PedAM

Pediatric Disease Annotations & Medicines


	tuberculous meningitis

Disease ID	1258
Disease	tuberculous meningitis
Definition	A form of bacterial meningitis caused by MYCOBACTERIUM TUBERCULOSIS or rarely MYCOBACTERIUM BOVIS. The organism seeds the meninges and forms microtuberculomas which subsequently rupture. The clinical course tends to be subacute, with progressions occurring over a period of several days or longer. Headache and meningeal irritation may be followed by SEIZURES, cranial neuropathies, focal neurologic deficits, somnolence, and eventually COMA. The illness may occur in immunocompetent individuals or as an OPPORTUNISTIC INFECTION in the ACQUIRED IMMUNODEFICIENCY SYNDROME and other immunodeficiency syndromes. (From Adams et al., Principles of Neurology, 6th ed, pp717-9)
Synonym	meningeal tuberculoses meningeal tuberculosis meninges--tuberculosis meningitides, tubercular meningitides, tuberculosis meningitides, tuberculous meningitis tb meningitis tuberculosis meningitis tuberculous meningitis, tubercular meningitis, tuberculosis meningitis, tuberculous tb - tuberculous meningitis tb meningitides tb meningitis tb meningitis-unspec tbm - tuberculous meningitis tubercular meningitides tubercular meningitis tuberculoses, meningeal tuberculosis meningeal tuberculosis meninges tuberculosis meningitides tuberculosis meningitis tuberculosis of meninges tuberculosis of meninges (disorder) tuberculosis, meningeal tuberculosis, meningeal [disease/finding] tuberculous meningitides tuberculous meningitis (disorder) tuberculous meningitis nos tuberculous meningitis nos (disorder) tuberculous meningitis, unspecified
DOID	DOID:9795
ICD10	ICD10CM:A17.0
UMLS	C0041318
MeSH	D014390
SNOMED-CT	SNOMEDCT_US_2016_09_01:58437007
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:27) C0020255 \| hydrocephalus \| 13 C0041296 \| tuberculosis \| 3 C0151740 \| raised intracranial pressure \| 2 C0409974 \| lupus erythematosus \| 1 C0011847 \| diabetes \| 1 C0549423 \| obstructive hydrocephalus \| 1 C0011854 \| type 1 diabetes \| 1 C0040997 \| trigeminal neuralgia \| 1 C0011849 \| diabetes mellitus \| 1 C0025297 \| viral meningitis \| 1 C0020538 \| hypertension \| 1 C0040053 \| thrombosis \| 1 C0151740 \| intracranial hypertension \| 1 C0013421 \| dystonia \| 1 C0085437 \| bacterial meningitis \| 1 C0011880 \| diabetic ketoacidosis \| 1 C0011854 \| type 1 diabetes mellitus \| 1 C0078981 \| arachnoid cyst \| 1 C0151311 \| cranial nerve palsy \| 1 C0026769 \| multiple sclerosis \| 1 C0038220 \| status epilepticus \| 1 C0013182 \| drug hypersensitivity \| 1 C0042384 \| angiitis \| 1 C0151740 \| elevated intracranial pressure \| 1 C0456909 \| vision loss \| 1 C1527311 \| brain edema \| 1 C0024141 \| systemic lupus erythematosus \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) 7097 \| TLR2 \| infer
Text Mined Gene	(Waiting for update.)
Locus	(Waiting for update.)

Disease ID	1258
Disease	tuberculous meningitis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:26) HP:0000238 \| Nonsyndromal hydrocephalus \| 13 HP:0001297 \| Cerebral vascular events \| 6 HP:0001250 \| Seizures \| 2 HP:0001259 \| Coma \| 2 HP:0006824 \| Cranial nerve palsy \| 2 HP:0001291 \| Cranial nerve disease \| 1 HP:0002516 \| Intracranial pressure elevation \| 1 HP:0000505 \| Poor vision \| 1 HP:0004326 \| Cachexia \| 1 HP:0000819 \| Diabetes mellitus \| 1 HP:0004936 \| Blood clot in vein \| 1 HP:0100661 \| Trigeminal neuralgia \| 1 HP:0002633 \| Vasculitis \| 1 HP:0001945 \| Fever \| 1 HP:0002721 \| Immunodeficiency \| 1 HP:0001332 \| Dystonia \| 1 HP:0001953 \| Diabetic ketosis \| 1 HP:0100702 \| Arachnoid cyst \| 1 HP:0000572 \| Visual loss \| 1 HP:0002181 \| Cerebral edema \| 1 HP:0002725 \| Systemic lupus erythematosus \| 1 HP:0000822 \| Hypertension \| 1 HP:0100543 \| Cognitive deficits \| 1 HP:0005305 \| Cerebral vein thrombosis \| 1 HP:0000234 \| Head abnormality \| 1 HP:0002133 \| Status epilepticus \| 1

Disease ID	1258
Disease	tuberculous meningitis
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:9) C0020255 \| hydrocephalus \| 13 C0038454 \| stroke \| 6 C0041295 \| tuberculoma \| 4 C0041296 \| tuberculosis \| 3 C0151740 \| raised intracranial pressure \| 2 C0043046 \| wasting syndrome \| 1 C0549423 \| obstructive hydrocephalus \| 1 C0151740 \| intracranial hypertension \| 1 C0021308 \| infarction \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:2)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0041318	pyrazinamide	D011718	98-96-4	tuberculosis, meningeal	MESH:D014390	therapeutic	10962632
C0041318	rifampin	D012293	13292-46-1	tuberculosis, meningeal	MESH:D014390	therapeutic	10962632

FDA approved drug and dosage information(Total Drugs:0)
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FDA labeling changes(Total Drugs:0)
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