PedAM

Pediatric Disease Annotations & Medicines


	trigeminal neuralgia

Disease ID	528
Disease	trigeminal neuralgia
Definition	A syndrome characterized by recurrent episodes of excruciating pain lasting several seconds or longer in the sensory distribution of the TRIGEMINAL NERVE. Pain may be initiated by stimulation of trigger points on the face, lips, or gums or by movement of facial muscles or chewing. Associated conditions include MULTIPLE SCLEROSIS, vascular anomalies, ANEURYSMS, and neoplasms. (Adams et al., Principles of Neurology, 6th ed, p187)
Synonym	disease, fothergill epileptiform neuralgia epileptiform neuralgias fothergill dis fothergill disease fothergill's neuralgia neuralgia trigeminal neuralgia, epileptiform neuralgia, trifacial neuralgia, trigeminal neuralgias, epileptiform neuralgias, trifacial neuralgias, trigeminal tic douleureux tic douloureux tn - trigeminal neuralgia trifacial neuralgia trifacial neuralgias trifocal neuralgia trigeminal neuralgia (disorder) trigeminal neuralgia [disease/finding] trigeminal neuralgia [no drugs here] trigeminal neuralgia [no drugs here] (disorder) trigeminal neuralgia nos trigeminal neuralgia nos (disorder) trigeminal neuralgia, nos trigeminal neuralgias trigeminus neuralgia
Orphanet	ORPHANET:221091
OMIM	OMIM:190400
DOID	DOID:12098
ICD10	ICD10CM:G50.0
UMLS	C0040997
MeSH	D014277
SNOMED-CT	SNOMEDCT_US_2016_09_01:31681005
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:24) C0026769 \| multiple sclerosis \| 11 C0023798 \| lipoma \| 2 C1263881 \| cerebellopontine angle tumor \| 2 C0003857 \| arteriovenous malformation \| 2 C0006413 \| burkitt's lymphoma \| 1 C0025299 \| meningocele \| 1 C0679466 \| cognitive deficits \| 1 C1263881 \| cerebellopontine angle tumour \| 1 C0442874 \| neuropathy \| 1 C1335976 \| skull base meningioma \| 1 C0025286 \| meningiomas \| 1 C0085404 \| poems syndrome \| 1 C0078981 \| arachnoid cyst \| 1 C0011649 \| dermoid cysts \| 1 C0024796 \| marfan syndrome \| 1 C0015469 \| facial paralysis \| 1 C0011649 \| dermoid cyst \| 1 C0009782 \| connective tissue disease \| 1 C0020538 \| hypertension \| 1 C1956391 \| temporal arteritis \| 1 C0041318 \| tuberculous meningitis \| 1 C0002766 \| analgesia \| 1 C0025286 \| meningioma \| 1 C0023343 \| leprosy \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) 2099 \| ESR1 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:107) 2288 \| FKBP4 \| DISEASES 84245 \| MRI1 \| DISEASES 1917 \| EEF1A2 \| DISEASES 10857 \| PGRMC1 \| DISEASES 3732 \| CD82 \| DISEASES 1432 \| MAPK14 \| DISEASES 55856 \| ACOT13 \| DISEASES 7799 \| PRDM2 \| DISEASES 84329 \| HVCN1 \| DISEASES 652 \| BMP4 \| DISEASES 2670 \| GFAP \| DISEASES 23225 \| NUP210 \| DISEASES 56923 \| NMUR2 \| DISEASES 759 \| CA1 \| DISEASES 2799 \| GNS \| DISEASES 2995 \| GYPC \| DISEASES 29113 \| C6orf15 \| DISEASES 2660 \| MSTN \| DISEASES 7434 \| VIPR2 \| DISEASES 8989 \| TRPA1 \| DISEASES 9739 \| SETD1A \| DISEASES 5024 \| P2RX3 \| DISEASES 5443 \| POMC \| DISEASES 3827 \| KNG1 \| DISEASES 4851 \| NOTCH1 \| DISEASES 4863 \| NPAT \| DISEASES 5903 \| RANBP2 \| DISEASES 6328 \| SCN3A \| DISEASES 55364 \| IMPACT \| DISEASES 50940 \| PDE11A \| DISEASES 163786 \| SASS6 \| DISEASES 5152 \| PDE9A \| DISEASES 8209 \| C21orf33 \| DISEASES 3889 \| KRT83 \| DISEASES 4041 \| LRP5 \| DISEASES 282974 \| STK32C \| DISEASES 6340 \| SCNN1G \| DISEASES 915 \| CD3D \| DISEASES 23636 \| NUP62 \| DISEASES 2353 \| FOS \| DISEASES 11280 \| SCN11A \| DISEASES 3350 \| HTR1A \| DISEASES 6863 \| TAC1 \| DISEASES 7156 \| TOP3A \| DISEASES 5745 \| PTH1R \| DISEASES 79054 \| TRPM8 \| DISEASES 5179 \| PENK \| DISEASES 7433 \| VIPR1 \| DISEASES 8905 \| AP1S2 \| DISEASES 286753 \| TUSC5 \| DISEASES 796 \| CALCA \| DISEASES 27445 \| PCLO \| DISEASES 1982 \| EIF4G2 \| DISEASES 5764 \| PTN \| DISEASES 51393 \| TRPV2 \| DISEASES 467 \| ATF3 \| DISEASES 10516 \| FBLN5 \| DISEASES 6050 \| RNH1 \| DISEASES 6334 \| SCN8A \| DISEASES 8650 \| NUMB \| DISEASES 4149 \| MAX \| DISEASES 1902 \| LPAR1 \| DISEASES 23607 \| CD2AP \| DISEASES 9361 \| LONP1 \| DISEASES 5646 \| PRSS3 \| DISEASES 83881 \| MIXL1 \| DISEASES 7432 \| VIP \| DISEASES 4720 \| NDUFS2 \| DISEASES 10763 \| NES \| DISEASES 7062 \| TCHH \| DISEASES 149428 \| BNIPL \| DISEASES 1268 \| CNR1 \| DISEASES 9446 \| GSTO1 \| DISEASES 5730 \| PTGDS \| DISEASES 81562 \| LMAN2L \| DISEASES 114798 \| SLITRK1 \| DISEASES 650 \| BMP2 \| DISEASES 192668 \| CYS1 \| DISEASES 11009 \| IL24 \| DISEASES 9244 \| CRLF1 \| DISEASES 78996 \| C7orf49 \| DISEASES 5627 \| PROS1 \| DISEASES 64115 \| C10orf54 \| DISEASES 594857 \| NPS \| DISEASES 2687 \| GGT5 \| DISEASES 7442 \| TRPV1 \| DISEASES 100463285 \| MTRNR2L4 \| DISEASES 643418 \| LIPN \| DISEASES 1363 \| CPE \| DISEASES 6335 \| SCN9A \| DISEASES 6336 \| SCN10A \| DISEASES 146713 \| RBFOX3 \| DISEASES 23210 \| JMJD6 \| DISEASES 23705 \| CADM1 \| DISEASES 4152 \| MBD1 \| DISEASES 374308 \| PTCHD3 \| DISEASES 10243 \| GPHN \| DISEASES 26298 \| EHF \| DISEASES 100463289 \| MTRNR2L5 \| DISEASES 10846 \| PDE10A \| DISEASES 83742 \| MARVELD1 \| DISEASES 8972 \| MGAM \| DISEASES 3892 \| KRT86 \| DISEASES 91056 \| AP5B1 \| DISEASES 11201 \| POLI \| DISEASES 102723508 \| KANTR \| DISEASES 4511 \| MT-TC \| DISEASES
Locus	(Waiting for update.)

Disease ID	528
Disease	trigeminal neuralgia
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:21) HP:0012531 \| Pain \| 23 HP:0012721 \| Venous malformations \| 3 HP:0012032 \| Lipoma \| 2 HP:0002315 \| Headaches \| 2 HP:0002617 \| Aneurysmal dilatation \| 2 HP:0100026 \| Arteriovenous malformation \| 2 HP:0012532 \| Chronic pain \| 2 HP:0100702 \| Arachnoid cyst \| 1 HP:0002858 \| Mengiomia \| 1 HP:0012089 \| Arteritis \| 1 HP:0100543 \| Cognitive deficits \| 1 HP:0000365 \| Hearing impairment \| 1 HP:0001291 \| Cranial nerve disease \| 1 HP:0007209 \| Facial paresis \| 1 HP:0000822 \| Hypertension \| 1 HP:0002435 \| Meningocele \| 1 HP:0200040 \| Epidermal inclusion cyst \| 1 HP:0010828 \| Hemifacial spasm \| 1 HP:0009733 \| Glioma \| 1 HP:0005758 \| Basilar impression \| 1 HP:0003470 \| Inability to move \| 1

Disease ID	528
Disease	trigeminal neuralgia
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:9) C0030193 \| pain \| 23 C0015468 \| facial pain \| 7 C0150055 \| chronic pain \| 2 C0020538 \| hypertension \| 1 C0002766 \| analgesia \| 1 C1839611 \| n syndrome \| 1 C0948844 \| lancinating pain \| 1 C0178782 \| orofacial pain \| 1 C0025286 \| meningiomas \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:6)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0040997	baclofen	D001418	1134-47-0	trigeminal neuralgia	MESH:D014277	therapeutic	4026235
C0040997	capsaicin	D002211	404-86-4	trigeminal neuralgia	MESH:D014277	marker/mechanism	19004549
C0040997	carbamazepine	D002220	298-46-4	trigeminal neuralgia	MESH:D014277	therapeutic	1464298
C0040997	digoxin	D004077	20830-75-5	trigeminal neuralgia	MESH:D014277	marker/mechanism	758516
C0040997	gabapentin	C040029	60142-96-3	trigeminal neuralgia	MESH:D014277	therapeutic	19224505
C0040997	phenytoin	D010672	57-41-0	trigeminal neuralgia	MESH:D014277	therapeutic	14698717

FDA approved drug and dosage information(Total Drugs:7)
DiseaseID	Drug_name	active_ingredients	strength	Dosage Form/Route	Marketing Status	TE code	RLD	RS
MESH:D014277	neurontin	gabapentin	100MG	CAPSULE;ORAL	Prescription	AB	Yes	No
MESH:D014277	neurontin	gabapentin	600MG	TABLET;ORAL	Prescription	AB	Yes	No
MESH:D014277	neurontin	gabapentin	250MG/5ML	SOLUTION;ORAL	Prescription	AA	Yes	Yes
MESH:D014277	neurontin	gabapentin	0	SOLUTION; ORAL	Prescription	None	No	No
MESH:D014277	neurontin	gabapentin	600MG	TABLET; ORAL	Prescription	None	No	No
MESH:D014277	neurontin	gabapentin	800MG	CAPSULE; ORAL	Prescription	None	No	No
MESH:D014277	neurontin	gabapentin	250MG/5ML	SOLUTION; ORAL	Prescription	None	No	No

FDA labeling changes(Total Drugs:7)
DiseaseID	Pediatric_Labeling_Date	Trade_Name	Generic_Name_or_Proper_Name	Indications Studied	Label Changes Summary	Product Labeling	BPCA(B)	PREA(P)	BPCA(B) and PREA(P)	Pediatric Rule (R)	Sponsor	Pediatric Exclusivity Granted Date	NNPS
MESH:D014277	12/10/2000	neurontin	gabapentin	Adjunctive therapy in the treatment of partial seizures	Safety and effectiveness established down to 3 years Neuropsychiatric AE's identified in 3-12 year olds Oral clearance normalized per body weight increased in children	Labeling	B	-	-	-	Parke-Davis	2/2/2000	FALSE'
MESH:D014277	12/10/2000	neurontin	gabapentin	Adjunctive therapy in the treatment of partial seizures	Safety and effectiveness established down to 3 years Neuropsychiatric AE's identified in 3-12 year olds Oral clearance normalized per body weight increased in children	Labeling	B	-	-	-	Parke-Davis	2/2/2000	FALSE'
MESH:D014277	12/10/2000	neurontin	gabapentin	Adjunctive therapy in the treatment of partial seizures	Safety and effectiveness established down to 3 years Neuropsychiatric AE's identified in 3-12 year olds Oral clearance normalized per body weight increased in children	Labeling	B	-	-	-	Parke-Davis	2/2/2000	FALSE'
MESH:D014277	12/10/2000	neurontin	gabapentin	Adjunctive therapy in the treatment of partial seizures	Safety and effectiveness established down to 3 years Neuropsychiatric AE's identified in 3-12 year olds Oral clearance normalized per body weight increased in children	Labeling	B	-	-	-	Parke-Davis	2/2/2000	FALSE'
MESH:D014277	12/10/2000	neurontin	gabapentin	Adjunctive therapy in the treatment of partial seizures	Safety and effectiveness established down to 3 years Neuropsychiatric AE's identified in 3-12 year olds Oral clearance normalized per body weight increased in children	Labeling	B	-	-	-	Parke-Davis	2/2/2000	FALSE'
MESH:D014277	12/10/2000	neurontin	gabapentin	Adjunctive therapy in the treatment of partial seizures	Safety and effectiveness established down to 3 years Neuropsychiatric AE's identified in 3-12 year olds Oral clearance normalized per body weight increased in children	Labeling	B	-	-	-	Parke-Davis	2/2/2000	FALSE'
MESH:D014277	12/10/2000	neurontin	gabapentin	Adjunctive therapy in the treatment of partial seizures	Safety and effectiveness established down to 3 years Neuropsychiatric AE's identified in 3-12 year olds Oral clearance normalized per body weight increased in children	Labeling	B	-	-	-	Parke-Davis	2/2/2000	FALSE'

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