PedAM
Pediatric Disease Annotations & Medicines
| transient cerebral ischemia | ||||
| Disease ID | 1066 |
|---|---|
| Disease | transient cerebral ischemia |
| Integrated Phenotype | (Waiting for update.) |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:4) HP:0002354 | Memory loss | 1 HP:0000488 | Noninflammatory retina disease | 1 HP:0001250 | Seizures | 1 HP:0000716 | Depression | 1 |
| Disease ID | 1066 |
|---|---|
| Disease | transient cerebral ischemia |
| Manually Symptom | (Waiting for update.) |
| Text Mined Symptom | (Waiting for update.) |
Manually Genotype(Total Text Mining Genotypes:0) |
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| (Waiting for update.) |
All Snps(Total Genotypes:11) | |||||||||||||
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| snpId | pubmedId | geneId | geneSymbol | diseaseId | sourceId | sentence | score | Year | geneSymbol_dbSNP | CHROMOSOME | POS | REF | ALT |
| rs397507444 | 20833086 | 4524 | MTHFR | umls:C0007787 | BeFree | Cerebral venous sinus thrombosis presenting as transient ischemic attacks in a case with homozygous mutations of MTHFR A1298C and CG677T. | 0.011368221 | 2012 | MTHFR | 1 | 11794407 | T | G |
| rs4986790 | 16879054 | 3569 | IL6 | umls:C0007787 | BeFree | We determined the frequency of polymorphisms in tumor necrosis factor-alpha[(TNF-alpha) G(-376)A, G(-244)A, G(-238)A, G(-308)A], Toll-like receptor 4 [(TLR4) Gly299Asp and Thr399Ile], interleukin-1-receptor antagonist [(IL-1-RA) intron 2 variable-number tandem repeat], monocyte differentiation antigen CD14 receptor C(-260)T, and interleukin-6 [(IL-6) G(-174)C] genes in 404 patients with acute stroke or transient ischemic attack before the age of 60 years and in 415 healthy individuals. | 0.002909916 | 2006 | TLR4 | 9 | 117713024 | A | G |
| rs4986790 | 16879054 | 7124 | TNF | umls:C0007787 | BeFree | We determined the frequency of polymorphisms in tumor necrosis factor-alpha[(TNF-alpha) G(-376)A, G(-244)A, G(-238)A, G(-308)A], Toll-like receptor 4 [(TLR4) Gly299Asp and Thr399Ile], interleukin-1-receptor antagonist [(IL-1-RA) intron 2 variable-number tandem repeat], monocyte differentiation antigen CD14 receptor C(-260)T, and interleukin-6 [(IL-6) G(-174)C] genes in 404 patients with acute stroke or transient ischemic attack before the age of 60 years and in 415 healthy individuals. | 0.080271442 | 2006 | TLR4 | 9 | 117713024 | A | G |
| rs4986790 | 16879054 | 3554 | IL1R1 | umls:C0007787 | BeFree | We determined the frequency of polymorphisms in tumor necrosis factor-alpha[(TNF-alpha) G(-376)A, G(-244)A, G(-238)A, G(-308)A], Toll-like receptor 4 [(TLR4) Gly299Asp and Thr399Ile], interleukin-1-receptor antagonist [(IL-1-RA) intron 2 variable-number tandem repeat], monocyte differentiation antigen CD14 receptor C(-260)T, and interleukin-6 [(IL-6) G(-174)C] genes in 404 patients with acute stroke or transient ischemic attack before the age of 60 years and in 415 healthy individuals. | 0.000271442 | 2006 | TLR4 | 9 | 117713024 | A | G |
| rs4986790 | 16879054 | 3557 | IL1RN | umls:C0007787 | BeFree | We determined the frequency of polymorphisms in tumor necrosis factor-alpha[(TNF-alpha) G(-376)A, G(-244)A, G(-238)A, G(-308)A], Toll-like receptor 4 [(TLR4) Gly299Asp and Thr399Ile], interleukin-1-receptor antagonist [(IL-1-RA) intron 2 variable-number tandem repeat], monocyte differentiation antigen CD14 receptor C(-260)T, and interleukin-6 [(IL-6) G(-174)C] genes in 404 patients with acute stroke or transient ischemic attack before the age of 60 years and in 415 healthy individuals. | 0.080271442 | 2006 | TLR4 | 9 | 117713024 | A | G |
| rs4986790 | 16879054 | 7099 | TLR4 | umls:C0007787 | BeFree | We determined the frequency of polymorphisms in tumor necrosis factor-alpha[(TNF-alpha) G(-376)A, G(-244)A, G(-238)A, G(-308)A], Toll-like receptor 4 [(TLR4) Gly299Asp and Thr399Ile], interleukin-1-receptor antagonist [(IL-1-RA) intron 2 variable-number tandem repeat], monocyte differentiation antigen CD14 receptor C(-260)T, and interleukin-6 [(IL-6) G(-174)C] genes in 404 patients with acute stroke or transient ischemic attack before the age of 60 years and in 415 healthy individuals. | 0.000271442 | 2006 | TLR4 | 9 | 117713024 | A | G |
| rs4986791 | 16879054 | 3554 | IL1R1 | umls:C0007787 | BeFree | We determined the frequency of polymorphisms in tumor necrosis factor-alpha[(TNF-alpha) G(-376)A, G(-244)A, G(-238)A, G(-308)A], Toll-like receptor 4 [(TLR4) Gly299Asp and Thr399Ile], interleukin-1-receptor antagonist [(IL-1-RA) intron 2 variable-number tandem repeat], monocyte differentiation antigen CD14 receptor C(-260)T, and interleukin-6 [(IL-6) G(-174)C] genes in 404 patients with acute stroke or transient ischemic attack before the age of 60 years and in 415 healthy individuals. | 0.000271442 | 2006 | TLR4 | 9 | 117713324 | C | T |
| rs4986791 | 16879054 | 7099 | TLR4 | umls:C0007787 | BeFree | We determined the frequency of polymorphisms in tumor necrosis factor-alpha[(TNF-alpha) G(-376)A, G(-244)A, G(-238)A, G(-308)A], Toll-like receptor 4 [(TLR4) Gly299Asp and Thr399Ile], interleukin-1-receptor antagonist [(IL-1-RA) intron 2 variable-number tandem repeat], monocyte differentiation antigen CD14 receptor C(-260)T, and interleukin-6 [(IL-6) G(-174)C] genes in 404 patients with acute stroke or transient ischemic attack before the age of 60 years and in 415 healthy individuals. | 0.000271442 | 2006 | TLR4 | 9 | 117713324 | C | T |
| rs4986791 | 16879054 | 3557 | IL1RN | umls:C0007787 | BeFree | We determined the frequency of polymorphisms in tumor necrosis factor-alpha[(TNF-alpha) G(-376)A, G(-244)A, G(-238)A, G(-308)A], Toll-like receptor 4 [(TLR4) Gly299Asp and Thr399Ile], interleukin-1-receptor antagonist [(IL-1-RA) intron 2 variable-number tandem repeat], monocyte differentiation antigen CD14 receptor C(-260)T, and interleukin-6 [(IL-6) G(-174)C] genes in 404 patients with acute stroke or transient ischemic attack before the age of 60 years and in 415 healthy individuals. | 0.080271442 | 2006 | TLR4 | 9 | 117713324 | C | T |
| rs4986791 | 16879054 | 7124 | TNF | umls:C0007787 | BeFree | We determined the frequency of polymorphisms in tumor necrosis factor-alpha[(TNF-alpha) G(-376)A, G(-244)A, G(-238)A, G(-308)A], Toll-like receptor 4 [(TLR4) Gly299Asp and Thr399Ile], interleukin-1-receptor antagonist [(IL-1-RA) intron 2 variable-number tandem repeat], monocyte differentiation antigen CD14 receptor C(-260)T, and interleukin-6 [(IL-6) G(-174)C] genes in 404 patients with acute stroke or transient ischemic attack before the age of 60 years and in 415 healthy individuals. | 0.080271442 | 2006 | TLR4 | 9 | 117713324 | C | T |
| rs4986791 | 16879054 | 3569 | IL6 | umls:C0007787 | BeFree | We determined the frequency of polymorphisms in tumor necrosis factor-alpha[(TNF-alpha) G(-376)A, G(-244)A, G(-238)A, G(-308)A], Toll-like receptor 4 [(TLR4) Gly299Asp and Thr399Ile], interleukin-1-receptor antagonist [(IL-1-RA) intron 2 variable-number tandem repeat], monocyte differentiation antigen CD14 receptor C(-260)T, and interleukin-6 [(IL-6) G(-174)C] genes in 404 patients with acute stroke or transient ischemic attack before the age of 60 years and in 415 healthy individuals. | 0.002909916 | 2006 | TLR4 | 9 | 117713324 | C | T |
GWASdb Annotation(Total Genotypes:0) | |
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| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
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| (Waiting for update.) | |
Mapped by lexical matching(Total Items:0) |
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| (Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
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| (Waiting for update.) |
Chemical(Total Drugs:14) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| CUI | ChemicalName | ChemicalID | CasRN | DiseaseName | DiseaseID | DirectEvidence | PubMedIDs | ||
| C0007787 | bisoprolol | D017298 | 66722-44-9 | ischemic attack, transient | MESH:D002546 | therapeutic | 7798508 | ||
| C0007787 | diethylstilbestrol | D004054 | 56-53-1 | ischemic attack, transient | MESH:D002546 | marker/mechanism | 11502463 | ||
| C0007787 | fluoxetine | D005473 | 54910-89-3 | ischemic attack, transient | MESH:D002546 | therapeutic | 17328894 | ||
| C0007787 | hydroxyurea | D006918 | 127-07-1 | ischemic attack, transient | MESH:D002546 | marker/mechanism | 16398570 | ||
| C0007787 | labetalol | D007741 | 36894-69-6 | ischemic attack, transient | MESH:D002546 | marker/mechanism | 11074327 | ||
| C0007787 | lidocaine | D008012 | 137-58-6 | ischemic attack, transient | MESH:D002546 | therapeutic | 15099683 | ||
| C0007787 | methotrexate | D008727 | 1959/5/2 | ischemic attack, transient | MESH:D002546 | marker/mechanism | 2004323 | ||
| C0007787 | nimodipine | D009553 | 66085-59-4 | ischemic attack, transient | MESH:D002546 | therapeutic | 11086739 | ||
| C0007787 | rosiglitazone | C089730 | - | ischemic attack, transient | MESH:D002546 | marker/mechanism | 19591532 | ||
| C0007787 | rosiglitazone | C089730 | - | ischemic attack, transient | MESH:D002546 | therapeutic | 21826699 | ||
| C0007787 | tacrolimus | D016559 | 109581-93-3 | ischemic attack, transient | MESH:D002546 | marker/mechanism | 17112920 | ||
| C0007787 | thiopental | D013874 | 76-75-5 | ischemic attack, transient | MESH:D002546 | therapeutic | 116395 | ||
| C0007787 | ticlopidine | D013988 | 55142-85-3 | ischemic attack, transient | MESH:D002546 | therapeutic | 10965556 | ||
| C0007787 | timolol | D013999 | 26839-75-8 | ischemic attack, transient | MESH:D002546 | marker/mechanism | 3977221 | ||
FDA approved drug and dosage information(Total Drugs:0) | |
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| (Waiting for update.) | |
FDA labeling changes(Total Drugs:0) | |
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| (Waiting for update.) | |