PedAM
Pediatric Disease Annotations & Medicines
| trichotillomania | ||||
| Disease ID | 370 |
|---|---|
| Disease | trichotillomania |
| Definition | Compulsion to pull out one's hair. |
| Synonym | hair plucking hair pull hair pulling hair pulling, chronic, compulsive, repetitive hair-pulling plucking hair pull hair pulling hair trichologia trichotillomania (disorder) trichotillomania [disease/finding] trichotillomanias ttm |
| OMIM | |
| DOID | |
| ICD10 | |
| UMLS | C0040953 |
| MeSH | |
| SNOMED-CT | |
| Comorbidity | UMLS | Disease | Sentences' Count(Total Sentences:11) C0003469 | anxiety disorder | 2 C0003467 | anxiety | 2 C0028768 | obsessive-compulsive disorder | 1 C0032914 | preeclampsia | 1 C0497327 | dementia | 1 C0038436 | post-traumatic stress disorder | 1 C0037274 | skin disorder | 1 C0036341 | schizophrenia | 1 C0011269 | vascular dementia | 1 C0005586 | bipolar disorder | 1 C0037274 | skin disorders | 1 |
| Curated Gene | Entrez_id | Symbol | Resource(Total Genes:2) |
| Inferring Gene | (Waiting for update.) |
| Text Mined Gene | Entrez_id | Symbol | Score | Resource(Total Genes:22) 1815 | DRD4 | DISEASES 116449 | CLNK | DISEASES 58512 | DLGAP3 | DISEASES 3218 | HOXB8 | DISEASES 9360 | PPIG | DISEASES 5687 | PSMA6 | DISEASES 10058 | ABCB6 | DISEASES 3358 | HTR2C | DISEASES 5047 | PAEP | DISEASES 1742 | DLG4 | DISEASES 57142 | RTN4 | DISEASES 4128 | MAOA | DISEASES 2879 | GPX4 | DISEASES 23230 | VPS13A | DISEASES 170482 | CLEC4C | DISEASES 1557 | CYP2C19 | DISEASES 114798 | SLITRK1 | DISEASES 3356 | HTR2A | DISEASES 4599 | MX1 | DISEASES 57506 | MAVS | DISEASES 2593 | GAMT | DISEASES 488 | ATP2A2 | DISEASES |
| Locus | (Waiting for update.) |
| Disease ID | 370 |
|---|---|
| Disease | trichotillomania |
| Integrated Phenotype | (Waiting for update.) |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:8) HP:0000708 | Behavioral problems | 2 HP:0000739 | Anxiety | 2 HP:0100022 | Movement disorder | 2 HP:0000722 | Obsessive compulsive disorder | 1 HP:0000726 | Dementia | 1 HP:0100602 | Pre-eclampsia | 1 HP:0007302 | Bipolar disorder | 1 HP:0100753 | Schizophrenia | 1 |
| Disease ID | 370 |
|---|---|
| Disease | trichotillomania |
| Manually Symptom | (Waiting for update.) |
| Text Mined Symptom | (Waiting for update.) |
Manually Genotype(Total Text Mining Genotypes:0) |
|---|
| (Waiting for update.) |
All Snps(Total Genotypes:1) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| snpId | pubmedId | geneId | geneSymbol | diseaseId | sourceId | sentence | score | Year | geneSymbol_dbSNP | CHROMOSOME | POS | REF | ALT |
| rs193302861 | NA | 114798 | SLITRK1 | umls:C0040953 | CLINVAR | NA | 0.240271442 | NA | SLITRK1 | 13 | 83880244 | G | - |
GWASdb Annotation(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
Mapped by lexical matching(Total Items:0) |
|---|
| (Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
|---|
| (Waiting for update.) |
Chemical(Total Drugs:2) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| CUI | ChemicalName | ChemicalID | CasRN | DiseaseName | DiseaseID | DirectEvidence | PubMedIDs | ||
| C0040953 | methylphenidate | D008774 | 113-45-1 | trichotillomania | MESH:D014256 | marker/mechanism | 9549952 | ||
| C0040953 | ropinirole | C046649 | 91374-21-9 | trichotillomania | MESH:D014256 | marker/mechanism | 18855926 | ||
FDA approved drug and dosage information(Total Drugs:3) | ||||||||
|---|---|---|---|---|---|---|---|---|
| DiseaseID | Drug_name | active_ingredients | strength | Dosage Form/Route | Marketing Status | TE code | RLD | RS |
| MESH:D014256 | daytrana | methylphenidate | 10MG/9HR (1.1MG/HR) | FILM, EXTENDED RELEASE;TRANSDERMAL | Prescription | None | Yes | No |
| MESH:D014256 | daytrana | methylphenidate | 10MG/9HR (1.1MG/HR) | FILM, EXTENDED RELEASE;TRANSDERMAL | Prescription | None | Yes | No |
| MESH:D014256 | daytrana | methylphenidate | 10MG/9HR (1.1MG/HR) | FILM, EXTENDED RELEASE;TRANSDERMAL | Prescription | None | Yes | No |
FDA labeling changes(Total Drugs:3) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| DiseaseID | Pediatric_Labeling_Date | Trade_Name | Generic_Name_or_Proper_Name | Indications Studied | Label Changes Summary | Product Labeling | BPCA(B) | PREA(P) | BPCA(B) and PREA(P) | Pediatric Rule (R) | Sponsor | Pediatric Exclusivity Granted Date | NNPS |
| MESH:D014256 | 6/4/2006 | daytrana | methylphenidate | ADHD | Summary is pending | Labeling | - | P | - | - | Shire | - | FALSE' |
| MESH:D014256 | 12/14/2009 | daytrana | methylphenidate | Postmarketing safety study | Information added to Warnings and Adverse Reactions on skin reactions observed in a postmarketing dermal study in pediatric patients | Labeling | - | P | - | - | Shire | - | FALSE' |
| MESH:D014256 | 06/29/2010 | daytrana | methylphenidate | ADHD | Expanded pediatric indication to include adolescent patients ages13-17 years The most commonly reported adverse reactions in a trial in patients 13-17 years included appetite decreased, nausea, insomnia, weight decreased, dizziness, abdominal pain, and anorexia. The majority of patients had erythema at the application site Information on PK parameters, Adverse Event profile and clinical studies | Labeling | - | P | - | - | Shire | - | FALSE' |