \| 22 HP:0012115 \| Liver inflammation \| 21 HP:0000979 \| Purpura \| 19 HP:0001297 \| Cerebral vascular events \| 16 HP:0001370 \| Rheumatoid arthritis \| 16 HP:0012490 \| Inflammation of fat tissue \| 14 HP:0000099 \| Glomerular nephritis \| 12 HP:0000554 \| Uveitis \| 11 HP:0002099 \| Asthma \| 10 HP:0001945 \| Fever \| 10 HP:0002955 \| Granulomatosis \| 10 HP:0100778 \| Cryoglobulinemia \| 10 HP:0002617 \| Aneurysmal dilatation \| 10 HP:0012123 \| Posterior uveitis \| 9 HP:0001880 \| Eosinophilia \| 9 HP:0001369 \| Arthritis \| 9 HP:0000969 \| Dropsy \| 9 HP:0100280 \| Morbus Crohn \| 8 HP:0100279 \| Ulcerative colitis \| 8 HP:0000083 \| Renal insufficiency \| 6 HP:0002583 \| Colitis \| 6 HP:0008653 \| Crescentic glomerulonephritis \| 6 HP:0012531 \| Pain \| 6 HP:0000123 \| Nephritis \| 5 HP:0002664 \| Neoplasia \| 5 HP:0012089 \| Arteritis \| 5 HP:0001658 \| Myocardial infarction \| 5 HP:0002090 \| Pneumonia \| 5 HP:0012819 \| Myocarditis \| 4 HP:0012121 \| Panuveitis \| 4 HP:0010783 \| Erythema \| 4 HP:0011531 \| Hyalitis \| 4 HP:0012578 \| Membranous glomerulonephritis \| 3 HP:0002960 \| Autoimmune condition \| 3 HP:0000388 \| Otitis media \| 3 HP:0000572 \| Visual loss \| 3 HP:0000618 \| Blindness \| 3 HP:0001025 \| Hives \| 3 HP:0002863 \| Myelodysplastic syndrome \| 3 HP:0011950 \| Bronchiolitis \| 3 HP:0009830 \| Peripheral neuritis \| 3 HP:0002584 \| Intestinal hemorrhage \| 2 HP:0000988 \| Exanthem \| 2 HP:0006775 \| Multiple myeloma \| 2 HP:0002383 \| Encephalitis \| 2 HP:0040049 \| Macular edema \| 2 HP:0001287 \| Meningitis \| 2 HP:0003774 \| End-stage renal failure \| 2 HP:0100532 \| Scleritis \| 2 HP:0005584 \| Renal cell carcinoma \| 2 HP:0200042 \| Skin ulcer \| 2 HP:0002239 \| Gastrointestinal hemorrhage \| 2 HP:0002621 \| Atherosclerosis \| 2 HP:0100653 \| Optic neuritis \| 2 HP:0002204 \| Pulmonary embolism \| 2 HP:0001878 \| Haemolytic anaemia \| 2 HP:0002092 \| Pulmonary artery hypertension \| 2 HP:0100584 \| Endocarditis \| 2 HP:0100758 \| Gangrene \| 2 HP:0012124 \| Intermediate uveitis \| 2 HP:0012636 \| Retinal vein occlusion \| 2 HP:0100533 \| Ocular inflammation \| 2 HP:0002206 \| Pulmonary fibrosis \| 2 HP:0012126 \| Gastric cancer \| 2 HP:0001909 \| Leukemia \| 2 HP:0012378 \| Fatigue \| 2 HP:0100310 \| Extradural hematoma \| 2 HP:0002716 \| Lymph node hyperplasia \| 2 HP:0200029 \| Cutaneous vasculitis \| 2 HP:0001970 \| Interstitial nephritis \| 2 HP:0005550 \| Chronic lymphatic leukemia \| 2 HP:0003761 \| Calcinosis \| 2 HP:0030731 \| Carcinoma \| 2 HP:0002140 \| Ischemic stroke \| 2 HP:0000999 \| Pyoderma \| 2 HP:0001903 \| Anemia \| 2 HP:0000573 \| Retinal hemorrhage \| 2 HP:0001635 \| Congestive heart failure \| 1 HP:0000112 \| Nephropathy \| 1 HP:0000265 \| Mastoiditis \| 1 HP:0000704 \| Pyorrhea \| 1 HP:0005575 \| Hemolytic-uremic syndrome \| 1 HP:0001907 \| Thromboembolic disease \| 1 HP:0002637 \| Brain ischemia \| 1 HP:0011874 \| Heparin-induced thrombocytopenia \| 1 HP:0040078 \| Axonal degeneration \| 1 HP:0030830 \| Crackles \| 1 HP:0100762 \| Hemobilia \| 1 HP:0012622 \| Chronic kidney disease \| 1 HP:0001300 \| Parkinsonism \| 1 HP:0003765 \| Psoriasis \| 1 HP:0002315 \| Headaches \| 1 HP:0002098 \| Respiratory distress \| 1 HP:0002633 \| Vasculitis \| 1 HP:0000790 \| Hematuria \| 1 HP:0001047 \| Atopic dermatitis \| 1 HP:0000488 \| Noninflammatory retina disease \| 1 HP:0001698 \| Pericardial effusions \| 1 HP:0001901 \| Abnormally shaped erythrocytes \| 1 HP:0000602 \| Ophthalmoplegia \| 1 HP:0100724 \| Hypercoagulability \| 1 HP:0002097 \| Pulmonary emphysema \| 1 HP:0100658 \| Bacterial infection of skin \| 1 HP:0001824 \| Weight loss \| 1 HP:0200123 \| Chronic liver inflammation \| 1 HP:0011484 \| Posterior synechiae \| 1 HP:0011505 \| Cystoid macular edema \| 1 HP:0004326 \| Cachexia \| 1 HP:0002840 \| Lymphadenitis \| 1 HP:0200037 \| Skin vesicle \| 1 HP:0001937 \| Microangiopathic hemolytic anemia \| 1 HP:0006554 \| Acute hepatic failure \| 1 HP:0002171 \| Cerebral gliosis \| 1 HP:0012539 \| Non-Hodgkin lymphoma \| 1 HP:0001882 \| Decreased blood leukocyte number \| 1 HP:0030746 \| Intraventricular hemorrhage \| 1 HP:0002829 \| Arthralgias \| 1 HP:0012847 \| Epilepsia partialis continua \| 1 HP:0000822 \| Hypertension \| 1 HP:0000965 \| Livedo reticularis \| 1 HP:0011695 \| Cerebellar hemorrhage \| 1 HP:0003249 \| Genital ulcers \| 1 HP:0100324 \| Progressive systemic scleroderma \| 1 HP:0040276 \| Adenocarcinoma of the colon \| 1 HP:0001645 \| Sudden cardiac death \| 1 HP:0005523 \| Lymphoproliferative disorder \| 1 HP:0002907 \| Microhematuria \| 1 HP:0000975 \| Increased sweating \| 1 HP:0003565 \| Elevated sedimentation rate \| 1 HP:0002196 \| Myelopathy \| 1 HP:0001596 \| Hair loss \| 1 HP:0012128 \| Basal ganglia necrosis \| 1 HP:0000771 \| Gynaecomastia \| 1 HP:0007902 \| Vitreous hemorrhage \| 1 HP:0001875 \| Neutropenia \| 1 HP:0000726 \| Dementia \| 1 HP:0002665 \| Lymphoma \| 1 HP:0001254 \| Lethargy \| 1 HP:0002321 \| Vertigo \| 1 HP:0200039 \| Pustules \| 1 HP:0000501 \| Glaucoma \| 1 HP:0002445 \| Paralysis of all four limbs \| 1 HP:0011034 \| Amyloid disease \| 1 HP:0002326 \| TIA \| 1 HP:0008619 \| Bilateral sensorineural hearing impairment \| 1 HP:0001873 \| Low platelet count \| 1 HP:0010628 \| Facial palsy, unilateral or bilateral \| 1 HP:0000093 \| Proteinuria \| 1 HP:0012189 \| Hodgkin disease \| 1 HP:0011970 \| Cerebral amyloid angiopathy \| 1 HP:0002613 \| Biliary cirrhosis \| 1 HP:0001342 \| Intracerebral hemorrhage \| 1 HP:0000491 \| Corneal inflammation \| 1 HP:0011096 \| Demyelination \| 1 HP:0006689 \| Bacterial endocarditis \| 1 HP:0009831 \| Single damaged nerve \| 1 HP:0003613 \| Antiphospholipid antibodies \| 1 HP:0002170 \| Intracranial hemorrhage \| 1 HP:0012486 \| Inflammation of spinal cord \| 1 HP:0001541 \| Ascites \| 1 HP:0005549 \| Low blood neutrophil level since birth \| 1 HP:0000407 \| sensorineural hearing loss \| 1 HP:0001695 \| Cardiac arrest \| 1 HP:0001045 \| Blotchy loss of skin color \| 1 HP:0007722 \| Retinal pigment epithelial atrophy \| 1 HP:0000836 \| Overactive thyroid \| 1 HP:0040165 \| Periostitis \| 1

Disease ID	37
Disease	vasculitis
Manually Symptom	UMLS \| Name(Total Manually Symptoms:88) C2697391 \| rheumatoid arthritis C2364133 \| infection C1994997 \| intestinal symptoms C1963736 \| tongue necrosis C1963220 \| pulmonary hypertension C1963138 \| hypertension C1960872 \| sural neuropathy C1959635 \| parvovirus b19 C1546654 \| granuloma C1504530 \| secondary epilepsy C1408247 \| acute renal disease C1393529 \| vascular complications C1299884 \| eosinophilic myositis C1090821 \| sepsis C0948976 \| leukemia cutis C0920157 \| mesenteric ischemia C0878643 \| epiphenomenon C0856805 \| acute paraplegia C0856169 \| endothelial dysfunction C0852949 \| arterial disease C0752303 \| urological manifestations C0752303 \| urological manifestation C0748159 \| pulmonary involvement C0740343 \| mononeuropathy multiplex C0728936 \| circulatory disorders C0543697 \| mixed cryoglobulinemia C0542007 \| cerebral haematoma C0494491 \| mononeuropathy C0442874 \| neuropathy C0426768 \| o sign C0398701 \| igg2 deficiency C0398623 \| hypercoagulability C0398359 \| trousseau's syndrome C0393483 \| brainstem encephalitis C0376293 \| stigmata C0341221 \| gastric necrosis C0340076 \| pulmonary eosinophilia C0276908 \| pneumocystis jiroveci infection C0271681 \| sensory polyneuropathy C0264490 \| acute respiratory failure C0238304 \| chronic tubulointerstitial nephritis C0221239 \| rapidly progressive glomerulonephritis C0220847 \| hepatitis c C0206062 \| interstitial lung disease C0152025 \| polyneuropathy C0151313 \| sensory neuropathy C0151295 \| mononeuritis multiplex C0149678 \| epstein-barr virus infection C0149520 \| acute cholecystitis C0043092 \| wegener's granulomatosis C0042769 \| viral infection C0041956 \| ureteral obstruction C0040046 \| thrombophlebitis C0040038 \| thromboembolic disease C0039591 \| testicular pain C0038525 \| subarachnoid hemorrhages C0038454 \| stroke C0038454 \| cerebral infarction C0037299 \| cutaneous ulcers C0037285 \| skin manifestations C0037284 \| skin lesions C0036416 \| scleritis C0035435 \| rheumatic diseases C0034150 \| purpura C0031117 \| peripheral neuropathy C0029883 \| otitis media with effusion C0029191 \| orchitis C0025309 \| meningoencephalitis C0024141 \| systemic lupus erythematosus C0023223 \| leg ulcers C0022661 \| end-stage renal disease C0022661 \| chronic renal failure C0022660 \| acute renal failure C0022116 \| ischemia C0021308 \| infarction C0020545 \| renovascular hypertension C0019080 \| hemorrhage C0018994 \| hemobilia C0014335 \| enteritis C0013604 \| oedema C0011633 \| dermatomyositis C0010823 \| cytomegalovirus infection C0009951 \| convulsions C0006666 \| calciphylaxis C0004153 \| atherosclerosis C0001824 \| granulocytopenia C0001363 \| acute mesenteric ischemia C0000727 \| acute abdomen
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:42) C0009450 \| infection \| 28 C0024141 \| systemic lupus erythematosus \| 22 C0034150 \| purpura \| 19 C0019080 \| hemorrhage \| 19 C0019196 \| hepatitis c \| 17 C0038454 \| stroke \| 16 C0003873 \| rheumatoid arthritis \| 16 C0022116 \| ischemia \| 14 C0021308 \| infarction \| 10 C0426768 \| o sign \| 7 C0043092 \| wegener's granulomatosis \| 7 C0543697 \| mixed cryoglobulinemia \| 6 C0018188 \| granuloma \| 6 C0442874 \| neuropathy \| 6 C0013604 \| oedema \| 5 C0025309 \| meningoencephalitis \| 5 C0748159 \| pulmonary involvement \| 4 C0037284 \| skin lesions \| 4 C0011633 \| dermatomyositis \| 4 C0031117 \| peripheral neuropathy \| 3 C0035435 \| rheumatic diseases \| 3 C0036416 \| scleritis \| 2 C0020542 \| pulmonary hypertension \| 2 C0004153 \| atherosclerosis \| 2 C0022661 \| end-stage renal disease \| 2 C1393529 \| vascular complications \| 2 C0018994 \| hemobilia \| 1 C0014335 \| enteritis \| 1 C0037285 \| skin manifestations \| 1 C0042769 \| viral infection \| 1 C0151295 \| mononeuritis multiplex \| 1 C0398623 \| hypercoagulability \| 1 C0023223 \| leg ulcers \| 1 C0494491 \| mononeuropathy \| 1 C0856169 \| endothelial dysfunction \| 1 C0221239 \| rapidly progressive glomerulonephritis \| 1 C0020538 \| hypertension \| 1 C0001363 \| acute mesenteric ischemia \| 1 C0006666 \| calciphylaxis \| 1 C0149678 \| epstein-barr virus infection \| 1 C0752303 \| urological manifestations \| 1 C0920157 \| mesenteric ischemia \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:3)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs2476601	22696186	26191	PTPN22	umls:C0042384	BeFree	This meta-analysis does not show that the PTPN22 C1858T polymorphism is associated with vasculitis susceptibility, but does show that this polymorphism is associated with susceptibility to AAV, WG, and ANCA status in WG.	0.000814326	2012	PTPN22;AP4B1-AS1	1	113834946	A	G
rs3743930	19026701	4210	MEFV	umls:C0042384	BeFree	We investigated a possible association between Kawasaki disease (KD), a systemic vasculitis of unknown etiology, or its coronary artery lesions (CAL) and MEFV gene variants including E148Q, the most common and mild mutation in the MEFV gene for familial Mediterranean fever or vasculitis-related disorders.	0.003810118	2009	MEFV	16	3254626	C	G
rs6822844	21269573	59067	IL21	umls:C0042384	BeFree	To assess the influence of the interleukin (IL)2-IL21 rs6822844 G/T polymorphism in the susceptibility to biopsy-proven giant cell arteritis (GCA) and in the clinical spectrum of manifestations of this vasculitis.	0.000271442	2011	NA	4	122588266	G	T

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:44)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
1	58452314	rs4912290	G	A	rs4912290	22808956	5.77E-05	NA	NA	NA	914 European ancestry cases; 5,259 European ancestry controls	European(6173)	ALL(6173)	EUR(6173)	ALL(6173)	Antineutrophil cytoplasmic antibody-associated vasculitis	HPOID:0002633	Vasculitis	DOID:865	vasculitis	D056648	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	EFOID:0004826	anti-neutrophil antibody associated vasculitis	Vasculitis	NA	Research Support, Non-U.S. Gov't	A	DAB1
2	204731519	rs16840252	C	T	rs16840252	22808956	1.28E-05	NA	NA	NA	914 European ancestry cases; 5,259 European ancestry controls	European(6173)	ALL(6173)	EUR(6173)	ALL(6173)	Antineutrophil cytoplasmic antibody-associated vasculitis	HPOID:0002633	Vasculitis	DOID:865	vasculitis	D056648	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	EFOID:0004826	anti-neutrophil antibody associated vasculitis	Vasculitis	NA	Research Support, Non-U.S. Gov't	C	CTLA4
3	191956119	rs2126071	G	A	rs2126071	22808956	4.96E-04	NA	NA	NA	914 European ancestry cases; 5,259 European ancestry controls	European(6173)	ALL(6173)	EUR(6173)	ALL(6173)	Antineutrophil cytoplasmic antibody-associated vasculitis	HPOID:0002633	Vasculitis	DOID:865	vasculitis	D056648	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	EFOID:0004826	anti-neutrophil antibody associated vasculitis	Vasculitis	NA	Research Support, Non-U.S. Gov't	A	FGF12
4	71021940	rs17148265	T	C	rs17148265	22808956	1.47E-05	NA	NA	NA	914 European ancestry cases; 5,259 European ancestry controls	European(6173)	ALL(6173)	EUR(6173)	ALL(6173)	Antineutrophil cytoplasmic antibody-associated vasculitis	HPOID:0002633	Vasculitis	DOID:865	vasculitis	D056648	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	EFOID:0004826	anti-neutrophil antibody associated vasculitis	Vasculitis	NA	Research Support, Non-U.S. Gov't	T	C4orf40
5	86893820	rs984026	A	G	rs984026	22808956	1.02E-04	NA	NA	NA	914 European ancestry cases; 5,259 European ancestry controls	European(6173)	ALL(6173)	EUR(6173)	ALL(6173)	Antineutrophil cytoplasmic antibody-associated vasculitis	HPOID:0002633	Vasculitis	DOID:865	vasculitis	D056648	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	EFOID:0004826	anti-neutrophil antibody associated vasculitis	Vasculitis	NA	Research Support, Non-U.S. Gov't	A	NA
6	33069893	rs3117242	A	G	rs3117242	22808956	1.00E-71	NA	3.67	NA	914 European ancestry cases; 5,259 European ancestry controls	European(6173)	ALL(6173)	EUR(6173)	ALL(6173)	Antineutrophil cytoplasmic antibody-associated vasculitis	HPOID:0002633	Vasculitis	DOID:865	vasculitis	D056648	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	EFOID:0004826	anti-neutrophil antibody associated vasculitis	Vasculitis	NA	Research Support, Non-U.S. Gov't	T	NA
6	33095176	rs3130233	T	C	rs3130233	22808956	7.78E-15	NA	NA	NA	914 European ancestry cases; 5,259 European ancestry controls	European(6173)	ALL(6173)	EUR(6173)	ALL(6173)	Antineutrophil cytoplasmic antibody-associated vasculitis	HPOID:0002633	Vasculitis	DOID:865	vasculitis	D056648	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	EFOID:0004826	anti-neutrophil antibody associated vasculitis	Vasculitis	NA	Research Support, Non-U.S. Gov't	C	NA
6	33095516	rs3117016	G	A	rs3117016	22808956	6.41E-24	NA	NA	NA	914 European ancestry cases; 5,259 European ancestry controls	European(6173)	ALL(6173)	EUR(6173)	ALL(6173)	Antineutrophil cytoplasmic antibody-associated vasculitis	HPOID:0002633	Vasculitis	DOID:865	vasculitis	D056648	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	EFOID:0004826	anti-neutrophil antibody associated vasculitis	Vasculitis	NA	Research Support, Non-U.S. Gov't	C	HLA-DPB2
6	89152479	rs936495	G	T	rs936495	22808956	2.46E-05	NA	NA	NA	914 European ancestry cases; 5,259 European ancestry controls	European(6173)	ALL(6173)	EUR(6173)	ALL(6173)	Antineutrophil cytoplasmic antibody-associated vasculitis	HPOID:0002633	Vasculitis	DOID:865	vasculitis	D056648	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	EFOID:0004826	anti-neutrophil antibody associated vasculitis	Vasculitis	NA	Research Support, Non-U.S. Gov't	A	NA
6	130031493	rs17057678	T	C	rs17057678	22808956	6.00E-07	NA	1.25	NA	914 European ancestry cases; 5,259 European ancestry controls	European(6173)	ALL(6173)	EUR(6173)	ALL(6173)	Antineutrophil cytoplasmic antibody-associated vasculitis	HPOID:0002633	Vasculitis	DOID:865	vasculitis	D056648	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	EFOID:0004826	anti-neutrophil antibody associated vasculitis	Vasculitis	NA	Research Support, Non-U.S. Gov't	T	NA
6	150365343	rs12207804	G	C	rs12207804	22808956	3.45E-05	NA	NA	NA	914 European ancestry cases; 5,259 European ancestry controls	European(6173)	ALL(6173)	EUR(6173)	ALL(6173)	Antineutrophil cytoplasmic antibody-associated vasculitis	HPOID:0002633	Vasculitis	DOID:865	vasculitis	D056648	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	EFOID:0004826	anti-neutrophil antibody associated vasculitis	Vasculitis	NA	Research Support, Non-U.S. Gov't	C	NA
8	134247127	rs13263504	G	A	rs13263504	22808956	6.05E-05	NA	NA	NA	914 European ancestry cases; 5,259 European ancestry controls	European(6173)	ALL(6173)	EUR(6173)	ALL(6173)	Antineutrophil cytoplasmic antibody-associated vasculitis	HPOID:0002633	Vasculitis	DOID:865	vasculitis	D056648	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	EFOID:0004826	anti-neutrophil antibody associated vasculitis	Vasculitis	NA	Research Support, Non-U.S. Gov't	A	NA
8	136421680	rs2873417	G	A	rs2873417	22808956	2.17E-05	NA	NA	NA	914 European ancestry cases; 5,259 European ancestry controls	European(6173)	ALL(6173)	EUR(6173)	ALL(6173)	Antineutrophil cytoplasmic antibody-associated vasculitis	HPOID:0002633	Vasculitis	DOID:865	vasculitis	D056648	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	EFOID:0004826	anti-neutrophil antibody associated vasculitis	Vasculitis	NA	Research Support, Non-U.S. Gov't	G	NA
9	7209284	rs7020238	T	C	rs7020238	22808956	6.76E-05	NA	NA	NA	914 European ancestry cases; 5,259 European ancestry controls	European(6173)	ALL(6173)	EUR(6173)	ALL(6173)	Antineutrophil cytoplasmic antibody-associated vasculitis	HPOID:0002633	Vasculitis	DOID:865	vasculitis	D056648	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	EFOID:0004826	anti-neutrophil antibody associated vasculitis	Vasculitis	NA	Research Support, Non-U.S. Gov't	C	NA
9	13115422	rs2274647	T	G	rs2274647	22808956	7.42E-05	NA	NA	NA	914 European ancestry cases; 5,259 European ancestry controls	European(6173)	ALL(6173)	EUR(6173)	ALL(6173)	Antineutrophil cytoplasmic antibody-associated vasculitis	HPOID:0002633	Vasculitis	DOID:865	vasculitis	D056648	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	EFOID:0004826	anti-neutrophil antibody associated vasculitis	Vasculitis	NA	Research Support, Non-U.S. Gov't	T	MPDZ
10	26663922	rs4749119	A	G	rs4749119	22808956	4.21E-05	NA	NA	NA	914 European ancestry cases; 5,259 European ancestry controls	European(6173)	ALL(6173)	EUR(6173)	ALL(6173)	Antineutrophil cytoplasmic antibody-associated vasculitis	HPOID:0002633	Vasculitis	DOID:865	vasculitis	D056648	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	EFOID:0004826	anti-neutrophil antibody associated vasculitis	Vasculitis	NA	Research Support, Non-U.S. Gov't	A	NA
10	36060309	rs11010290	A	G	rs11010290	22808956	9.00E-06	NA	NA	NA	914 European ancestry cases; 5,259 European ancestry controls	European(6173)	ALL(6173)	EUR(6173)	ALL(6173)	Antineutrophil cytoplasmic antibody-associated vasculitis	HPOID:0002633	Vasculitis	DOID:865	vasculitis	D056648	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	EFOID:0004826	anti-neutrophil antibody associated vasculitis	Vasculitis	NA	Research Support, Non-U.S. Gov't	A	NA
11	20881437	rs1429794	A	G	rs1429794	22808956	3.59E-05	NA	NA	NA	914 European ancestry cases; 5,259 European ancestry controls	European(6173)	ALL(6173)	EUR(6173)	ALL(6173)	Antineutrophil cytoplasmic antibody-associated vasculitis	HPOID:0002633	Vasculitis	DOID:865	vasculitis	D056648	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	EFOID:0004826	anti-neutrophil antibody associated vasculitis	Vasculitis	NA	Research Support, Non-U.S. Gov't	A	NELL1
11	89062444	rs3897708	C	T	rs3897708	22808956	1.57E-05	NA	NA	NA	914 European ancestry cases; 5,259 European ancestry controls	European(6173)	ALL(6173)	EUR(6173)	ALL(6173)	Antineutrophil cytoplasmic antibody-associated vasculitis	HPOID:0002633	Vasculitis	DOID:865	vasculitis	D056648	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	EFOID:0004826	anti-neutrophil antibody associated vasculitis	Vasculitis	NA	Research Support, Non-U.S. Gov't	T	NOX4
12	6170486	rs12319392	G	T	rs12319392	22808956	6.23E-04	NA	NA	NA	914 European ancestry cases; 5,259 European ancestry controls	European(6173)	ALL(6173)	EUR(6173)	ALL(6173)	Antineutrophil cytoplasmic antibody-associated vasculitis	HPOID:0002633	Vasculitis	DOID:865	vasculitis	D056648	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	EFOID:0004826	anti-neutrophil antibody associated vasculitis	Vasculitis	NA	Research Support, Non-U.S. Gov't	T	VWF
12	96159659	rs11612530	C	T	rs11612530	22808956	1.02E-05	NA	NA	NA	914 European ancestry cases; 5,259 European ancestry controls	European(6173)	ALL(6173)	EUR(6173)	ALL(6173)	Antineutrophil cytoplasmic antibody-associated vasculitis	HPOID:0002633	Vasculitis	DOID:865	vasculitis	D056648	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	EFOID:0004826	anti-neutrophil antibody associated vasculitis	Vasculitis	NA	Research Support, Non-U.S. Gov't	C	NTN4
13	30885223	rs185694	A	G	rs185694	22808956	4.00E-06	NA	NA	NA	914 European ancestry cases; 5,259 European ancestry controls	European(6173)	ALL(6173)	EUR(6173)	ALL(6173)	Antineutrophil cytoplasmic antibody-associated vasculitis	HPOID:0002633	Vasculitis	DOID:865	vasculitis	D056648	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	EFOID:0004826	anti-neutrophil antibody associated vasculitis	Vasculitis	NA	Research Support, Non-U.S. Gov't	T	NA
13	45055091	rs17065868	T	C	rs17065868	22808956	3.00E-06	NA	NA	NA	914 European ancestry cases; 5,259 European ancestry controls	European(6173)	ALL(6173)	EUR(6173)	ALL(6173)	Antineutrophil cytoplasmic antibody-associated vasculitis	HPOID:0002633	Vasculitis	DOID:865	vasculitis	D056648	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	EFOID:0004826	anti-neutrophil antibody associated vasculitis	Vasculitis	NA	Research Support, Non-U.S. Gov't	C	TSC22D1
13	56663210	rs166940	T	C	rs166940	22808956	2.32E-05	NA	NA	NA	914 European ancestry cases; 5,259 European ancestry controls	European(6173)	ALL(6173)	EUR(6173)	ALL(6173)	Antineutrophil cytoplasmic antibody-associated vasculitis	HPOID:0002633	Vasculitis	DOID:865	vasculitis	D056648	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	EFOID:0004826	anti-neutrophil antibody associated vasculitis	Vasculitis	NA	Research Support, Non-U.S. Gov't	A	NA
14	94863636	rs7151526	C	A	rs7151526	22808956	2.00E-09	NA	1.69	NA	914 European ancestry cases; 5,259 European ancestry controls	European(6173)	ALL(6173)	EUR(6173)	ALL(6173)	Antineutrophil cytoplasmic antibody-associated vasculitis	HPOID:0002633	Vasculitis	DOID:865	vasculitis	D056648	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	EFOID:0004826	anti-neutrophil antibody associated vasculitis	Vasculitis	NA	Research Support, Non-U.S. Gov't	C	NA
17	44949100	rs11079740	G	C	rs11079740	22808956	9.00E-06	NA	1.1	NA	914 European ancestry cases; 5,259 European ancestry controls	European(6173)	ALL(6173)	EUR(6173)	ALL(6173)	Antineutrophil cytoplasmic antibody-associated vasculitis	HPOID:0002633	Vasculitis	DOID:865	vasculitis	D056648	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	EFOID:0004826	anti-neutrophil antibody associated vasculitis	Vasculitis	NA	Research Support, Non-U.S. Gov't	G	WNT9B
18	3328746	rs1623523	T	C	rs1623523	22808956	3.00E-06	NA	NA	NA	914 European ancestry cases; 5,259 European ancestry controls	European(6173)	ALL(6173)	EUR(6173)	ALL(6173)	Antineutrophil cytoplasmic antibody-associated vasculitis	HPOID:0002633	Vasculitis	DOID:865	vasculitis	D056648	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	EFOID:0004826	anti-neutrophil antibody associated vasculitis	Vasculitis	NA	Research Support, Non-U.S. Gov't	A	NA
18	55627840	rs11875185	A	G	rs11875185	22808956	7.00E-06	NA	NA	NA	914 European ancestry cases; 5,259 European ancestry controls	European(6173)	ALL(6173)	EUR(6173)	ALL(6173)	Antineutrophil cytoplasmic antibody-associated vasculitis	HPOID:0002633	Vasculitis	DOID:865	vasculitis	D056648	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	EFOID:0004826	anti-neutrophil antibody associated vasculitis	Vasculitis	NA	Research Support, Non-U.S. Gov't	G	NA
22	45738327	rs2294202	T	A	rs2294202	22808956	4.52E-05	NA	NA	NA	914 European ancestry cases; 5,259 European ancestry controls	European(6173)	ALL(6173)	EUR(6173)	ALL(6173)	Antineutrophil cytoplasmic antibody-associated vasculitis	HPOID:0002633	Vasculitis	DOID:865	vasculitis	D056648	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	EFOID:0004826	anti-neutrophil antibody associated vasculitis	Vasculitis	NA	Research Support, Non-U.S. Gov't	T	NA
X	3410669	rs7059886	A	G	rs7059886	22808956	1.00E-06	NA	1.16	NA	914 European ancestry cases; 5,259 European ancestry controls	European(6173)	ALL(6173)	EUR(6173)	ALL(6173)	Antineutrophil cytoplasmic antibody-associated vasculitis	HPOID:0002633	Vasculitis	DOID:865	vasculitis	D056648	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	EFOID:0004826	anti-neutrophil antibody associated vasculitis	Vasculitis	NA	Research Support, Non-U.S. Gov't	A	NA
X	5184702	rs6638512	C	T	rs6638512	22808956	2.00E-25	NA	NA	NA	914 European ancestry cases; 5,259 European ancestry controls	European(6173)	ALL(6173)	EUR(6173)	ALL(6173)	Antineutrophil cytoplasmic antibody-associated vasculitis	HPOID:0002633	Vasculitis	DOID:865	vasculitis	D056648	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	EFOID:0004826	anti-neutrophil antibody associated vasculitis	Vasculitis	NA	Research Support, Non-U.S. Gov't	T	NA
X	6134432	rs16983988	A	T	rs16983988	22808956	3.13E-05	NA	NA	NA	914 European ancestry cases; 5,259 European ancestry controls	European(6173)	ALL(6173)	EUR(6173)	ALL(6173)	Antineutrophil cytoplasmic antibody-associated vasculitis	HPOID:0002633	Vasculitis	DOID:865	vasculitis	D056648	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	EFOID:0004826	anti-neutrophil antibody associated vasculitis	Vasculitis	NA	Research Support, Non-U.S. Gov't	A	NLGN4X
X	15180610	rs6628825	T	C	rs6628825	22808956	9.78E-06	NA	NA	NA	914 European ancestry cases; 5,259 European ancestry controls	European(6173)	ALL(6173)	EUR(6173)	ALL(6173)	Antineutrophil cytoplasmic antibody-associated vasculitis	HPOID:0002633	Vasculitis	DOID:865	vasculitis	D056648	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	EFOID:0004826	anti-neutrophil antibody associated vasculitis	Vasculitis	NA	Research Support, Non-U.S. Gov't	C	NA
X	23804871	rs873637	T	C	rs873637	22808956	2.78E-05	NA	NA	NA	914 European ancestry cases; 5,259 European ancestry controls	European(6173)	ALL(6173)	EUR(6173)	ALL(6173)	Antineutrophil cytoplasmic antibody-associated vasculitis	HPOID:0002633	Vasculitis	DOID:865	vasculitis	D056648	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	EFOID:0004826	anti-neutrophil antibody associated vasculitis	Vasculitis	NA	Research Support, Non-U.S. Gov't	C	NA
X	89804127	rs2755459	A	G	rs2755459	22808956	9.00E-14	NA	1.67	NA	914 European ancestry cases; 5,259 European ancestry controls	European(6173)	ALL(6173)	EUR(6173)	ALL(6173)	Antineutrophil cytoplasmic antibody-associated vasculitis	HPOID:0002633	Vasculitis	DOID:865	vasculitis	D056648	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	EFOID:0004826	anti-neutrophil antibody associated vasculitis	Vasculitis	NA	Research Support, Non-U.S. Gov't	G	NA
X	90812718	rs6618677	A	G	rs6618677	22808956	4.00E-08	NA	1.43	NA	914 European ancestry cases; 5,259 European ancestry controls	European(6173)	ALL(6173)	EUR(6173)	ALL(6173)	Antineutrophil cytoplasmic antibody-associated vasculitis	HPOID:0002633	Vasculitis	DOID:865	vasculitis	D056648	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	EFOID:0004826	anti-neutrophil antibody associated vasculitis	Vasculitis	NA	Research Support, Non-U.S. Gov't	A	NA
X	109365260	rs5985446	A	T	rs5985446	22808956	1.08E-05	NA	NA	NA	914 European ancestry cases; 5,259 European ancestry controls	European(6173)	ALL(6173)	EUR(6173)	ALL(6173)	Antineutrophil cytoplasmic antibody-associated vasculitis	HPOID:0002633	Vasculitis	DOID:865	vasculitis	D056648	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	EFOID:0004826	anti-neutrophil antibody associated vasculitis	Vasculitis	NA	Research Support, Non-U.S. Gov't	A	TMEM164
X	119867475	rs1972809	A	G	rs1972809	22808956	1.00E-24	NA	1.28	NA	914 European ancestry cases; 5,259 European ancestry controls	European(6173)	ALL(6173)	EUR(6173)	ALL(6173)	Antineutrophil cytoplasmic antibody-associated vasculitis	HPOID:0002633	Vasculitis	DOID:865	vasculitis	D056648	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	EFOID:0004826	anti-neutrophil antibody associated vasculitis	Vasculitis	NA	Research Support, Non-U.S. Gov't	A	NA
X	121575911	rs982834	T	C	rs982834	22808956	4.35E-05	NA	NA	NA	914 European ancestry cases; 5,259 European ancestry controls	European(6173)	ALL(6173)	EUR(6173)	ALL(6173)	Antineutrophil cytoplasmic antibody-associated vasculitis	HPOID:0002633	Vasculitis	DOID:865	vasculitis	D056648	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	EFOID:0004826	anti-neutrophil antibody associated vasculitis	Vasculitis	NA	Research Support, Non-U.S. Gov't	G	NA
X	127028955	rs766417	C	T	rs766417	22808956	1.46E-05	NA	NA	NA	914 European ancestry cases; 5,259 European ancestry controls	European(6173)	ALL(6173)	EUR(6173)	ALL(6173)	Antineutrophil cytoplasmic antibody-associated vasculitis	HPOID:0002633	Vasculitis	DOID:865	vasculitis	D056648	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	EFOID:0004826	anti-neutrophil antibody associated vasculitis	Vasculitis	NA	Research Support, Non-U.S. Gov't	A	NA
X	141360571	rs5954596	C	T	rs5954596	22808956	5.00E-09	NA	NA	NA	914 European ancestry cases; 5,259 European ancestry controls	European(6173)	ALL(6173)	EUR(6173)	ALL(6173)	Antineutrophil cytoplasmic antibody-associated vasculitis	HPOID:0002633	Vasculitis	DOID:865	vasculitis	D056648	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	EFOID:0004826	anti-neutrophil antibody associated vasculitis	Vasculitis	NA	Research Support, Non-U.S. Gov't	C	NA
X	147042774	rs5904818	C	T	rs5904818	22808956	2.00E-08	NA	NA	NA	914 European ancestry cases; 5,259 European ancestry controls	European(6173)	ALL(6173)	EUR(6173)	ALL(6173)	Antineutrophil cytoplasmic antibody-associated vasculitis	HPOID:0002633	Vasculitis	DOID:865	vasculitis	D056648	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	EFOID:0004826	anti-neutrophil antibody associated vasculitis	Vasculitis	NA	Research Support, Non-U.S. Gov't	C	NA
X	149624776	rs2266831	A	G	rs2266831	22808956	4.78E-05	NA	NA	NA	914 European ancestry cases; 5,259 European ancestry controls	European(6173)	ALL(6173)	EUR(6173)	ALL(6173)	Antineutrophil cytoplasmic antibody-associated vasculitis	HPOID:0002633	Vasculitis	DOID:865	vasculitis	D056648	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	EFOID:0004826	anti-neutrophil antibody associated vasculitis	Vasculitis	NA	Research Support, Non-U.S. Gov't	G	MAMLD1
X	154233774	rs17281398	A	G	rs17281398	22808956	4.00E-07	NA	NA	NA	914 European ancestry cases; 5,259 European ancestry controls	European(6173)	ALL(6173)	EUR(6173)	ALL(6173)	Antineutrophil cytoplasmic antibody-associated vasculitis	HPOID:0002633	Vasculitis	DOID:865	vasculitis	D056648	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	EFOID:0004826	anti-neutrophil antibody associated vasculitis	Vasculitis	NA	Research Support, Non-U.S. Gov't	A	F8

Mapped by lexical matching(Total Items:1)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0001919	Acute kidney injury	MP:0002135	abnormal kidney morphology;HP:0002725	Systemic lupus erythematosus

Mapped by homologous gene(Total Items:1)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0100796	Orchitis	MP:0002498	abnormal acute inflammation;HP:0001919	Acute kidney injury

Chemical(Total Drugs:39)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0042384	amphetamine	D000661	300-62-9	vasculitis	MESH:D014657	marker/mechanism	841359
C0042384	betaxolol	D015784	63659-18-7	vasculitis	MESH:D014657	therapeutic	1977670
C0042384	carbimazole	D002231	22232-54-8	vasculitis	MESH:D014657	marker/mechanism	1681385
C0042384	cefotaxime	D002439	63527-52-6	vasculitis	MESH:D014657	marker/mechanism	10803769
C0042384	cimetidine	D002927	51481-61-9	vasculitis	MESH:D014657	marker/mechanism	7241779
C0042384	ciprofloxacin	D002939	85721-33-1	vasculitis	MESH:D014657	marker/mechanism	11464656
C0042384	cyclophosphamide	D003520	50-18-0	vasculitis	MESH:D014657	therapeutic	1392448
C0042384	dapsone	D003622	80-08-0	vasculitis	MESH:D014657	marker/mechanism	16183407
C0042384	cisplatin	D002945	15663-27-1	vasculitis	MESH:D014657	marker/mechanism	11955656
C0042384	enalapril	D004656	75847-73-3	vasculitis	MESH:D014657	marker/mechanism	8453893
C0042384	erythromycin	D004917	114-07-8	vasculitis	MESH:D014657	marker/mechanism	2138443
C0042384	fluoxetine	D005473	54910-89-3	vasculitis	MESH:D014657	marker/mechanism	10868505
C0042384	gemcitabine	C056507	103882-84-4	vasculitis	MESH:D014657	marker/mechanism	11955656
C0042384	glimepiride	C057619	-	vasculitis	MESH:D014657	marker/mechanism	17324240
C0042384	hydroxyurea	D006918	127-07-1	vasculitis	MESH:D014657	marker/mechanism	9095664
C0042384	imatinib mesylate	D000068877	-	vasculitis	MESH:D014657	marker/mechanism	14576606
C0042384	melphalan	D008558	148-82-3	vasculitis	MESH:D014657	marker/mechanism	713003
C0042384	methotrexate	D008727	1959/5/2	vasculitis	MESH:D014657	marker/mechanism	1065218
C0042384	nicotine	D009538	-	vasculitis	MESH:D014657	marker/mechanism	8746358
C0042384	nitroprusside	D009599	15078-28-1	vasculitis	MESH:D014657	marker/mechanism	11549511
C0042384	ofloxacin	D015242	82419-36-1	vasculitis	MESH:D014657	marker/mechanism	2504412
C0042384	peginterferon alfa-2a	C100416	-	vasculitis	MESH:D014657	marker/mechanism	17898559
C0042384	peginterferon alfa-2b	C417083	-	vasculitis	MESH:D014657	marker/mechanism	16169782
C0042384	phenindione	D010630	1983/12/5	vasculitis	MESH:D014657	marker/mechanism	228409
C0042384	pramipexole	C061333	-	vasculitis	MESH:D014657	marker/mechanism	15638058
C0042384	propylthiouracil	D011441	51-52-5	vasculitis	MESH:D014657	marker/mechanism	10534640
C0042384	quinine	D011803	130-95-0	vasculitis	MESH:D014657	marker/mechanism	1457303
C0042384	ramipril	D017257	87333-19-5	vasculitis	MESH:D014657	marker/mechanism	14964753
C0042384	ribavirin	D012254	36791-04-5	vasculitis	MESH:D014657	marker/mechanism	16169782
C0042384	rifampin	D012293	13292-46-1	vasculitis	MESH:D014657	marker/mechanism	1493242
C0042384	rofecoxib	C116926	-	vasculitis	MESH:D014657	marker/mechanism	16225254
C0042384	streptozocin	D013311	18883-66-4	vasculitis	MESH:D014657	marker/mechanism	9131432
C0042384	tacrolimus	D016559	109581-93-3	vasculitis	MESH:D014657	marker/mechanism	20443058
C0042384	temozolomide	C047246	85622-93-1	vasculitis	MESH:D014657	marker/mechanism	15360003
C0042384	thalidomide	D013792	50-35-1	vasculitis	MESH:D014657	marker/mechanism	15550052
C0042384	tretinoin	D014212	302-79-4	vasculitis	MESH:D014657	marker/mechanism	10214877
C0042384	trimethoprim	D014295	738-70-5	vasculitis	MESH:D014657	marker/mechanism	1630995
C0042384	vancomycin	D014640	1404-90-6	vasculitis	MESH:D014657	marker/mechanism	2937155
C0042384	zafirlukast	C062735	107753-78-6	vasculitis	MESH:D014657	marker/mechanism	12189465

FDA approved drug and dosage information(Total Drugs:10)
DiseaseID	Drug_name	active_ingredients	strength	Dosage Form/Route	Marketing Status	TE code	RLD	RS
MESH:D014657	temodar	temozolomide	5MG	CAPSULE;ORAL	Prescription	AB	Yes	No
MESH:D014657	temodar	temozolomide	100MG/VIAL	POWDER;INTRAVENOUS	Prescription	None	Yes	Yes
MESH:D014657	cipro	ciprofloxacin	400MG/40ML (10MG/ML)	INJECTABLE;INJECTION	Discontinued	None	Yes	No
MESH:D014657	cipro	ciprofloxacin	250MG/5ML	FOR SUSPENSION;ORAL	Prescription	AB	Yes	No
MESH:D014657	vioxx	rofecoxib	12.5MG	TABLET;ORAL	Discontinued	None	No	No
MESH:D014657	vioxx	rofecoxib	12.5MG/5ML	SUSPENSION;ORAL	Discontinued	None	No	No
MESH:D014657	vioxx	rofecoxib	12.5MG	TABLET; ORAL	Discontinued	None	No	No
MESH:D014657	amaryl	glimepiride	1MG	TABLET;ORAL	Prescription	AB	Yes	Yes
MESH:D014657	gleevec	imatinib mesylate	EQ 50MG BASE Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons	CAPSULE;ORAL	Discontinued	None	Yes	No
MESH:D014657	gleevec	imatinib mesylate	EQ 100MG BASE	TABLET;ORAL	Prescription	AB	Yes	No

FDA labeling changes(Total Drugs:10)
DiseaseID	Pediatric_Labeling_Date	Trade_Name	Generic_Name_or_Proper_Name	Indications Studied	Label Changes Summary	Product Labeling	BPCA(B)	PREA(P)	BPCA(B) and PREA(P)	Pediatric Rule (R)	Sponsor	Pediatric Exclusivity Granted Date	NNPS
MESH:D014657	11/3/2003	temodar	temozolomide	Recurrent CNS tumors	Temozolomide effectiveness in children has not been demonstrated New data from 2 open-label Phase 2 studies in pediatric patients 3-18 years of age. In one study there were 29 patients with recurrent brain stem glioma and 34 patients with recurrent high grade astrocyoma. In a second study there were 122 patients enrolled with various types of tumors; 113 CNS tumors and 9 non-CNS tumors. The temozolomide toxicity profile in children is similar to adults	Labeling	B	-	-	-	Schering	11/20/2002	FALSE'
MESH:D014657	11/3/2003	temodar	temozolomide	Recurrent CNS tumors	Temozolomide effectiveness in children has not been demonstrated New data from 2 open-label Phase 2 studies in pediatric patients 3-18 years of age. In one study there were 29 patients with recurrent brain stem glioma and 34 patients with recurrent high grade astrocyoma. In a second study there were 122 patients enrolled with various types of tumors; 113 CNS tumors and 9 non-CNS tumors. The temozolomide toxicity profile in children is similar to adults	Labeling	B	-	-	-	Schering	11/20/2002	FALSE'
MESH:D014657	03/25/2004	cipro	ciprofloxacin	Complicated UTI and pyelonephritis	Indicated for the treatment of complicated urinary tract infections (cUTIs) and pyelonephritis in pediatric patients 1 17 years of age Not drug of first choice due to increased adverse events compared to controls including events related to joints and/or surrounding tissues Information on PK and dose in pediatric patients 1 17 years of age The most frequent adverse events observed within 6 weeks of treatment initiation during the cUTI clinical trial were gastrointestinal 15% compared to 9% and musculoskeletal 9.3% compared to 6% in ciprofloxacin-treated compared to control-treated patients, respectively	Labeling	B	-	-	-	Bayer	12/18/2003	FALSE'
MESH:D014657	03/25/2004	cipro	ciprofloxacin	Complicated UTI and pyelonephritis	Indicated for the treatment of complicated urinary tract infections (cUTIs) and pyelonephritis in pediatric patients 1 17 years of age Not drug of first choice due to increased adverse events compared to controls including events related to joints and/or surrounding tissues Information on PK and dose in pediatric patients 1 17 years of age The most frequent adverse events observed within 6 weeks of treatment initiation during the cUTI clinical trial were gastrointestinal 15% compared to 9% and musculoskeletal 9.3% compared to 6% in ciprofloxacin-treated compared to control-treated patients, respectively	Labeling	B	-	-	-	Bayer	12/18/2003	FALSE'
MESH:D014657	08/19/2004	vioxx	rofecoxib	Pauciarticular or polyarticular course Juvenile Rheumatoid Arthritis	Merck announced a voluntary worldwide withdrawal of Vioxx (rofecoxib) due to safety concerns on September 30, 2004.	Labeling	B	-	-	-	Merck	02/18/2004	FALSE'
MESH:D014657	08/19/2004	vioxx	rofecoxib	Pauciarticular or polyarticular course Juvenile Rheumatoid Arthritis	Merck announced a voluntary worldwide withdrawal of Vioxx (rofecoxib) due to safety concerns on September 30, 2004.	Labeling	B	-	-	-	Merck	02/18/2004	FALSE'
MESH:D014657	08/19/2004	vioxx	rofecoxib	Pauciarticular or polyarticular course Juvenile Rheumatoid Arthritis	Merck announced a voluntary worldwide withdrawal of Vioxx (rofecoxib) due to safety concerns on September 30, 2004.	Labeling	B	-	-	-	Merck	02/18/2004	FALSE'
MESH:D014657	11/28/2005	amaryl	glimepiride	Type-2 Diabetes Mellitus	Data are insufficient to recommend pediatric use of glimepiride In an active-controlled, single-blind, 24-week trial, 272 pediatric patients aged 8 to 17 years with Type 2 diabetes were randomized to treatment with glimepiride or metformin. Trial suggested differences favoring metformin AE profile in the pediatric population was similar to that for adults Information on PK parameters	Labeling	-	-	B, P	-	Aventis	9/6/2005	FALSE'
MESH:D014657	09/27/2006	gleevec	imatinib mesylate	Treatment of newly diagnosed pediatric patients with Philadelphia chromosome positive (Ph+) chronic myeloid leukemia (CML) in chronic phase	Extended age range for the treatment of newly diagnosed CML down to pediatric patients There are no data in children < 2 years of age Follow-up in children with newly diagnosed Ph+ chronic phase CML is limited Information on hematologic toxicities, AE profile, clinical studies and dosing guidelines new for newly diagnosed pediatric patients	Labeling	-	-	B, P	-	Novartis	9/6/2006	FALSE'
MESH:D014657	09/27/2006	gleevec	imatinib mesylate	Treatment of newly diagnosed pediatric patients with Philadelphia chromosome positive (Ph+) chronic myeloid leukemia (CML) in chronic phase	Extended age range for the treatment of newly diagnosed CML down to pediatric patients There are no data in children < 2 years of age Follow-up in children with newly diagnosed Ph+ chronic phase CML is limited Information on hematologic toxicities, AE profile, clinical studies and dosing guidelines new for newly diagnosed pediatric patients	Labeling	-	-	B, P	-	Novartis	9/6/2006	FALSE'