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Pediatric Disease Annotations & Medicines



   transitional cell carcinoma
  

Disease ID 597
Disease transitional cell carcinoma
Definition
A malignant neoplasm derived from TRANSITIONAL EPITHELIAL CELLS, occurring chiefly in the URINARY BLADDER; URETERS; or RENAL PELVIS.
Synonym
[m]transitional cell carcinoma nos
[m]transitional cell carcinoma nos (morphologic abnormality)
carcinoma cell transitional
carcinoma transitional cell
carcinoma, transitional cell
carcinoma, transitional cell [disease/finding]
carcinoma, urothelial, malignant
carcinomas urothelial
carcinomas, transitional cell
cell carcinoma, transitional
cell carcinomas, transitional
tcc - transitional cell carcinoma
transitional carcinoma
transitional cell carcinoma (morphologic abnormality)
transitional cell carcinoma, nos
transitional cell carcinomas
urothelial carcinoma
DOID
UMLS
C0007138
MeSH
Comorbidity
UMLS | Disease | Sentences' Count(Total Sentences:15)
C0005684  |  bladder cancer  |  3
C0699885  |  bladder carcinoma  |  1
C0178879  |  urinary tract obstruction  |  1
C0007134  |  renal cell cancer  |  1
C0206681  |  clear cell carcinoma  |  1
C0002726  |  amyloidosis  |  1
C0023267  |  leiomyoma  |  1
C0024299  |  lymphoma  |  1
C0153687  |  skin metastasis  |  1
C0699790  |  colon carcinoma  |  1
C0000889  |  acanthosis nigricans  |  1
C0019829  |  hodgkin's lymphoma  |  1
C0153676  |  pulmonary metastases  |  1
C0398689  |  x-linked hyperimmunoglobulin m syndrome  |  1
C0740457  |  renal cancer  |  1
Curated Gene
Entrez_id | Symbol | Resource(Total Genes:31)
TNF  |  7124  |  CTD_human
TP53  |  7157  |  CTD_human
PLAU  |  5328  |  CTD_human
CCND1  |  595  |  CTD_human
GPX1  |  2876  |  CTD_human
PTGS2  |  5743  |  CTD_human
HRAS  |  3265  |  CTD_human
CREBBP  |  1387  |  CTD_human
CDKN1A  |  1026  |  CTD_human
IFNA2  |  3440  |  CTD_human
NCOR1  |  9611  |  CTD_human
CSF3  |  1440  |  CTD_human
KMT2C  |  58508  |  CTD_human
KMT2A  |  4297  |  CTD_human
ARID1A  |  8289  |  CTD_human
FGFR3  |  2261  |  CTD_human
GGH  |  8836  |  CTD_human
ESPL1  |  9700  |  CTD_human
EP300  |  2033  |  CTD_human
KDM6A  |  7403  |  CTD_human
ESR2  |  2100  |  CTD_human
PABPC1  |  26986  |  CTD_human
APAF1  |  317  |  CTD_human
VDR  |  7421  |  CTD_human
CHD6  |  84181  |  CTD_human
TACC3  |  10460  |  CTD_human
DAPK1  |  1612  |  CTD_human
IGFBP3  |  3486  |  CTD_human
HRH2  |  3274  |  CTD_human
STAG2  |  10735  |  CTD_human
AMBP  |  259  |  CTD_human
Inferring Gene(Waiting for update.)
Text Mined Gene
Entrez_id | Symbol | Score | Resource(Total Genes:266)
282706  |  DAOA-AS1  |  DISEASES
4830  |  NME1  |  DISEASES
1015  |  CDH17  |  DISEASES
340533  |  KIAA2022  |  DISEASES
3861  |  KRT14  |  DISEASES
54474  |  KRT20  |  DISEASES
6793  |  STK10  |  DISEASES
7380  |  UPK3A  |  DISEASES
1113  |  CHGA  |  DISEASES
81027  |  TUBB1  |  DISEASES
57136  |  APMAP  |  DISEASES
7076  |  TIMP1  |  DISEASES
123876  |  ACSM2A  |  DISEASES
4313  |  MMP2  |  DISEASES
10423  |  CDIPT  |  DISEASES
7040  |  TGFB1  |  DISEASES
1048  |  CEACAM5  |  DISEASES
11045  |  UPK1A  |  DISEASES
5054  |  SERPINE1  |  DISEASES
29760  |  BLNK  |  DISEASES
1440  |  CSF3  |  DISEASES
3558  |  IL2  |  DISEASES
595  |  CCND1  |  DISEASES
1027  |  CDKN1B  |  DISEASES
2597  |  GAPDH  |  DISEASES
84519  |  ACRBP  |  DISEASES
2026  |  ENO2  |  DISEASES
1611  |  DAP  |  DISEASES
1839  |  HBEGF  |  DISEASES
4292  |  MLH1  |  DISEASES
4436  |  MSH2  |  DISEASES
2956  |  MSH6  |  DISEASES
10459  |  MAD2L2  |  DISEASES
10352  |  WARS2  |  DISEASES
1509  |  CTSD  |  DISEASES
2946  |  GSTM2  |  DISEASES
51426  |  POLK  |  DISEASES
3223  |  HOXC6  |  DISEASES
1026  |  CDKN1A  |  DISEASES
6659  |  SOX4  |  DISEASES
3860  |  KRT13  |  DISEASES
9787  |  DLGAP5  |  DISEASES
2952  |  GSTT1  |  DISEASES
968  |  CD68  |  DISEASES
1890  |  TYMP  |  DISEASES
3852  |  KRT5  |  DISEASES
10343  |  PKDREJ  |  DISEASES
3958  |  LGALS3  |  DISEASES
56163  |  RNF17  |  DISEASES
5920  |  RARRES3  |  DISEASES
2947  |  GSTM3  |  DISEASES
5156  |  PDGFRA  |  DISEASES
80761  |  UPK3B  |  DISEASES
9700  |  ESPL1  |  DISEASES
9038  |  TAAR5  |  DISEASES
3569  |  IL6  |  DISEASES
2995  |  GYPC  |  DISEASES
999  |  CDH1  |  DISEASES
7077  |  TIMP2  |  DISEASES
7515  |  XRCC1  |  DISEASES
6855  |  SYP  |  DISEASES
822  |  CAPG  |  DISEASES
7379  |  UPK2  |  DISEASES
7348  |  UPK1B  |  DISEASES
941  |  CD80  |  DISEASES
119  |  ADD2  |  DISEASES
2247  |  FGF2  |  DISEASES
3383  |  ICAM1  |  DISEASES
4171  |  MCM2  |  DISEASES
1950  |  EGF  |  DISEASES
5423  |  POLB  |  DISEASES
5243  |  ABCB1  |  DISEASES
11178  |  LZTS1  |  DISEASES
10180  |  RBM6  |  DISEASES
939  |  CD27  |  DISEASES
2065  |  ERBB3  |  DISEASES
5925  |  RB1  |  DISEASES
27132  |  CPNE7  |  DISEASES
7157  |  TP53  |  DISEASES
2064  |  ERBB2  |  DISEASES
134864  |  TAAR1  |  DISEASES
1956  |  EGFR  |  DISEASES
1030  |  CDKN2B  |  DISEASES
3439  |  IFNA1  |  DISEASES
4915  |  NTRK2  |  DISEASES
3145  |  HMBS  |  DISEASES
4319  |  MMP10  |  DISEASES
7424  |  VEGFC  |  DISEASES
10666  |  CD226  |  DISEASES
5458  |  POU4F2  |  DISEASES
6317  |  SERPINB3  |  DISEASES
84959  |  UBASH3B  |  DISEASES
351  |  APP  |  DISEASES
64798  |  DEPTOR  |  DISEASES
10  |  NAT2  |  DISEASES
23420  |  NOMO1  |  DISEASES
3815  |  KIT  |  DISEASES
3242  |  HPD  |  DISEASES
267  |  AMFR  |  DISEASES
126205  |  NLRP8  |  DISEASES
3856  |  KRT8  |  DISEASES
10630  |  PDPN  |  DISEASES
2215  |  FCGR3B  |  DISEASES
27306  |  HPGDS  |  DISEASES
6259  |  RYK  |  DISEASES
308  |  ANXA5  |  DISEASES
6690  |  SPINK1  |  DISEASES
134288  |  TMEM174  |  DISEASES
3562  |  IL3  |  DISEASES
1437  |  CSF2  |  DISEASES
220296  |  HEPACAM  |  DISEASES
9317  |  PTER  |  DISEASES
29123  |  ANKRD11  |  DISEASES
8000  |  PSCA  |  DISEASES
21  |  ABCA3  |  DISEASES
956  |  ENTPD3  |  DISEASES
116285  |  ACSM1  |  DISEASES
5734  |  PTGER4  |  DISEASES
140738  |  TMEM37  |  DISEASES
171558  |  PTCRA  |  DISEASES
729201  |  SPACA5B  |  DISEASES
389852  |  SPACA5  |  DISEASES
3575  |  IL7R  |  DISEASES
4493  |  MT1E  |  DISEASES
5340  |  PLG  |  DISEASES
7015  |  TERT  |  DISEASES
3265  |  HRAS  |  DISEASES
29127  |  RACGAP1  |  DISEASES
947  |  CD34  |  DISEASES
51172  |  NAGPA  |  DISEASES
836  |  CASP3  |  DISEASES
2944  |  GSTM1  |  DISEASES
26986  |  PABPC1  |  DISEASES
354  |  KLK3  |  DISEASES
1442  |  CSH1  |  DISEASES
4684  |  NCAM1  |  DISEASES
8851  |  CDK5R1  |  DISEASES
58492  |  ZNF77  |  DISEASES
6817  |  SULT1A1  |  DISEASES
3039  |  HBA1  |  DISEASES
4312  |  MMP1  |  DISEASES
923  |  CD6  |  DISEASES
29946  |  SERTAD3  |  DISEASES
338322  |  NLRP10  |  DISEASES
3855  |  KRT7  |  DISEASES
4496  |  MT1H  |  DISEASES
6900  |  CNTN2  |  DISEASES
7490  |  WT1  |  DISEASES
5727  |  PTCH1  |  DISEASES
682  |  BSG  |  DISEASES
51339  |  DACT1  |  DISEASES
3091  |  HIF1A  |  DISEASES
2246  |  FGF1  |  DISEASES
23583  |  SMUG1  |  DISEASES
5329  |  PLAUR  |  DISEASES
2261  |  FGFR3  |  DISEASES
166824  |  RASSF6  |  DISEASES
7743  |  ZNF189  |  DISEASES
1508  |  CTSB  |  DISEASES
2272  |  FHIT  |  DISEASES
51393  |  TRPV2  |  DISEASES
2066  |  ERBB4  |  DISEASES
9536  |  PTGES  |  DISEASES
149998  |  LIPI  |  DISEASES
23215  |  PRRC2C  |  DISEASES
3455  |  IFNAR2  |  DISEASES
5757  |  PTMA  |  DISEASES
9232  |  PTTG1  |  DISEASES
119391  |  GSTO2  |  DISEASES
80142  |  PTGES2  |  DISEASES
22881  |  ANKRD6  |  DISEASES
11186  |  RASSF1  |  DISEASES
51161  |  C3orf18  |  DISEASES
9961  |  MVP  |  DISEASES
29950  |  SERTAD1  |  DISEASES
1612  |  DAPK1  |  DISEASES
5079  |  PAX5  |  DISEASES
2526  |  FUT4  |  DISEASES
1995  |  ELAVL3  |  DISEASES
1786  |  DNMT1  |  DISEASES
1201  |  CLN3  |  DISEASES
51150  |  SDF4  |  DISEASES
7037  |  TFRC  |  DISEASES
2475  |  MTOR  |  DISEASES
5742  |  PTGS1  |  DISEASES
3880  |  KRT19  |  DISEASES
5788  |  PTPRC  |  DISEASES
3075  |  CFH  |  DISEASES
5743  |  PTGS2  |  DISEASES
2214  |  FCGR3A  |  DISEASES
6283  |  S100A12  |  DISEASES
1755  |  DMBT1  |  DISEASES
8661  |  EIF3A  |  DISEASES
9446  |  GSTO1  |  DISEASES
1647  |  GADD45A  |  DISEASES
1791  |  DNTT  |  DISEASES
3725  |  JUN  |  DISEASES
1558  |  CYP2C8  |  DISEASES
55165  |  CEP55  |  DISEASES
6491  |  STIL  |  DISEASES
5728  |  PTEN  |  DISEASES
7422  |  VEGFA  |  DISEASES
958  |  CD40  |  DISEASES
4318  |  MMP9  |  DISEASES
5328  |  PLAU  |  DISEASES
84181  |  CHD6  |  DISEASES
8565  |  YARS  |  DISEASES
10904  |  BLCAP  |  DISEASES
2934  |  GSN  |  DISEASES
714  |  C1QC  |  DISEASES
367  |  AR  |  DISEASES
778  |  CACNA1F  |  DISEASES
3105  |  HLA-A  |  DISEASES
29914  |  UBIAD1  |  DISEASES
7056  |  THBD  |  DISEASES
4609  |  MYC  |  DISEASES
768  |  CA9  |  DISEASES
164312  |  LRRN4  |  DISEASES
7905  |  REEP5  |  DISEASES
3440  |  IFNA2  |  DISEASES
283820  |  NOMO2  |  DISEASES
5268  |  SERPINB5  |  DISEASES
10232  |  MSLN  |  DISEASES
3875  |  KRT18  |  DISEASES
146183  |  OTOA  |  DISEASES
57634  |  EP400  |  DISEASES
3903  |  LAIR1  |  DISEASES
7187  |  TRAF3  |  DISEASES
1443  |  CSH2  |  DISEASES
4831  |  NME2  |  DISEASES
4926  |  NUMA1  |  DISEASES
3161  |  HMMR  |  DISEASES
3885  |  KRT34  |  DISEASES
4501  |  MT1X  |  DISEASES
174  |  AFP  |  DISEASES
5744  |  PTHLH  |  DISEASES
23072  |  HECW1  |  DISEASES
4357  |  MPST  |  DISEASES
7913  |  DEK  |  DISEASES
2950  |  GSTP1  |  DISEASES
408050  |  NOMO3  |  DISEASES
6345  |  SRL  |  DISEASES
100463285  |  MTRNR2L4  |  DISEASES
27247  |  NFU1  |  DISEASES
6916  |  TBXAS1  |  DISEASES
4495  |  MT1G  |  DISEASES
2086  |  ERV3-1  |  DISEASES
8671  |  SLC4A4  |  DISEASES
1029  |  CDKN2A  |  DISEASES
960  |  CD44  |  DISEASES
7124  |  TNF  |  DISEASES
9498  |  SLC4A8  |  DISEASES
5378  |  PMS1  |  DISEASES
3451  |  IFNA17  |  DISEASES
283987  |  HID1  |  DISEASES
6513  |  SLC2A1  |  DISEASES
4193  |  MDM2  |  DISEASES
139804  |  RBMXL3  |  DISEASES
10793  |  ZNF273  |  DISEASES
285782  |  CAGE1  |  DISEASES
4914  |  NTRK1  |  DISEASES
7694  |  ZNF135  |  DISEASES
27164  |  SALL3  |  DISEASES
317  |  APAF1  |  DISEASES
100506195  |  LARGE-AS1  |  DISEASES
6055  |  RNR4  |  DISEASES
Locus(Waiting for update.)
Disease ID 597
Disease transitional cell carcinoma
Integrated Phenotype(Waiting for update.)
Text Mined Phenotype
HPO | Name | Sentences' Count(Total Phenotypes:12)
HP:0002664  |  Neoplasia  |  4
HP:0030731  |  Carcinoma  |  3
HP:0009725  |  Bladder neoplasm  |  3
HP:0000010  |  Frequent urinary tract infections  |  1
HP:0002665  |  Lymphoma  |  1
HP:0002862  |  Bladder carcinoma  |  1
HP:0011034  |  Amyloid disease  |  1
HP:0000787  |  Renal calculi  |  1
HP:0000956  |  Keratosis nigricans  |  1
HP:0000790  |  Hematuria  |  1
HP:0000071  |  Narrowing of the ureter  |  1
HP:0012189  |  Hodgkin disease  |  1
Disease ID 597
Disease transitional cell carcinoma
Manually Symptom
UMLS  | Name(Total Manually Symptoms:31)
C1881254  |  inverted papilloma
C1335748  |  adenocarcinoma of the renal pelvis
C1332560  |  leiomyoma of the urinary bladder
C0850011  |  human papilloma virus
C0745091  |  hypereosinophilia
C0742965  |  eosinophilic cystitis
C0699885  |  carcinoma of the urinary bladder
C0684830  |  axillary metastasis
C0494165  |  liver metastases
C0347016  |  spinal cord metastasis
C0267361  |  pyeloduodenal fistula
C0238457  |  renal vein thrombosis
C0153687  |  skin metastasis
C0153687  |  cutaneous metastasis
C0153676  |  pulmonary metastasis
C0153676  |  pulmonary metastases
C0153676  |  lung metastases
C0041960  |  ureterocele
C0023501  |  leukemoid reaction
C0022679  |  cystic kidneys
C0022661  |  end stage renal disease
C0022658  |  nephropathy
C0021841  |  intestinal tumor
C0020758  |  ichthyosis
C0020437  |  hypercalcemia
C0020295  |  hydronephrosis
C0008497  |  choriocarcinoma
C0005695  |  tumor of the bladder
C0005695  |  bladder tumor
C0002880  |  autoimmune haemolytic anaemia
C0002793  |  anaplasia
Text Mined Symptom
UMLS | Name | Sentences' Count(Total Symptoms:4)
C0023501  |  leukemoid reaction  |  1
C0153687  |  cutaneous metastasis  |  1
C0153676  |  pulmonary metastases  |  1
C0153687  |  skin metastasis  |  1
Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)
All Snps(Total Genotypes:12)
snpId pubmedId geneId geneSymbol diseaseId sourceId sentence score Year geneSymbol_dbSNP CHROMOSOME POS REF ALT
rs13181250180582068ERCC2umls:C0007138BeFreeThe aim of this study was to examine the association between polymorphisms of the DNA repair genes, XRCC1 Arg194Trp, XRCC1 Arg399Gln, XRCC3 Thr241Met, and XPD Lys751Gln, with urinary arsenic profiles and UC.0.0029099162014ERCC2;KLC31945351661TA,G
rs13181250180582068ERCC2umls:C2145472BeFreeThe aim of this study was to examine the association between polymorphisms of the DNA repair genes, XRCC1 Arg194Trp, XRCC1 Arg399Gln, XRCC3 Thr241Met, and XPD Lys751Gln, with urinary arsenic profiles and UC.0.0005428842014ERCC2;KLC31945351661TA,G
rs1799782250180587515XRCC1umls:C0007138BeFreeXRCC1 Arg194Trp and Arg399Gln polymorphisms and arsenic methylation capacity are associated with urothelial carcinoma.0.005548392014XRCC11943553422GA
rs1799782250180587515XRCC1umls:C2145472BeFreeXRCC1 Arg194Trp and Arg399Gln polymorphisms and arsenic methylation capacity are associated with urothelial carcinoma.0.0005428842014XRCC11943553422GA
rs25487250180587515XRCC1umls:C0007138BeFreeXRCC1 Arg194Trp and Arg399Gln polymorphisms and arsenic methylation capacity are associated with urothelial carcinoma.0.005548392014XRCC11943551574TC
rs25487250180587515XRCC1umls:C2145472BeFreeXRCC1 Arg194Trp and Arg399Gln polymorphisms and arsenic methylation capacity are associated with urothelial carcinoma.0.0005428842014XRCC11943551574TC
rs386493716250180587515XRCC1umls:C0007138BeFreeXRCC1 Arg194Trp and Arg399Gln polymorphisms and arsenic methylation capacity are associated with urothelial carcinoma.0.005548392014NANANANANA
rs386493716250180587515XRCC1umls:C2145472BeFreeXRCC1 Arg194Trp and Arg399Gln polymorphisms and arsenic methylation capacity are associated with urothelial carcinoma.0.0005428842014NANANANANA
rs386545546250180587515XRCC1umls:C0007138BeFreeXRCC1 Arg194Trp and Arg399Gln polymorphisms and arsenic methylation capacity are associated with urothelial carcinoma.0.005548392014NANANANANA
rs386545546250180587515XRCC1umls:C2145472BeFreeXRCC1 Arg194Trp and Arg399Gln polymorphisms and arsenic methylation capacity are associated with urothelial carcinoma.0.0005428842014NANANANANA
rs7121158241582778GNASumls:C0007138BeFreeTo assess the role of the GNAS1 locus encoding G(alpha)s as a genetic factor for disease progression of transitional cell carcinoma (TCC) of the bladder, we genotyped the synonymous T393C polymorphism in 254 patients with TCC (minor allele frequency: 0.43) to examine a potential association between genotypes and disease progression.0.0002714422005GNAS2058903752CT
rs990434119038421332BIRC5umls:C0007138BeFreeAssociation between survivin gene promoter -31 C/G polymorphism and urothelial carcinoma risk in Taiwanese population.0.0026384742009BIRC51778214286GC
GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)
GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)
Mapped by lexical matching(Total Items:0)
(Waiting for update.)
Mapped by homologous gene(Total Items:0)
(Waiting for update.)
Chemical(Total Drugs:26)
CUI ChemicalName ChemicalID CasRN DiseaseName DiseaseID DirectEvidence PubMedIDs
C0007138allopurinolD000493315-30-0carcinoma, transitional cellMESH:D002295marker/mechanism1268818
C0007138amilorideD0005842609-46-3carcinoma, transitional cellMESH:D002295therapeutic14644129
C0007138baclofenD0014181134-47-0carcinoma, transitional cellMESH:D002295marker/mechanism17924939
C0007138bortezomibD000069286-carcinoma, transitional cellMESH:D002295therapeutic17172406
C0007138caffeineD0021101958/8/2carcinoma, transitional cellMESH:D002295marker/mechanism4638853
C0007138chlorambucilD002699305-03-3carcinoma, transitional cellMESH:D002295marker/mechanism1949449
C0007138ciprofloxacinD00293985721-33-1carcinoma, transitional cellMESH:D002295therapeutic10741713
C0007138codeineD00306176-57-3carcinoma, transitional cellMESH:D002295marker/mechanism4638853
C0007138cyclophosphamideD00352050-18-0carcinoma, transitional cellMESH:D002295marker/mechanism10806575
C0007138cyclophosphamideD00352050-18-0carcinoma, transitional cellMESH:D002295therapeutic2993671
C0007138cisplatinD00294515663-27-1carcinoma, transitional cellMESH:D002295therapeutic11104554
C0007138gefitinibC419708184475-35-2carcinoma, transitional cellMESH:D002295therapeutic16813948
C0007138gemcitabineC056507103882-84-4carcinoma, transitional cellMESH:D002295therapeutic11113764
C0007138ifosfamideD0070693778-73-2carcinoma, transitional cellMESH:D002295therapeutic12425514
C0007138mesnaD01508019767-45-4carcinoma, transitional cellMESH:D002295therapeutic12425514
C0007138methotrexateD0087271959/5/2carcinoma, transitional cellMESH:D002295marker/mechanism7909881
C0007138methotrexateD0087271959/5/2carcinoma, transitional cellMESH:D002295therapeutic15518130
C0007138mitomycinD0166851950/7/7carcinoma, transitional cellMESH:D002295therapeutic10071561
C0007138mitoxantroneD00894265271-80-9carcinoma, transitional cellMESH:D002295therapeutic18510180
C0007138paclitaxelD017239-carcinoma, transitional cellMESH:D002295therapeutic11104554
C0007138romidepsinC087123-carcinoma, transitional cellMESH:D002295therapeutic17230511
C0007138thiotepaD01385252-24-4carcinoma, transitional cellMESH:D002295therapeutic806708
C0007138vinblastineD014747865-21-4carcinoma, transitional cellMESH:D002295marker/mechanism1949449
C0007138vinblastineD014747865-21-4carcinoma, transitional cellMESH:D002295therapeutic11104554
C0007138vincristineD014750-carcinoma, transitional cellMESH:D002295marker/mechanism8602639
C0007138vindesineD01475153643-48-4carcinoma, transitional cellMESH:D002295marker/mechanism8602639
FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)
FDA labeling changes(Total Drugs:0)
(Waiting for update.)