PedAM

Pediatric Disease Annotations & Medicines


	toxoplasmosis

Disease ID	268
Disease	toxoplasmosis
Definition	The acquired form of infection by Toxoplasma gondii in animals and man.
Synonym	[x]toxoplasmosis, unspecified [x]toxoplasmosis, unspecified (disorder) infect toxoplasma gondii infection by toxoplasma gondii infection by toxoplasma gondii (disorder) infection by toxoplasma gondii (disorder) [ambiguous] infection, toxoplasma gondii infections, toxoplasma gondii toxoplasma gondii infect toxoplasma gondii infection toxoplasma gondii infections toxoplasmoses toxoplasmosis (disorder) toxoplasmosis [disease/finding] toxoplasmosis nos toxoplasmosis nos (disorder) toxoplasmosis, unspecified
DOID	DOID:9965
ICD10	ICD10CM:B58.9
UMLS	C0040558
MeSH	D014123
SNOMED-CT	SNOMEDCT_US_2016_09_01:187192000
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:93) C0042164 \| uveitis \| 7 C0036341 \| schizophrenia \| 6 C0020255 \| hydrocephalus \| 3 C0026975 \| myelitis \| 3 C0001175 \| acquired immunodeficiency syndrome \| 3 C0014038 \| encephalitis \| 3 C0008513 \| retinochoroiditis \| 3 C0001175 \| acquired immune deficiency \| 2 C0042167 \| posterior uveitis \| 2 C0026896 \| myasthenia gravis \| 2 C0040560 \| congenital toxoplasmosis \| 2 C0027765 \| nervous system disease \| 2 C0014059 \| acute disseminated encephalomyelitis \| 2 C0025289 \| meningitis \| 2 C0000786 \| spontaneous abortion \| 2 C0001175 \| acquired immunodeficiency syndrome (aids) \| 2 C0014544 \| epilepsy \| 2 C0014070 \| encephalomyelitis \| 2 C0001175 \| acquired immune deficiency syndrome \| 2 C0038379 \| strabismus \| 1 C0030499 \| parasitic diseases \| 1 C0153633 \| brain cancer \| 1 C0011603 \| dermatitis \| 1 C0001175 \| acquired immune deficiency syndrome (aids) \| 1 C0031036 \| polyarteritis nodosa \| 1 C0242379 \| lung cancer \| 1 C0024141 \| systemic lupus erythematosus \| 1 C0029132 \| optic neuropathy \| 1 C0014556 \| temporal lobe epilepsy \| 1 C0038012 \| spondylitis \| 1 C0376545 \| hematologic malignancies \| 1 C0026848 \| muscular diseases \| 1 C0019196 \| hepatitis c \| 1 C0036220 \| kaposi sarcoma \| 1 C0011615 \| atopic dermatitis \| 1 C0041296 \| tuberculosis \| 1 C0039128 \| syphilis \| 1 C0008513 \| chorioretinitis \| 1 C0024419 \| waldenstrom's macroglobulinemia \| 1 C0008370 \| cholestasis \| 1 C1960469 \| left ventricular noncompaction \| 1 C0016085 \| filariasis \| 1 C0035309 \| retinal disease \| 1 C0017178 \| gastrointestinal disorders \| 1 C0032310 \| viral pneumonitis \| 1 C0032285 \| pneumonia \| 1 C0030312 \| pancytopenia \| 1 C0027868 \| neuromuscular diseases \| 1 C1261473 \| sarcoma \| 1 C0027765 \| nervous system diseases \| 1 C0017178 \| gastrointestinal disorder \| 1 C0011633 \| dermatomyositis \| 1 C0549423 \| obstructive hydrocephalus \| 1 C0025362 \| mental retardation \| 1 C0000786 \| miscarriage \| 1 C0019212 \| hepatorenal syndrome \| 1 C0002874 \| aplastic anemia \| 1 C0027765 \| neurological disorder \| 1 C0027868 \| neuromuscular disease \| 1 C0679466 \| cognitive deficits \| 1 C0032000 \| pituitary adenoma \| 1 C0040561 \| ocular toxoplasmosis \| 1 C0030567 \| parkinson's disease \| 1 C0025958 \| microcephaly \| 1 C0008148 \| chlamydia \| 1 C0442874 \| neuropathy \| 1 C0030499 \| parasitic disease \| 1 C0007107 \| cancer of the larynx \| 1 C0035305 \| retinal detachment \| 1 C0042075 \| urological disorders \| 1 C0747256 \| parasitic infection \| 1 C0025202 \| melanoma \| 1 C0019158 \| hepatitis \| 1 C0038013 \| ankylosing spondylitis \| 1 C0037769 \| west syndrome \| 1 C0015397 \| ocular disease \| 1 C0030305 \| pancreatitis \| 1 C0023418 \| leukaemia \| 1 C0024314 \| lymphoproliferative disease \| 1 C0022661 \| end-stage renal disease \| 1 C0007682 \| central nervous system diseases \| 1 C0022658 \| renal disease \| 1 C0024291 \| hemophagocytic syndrome \| 1 C0021053 \| immunologic disorders \| 1 C0007682 \| central nervous system disease \| 1 C0014130 \| endocrine disorders \| 1 C0035333 \| retinitis \| 1 C0003467 \| anxiety \| 1 C0027765 \| neurological disorders \| 1 C0001430 \| adenoma \| 1 C0040558 \| toxoplasmosis \| 1 C0042384 \| angiitis \| 1 C1263846 \| attention deficit hyperactivity disorder \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:169) 928 \| CD9 \| DISEASES 30009 \| TBX21 \| DISEASES 151887 \| CCDC80 \| DISEASES 25807 \| RHBDD3 \| DISEASES 2137 \| EXTL3 \| DISEASES 973 \| CD79A \| DISEASES 6348 \| CCL3 \| DISEASES 6347 \| CCL2 \| DISEASES 3558 \| IL2 \| DISEASES 81622 \| UNC93B1 \| DISEASES 3458 \| IFNG \| DISEASES 2026 \| ENO2 \| DISEASES 3003 \| GZMK \| DISEASES 3565 \| IL4 \| DISEASES 6500 \| SKP1 \| DISEASES 51692 \| CPSF3 \| DISEASES 6718 \| AKR1D1 \| DISEASES 30833 \| NT5C \| DISEASES 826 \| CAPNS1 \| DISEASES 92797 \| HELB \| DISEASES 2678 \| GGT1 \| DISEASES 417 \| ART1 \| DISEASES 47 \| ACLY \| DISEASES 1401 \| CRP \| DISEASES 1794 \| DOCK2 \| DISEASES 9662 \| CEP135 \| DISEASES 3569 \| IL6 \| DISEASES 2995 \| GYPC \| DISEASES 7097 \| TLR2 \| DISEASES 6496 \| SIX3 \| DISEASES 51816 \| CECR1 \| DISEASES 9878 \| TOX4 \| DISEASES 10133 \| OPTN \| DISEASES 3553 \| IL1B \| DISEASES 9466 \| IL27RA \| DISEASES 80725 \| SRCIN1 \| DISEASES 3383 \| ICAM1 \| DISEASES 10923 \| SUB1 \| DISEASES 27125 \| AFF4 \| DISEASES 23395 \| LARS2 \| DISEASES 6636 \| SNRPF \| DISEASES 3687 \| ITGAX \| DISEASES 3394 \| IRF8 \| DISEASES 7462 \| LAT2 \| DISEASES 4715 \| NDUFB9 \| DISEASES 55004 \| LAMTOR1 \| DISEASES 3606 \| IL18 \| DISEASES 9453 \| GGPS1 \| DISEASES 132 \| ADK \| DISEASES 163786 \| SASS6 \| DISEASES 729230 \| CCR2 \| DISEASES 1234 \| CCR5 \| DISEASES 6352 \| CCL5 \| DISEASES 1973 \| EIF4A1 \| DISEASES 55692 \| LUC7L \| DISEASES 6006 \| RHCE \| DISEASES 27306 \| HPGDS \| DISEASES 84283 \| TMEM79 \| DISEASES 213 \| ALB \| DISEASES 3015 \| H2AFZ \| DISEASES 51752 \| ERAP1 \| DISEASES 9607 \| CARTPT \| DISEASES 1437 \| CSF2 \| DISEASES 5224 \| PGAM2 \| DISEASES 84889 \| SLC7A3 \| DISEASES 115825 \| WDFY2 \| DISEASES 6901 \| TAZ \| DISEASES 201161 \| CENPV \| DISEASES 5347 \| PLK1 \| DISEASES 3308 \| HSPA4 \| DISEASES 54463 \| FAM134B \| DISEASES 3627 \| CXCL10 \| DISEASES 4430 \| MYO1B \| DISEASES 7386 \| UQCRFS1 \| DISEASES 56246 \| MRAP \| DISEASES 6363 \| CCL19 \| DISEASES 125988 \| C19orf70 \| DISEASES 947 \| CD34 \| DISEASES 7351 \| UCP2 \| DISEASES 57101 \| ANO2 \| DISEASES 2907 \| GRINA \| DISEASES 5551 \| PRF1 \| DISEASES 6950 \| TCP1 \| DISEASES 58492 \| ZNF77 \| DISEASES 2193 \| FARSA \| DISEASES 1974 \| EIF4A2 \| DISEASES 7378 \| UPP1 \| DISEASES 10539 \| GLRX3 \| DISEASES 6007 \| RHD \| DISEASES 1937 \| EEF1G \| DISEASES 54101 \| RIPK4 \| DISEASES 79621 \| RNASEH2B \| DISEASES 7189 \| TRAF6 \| DISEASES 23583 \| SMUG1 \| DISEASES 9529 \| BAG5 \| DISEASES 7204 \| TRIO \| DISEASES 8835 \| SOCS2 \| DISEASES 3006 \| HIST1H1C \| DISEASES 966 \| CD59 \| DISEASES 28986 \| MAGEH1 \| DISEASES 3605 \| IL17A \| DISEASES 390259 \| BSX \| DISEASES 25813 \| SAMM50 \| DISEASES 419 \| ART3 \| DISEASES 2224 \| FDPS \| DISEASES 10219 \| KLRG1 \| DISEASES 26136 \| TES \| DISEASES 55010 \| PARPBP \| DISEASES 54106 \| TLR9 \| DISEASES 4519 \| MT-CYB \| DISEASES 257202 \| GPX6 \| DISEASES 9760 \| TOX \| DISEASES 10580 \| SORBS1 \| DISEASES 54617 \| INO80 \| DISEASES 163882 \| CNST \| DISEASES 383 \| ARG1 \| DISEASES 51175 \| TUBE1 \| DISEASES 6280 \| S100A9 \| DISEASES 8349 \| HIST2H2BE \| DISEASES 5016 \| OVGP1 \| DISEASES 51750 \| RTEL1 \| DISEASES 2633 \| GBP1 \| DISEASES 959 \| CD40LG \| DISEASES 680 \| BRS3 \| DISEASES 958 \| CD40 \| DISEASES 51552 \| RAB14 \| DISEASES 7321 \| UBE2D1 \| DISEASES 7099 \| TLR4 \| DISEASES 64061 \| TSPYL2 \| DISEASES 7133 \| TNFRSF1B \| DISEASES 3105 \| HLA-A \| DISEASES 127262 \| TPRG1L \| DISEASES 79906 \| MORN1 \| DISEASES 9445 \| ITM2B \| DISEASES 3704 \| ITPA \| DISEASES 4267 \| CD99 \| DISEASES 55835 \| CENPJ \| DISEASES 55576 \| STAB2 \| DISEASES 29994 \| BAZ2B \| DISEASES 51343 \| FZR1 \| DISEASES 10521 \| DDX17 \| DISEASES 4901 \| NRL \| DISEASES 3029 \| HAGH \| DISEASES 3119 \| HLA-DQB1 \| DISEASES 8505 \| PARG \| DISEASES 23308 \| ICOSLG \| DISEASES 728441 \| GGT2 \| DISEASES 6295 \| SAG \| DISEASES 1719 \| DHFR \| DISEASES 960 \| CD44 \| DISEASES 7124 \| TNF \| DISEASES 3106 \| HLA-B \| DISEASES 159371 \| SLC35G1 \| DISEASES 4615 \| MYD88 \| DISEASES 3586 \| IL10 \| DISEASES 135656 \| DPCR1 \| DISEASES 27333 \| GOLIM4 \| DISEASES 5890 \| RAD51B \| DISEASES 573 \| BAG1 \| DISEASES 10189 \| ALYREF \| DISEASES 51428 \| DDX41 \| DISEASES 3684 \| ITGAM \| DISEASES 169355 \| IDO2 \| DISEASES 4065 \| LY75 \| DISEASES 567 \| B2M \| DISEASES 22861 \| NLRP1 \| DISEASES 2232 \| FDXR \| DISEASES 246734 \| NPCDR1 \| DISEASES 9303 \| SNORD25 \| DISEASES
Locus	(Waiting for update.)

Disease ID	268
Disease	toxoplasmosis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:52) HP:0000554 \| Uveitis \| 7 HP:0100753 \| Schizophrenia \| 6 HP:0002716 \| Lymph node hyperplasia \| 5 HP:0002721 \| Immunodeficiency \| 4 HP:0001250 \| Seizures \| 4 HP:0002383 \| Encephalitis \| 3 HP:0012486 \| Inflammation of spinal cord \| 3 HP:0000238 \| Nonsyndromal hydrocephalus \| 3 HP:0012123 \| Posterior uveitis \| 2 HP:0000969 \| Dropsy \| 2 HP:0000708 \| Behavioral problems \| 2 HP:0001287 \| Meningitis \| 2 HP:0003473 \| Fatigable weakness \| 2 HP:0005268 \| Spontaneous abortion \| 2 HP:0100242 \| Sarcoma \| 1 HP:0000486 \| Squint eyes \| 1 HP:0012054 \| Choroidal melanoma \| 1 HP:0030682 \| Left ventricular noncompaction \| 1 HP:0000365 \| Hearing impairment \| 1 HP:0002893 \| Pituitary adenoma \| 1 HP:0000541 \| Detached retina \| 1 HP:0001138 \| Damaged optic nerve \| 1 HP:0000739 \| Anxiety \| 1 HP:0002090 \| Pneumonia \| 1 HP:0030049 \| Brain abscess \| 1 HP:0001396 \| Cholestasis \| 1 HP:0001047 \| Atopic dermatitis \| 1 HP:0001249 \| Mental retardation \| 1 HP:0100533 \| Ocular inflammation \| 1 HP:0012424 \| Chorioretinitis \| 1 HP:0001733 \| Pancreatic inflammation \| 1 HP:0012115 \| Liver inflammation \| 1 HP:0002861 \| Melanoma \| 1 HP:0000252 \| Small head circumference \| 1 HP:0011531 \| Hyalitis \| 1 HP:0200056 \| Macular scar \| 1 HP:0100543 \| Cognitive deficits \| 1 HP:0004305 \| Involuntary muscle contractions \| 1 HP:0002633 \| Vasculitis \| 1 HP:0003774 \| End-stage renal failure \| 1 HP:0011450 \| CNS infection \| 1 HP:0001876 \| Low blood cell count \| 1 HP:0000303 \| Increased size of lower jaw \| 1 HP:0012118 \| Cancer of the larynx \| 1 HP:0001945 \| Fever \| 1 HP:0002725 \| Systemic lupus erythematosus \| 1 HP:0001141 \| Severe visual impairment \| 1 HP:0000505 \| Poor vision \| 1 HP:0007018 \| Attention deficits \| 1 HP:0004749 \| Atrial flutter \| 1 HP:0001297 \| Cerebral vascular events \| 1 HP:0001915 \| Aplastic anemia \| 1

Disease ID	268
Disease	toxoplasmosis
Manually Symptom	UMLS \| Name(Total Manually Symptoms:58) C2712322 \| tachycardia C2364133 \| infection C2242550 \| acute polyradiculoneuritis C1963266 \| uveitis C1963229 \| retinal detachment C1963211 \| pericarditis C1962971 \| myocarditis C1840264 \| immune suppression C1527383 \| morphea C1510428 \| cerebral abscess C1412002 \| atypical pneumonia C1397626 \| fetal hydrocephalus C1373218 \| immunosuppression C1270169 \| villitis C0948714 \| vestibular paralysis C0948600 \| organ failure C0936254 \| polyradiculoneuritis C0936251 \| polyradiculitis C0854268 \| fetal damage C0796095 \| c syndrome C0728936 \| circulatory disorders C0581883 \| deafness C0497156 \| lymphadenopathy C0456909 \| blindness C0393799 \| miller-fisher syndrome C0275519 \| subacute infection C0272293 \| chronic thrombocytopenic purpura C0265144 \| chronic constrictive pericarditis C0263666 \| juvenile dermatomyositis C0235031 \| neurological symptoms C0206061 \| interstitial pneumonia C0158944 \| congenital infections C0155686 \| acute myocarditis C0085655 \| polymyositis C0043117 \| autoimmune thrombocytopenic purpura C0042167 \| posterior uveitis C0037285 \| skin manifestations C0035333 \| retinitis C0033975 \| psychoses C0032059 \| placentitis C0029132 \| optic neuropathy C0028866 \| oculomotor nerve palsies C0026847 \| spinal amyotrophy C0025469 \| mesenteric lymphadenitis C0025309 \| meningoencephalitis C0024205 \| lymphadenitis C0023501 \| leukemoid reaction C0019270 \| herniation C0018784 \| sensorineural hearing loss C0015403 \| ocular infection C0014038 \| encephalitis C0013418 \| dystocia C0011633 \| dermatomyositis C0008513 \| retinochoroiditis C0008512 \| chorioretinal scars C0007137 \| squamous cell carcinoma C0004943 \| behcet's syndrome C0004936 \| mental disorders
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:13) C0009450 \| infection \| 28 C0042164 \| uveitis \| 7 C0024228 \| lymphadenopathy \| 5 C0008513 \| retinochoroiditis \| 3 C0014038 \| encephalitis \| 3 C0158944 \| congenital infections \| 3 C0021079 \| immunosuppression \| 3 C0042167 \| posterior uveitis \| 2 C0035305 \| retinal detachment \| 1 C0035333 \| retinitis \| 1 C0029132 \| optic neuropathy \| 1 C0796095 \| c syndrome \| 1 C0011633 \| dermatomyositis \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:1)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0002860	Squamous cell carcinoma	MP:0003331	increased hepatocellular carcinoma incidence;HP:0000407	Sensorineural hearing impairment

Mapped by homologous gene(Total Items:1)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0002860	Squamous cell carcinoma	MP:0000639	abnormal adrenal gland morphology;HP:0002716	Lymphadenopathy

Chemical(Total Drugs:7)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0040558	atovaquone	D053626	94015-53-9	toxoplasmosis	MESH:D014123	therapeutic	10447880
C0040558	ciprofloxacin	D002939	85721-33-1	toxoplasmosis	MESH:D014123	therapeutic	20186551
C0040558	cyclophosphamide	D003520	50-18-0	toxoplasmosis	MESH:D014123	marker/mechanism	5120183
C0040558	dapsone	D003622	80-08-0	toxoplasmosis	MESH:D014123	therapeutic	18602405
C0040558	folic acid	D005492	59-30-3	toxoplasmosis	MESH:D014123	therapeutic	8228015
C0040558	pyrimethamine	D011739	58-14-0	toxoplasmosis	MESH:D014123	therapeutic	15909603
C0040558	sulfadiazine	D013411	68-35-9	toxoplasmosis	MESH:D014123	therapeutic	14650303

FDA approved drug and dosage information(Total Drugs:2)
DiseaseID	Drug_name	active_ingredients	strength	Dosage Form/Route	Marketing Status	TE code	RLD	RS
MESH:D014123	cipro	ciprofloxacin	400MG/40ML (10MG/ML)	INJECTABLE;INJECTION	Discontinued	None	Yes	No
MESH:D014123	cipro	ciprofloxacin	250MG/5ML	FOR SUSPENSION;ORAL	Prescription	AB	Yes	No

FDA labeling changes(Total Drugs:2)
DiseaseID	Pediatric_Labeling_Date	Trade_Name	Generic_Name_or_Proper_Name	Indications Studied	Label Changes Summary	Product Labeling	BPCA(B)	PREA(P)	BPCA(B) and PREA(P)	Pediatric Rule (R)	Sponsor	Pediatric Exclusivity Granted Date	NNPS
MESH:D014123	03/25/2004	cipro	ciprofloxacin	Complicated UTI and pyelonephritis	Indicated for the treatment of complicated urinary tract infections (cUTIs) and pyelonephritis in pediatric patients 1 17 years of age Not drug of first choice due to increased adverse events compared to controls including events related to joints and/or surrounding tissues Information on PK and dose in pediatric patients 1 17 years of age The most frequent adverse events observed within 6 weeks of treatment initiation during the cUTI clinical trial were gastrointestinal 15% compared to 9% and musculoskeletal 9.3% compared to 6% in ciprofloxacin-treated compared to control-treated patients, respectively	Labeling	B	-	-	-	Bayer	12/18/2003	FALSE'
MESH:D014123	03/25/2004	cipro	ciprofloxacin	Complicated UTI and pyelonephritis	Indicated for the treatment of complicated urinary tract infections (cUTIs) and pyelonephritis in pediatric patients 1 17 years of age Not drug of first choice due to increased adverse events compared to controls including events related to joints and/or surrounding tissues Information on PK and dose in pediatric patients 1 17 years of age The most frequent adverse events observed within 6 weeks of treatment initiation during the cUTI clinical trial were gastrointestinal 15% compared to 9% and musculoskeletal 9.3% compared to 6% in ciprofloxacin-treated compared to control-treated patients, respectively	Labeling	B	-	-	-	Bayer	12/18/2003	FALSE'

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