PedAM
Pediatric Disease Annotations & Medicines
| varicocele | ||||
| Disease ID | 718 |
|---|---|
| Disease | varicocele |
| Integrated Phenotype | (Waiting for update.) |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:17) HP:0000789 | Infertility | 31 HP:0003251 | Male infertility | 15 HP:0012531 | Pain | 8 HP:0002619 | Varicose veins | 5 HP:0000027 | Azoospermia | 5 HP:0011962 | Obstructive azoospermia | 3 HP:0000135 | Hypogonadism | 2 HP:0000798 | Oligospermia | 2 HP:0030155 | Scrotal pain | 2 HP:0002019 | Dyschezia | 1 HP:0000023 | Inguinal hernia | 1 HP:0000802 | Erectile dysfunction | 1 HP:0100790 | Hernia | 1 HP:0012450 | Chronic constipation | 1 HP:0200040 | Epidermal inclusion cyst | 1 HP:0000819 | Diabetes mellitus | 1 HP:0000029 | Testicular degeneration | 1 |
| Disease ID | 718 |
|---|---|
| Disease | varicocele |
| Manually Symptom | (Waiting for update.) |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:10) C0021359 | infertility | 31 C0021364 | male infertility | 15 C0030193 | pain | 8 C0004509 | azoospermia | 5 C0236078 | scrotal pain | 2 C0405581 | testicular dysfunction | 2 C0156312 | testicular atrophy | 1 C0729353 | subfertility | 1 C2363955 | venous reflux | 1 C0039591 | orchialgia | 1 |
Manually Genotype(Total Text Mining Genotypes:0) |
|---|
| (Waiting for update.) |
All Snps(Total Genotypes:1) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| snpId | pubmedId | geneId | geneSymbol | diseaseId | sourceId | sentence | score | Year | geneSymbol_dbSNP | CHROMOSOME | POS | REF | ALT |
| rs397507444 | 24456105 | 4524 | MTHFR | umls:C0042341 | BeFree | Is methylenetetrahydrofolate reductase (MTHFR) gene A1298C polymorphism related with varicocele risk? | 0.000271442 | 2013 | MTHFR | 1 | 11794407 | T | G |
GWASdb Annotation(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
Mapped by lexical matching(Total Items:0) |
|---|
| (Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
|---|
| (Waiting for update.) |
Chemical(Total Drugs:2) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| CUI | ChemicalName | ChemicalID | CasRN | DiseaseName | DiseaseID | DirectEvidence | PubMedIDs | ||
| C0042341 | diethylstilbestrol | D004054 | 56-53-1 | varicocele | MESH:D014646 | marker/mechanism | 7463583 | ||
| C0042341 | nitric oxide | D009569 | 10102-43-9 | varicocele | MESH:D014646 | marker/mechanism | 18572859 | ||
FDA approved drug and dosage information(Total Drugs:1) | ||||||||
|---|---|---|---|---|---|---|---|---|
| DiseaseID | Drug_name | active_ingredients | strength | Dosage Form/Route | Marketing Status | TE code | RLD | RS |
| MESH:D014646 | inomax | nitric oxide | 100PPM Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons | GAS;INHALATION | Discontinued | None | Yes | No |
FDA labeling changes(Total Drugs:1) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| DiseaseID | Pediatric_Labeling_Date | Trade_Name | Generic_Name_or_Proper_Name | Indications Studied | Label Changes Summary | Product Labeling | BPCA(B) | PREA(P) | BPCA(B) and PREA(P) | Pediatric Rule (R) | Sponsor | Pediatric Exclusivity Granted Date | NNPS |
| MESH:D014646 | 12/21/2010 | inomax | nitric oxide | Prevention of bronchopulmonary dysplasia | INOmax is not indicated for prevention of BPD in preterm neonates d 34 weeks gestational age.Efficacy for the prevention of BPD in preterm infants was not established in three ldouble-blind, placebo-controlled clinical trials in a total of 2,149 preterm infants Information on clinical trials, adverse reaction | Labeling | B | - | - | - | INO Therapeutics | 2/11/2010 | FALSE' |