PedAM

Pediatric Disease Annotations & Medicines


	trachoma

Disease ID	424
Disease	trachoma
Definition	A chronic infection of the CONJUNCTIVA and CORNEA caused by CHLAMYDIA TRACHOMATIS.
Synonym	[x]trachoma, unspecified [x]trachoma, unspecified (disorder) egyptian ophthalmia ophthalmia, egyptian trachoma (disorder) trachoma [disease/finding] trachoma nos trachoma, nos trachoma, unspecified trachomas unspecified trachoma unspecified trachoma (disorder)
DOID	DOID:11265
ICD10	ICD10CM:A71.9
UMLS	C0040592
MeSH	D014141
SNOMED-CT	SNOMEDCT_US_2016_09_01:2576002
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:6) C0456909 \| blindness \| 23 C0008148 \| chlamydia \| 3 C0024530 \| malaria \| 1 C0004623 \| bacterial infection \| 1 C0029001 \| onchocerciasis \| 1 C0009766 \| allergic conjunctivitis \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:7) 3106 \| HLA-B \| infer 3119 \| HLA-DQB1 \| infer 3123 \| HLA-DRB1 \| infer 3586 \| IL10 \| infer 3565 \| IL4 \| infer 4153 \| MBL2 \| infer 7124 \| TNF \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:50) 3566 \| IL4R \| DISEASES 4792 \| NFKBIA \| DISEASES 973 \| CD79A \| DISEASES 3458 \| IFNG \| DISEASES 11034 \| DSTN \| DISEASES 7355 \| SLC35A2 \| DISEASES 968 \| CD68 \| DISEASES 59272 \| ACE2 \| DISEASES 10894 \| LYVE1 \| DISEASES 27348 \| TOR1B \| DISEASES 5687 \| PSMA6 \| DISEASES 10133 \| OPTN \| DISEASES 3553 \| IL1B \| DISEASES 118 \| ADD1 \| DISEASES 3578 \| IL9 \| DISEASES 1409 \| CRYAA \| DISEASES 9437 \| NCR1 \| DISEASES 6374 \| CXCL5 \| DISEASES 3600 \| IL15 \| DISEASES 3251 \| HPRT1 \| DISEASES 6356 \| CCL11 \| DISEASES 92483 \| LDHAL6B \| DISEASES 1241 \| LTB4R \| DISEASES 344561 \| GPR148 \| DISEASES 27165 \| GLS2 \| DISEASES 8557 \| TCAP \| DISEASES 4312 \| MMP1 \| DISEASES 4843 \| NOS2 \| DISEASES 3804 \| KIR2DL3 \| DISEASES 26151 \| NAT9 \| DISEASES 79947 \| DHDDS \| DISEASES 58484 \| NLRC4 \| DISEASES 4283 \| CXCL9 \| DISEASES 1660 \| DHX9 \| DISEASES 1490 \| CTGF \| DISEASES 6278 \| S100A7 \| DISEASES 4318 \| MMP9 \| DISEASES 2022 \| ENG \| DISEASES 3339 \| HSPG2 \| DISEASES 100507436 \| MICA \| DISEASES 3107 \| HLA-C \| DISEASES 9308 \| CD83 \| DISEASES 29103 \| DNAJC15 \| DISEASES 6443 \| SGCB \| DISEASES 3652 \| IPP \| DISEASES 3803 \| KIR2DL2 \| DISEASES 7124 \| TNF \| DISEASES 3586 \| IL10 \| DISEASES 51071 \| DERA \| DISEASES 246744 \| STH \| DISEASES
Locus	(Waiting for update.)

Disease ID	424
Disease	trachoma
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:11) HP:0000618 \| Blindness \| 23 HP:0007957 \| Corneal clouding \| 3 HP:0000559 \| Corneal scarring \| 2 HP:0001128 \| Trichiasis of eyelid eyelashes \| 2 HP:0000505 \| Poor vision \| 2 HP:0100699 \| Scarring \| 2 HP:0006532 \| Pneumonia, recurrent episodes \| 1 HP:0007879 \| Allergic conjunctivitis \| 1 HP:0000662 \| Poor night vision \| 1 HP:0001289 \| Confusion \| 1 HP:0000529 \| Slowly progressive visual loss \| 1

Disease ID	424
Disease	trachoma
Manually Symptom	UMLS \| Name(Total Manually Symptoms:23) C2707258 \| infections C2364133 \| infection C1962986 \| glaucoma C1962983 \| cataract C1707516 \| corneal sensitivity C1611280 \| allergy C0700109 \| rigidity C0521573 \| coloboma palpebrale C0456909 \| blindness C0221259 \| trichiasis C0155191 \| cicatricial entropion C0155141 \| acute conjunctivitis C0155118 \| corneal degeneration C0086543 \| cataracts C0043349 \| xerophthalmia C0042798 \| low vision C0038826 \| superinfection C0033377 \| ptosis C0019080 \| hemorrhage C0014390 \| entropion C0010930 \| dacryocystitis C0008149 \| chlamydial infection C0008149 \| chlamydia
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:7) C0456909 \| blindness \| 23 C0009450 \| infection \| 18 C0021311 \| infections \| 6 C0042798 \| low vision \| 4 C0008148 \| chlamydia \| 3 C0221259 \| trichiasis \| 2 C0008149 \| chlamydial infection \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:3)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs334	20552021	283297	OR10A4	umls:C0040592	BeFree	The objective was to investigate whether haptoglobin (Hp) haplotypes constructed from the functional polymorphism (Hp1/Hp2) plus the functional promoter SNPs -61A-C (rs5471) and -101C-G (rs5470), or sickle cell trait (HbAS, rs334) were associated with risk of active trachoma when stratified by age and sex, in rural Gambian children.	0.000271442	2010	HBB	11	5227002	T	G,C,A
rs5470	20552021	283297	OR10A4	umls:C0040592	BeFree	The objective was to investigate whether haptoglobin (Hp) haplotypes constructed from the functional polymorphism (Hp1/Hp2) plus the functional promoter SNPs -61A-C (rs5471) and -101C-G (rs5470), or sickle cell trait (HbAS, rs334) were associated with risk of active trachoma when stratified by age and sex, in rural Gambian children.	0.000271442	2010	HP	16	72054522	C	G
rs5471	20552021	283297	OR10A4	umls:C0040592	BeFree	The objective was to investigate whether haptoglobin (Hp) haplotypes constructed from the functional polymorphism (Hp1/Hp2) plus the functional promoter SNPs -61A-C (rs5471) and -101C-G (rs5470), or sickle cell trait (HbAS, rs334) were associated with risk of active trachoma when stratified by age and sex, in rural Gambian children.	0.000271442	2010	HP	16	72054562	A	C,G

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:0)
(Waiting for update.)

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

Web
Analytics