PedAM

Pediatric Disease Annotations & Medicines


	toxemia

Disease ID	356
Disease	toxemia
Definition	A complication of PREGNANCY, characterized by a complex of symptoms including maternal HYPERTENSION and PROTEINURIA with or without pathological EDEMA. Symptoms may range between mild and severe. Pre-eclampsia usually occurs after the 20th week of gestation, but may develop before this time in the presence of trophoblastic disease.
Synonym	1, preeclampsia eclampsia 1s, preeclampsia eclampsia eclampsia 1, preeclampsia eclampsia 1s, preeclampsia edema proteinuria hypertension gestosis edema-proteinuria-hypertension gestosis eph - edema, proteinuria and hypertension of pregnancy eph - oedema, proteinuria and hypertension of pregnancy eph complex eph gestosis eph toxemia eph toxemias gestosis, edema-proteinuria-hypertension gestosis, eph gestosis, hypertension-edema-proteinuria gestosis, proteinuria-edema-hypertension hypertension edema proteinuria gestosis hypertension-edema-proteinuria gestosis hypertensive disorder of pregnancy maternal toxemia of pregnancies, toxemia of pregnancy, toxemia pe - pre-eclampsia pee pee1 pet - pre-eclamptic toxaemia pet - pre-eclamptic toxemia pre eclampsia pre-eclampsia pre-eclampsia (disorder) pre-eclampsia [disease/finding] pre-eclampsia nos pre-eclampsia nos (disorder) pre-eclampsia, nos pre-eclampsia, unspecified pre-eclamptic nos pre-eclamptic toxaemia pre-eclamptic toxemia pre-eclamptic toxemia, nos preeclampsia preeclampsia eclampsia 1 preeclampsia eclampsia 1s preeclampsia/eclampsia 1 preg1 pregn toxemias pregnancies, toxemia of pregnancy toxaemia pregnancy toxemia pregnancy toxemia/hypertension pregnancy toxemias pregnancy, toxemia of proteinuria edema hypertension gestosis proteinuria-edema-hypertension gestosis proteinuric hypertension of pregnancy proteinuric hypertension of pregnancy (disorder) toxaemia nos toxaemia of pregnancy toxaemia of pregnancy, nos toxaemia pregnancy toxemia (pre)eclampsia toxemia in pregnancy toxemia nos toxemia nos (disorder) toxemia of pregnancies toxemia of pregnancy toxemia of pregnancy (disorder) toxemia of pregnancy, nos toxemia pregnancy toxemia, eph toxemia, pregnancy toxemias, eph toxemias, pregnancy
Orphanet	ORPHANET:275555
OMIM	OMIM:189800
DOID	DOID:10591
UMLS	C0032914
MeSH	D011225 D014115
SNOMED-CT	SNOMEDCT_US_2016_09_01:398254007;SNOMEDCT_US_2016_09_01:15394000
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:2) C0343386 \| clostridium difficile infection \| 1 C0037354 \| smallpox \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:19) CP \| 1356 \| CTD_human NOS3 \| 4846 \| CTD_human EPHX1 \| 2052 \| CTD_human;GHR HMOX1 \| 3162 \| CTD_human EDN1 \| 1906 \| CTD_human AGT \| 183 \| CTD_human ACE \| 1636 \| CTD_human FLT1 \| 2321 \| CTD_human SERPINE1 \| 5054 \| CTD_human STOX1 \| 219736 \| CTD_human;ORPHANET;GHR FGF14 \| 2259 \| GWASCAT CORIN \| 10699 \| ORPHANET;GHR ANXA5 \| 308 \| CTD_human SCNN1A \| 6337 \| CTD_human PEE1 \| 5177 \| CTD_human;OMIM INHBA \| 3624 \| CTD_human ZNF295-AS1 \| 150142 \| GWASCAT MYCBP2 \| 23077 \| GWASCAT DDAH2 \| 23564 \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:122) 1636 \| ACE \| infer 9370 \| ADIPOQ \| infer 155 \| ADRB3 \| infer 183 \| AGT \| infer 185 \| AGTR1 \| infer 186 \| AGTR2 \| infer 308 \| ANXA5 \| infer 348 \| APOE \| infer 929 \| CD14 \| infer 1277 \| COL1A1 \| infer 1361 \| CPB2 \| infer 1493 \| CTLA4 \| infer 1543 \| CYP1A1 \| infer 1565 \| CYP2D6 \| infer 1571 \| CYP2E1 \| infer 23576 \| DDAH1 \| infer 1815 \| DRD4 \| infer 1909 \| EDNRA \| infer 5167 \| ENPP1 \| infer 2052 \| EPHX1 \| infer 2099 \| ESR1 \| infer 2100 \| ESR2 \| infer 2162 \| F13A1 \| infer 2147 \| F2 \| infer 2153 \| F5 \| infer 2155 \| F7 \| infer 355 \| FAS \| infer 356 \| FASLG \| infer 2244 \| FGB \| infer 2944 \| GSTM1 \| infer 2950 \| GSTP1 \| infer 2952 \| GSTT1 \| infer 3030 \| HADHA \| infer 3105 \| HLA-A \| infer 3117 \| HLA-DQA1 \| infer 3119 \| HLA-DQB1 \| infer 3123 \| HLA-DRB1 \| infer 3135 \| HLA-G \| infer 3240 \| HP \| infer 3303 \| HSPA1A \| infer 3304 \| HSPA1B \| infer 3305 \| HSPA1L \| infer 3458 \| IFNG \| infer 3479 \| IGF1 \| infer 3586 \| IL10 \| infer 3552 \| IL1A \| infer 3557 \| IL1RN \| infer 3566 \| IL4R \| infer 3569 \| IL6 \| infer 3623 \| INHA \| infer 3690 \| ITGB3 \| infer 3805 \| KIR2DL4 \| infer 3952 \| LEP \| infer 3953 \| LEPR \| infer 4023 \| LPL \| infer 4314 \| MMP3 \| infer 4318 \| MMP9 \| infer 4353 \| MPO \| infer 4524 \| MTHFR \| infer 4567 \| MT-TL1 \| infer 10 \| NAT2 \| infer 4846 \| NOS3 \| infer 4306 \| NR3C2 \| infer 5444 \| PON1 \| infer 5547 \| PRCP \| infer 5972 \| REN \| infer 6338 \| SCNN1B \| infer 5054 \| SERPINE1 \| infer 6648 \| SOD2 \| infer 219736 \| STOX1 \| infer 6890 \| TAP1 \| infer 6891 \| TAP2 \| infer 7040 \| TGFB1 \| infer 7056 \| THBD \| infer 7124 \| TNF \| infer 7422 \| VEGFA \| infer 92 \| ACVR2A \| infer 328 \| APEX1 \| infer 11132 \| CAPN10 \| infer 3075 \| CFH \| infer 1312 \| COMT \| infer 1524 \| CX3CR1 \| infer 1585 \| CYP11B2 \| infer 1586 \| CYP17A1 \| infer 1906 \| EDN1 \| infer 1950 \| EGF \| infer 2022 \| ENG \| infer 2068 \| ERCC2 \| infer 2321 \| FLT1 \| infer 2324 \| FLT4 \| infer 2492 \| FSHR \| infer 2784 \| GNB3 \| infer 2868 \| GRK4 \| infer 283120 \| H19 \| infer 3091 \| HIF1A \| infer 3113 \| HLA-DPA1 \| infer 3620 \| IDO1 \| infer 3459 \| IFNGR1 \| infer 3553 \| IL1B \| infer 3565 \| IL4 \| infer 3630 \| INS \| infer 3643 \| INSR \| infer 3667 \| IRS1 \| infer 3674 \| ITGA2B \| infer 3812 \| KIR3DL2 \| infer 3990 \| LIPC \| infer 4153 \| MBL2 \| infer 1728 \| NQO1 \| infer 5468 \| PPARG \| infer 9475 \| ROCK2 \| infer 6550 \| SLC9A3 \| infer 6647 \| SOD1 \| infer 7039 \| TGFA \| infer 7054 \| TH \| infer 7097 \| TLR2 \| infer 7099 \| TLR4 \| infer 10673 \| TNFSF13B \| infer 10911 \| UTS2 \| infer 7423 \| VEGFB \| infer 7424 \| VEGFC \| infer 7450 \| VWF \| infer 7515 \| XRCC1 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:675) 2288 \| FKBP4 \| DISEASES 1015 \| CDH17 \| DISEASES 1634 \| DCN \| DISEASES 10911 \| UTS2 \| DISEASES 7132 \| TNFRSF1A \| DISEASES 10272 \| FSTL3 \| DISEASES 29090 \| TIMM21 \| DISEASES 1361 \| CPB2 \| DISEASES 10683 \| DLL3 \| DISEASES 350 \| APOH \| DISEASES 2099 \| ESR1 \| DISEASES 7593 \| MZF1 \| DISEASES 4282 \| MIF \| DISEASES 3956 \| LGALS1 \| DISEASES 3162 \| HMOX1 \| DISEASES 5283 \| PIGH \| DISEASES 328 \| APEX1 \| DISEASES 1591 \| CYP24A1 \| DISEASES 5834 \| PYGB \| DISEASES 10544 \| PROCR \| DISEASES 128674 \| PROKR2 \| DISEASES 5020 \| OXT \| DISEASES 10084 \| PQBP1 \| DISEASES 7076 \| TIMP1 \| DISEASES 4313 \| MMP2 \| DISEASES 4324 \| MMP15 \| DISEASES 4350 \| MPG \| DISEASES 3163 \| HMOX2 \| DISEASES 366 \| AQP9 \| DISEASES 30844 \| EHD4 \| DISEASES 1666 \| DECR1 \| DISEASES 5327 \| PLAT \| DISEASES 8797 \| TNFRSF10A \| DISEASES 3972 \| LHB \| DISEASES 11129 \| CLASRP \| DISEASES 268 \| AMH \| DISEASES 56729 \| RETN \| DISEASES 29124 \| LGALS13 \| DISEASES 2091 \| FBL \| DISEASES 7040 \| TGFB1 \| DISEASES 973 \| CD79A \| DISEASES 5296 \| PIK3R2 \| DISEASES 2077 \| ERF \| DISEASES 5444 \| PON1 \| DISEASES 3082 \| HGF \| DISEASES 7980 \| TFPI2 \| DISEASES 10135 \| NAMPT \| DISEASES 5054 \| SERPINE1 \| DISEASES 4899 \| NRF1 \| DISEASES 5919 \| RARRES2 \| DISEASES 8721 \| EDF1 \| DISEASES 4353 \| MPO \| DISEASES 6347 \| CCL2 \| DISEASES 7448 \| VTN \| DISEASES 3558 \| IL2 \| DISEASES 345 \| APOC3 \| DISEASES 969 \| CD69 \| DISEASES 1594 \| CYP27B1 \| DISEASES 3458 \| IFNG \| DISEASES 2597 \| GAPDH \| DISEASES 2784 \| GNB3 \| DISEASES 3910 \| LAMA4 \| DISEASES 1839 \| HBEGF \| DISEASES 56129 \| PCDHB7 \| DISEASES 4012 \| LNPEP \| DISEASES 3565 \| IL4 \| DISEASES 51294 \| PCDH12 \| DISEASES 3273 \| HRG \| DISEASES 7035 \| TFPI \| DISEASES 338 \| APOB \| DISEASES 83444 \| INO80B \| DISEASES 3488 \| IGFBP5 \| DISEASES 9173 \| IL1RL1 \| DISEASES 5624 \| PROC \| DISEASES 3398 \| ID2 \| DISEASES 84634 \| KISS1R \| DISEASES 5997 \| RGS2 \| DISEASES 6402 \| SELL \| DISEASES 1509 \| CTSD \| DISEASES 335 \| APOA1 \| DISEASES 7276 \| TTR \| DISEASES 7043 \| TGFB3 \| DISEASES 3641 \| INSL4 \| DISEASES 4360 \| MRC1 \| DISEASES 1748 \| DLX4 \| DISEASES 847 \| CAT \| DISEASES 92 \| ACVR2A \| DISEASES 3624 \| INHBA \| DISEASES 10268 \| RAMP3 \| DISEASES 130399 \| ACVR1C \| DISEASES 3623 \| INHA \| DISEASES 5740 \| PTGIS \| DISEASES 1088 \| CEACAM8 \| DISEASES 1948 \| EFNB2 \| DISEASES 6584 \| SLC22A5 \| DISEASES 718 \| C3 \| DISEASES 10893 \| MMP24 \| DISEASES 84306 \| PDCD2L \| DISEASES 3315 \| HSPB1 \| DISEASES 5189 \| PEX1 \| DISEASES 2952 \| GSTT1 \| DISEASES 80831 \| APOL5 \| DISEASES 3976 \| LIF \| DISEASES 2658 \| GDF2 \| DISEASES 54567 \| DLL4 \| DISEASES 968 \| CD68 \| DISEASES 6351 \| CCL4 \| DISEASES 1215 \| CMA1 \| DISEASES 3630 \| INS \| DISEASES 348 \| APOE \| DISEASES 59272 \| ACE2 \| DISEASES 2056 \| EPO \| DISEASES 9518 \| GDF15 \| DISEASES 83854 \| ANGPTL6 \| DISEASES 7376 \| NR1H2 \| DISEASES 6382 \| SDC1 \| DISEASES 10267 \| RAMP1 \| DISEASES 5791 \| PTPRE \| DISEASES 182 \| JAG1 \| DISEASES 1401 \| CRP \| DISEASES 56163 \| RNF17 \| DISEASES 4608 \| MYBPH \| DISEASES 23640 \| HSPBP1 \| DISEASES 2167 \| FABP4 \| DISEASES 8553 \| BHLHE40 \| DISEASES 4853 \| NOTCH2 \| DISEASES 10468 \| FST \| DISEASES 187 \| APLNR \| DISEASES 4907 \| NT5E \| DISEASES 967 \| CD63 \| DISEASES 9038 \| TAAR5 \| DISEASES 9392 \| TGFBRAP1 \| DISEASES 84102 \| SLC41A2 \| DISEASES 3569 \| IL6 \| DISEASES 4856 \| NOV \| DISEASES 84681 \| HINT2 \| DISEASES 8521 \| GCM1 \| DISEASES 7097 \| TLR2 \| DISEASES 4316 \| MMP7 \| DISEASES 102 \| ADAM10 \| DISEASES 1588 \| CYP19A1 \| DISEASES 9581 \| PREPL \| DISEASES 2660 \| MSTN \| DISEASES 490 \| ATP2B1 \| DISEASES 5858 \| PZP \| DISEASES 7450 \| VWF \| DISEASES 3290 \| HSD11B1 \| DISEASES 1535 \| CYBA \| DISEASES 999 \| CDH1 \| DISEASES 2324 \| FLT4 \| DISEASES 3690 \| ITGB3 \| DISEASES 7728 \| ZNF175 \| DISEASES 23071 \| ERP44 \| DISEASES 7077 \| TIMP2 \| DISEASES 25939 \| SAMHD1 \| DISEASES 5595 \| MAPK3 \| DISEASES 3552 \| IL1A \| DISEASES 3553 \| IL1B \| DISEASES 23476 \| BRD4 \| DISEASES 54776 \| PPP1R12C \| DISEASES 54414 \| SIAE \| DISEASES 1991 \| ELANE \| DISEASES 6403 \| SELP \| DISEASES 57669 \| EPB41L5 \| DISEASES 2034 \| EPAS1 \| DISEASES 10578 \| GNLY \| DISEASES 390 \| RND3 \| DISEASES 55850 \| USE1 \| DISEASES 3791 \| KDR \| DISEASES 4162 \| MCAM \| DISEASES 60482 \| SLC5A7 \| DISEASES 2247 \| FGF2 \| DISEASES 3589 \| IL11 \| DISEASES 51665 \| ASB1 \| DISEASES 1356 \| CP \| DISEASES 7474 \| WNT5A \| DISEASES 6774 \| STAT3 \| DISEASES 5443 \| POMC \| DISEASES 10686 \| CLDN16 \| DISEASES 3383 \| ICAM1 \| DISEASES 3827 \| KNG1 \| DISEASES 259 \| AMBP \| DISEASES 2028 \| ENPEP \| DISEASES 1950 \| EGF \| DISEASES 56302 \| TRPV5 \| DISEASES 8829 \| NRP1 \| DISEASES 7472 \| WNT2 \| DISEASES 25824 \| PRDX5 \| DISEASES 3263 \| HPX \| DISEASES 7078 \| TIMP3 \| DISEASES 1583 \| CYP11A1 \| DISEASES 3687 \| ITGAX \| DISEASES 409 \| ARRB2 \| DISEASES 5678 \| PSG9 \| DISEASES 207 \| AKT1 \| DISEASES 8547 \| FCN3 \| DISEASES 84432 \| PROK1 \| DISEASES 2052 \| EPHX1 \| DISEASES 5972 \| REN \| DISEASES 805 \| CALM2 \| DISEASES 185 \| AGTR1 \| DISEASES 90226 \| UCN2 \| DISEASES 10699 \| CORIN \| DISEASES 1393 \| CRHBP \| DISEASES 7941 \| PLA2G7 \| DISEASES 2768 \| GNA12 \| DISEASES 79017 \| GGCT \| DISEASES 3484 \| IGFBP1 \| DISEASES 2041 \| EPHA1 \| DISEASES 4841 \| NONO \| DISEASES 1392 \| CRH \| DISEASES 3934 \| LCN2 \| DISEASES 5047 \| PAEP \| DISEASES 4851 \| NOTCH1 \| DISEASES 133 \| ADM \| DISEASES 90952 \| ESAM \| DISEASES 7424 \| VEGFC \| DISEASES 3606 \| IL18 \| DISEASES 5281 \| PIGF \| DISEASES 5741 \| PTH \| DISEASES 284312 \| ZSCAN1 \| DISEASES 2321 \| FLT1 \| DISEASES 3672 \| ITGA1 \| DISEASES 2960 \| GTF2E1 \| DISEASES 23576 \| DDAH1 \| DISEASES 9955 \| HS3ST3A1 \| DISEASES 1436 \| CSF1R \| DISEASES 27163 \| NAAA \| DISEASES 5468 \| PPARG \| DISEASES 57798 \| GATAD1 \| DISEASES 653361 \| NCF1 \| DISEASES 56833 \| SLAMF8 \| DISEASES 1636 \| ACE \| DISEASES 5739 \| PTGIR \| DISEASES 6285 \| S100B \| DISEASES 2220 \| FCN2 \| DISEASES 1584 \| CYP11B1 \| DISEASES 85451 \| UNK \| DISEASES 6352 \| CCL5 \| DISEASES 7542 \| ZFPL1 \| DISEASES 6006 \| RHCE \| DISEASES 126820 \| WDR63 \| DISEASES 7412 \| VCAM1 \| DISEASES 2215 \| FCGR3B \| DISEASES 3973 \| LHCGR \| DISEASES 3625 \| INHBB \| DISEASES 27306 \| HPGDS \| DISEASES 27302 \| BMP10 \| DISEASES 4880 \| NPPC \| DISEASES 213 \| ALB \| DISEASES 5473 \| PPBP \| DISEASES 5196 \| PF4 \| DISEASES 7349 \| UCN \| DISEASES 327 \| APEH \| DISEASES 308 \| ANXA5 \| DISEASES 3600 \| IL15 \| DISEASES 4724 \| NDUFS4 \| DISEASES 51752 \| ERAP1 \| DISEASES 7098 \| TLR3 \| DISEASES 1437 \| CSF2 \| DISEASES 157869 \| SBSPON \| DISEASES 4846 \| NOS3 \| DISEASES 79937 \| CNTNAP3 \| DISEASES 364 \| AQP7 \| DISEASES 360 \| AQP3 \| DISEASES 115825 \| WDFY2 \| DISEASES 10935 \| PRDX3 \| DISEASES 219736 \| STOX1 \| DISEASES 23093 \| TTLL5 \| DISEASES 5055 \| SERPINB2 \| DISEASES 7184 \| HSP90B1 \| DISEASES 4314 \| MMP3 \| DISEASES 6866 \| TAC3 \| DISEASES 90678 \| LRSAM1 \| DISEASES 3904 \| LAIR2 \| DISEASES 64073 \| C19orf33 \| DISEASES 93659 \| CGB5 \| DISEASES 7001 \| PRDX2 \| DISEASES 4054 \| LTBP3 \| DISEASES 5617 \| PRL \| DISEASES 114900 \| C1QTNF4 \| DISEASES 3479 \| IGF1 \| DISEASES 2357 \| FPR1 \| DISEASES 10296 \| MAEA \| DISEASES 143501 \| C11orf40 \| DISEASES 3603 \| IL16 \| DISEASES 3308 \| HSPA4 \| DISEASES 59350 \| RXFP1 \| DISEASES 6870 \| TACR3 \| DISEASES 3688 \| ITGB1 \| DISEASES 8988 \| HSPB3 \| DISEASES 10887 \| PROKR1 \| DISEASES 136 \| ADORA2B \| DISEASES 375611 \| SLC26A5 \| DISEASES 1448 \| CSN3 \| DISEASES 8862 \| APLN \| DISEASES 3627 \| CXCL10 \| DISEASES 203100 \| HTRA4 \| DISEASES 5581 \| PRKCE \| DISEASES 3575 \| IL7R \| DISEASES 7369 \| UMOD \| DISEASES 10465 \| PPIH \| DISEASES 6373 \| CXCL11 \| DISEASES 112464 \| PRKCDBP \| DISEASES 8309 \| ACOX2 \| DISEASES 4493 \| MT1E \| DISEASES 624 \| BDKRB2 \| DISEASES 51162 \| EGFL7 \| DISEASES 4323 \| MMP14 \| DISEASES 2147 \| F2 \| DISEASES 5340 \| PLG \| DISEASES 4973 \| OLR1 \| DISEASES 7534 \| YWHAZ \| DISEASES 353189 \| SLCO4C1 \| DISEASES 116535 \| MRGPRF \| DISEASES 947 \| CD34 \| DISEASES 27165 \| GLS2 \| DISEASES 23479 \| ISCU \| DISEASES 56945 \| MRPS22 \| DISEASES 836 \| CASP3 \| DISEASES 84833 \| USMG5 \| DISEASES 56977 \| STOX2 \| DISEASES 10311 \| DSCR3 \| DISEASES 2944 \| GSTM1 \| DISEASES 407 \| ARR3 \| DISEASES 374879 \| ZNF699 \| DISEASES 5553 \| PRG2 \| DISEASES 246777 \| SPESP1 \| DISEASES 3952 \| LEP \| DISEASES 4179 \| CD46 \| DISEASES 666 \| BOK \| DISEASES 116068 \| LYSMD3 \| DISEASES 285 \| ANGPT2 \| DISEASES 1909 \| EDNRA \| DISEASES 1191 \| CLU \| DISEASES 151516 \| ASPRV1 \| DISEASES 30835 \| CD209 \| DISEASES 1604 \| CD55 \| DISEASES 1442 \| CSH1 \| DISEASES 3291 \| HSD11B2 \| DISEASES 4233 \| MET \| DISEASES 222171 \| PRR15 \| DISEASES 9475 \| ROCK2 \| DISEASES 4684 \| NCAM1 \| DISEASES 5680 \| PSG11 \| DISEASES 7262 \| PHLDA2 \| DISEASES 8490 \| RGS5 \| DISEASES 5652 \| PRSS8 \| DISEASES 10397 \| NDRG1 \| DISEASES 2193 \| FARSA \| DISEASES 9370 \| ADIPOQ \| DISEASES 6863 \| TAC1 \| DISEASES 2149 \| F2R \| DISEASES 4018 \| LPA \| DISEASES 51666 \| ASB4 \| DISEASES 1400 \| CRMP1 \| DISEASES 3640 \| INSL3 \| DISEASES 5345 \| SERPINF2 \| DISEASES 730 \| C7 \| DISEASES 23212 \| RRS1 \| DISEASES 3039 \| HBA1 \| DISEASES 4312 \| MMP1 \| DISEASES 2 \| A2M \| DISEASES 3309 \| HSPA5 \| DISEASES 940 \| CD28 \| DISEASES 3812 \| KIR3DL2 \| DISEASES 1585 \| CYP11B2 \| DISEASES 54946 \| SLC41A3 \| DISEASES 9622 \| KLK4 \| DISEASES 4843 \| NOS2 \| DISEASES 716 \| C1S \| DISEASES 9364 \| RAB28 \| DISEASES 3855 \| KRT7 \| DISEASES 6906 \| SERPINA7 \| DISEASES 2811 \| GP1BA \| DISEASES 153579 \| BTNL9 \| DISEASES 9021 \| SOCS3 \| DISEASES 3953 \| LEPR \| DISEASES 5069 \| PAPPA \| DISEASES 55967 \| NDUFA12 \| DISEASES 219670 \| ENKUR \| DISEASES 6401 \| SELE \| DISEASES 2621 \| GAS6 \| DISEASES 6007 \| RHD \| DISEASES 9704 \| DHX34 \| DISEASES 1675 \| CFD \| DISEASES 5671 \| PSG3 \| DISEASES 430 \| ASCL2 \| DISEASES 6546 \| SLC8A1 \| DISEASES 25825 \| BACE2 \| DISEASES 2689 \| GH2 \| DISEASES 5104 \| SERPINA5 \| DISEASES 57419 \| SLC24A3 \| DISEASES 2152 \| F3 \| DISEASES 139886 \| SPIN4 \| DISEASES 130574 \| LYPD6 \| DISEASES 353322 \| ANKRD37 \| DISEASES 2938 \| GSTA1 \| DISEASES 139065 \| SLITRK4 \| DISEASES 283 \| ANG \| DISEASES 3802 \| KIR2DL1 \| DISEASES 114548 \| NLRP3 \| DISEASES 9166 \| EBAG9 \| DISEASES 3363 \| HTR7 \| DISEASES 3091 \| HIF1A \| DISEASES 3824 \| KLRD1 \| DISEASES 857 \| CAV1 \| DISEASES 5329 \| PLAUR \| DISEASES 3805 \| KIR2DL4 \| DISEASES 966 \| CD59 \| DISEASES 93 \| ACVR2B \| DISEASES 84144 \| SYDE2 \| DISEASES 4128 \| MAOA \| DISEASES 85360 \| SYDE1 \| DISEASES 7137 \| TNNI3 \| DISEASES 6692 \| SPINT1 \| DISEASES 132884 \| EVC2 \| DISEASES 866 \| SERPINA6 \| DISEASES 3146 \| HMGB1 \| DISEASES 155 \| ADRB3 \| DISEASES 1003 \| CDH5 \| DISEASES 3605 \| IL17A \| DISEASES 875 \| CBS \| DISEASES 57556 \| SEMA6A \| DISEASES 3767 \| KCNJ11 \| DISEASES 7005 \| TEAD3 \| DISEASES 302 \| ANXA2 \| DISEASES 2879 \| GPX4 \| DISEASES 2335 \| FN1 \| DISEASES 131920 \| TMEM207 \| DISEASES 100506658 \| OCLN \| DISEASES 80781 \| COL18A1 \| DISEASES 355 \| FAS \| DISEASES 5265 \| SERPINA1 \| DISEASES 3240 \| HP \| DISEASES 9644 \| SH3PXD2A \| DISEASES 3683 \| ITGAL \| DISEASES 801 \| CALM1 \| DISEASES 284119 \| PTRF \| DISEASES 11186 \| RASSF1 \| DISEASES 60 \| ACTB \| DISEASES 25972 \| UNC50 \| DISEASES 871 \| SERPINH1 \| DISEASES 2050 \| EPHB4 \| DISEASES 841 \| CASP8 \| DISEASES 405 \| ARNT \| DISEASES 3821 \| KLRC1 \| DISEASES 9332 \| CD163 \| DISEASES 5294 \| PIK3CG \| DISEASES 10761 \| PLAC1 \| DISEASES 55503 \| TRPV6 \| DISEASES 7037 \| TFRC \| DISEASES 404093 \| CUEDC1 \| DISEASES 2157 \| F8 \| DISEASES 3135 \| HLA-G \| DISEASES 5599 \| MAPK8 \| DISEASES 170482 \| CLEC4C \| DISEASES 1284 \| COL4A2 \| DISEASES 54106 \| TLR9 \| DISEASES 56891 \| LGALS14 \| DISEASES 140803 \| TRPM6 \| DISEASES 6772 \| STAT1 \| DISEASES 1312 \| COMT \| DISEASES 9374 \| PPT2 \| DISEASES 5742 \| PTGS1 \| DISEASES 10724 \| MGEA5 \| DISEASES 10580 \| SORBS1 \| DISEASES 347731 \| LRRTM3 \| DISEASES 23038 \| WDTC1 \| DISEASES 183 \| AGT \| DISEASES 22796 \| COG2 \| DISEASES 28514 \| DLL1 \| DISEASES 7042 \| TGFB2 \| DISEASES 254428 \| SLC41A1 \| DISEASES 3814 \| KISS1 \| DISEASES 5788 \| PTPRC \| DISEASES 3075 \| CFH \| DISEASES 23328 \| SASH1 \| DISEASES 5743 \| PTGS2 \| DISEASES 7827 \| NPHS2 \| DISEASES 60676 \| PAPPA2 \| DISEASES 462 \| SERPINC1 \| DISEASES 356 \| FASLG \| DISEASES 2153 \| F5 \| DISEASES 2214 \| FCGR3A \| DISEASES 57216 \| VANGL2 \| DISEASES 911 \| CD1C \| DISEASES 8038 \| ADAM12 \| DISEASES 117247 \| SLC16A10 \| DISEASES 8991 \| SELENBP1 \| DISEASES 5654 \| HTRA1 \| DISEASES 2209 \| FCGR1A \| DISEASES 5406 \| PNLIP \| DISEASES 23376 \| UFL1 \| DISEASES 11085 \| ADAM30 \| DISEASES 3283 \| HSD3B1 \| DISEASES 2316 \| FLNA \| DISEASES 1266 \| CNN3 \| DISEASES 1369 \| CPN1 \| DISEASES 959 \| CD40LG \| DISEASES 1486 \| CTBS \| DISEASES 55361 \| PI4K2A \| DISEASES 1491 \| CTH \| DISEASES 1573 \| CYP2J2 \| DISEASES 3725 \| JUN \| DISEASES 5950 \| RBP4 \| DISEASES 186 \| AGTR2 \| DISEASES 11093 \| ADAMTS13 \| DISEASES 7422 \| VEGFA \| DISEASES 958 \| CD40 \| DISEASES 4318 \| MMP9 \| DISEASES 1907 \| EDN2 \| DISEASES 84879 \| MFSD2A \| DISEASES 27286 \| SRPX2 \| DISEASES 2022 \| ENG \| DISEASES 9452 \| ITM2A \| DISEASES 1307 \| COL16A1 \| DISEASES 553115 \| PEF1 \| DISEASES 29119 \| CTNNA3 \| DISEASES 4153 \| MBL2 \| DISEASES 7099 \| TLR4 \| DISEASES 2268 \| FGR \| DISEASES 6676 \| SPAG4 \| DISEASES 57134 \| MAN1C1 \| DISEASES 400746 \| NCMAP \| DISEASES 7295 \| TXN \| DISEASES 8518 \| IKBKAP \| DISEASES 19 \| ABCA1 \| DISEASES 11326 \| VSIG4 \| DISEASES 1889 \| ECE1 \| DISEASES 203569 \| PAGE2 \| DISEASES 4855 \| NOTCH4 \| DISEASES 2155 \| F7 \| DISEASES 23564 \| DDAH2 \| DISEASES 3055 \| HCK \| DISEASES 9358 \| ITGBL1 \| DISEASES 50943 \| FOXP3 \| DISEASES 3107 \| HLA-C \| DISEASES 7133 \| TNFRSF1B \| DISEASES 414328 \| IDNK \| DISEASES 4879 \| NPPB \| DISEASES 4878 \| NPPA \| DISEASES 4524 \| MTHFR \| DISEASES 3133 \| HLA-E \| DISEASES 3105 \| HLA-A \| DISEASES 1471 \| CST3 \| DISEASES 7056 \| THBD \| DISEASES 1910 \| EDNRB \| DISEASES 221079 \| ARL5B \| DISEASES 728577 \| CNTNAP3B \| DISEASES 10159 \| ATP6AP2 \| DISEASES 3980 \| LIG3 \| DISEASES 5420 \| PODXL \| DISEASES 4868 \| NPHS1 \| DISEASES 1906 \| EDN1 \| DISEASES 7010 \| TEK \| DISEASES 9365 \| KL \| DISEASES 795 \| S100G \| DISEASES 551 \| AVP \| DISEASES 114131 \| UCN3 \| DISEASES 6462 \| SHBG \| DISEASES 8644 \| AKR1C3 \| DISEASES 3030 \| HADHA \| DISEASES 3486 \| IGFBP3 \| DISEASES 11082 \| ESM1 \| DISEASES 90865 \| IL33 \| DISEASES 6019 \| RLN2 \| DISEASES 11172 \| INSL6 \| DISEASES 3822 \| KLRC2 \| DISEASES 5268 \| SERPINB5 \| DISEASES 6736 \| SRY \| DISEASES 100506243 \| KRBOX1 \| DISEASES 9467 \| SH3BP5 \| DISEASES 2878 \| GPX3 \| DISEASES 3875 \| KRT18 \| DISEASES 53353 \| LRP1B \| DISEASES 6710 \| SPTB \| DISEASES 3811 \| KIR3DL1 \| DISEASES 147906 \| DACT3 \| DISEASES 148003 \| LGALS16 \| DISEASES 7341 \| SUMO1 \| DISEASES 10203 \| CALCRL \| DISEASES 1443 \| CSH2 \| DISEASES 5547 \| PRCP \| DISEASES 11346 \| SYNPO \| DISEASES 51520 \| LARS \| DISEASES 27297 \| CRCP \| DISEASES 79924 \| ADM2 \| DISEASES 174 \| AFP \| DISEASES 6387 \| CXCL12 \| DISEASES 3676 \| ITGA4 \| DISEASES 4780 \| NFE2L2 \| DISEASES 7106 \| TSPAN4 \| DISEASES 1394 \| CRHR1 \| DISEASES 2950 \| GSTP1 \| DISEASES 6093 \| ROCK1 \| DISEASES 23192 \| ATG4B \| DISEASES 5672 \| PSG4 \| DISEASES 57504 \| MTA3 \| DISEASES 3033 \| HADH \| DISEASES 84268 \| RPAIN \| DISEASES 7018 \| TF \| DISEASES 2104 \| ESRRG \| DISEASES 4648 \| MYO7B \| DISEASES 10062 \| NR1H3 \| DISEASES 3384 \| ICAM2 \| DISEASES 1747 \| DLX3 \| DISEASES 112724 \| RDH13 \| DISEASES 3481 \| IGF2 \| DISEASES 6399 \| TRAPPC2 \| DISEASES 197 \| AHSG \| DISEASES 115677 \| NOSTRIN \| DISEASES 23210 \| JMJD6 \| DISEASES 23705 \| CADM1 \| DISEASES 7124 \| TNF \| DISEASES 3491 \| CYR61 \| DISEASES 3106 \| HLA-B \| DISEASES 8823 \| FGF16 \| DISEASES 10216 \| PRG4 \| DISEASES 64167 \| ERAP2 \| DISEASES 79022 \| TMEM106C \| DISEASES 946 \| SIGLEC6 \| DISEASES 7258 \| TSPY1 \| DISEASES 4049 \| LTA \| DISEASES 94115 \| CGB8 \| DISEASES 100289087 \| TSPY10 \| DISEASES 2876 \| GPX1 \| DISEASES 408 \| ARRB1 \| DISEASES 834 \| CASP1 \| DISEASES 1028 \| CDKN1C \| DISEASES 3586 \| IL10 \| DISEASES 404672 \| GTF2H5 \| DISEASES 8842 \| PROM1 \| DISEASES 133396 \| IL31RA \| DISEASES 721 \| C4B \| DISEASES 6513 \| SLC2A1 \| DISEASES 629 \| CFB \| DISEASES 11279 \| KLF8 \| DISEASES 23089 \| PEG10 \| DISEASES 28988 \| DBNL \| DISEASES 9022 \| CLIC3 \| DISEASES 30816 \| ERVW-1 \| DISEASES 405754 \| ERVFRD-1 \| DISEASES 4345 \| CD200 \| DISEASES 813 \| CALU \| DISEASES 6949 \| TCOF1 \| DISEASES 2638 \| GC \| DISEASES 56034 \| PDGFC \| DISEASES 81792 \| ADAMTS12 \| DISEASES 284 \| ANGPT1 \| DISEASES 51366 \| UBR5 \| DISEASES 3620 \| IDO1 \| DISEASES 930 \| CD19 \| DISEASES 10603 \| SH2B2 \| DISEASES 3684 \| ITGAM \| DISEASES 6510 \| SLC1A5 \| DISEASES 3939 \| LDHA \| DISEASES 7421 \| VDR \| DISEASES 8972 \| MGAM \| DISEASES 91612 \| CHURC1 \| DISEASES 5228 \| PGF \| DISEASES 567 \| B2M \| DISEASES 3316 \| HSPB2 \| DISEASES 1506 \| CTRL \| DISEASES 100271846 \| ERVV-2 \| DISEASES 387742 \| FAM99A \| DISEASES 352990 \| HCP5B \| DISEASES 101101692 \| HELLPAR \| DISEASES 102723508 \| KANTR \| DISEASES 100073347 \| MIMT1 \| DISEASES 191585 \| PLAC4 \| DISEASES 677780 \| SCARNA11 \| DISEASES 677837 \| SNORA60 \| DISEASES 100642175 \| SPRY4-IT1 \| DISEASES 100128252 \| ZNF667-AS1 \| DISEASES
Locus	(Waiting for update.)

Disease ID	356
Disease	toxemia
Integrated Phenotype	HPO \| Name(Total Integrated Phenotypes:10) HP:0000093 \| Proteinuria HP:0100601 \| Eclampsia HP:0100602 \| Pre-eclampsia HP:0008071 \| Maternal hypertension HP:0001511 \| Prenatal onset growth retardation HP:0000969 \| Dropsy HP:0000822 \| Hypertension HP:0001873 \| Low platelet count HP:0001250 \| Seizures HP:0002910 \| Elevated transaminases
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:4) HP:0002098 \| Respiratory distress \| 1 HP:0002573 \| Bloody diarrhea \| 1 HP:0002721 \| Immunodeficiency \| 1 HP:0100806 \| Sepsis \| 1

Disease ID	356
Disease	toxemia
Manually Symptom	(Waiting for update.)
Text Mined Symptom	(Waiting for update.)

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:3)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs11617740	23551011	2259	FGF14	umls:C0032914	GWASCAT	Genome-wide association study of pre-eclampsia detects novel maternal single nucleotide polymorphisms and copy-number variants in subsets of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study cohort.	0.12	2013	FGF14	13	102027776	G	A
rs2839440	23551011	150142	ZNF295-AS1	umls:C0032914	GWASCAT	Genome-wide association study of pre-eclampsia detects novel maternal single nucleotide polymorphisms and copy-number variants in subsets of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study cohort.	0.12	2013	ZNF295-AS1	21	42023389	C	T
rs7322722	23551011	23077	MYCBP2	umls:C0032914	GWASCAT	Genome-wide association study of pre-eclampsia detects novel maternal single nucleotide polymorphisms and copy-number variants in subsets of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study cohort.	0.12	2013	MYCBP2	13	77305241	G	A

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:49)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
1	217185265	rs17686866	C	A	rs17686866	22748001	0.0000038	NA	NA	NA	293 Caucasian females	Caucasian(293)	ALL(293)	EUR(293)	ALL(293)	Preeclampsia	HPOID:0100602	Preeclampsia	DOID:10591	pre-eclampsia	D011225	Pre-Eclampsia	NA	NA	Pre-Eclampsia	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
1	217185265	rs17686866	C	A	rs17686866	23551011	8.99E-06	Caucasian	2.78	[1.79-4.35]	21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controls	Afro-Caribbean(1031)	European(1252)	Hispanic(720)	ALL(3003)	HIS(720)	AFR(1031)	EUR(1252)	ALL(3003)	Preeclampsia	HPOID:0100602	Preeclampsia	DOID:10591	pre-eclampsia	D011225	Pre-Eclampsia	NA	NA	Pre-Eclampsia
1	224916592	rs6660579	C	T	rs6660579	22432041	0.0000078	NA	NA	NA	538 European ancestry cases; 540 European ancestry controls	European(1078)	ALL(1078)	EUR(1078)	ALL(1078)	Preeclampsia	HPOID:0100602	Preeclampsia	DOID:10591	pre-eclampsia	D011225	Pre-Eclampsia	NA	NA	Pre-Eclampsia	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
2	26322040	rs9332419	A	G	rs9332419	22432041	0.00000617	NA	NA	NA	538 European ancestry cases; 540 European ancestry controls	European(1078)	ALL(1078)	EUR(1078)	ALL(1078)	Preeclampsia	HPOID:0100602	Preeclampsia	DOID:10591	pre-eclampsia	D011225	Pre-Eclampsia	NA	NA	Pre-Eclampsia	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
2	26344787	rs11126375	G	A	rs11126375	22432041	0.00000913	NA	NA	NA	538 European ancestry cases; 540 European ancestry controls	European(1078)	ALL(1078)	EUR(1078)	ALL(1078)	Preeclampsia	HPOID:0100602	Preeclampsia	DOID:10591	pre-eclampsia	D011225	Pre-Eclampsia	NA	NA	Pre-Eclampsia	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
2	46746963	rs4952830	A	G	rs4952830	22432041	0.00000674	NA	NA	NA	538 European ancestry cases; 540 European ancestry controls	European(1078)	ALL(1078)	EUR(1078)	ALL(1078)	Preeclampsia	HPOID:0100602	Preeclampsia	DOID:10591	pre-eclampsia	D011225	Pre-Eclampsia	NA	NA	Pre-Eclampsia	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
2	105877870	rs17636747	C	T	rs17636747	23551011	4.00E-06	Hispanic	8.35	[3.41-20.46]	21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controls	Afro-Caribbean(1031)	European(1252)	Hispanic(720)	ALL(3003)	HIS(720)	AFR(1031)	EUR(1252)	ALL(3003)	Preeclampsia	HPOID:0100602	Preeclampsia	DOID:10591	pre-eclampsia	D011225	Pre-Eclampsia	NA	NA	Pre-Eclampsia
2	108415702	rs6542736	G	A	rs6542736	22432041	0.00000731	NA	NA	NA	538 European ancestry cases; 540 European ancestry controls	European(1078)	ALL(1078)	EUR(1078)	ALL(1078)	Preeclampsia	HPOID:0100602	Preeclampsia	DOID:10591	pre-eclampsia	D011225	Pre-Eclampsia	NA	NA	Pre-Eclampsia	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
2	121118031	rs7576192	A	G	rs7576192	22432041	0.000000148	NA	NA	NA	538 European ancestry cases; 540 European ancestry controls	European(1078)	ALL(1078)	EUR(1078)	ALL(1078)	Preeclampsia	HPOID:0100602	Preeclampsia	DOID:10591	pre-eclampsia	D011225	Pre-Eclampsia	NA	NA	Pre-Eclampsia	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
2	121118124	rs7579169	T	C	rs7579169	22432041	0.000000358	NA	NA	NA	538 European ancestry cases; 540 European ancestry controls	European(1078)	ALL(1078)	EUR(1078)	ALL(1078)	Preeclampsia	HPOID:0100602	Preeclampsia	DOID:10591	pre-eclampsia	D011225	Pre-Eclampsia	NA	NA	Pre-Eclampsia	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
2	121123383	rs12711941	T	G	rs12711941	22432041	0.000000426	NA	NA	NA	538 European ancestry cases; 540 European ancestry controls	European(1078)	ALL(1078)	EUR(1078)	ALL(1078)	Preeclampsia	HPOID:0100602	Preeclampsia	DOID:10591	pre-eclampsia	D011225	Pre-Eclampsia	NA	NA	Pre-Eclampsia	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
3	8571110	rs9831647	G	A	rs9831647	22748001	0.00000936	NA	NA	NA	293 Caucasian females	Caucasian(293)	ALL(293)	EUR(293)	ALL(293)	Preeclampsia	HPOID:0100602	Preeclampsia	DOID:10591	pre-eclampsia	D011225	Pre-Eclampsia	NA	NA	Pre-Eclampsia	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
3	87257423	rs17024019	A	G	rs17024019	22432041	0.00000957	NA	NA	NA	538 European ancestry cases; 540 European ancestry controls	European(1078)	ALL(1078)	EUR(1078)	ALL(1078)	Preeclampsia	HPOID:0100602	Preeclampsia	DOID:10591	pre-eclampsia	D011225	Pre-Eclampsia	NA	NA	Pre-Eclampsia	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
3	87276699	rs2279720	C	T	rs2279720	22432041	0.00000866	NA	NA	NA	538 European ancestry cases; 540 European ancestry controls	European(1078)	ALL(1078)	EUR(1078)	ALL(1078)	Preeclampsia	HPOID:0100602	Preeclampsia	DOID:10591	pre-eclampsia	D011225	Pre-Eclampsia	NA	NA	Pre-Eclampsia	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
3	87299075	rs1044499	A	C	rs1044499	22432041	0.00000866	NA	NA	NA	538 European ancestry cases; 540 European ancestry controls	European(1078)	ALL(1078)	EUR(1078)	ALL(1078)	Preeclampsia	HPOID:0100602	Preeclampsia	DOID:10591	pre-eclampsia	D011225	Pre-Eclampsia	NA	NA	Pre-Eclampsia	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
3	149250589	rs17787940	T	C	rs17787940	23551011	3.00E-06	EA	3.17	[1.95-5.16]	21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controls	Afro-Caribbean(1031)	European(1252)	Hispanic(720)	ALL(3003)	HIS(720)	AFR(1031)	EUR(1252)	ALL(3003)	Preeclampsia	HPOID:0100602	Preeclampsia	DOID:10591	pre-eclampsia	D011225	Pre-Eclampsia	NA	NA	Pre-Eclampsia
4	37173944	rs1426409	G	A	rs1426409	22748001	0.00000314	NA	NA	NA	293 Caucasian females	Caucasian(293)	ALL(293)	EUR(293)	ALL(293)	Preeclampsia	HPOID:0100602	Preeclampsia	DOID:10591	pre-eclampsia	D011225	Pre-Eclampsia	NA	NA	Pre-Eclampsia	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
4	98965696	rs7677523	T	C	rs7677523	22432041	0.00000951	NA	NA	NA	538 European ancestry cases; 540 European ancestry controls	European(1078)	ALL(1078)	EUR(1078)	ALL(1078)	Preeclampsia	HPOID:0100602	Preeclampsia	DOID:10591	pre-eclampsia	D011225	Pre-Eclampsia	NA	NA	Pre-Eclampsia	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
4	182609865	rs12641856	G	A	rs12641856	23551011	2.00E-06	Afro-Caribbean	15.19	[4.98-46.35]	21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controls	Afro-Caribbean(1031)	European(1252)	Hispanic(720)	ALL(3003)	HIS(720)	AFR(1031)	EUR(1252)	ALL(3003)	Preeclampsia	HPOID:0100602	Preeclampsia	DOID:10591	pre-eclampsia	D011225	Pre-Eclampsia	NA	NA	Pre-Eclampsia
6	30976219	rs28360974	G	A	rs28360974	23551011	3.00E-06	Afro-Caribbean	10.13	[3.85-26.67]	21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controls	Afro-Caribbean(1031)	European(1252)	Hispanic(720)	ALL(3003)	HIS(720)	AFR(1031)	EUR(1252)	ALL(3003)	Preeclampsia	HPOID:0100602	Preeclampsia	DOID:10591	pre-eclampsia	D011225	Pre-Eclampsia	NA	NA	Pre-Eclampsia
7	25612661	rs975369	G	A	rs975369	23551011	8.00E-06	Afro-Caribbean	4.55	[2.34-8.83]	21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controls	Afro-Caribbean(1031)	European(1252)	Hispanic(720)	ALL(3003)	HIS(720)	AFR(1031)	EUR(1252)	ALL(3003)	Preeclampsia	HPOID:0100602	Preeclampsia	DOID:10591	pre-eclampsia	D011225	Pre-Eclampsia	NA	NA	Pre-Eclampsia
8	20246758	rs17412740	G	A	rs17412740	23551011	2.00E-06	Hispanic	6.08	[2.88-12.81]	21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controls	Afro-Caribbean(1031)	European(1252)	Hispanic(720)	ALL(3003)	HIS(720)	AFR(1031)	EUR(1252)	ALL(3003)	Preeclampsia	HPOID:0100602	Preeclampsia	DOID:10591	pre-eclampsia	D011225	Pre-Eclampsia	NA	NA	Pre-Eclampsia
8	20263408	rs1016646	G	A	rs1016646	23551011	9.45E-06	Hispanic	5.68	[2.63-12.25]	21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controls	Afro-Caribbean(1031)	European(1252)	Hispanic(720)	ALL(3003)	HIS(720)	AFR(1031)	EUR(1252)	ALL(3003)	Preeclampsia	HPOID:0100602	Preeclampsia	DOID:10591	pre-eclampsia	D011225	Pre-Eclampsia	NA	NA	Pre-Eclampsia
9	102808685	rs7028939	A	G	rs7028939	23551011	3.00E-06	EA	3.17	[1.95-5.15]	21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controls	Afro-Caribbean(1031)	European(1252)	Hispanic(720)	ALL(3003)	HIS(720)	AFR(1031)	EUR(1252)	ALL(3003)	Preeclampsia	HPOID:0100602	Preeclampsia	DOID:10591	pre-eclampsia	D011225	Pre-Eclampsia	NA	NA	Pre-Eclampsia
9	102854188	rs7849323	T	C	rs7849323	23551011	3.42E-06	EA	3.15	[1.94-5.11]	21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controls	Afro-Caribbean(1031)	European(1252)	Hispanic(720)	ALL(3003)	HIS(720)	AFR(1031)	EUR(1252)	ALL(3003)	Preeclampsia	HPOID:0100602	Preeclampsia	DOID:10591	pre-eclampsia	D011225	Pre-Eclampsia	NA	NA	Pre-Eclampsia
9	102911706	rs1415927	T	C	rs1415927	23551011	3.48E-06	EA	3.15	[1.94-5.11]	21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controls	Afro-Caribbean(1031)	European(1252)	Hispanic(720)	ALL(3003)	HIS(720)	AFR(1031)	EUR(1252)	ALL(3003)	Preeclampsia	HPOID:0100602	Preeclampsia	DOID:10591	pre-eclampsia	D011225	Pre-Eclampsia	NA	NA	Pre-Eclampsia
9	102918306	rs7047693	T	C	rs7047693	23551011	3.31E-06	EA	3.16	[1.94-5.12]	21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controls	Afro-Caribbean(1031)	European(1252)	Hispanic(720)	ALL(3003)	HIS(720)	AFR(1031)	EUR(1252)	ALL(3003)	Preeclampsia	HPOID:0100602	Preeclampsia	DOID:10591	pre-eclampsia	D011225	Pre-Eclampsia	NA	NA	Pre-Eclampsia
9	102922307	rs10988989	T	C	rs10988989	23551011	3.31E-06	EA	3.16	[1.94-5.12]	21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controls	Afro-Caribbean(1031)	European(1252)	Hispanic(720)	ALL(3003)	HIS(720)	AFR(1031)	EUR(1252)	ALL(3003)	Preeclampsia	HPOID:0100602	Preeclampsia	DOID:10591	pre-eclampsia	D011225	Pre-Eclampsia	NA	NA	Pre-Eclampsia
9	102958736	rs7020780	G	A	rs7020780	23551011	2.66E-06	EA	3.19	[1.96-5.17]	21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controls	Afro-Caribbean(1031)	European(1252)	Hispanic(720)	ALL(3003)	HIS(720)	AFR(1031)	EUR(1252)	ALL(3003)	Preeclampsia	HPOID:0100602	Preeclampsia	DOID:10591	pre-eclampsia	D011225	Pre-Eclampsia	NA	NA	Pre-Eclampsia
9	102976541	rs10989019	T	C	rs10989019	23551011	2.00E-06	EA	3.21	[1.98-5.20]	21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controls	Afro-Caribbean(1031)	European(1252)	Hispanic(720)	ALL(3003)	HIS(720)	AFR(1031)	EUR(1252)	ALL(3003)	Preeclampsia	HPOID:0100602	Preeclampsia	DOID:10591	pre-eclampsia	D011225	Pre-Eclampsia	NA	NA	Pre-Eclampsia
10	29027223	rs1248993	A	G	rs1248993	23551011	6.00E-06	Afro-Caribbean	4.27	[2.28-8.01]	21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controls	Afro-Caribbean(1031)	European(1252)	Hispanic(720)	ALL(3003)	HIS(720)	AFR(1031)	EUR(1252)	ALL(3003)	Preeclampsia	HPOID:0100602	Preeclampsia	DOID:10591	pre-eclampsia	D011225	Pre-Eclampsia	NA	NA	Pre-Eclampsia
10	105884116	rs10883969	C	T	rs10883969	23551011	3.00E-06	EA	2.97	[1.88-4.69]	21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controls	Afro-Caribbean(1031)	European(1252)	Hispanic(720)	ALL(3003)	HIS(720)	AFR(1031)	EUR(1252)	ALL(3003)	Preeclampsia	HPOID:0100602	Preeclampsia	DOID:10591	pre-eclampsia	D011225	Pre-Eclampsia	NA	NA	Pre-Eclampsia
11	118031986	rs11600901	G	A	rs11600901	23551011	9.00E-06	Afro-Caribbean	9.83	[3.58-27.00]	21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controls	Afro-Caribbean(1031)	European(1252)	Hispanic(720)	ALL(3003)	HIS(720)	AFR(1031)	EUR(1252)	ALL(3003)	Preeclampsia	HPOID:0100602	Preeclampsia	DOID:10591	pre-eclampsia	D011225	Pre-Eclampsia	NA	NA	Pre-Eclampsia
12	25660579	rs10743565	A	G	rs10743565	22748001	0.0000164	NA	NA	NA	293 Caucasian females	Caucasian(293)	ALL(293)	EUR(293)	ALL(293)	Preeclampsia	HPOID:0100602	Preeclampsia	DOID:10591	pre-eclampsia	D011225	Pre-Eclampsia	NA	NA	Pre-Eclampsia	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
12	25660579	rs10743565	A	G	rs10743565	23551011	6.77E-06	Caucasian	2.44	[1.67-3.70]	21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controls	Afro-Caribbean(1031)	European(1252)	Hispanic(720)	ALL(3003)	HIS(720)	AFR(1031)	EUR(1252)	ALL(3003)	Preeclampsia	HPOID:0100602	Preeclampsia	DOID:10591	pre-eclampsia	D011225	Pre-Eclampsia	NA	NA	Pre-Eclampsia
13	39903243	rs6563695	G	T	rs6563695	23551011	5.00E-06	EA	3.65	[2.09-6.36]	21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controls	Afro-Caribbean(1031)	European(1252)	Hispanic(720)	ALL(3003)	HIS(720)	AFR(1031)	EUR(1252)	ALL(3003)	Preeclampsia	HPOID:0100602	Preeclampsia	DOID:10591	pre-eclampsia	D011225	Pre-Eclampsia	NA	NA	Pre-Eclampsia
13	77488736	rs12431203	G	A	rs12431203	22432041	0.00000245	NA	NA	NA	538 European ancestry cases; 540 European ancestry controls	European(1078)	ALL(1078)	EUR(1078)	ALL(1078)	Preeclampsia	HPOID:0100602	Preeclampsia	DOID:10591	pre-eclampsia	D011225	Pre-Eclampsia	NA	NA	Pre-Eclampsia	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
13	77622818	rs624575	C	T	rs624575	23551011	1.50E-06	EA	2.9	[1.88-4.48]	21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controls	Afro-Caribbean(1031)	European(1252)	Hispanic(720)	ALL(3003)	HIS(720)	AFR(1031)	EUR(1252)	ALL(3003)	Preeclampsia	HPOID:0100602	Preeclampsia	DOID:10591	pre-eclampsia	D011225	Pre-Eclampsia	NA	NA	Pre-Eclampsia
13	77723410	rs7337686	G	A	rs7337686	23551011	6.60E-06	EA	2.68	[1.74-4.11]	21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controls	Afro-Caribbean(1031)	European(1252)	Hispanic(720)	ALL(3003)	HIS(720)	AFR(1031)	EUR(1252)	ALL(3003)	Preeclampsia	HPOID:0100602	Preeclampsia	DOID:10591	pre-eclampsia	D011225	Pre-Eclampsia	NA	NA	Pre-Eclampsia
13	77862984	rs9530631	G	A	rs9530631	23551011	5.91E-06	EA	2.69	[1.75-4.12]	21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controls	Afro-Caribbean(1031)	European(1252)	Hispanic(720)	ALL(3003)	HIS(720)	AFR(1031)	EUR(1252)	ALL(3003)	Preeclampsia	HPOID:0100602	Preeclampsia	DOID:10591	pre-eclampsia	D011225	Pre-Eclampsia	NA	NA	Pre-Eclampsia
13	77879376	rs7322722	G	A	rs7322722	23551011	1.00E-06	EA	2.93	[1.90-4.52]	21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controls	Afro-Caribbean(1031)	European(1252)	Hispanic(720)	ALL(3003)	HIS(720)	AFR(1031)	EUR(1252)	ALL(3003)	Preeclampsia	HPOID:0100602	Preeclampsia	DOID:10591	pre-eclampsia	D011225	Pre-Eclampsia	NA	NA	Pre-Eclampsia
13	102680126	rs11617740	G	A	rs11617740	23551011	7.00E-07	Afro-Caribbean	16.69	[5.53-51.97]	21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controls	Afro-Caribbean(1031)	European(1252)	Hispanic(720)	ALL(3003)	HIS(720)	AFR(1031)	EUR(1252)	ALL(3003)	Preeclampsia	HPOID:0100602	Preeclampsia	DOID:10591	pre-eclampsia	D011225	Pre-Eclampsia	NA	NA	Pre-Eclampsia
15	44774202	rs2453274	C	T	rs2453274	22432041	0.00000232	NA	NA	NA	538 European ancestry cases; 540 European ancestry controls	European(1078)	ALL(1078)	EUR(1078)	ALL(1078)	Preeclampsia	HPOID:0100602	Preeclampsia	DOID:10591	pre-eclampsia	D011225	Pre-Eclampsia	NA	NA	Pre-Eclampsia	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
16	76043201	rs7199697	A	G	rs7199697	23551011	9.59E-06	Hispanic	3.98	[2.16-7.33]	21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controls	Afro-Caribbean(1031)	European(1252)	Hispanic(720)	ALL(3003)	HIS(720)	AFR(1031)	EUR(1252)	ALL(3003)	Preeclampsia	HPOID:0100602	Preeclampsia	DOID:10591	pre-eclampsia	D011225	Pre-Eclampsia	NA	NA	Pre-Eclampsia
20	4215557	rs1556832	C	T	rs1556832	23551011	9.00E-06	Afro-Caribbean	4.33	[2.27-8.27]	21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controls	Afro-Caribbean(1031)	European(1252)	Hispanic(720)	ALL(3003)	HIS(720)	AFR(1031)	EUR(1252)	ALL(3003)	Preeclampsia	HPOID:0100602	Preeclampsia	DOID:10591	pre-eclampsia	D011225	Pre-Eclampsia	NA	NA	Pre-Eclampsia
20	5949534	rs4815879	G	A	rs4815879	23551011	2.00E-06	Afro-Caribbean	14.57	[4.81-44.17]	21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controls	Afro-Caribbean(1031)	European(1252)	Hispanic(720)	ALL(3003)	HIS(720)	AFR(1031)	EUR(1252)	ALL(3003)	Preeclampsia	HPOID:0100602	Preeclampsia	DOID:10591	pre-eclampsia	D011225	Pre-Eclampsia	NA	NA	Pre-Eclampsia
21	22188735	rs2826538	C	T	rs2826538	22432041	0.00000593	NA	NA	NA	538 European ancestry cases; 540 European ancestry controls	European(1078)	ALL(1078)	EUR(1078)	ALL(1078)	Preeclampsia	HPOID:0100602	Preeclampsia	DOID:10591	pre-eclampsia	D011225	Pre-Eclampsia	NA	NA	Pre-Eclampsia	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
21	36208062	rs9976946	C	T	rs9976946	23551011	5.00E-06	EA	5.5	[2.65-11.39]	21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controls	Afro-Caribbean(1031)	European(1252)	Hispanic(720)	ALL(3003)	HIS(720)	AFR(1031)	EUR(1252)	ALL(3003)	Preeclampsia	HPOID:0100602	Preeclampsia	DOID:10591	pre-eclampsia	D011225	Pre-Eclampsia	NA	NA	Pre-Eclampsia
21	43443498	rs2839440	C	T	rs2839440	23551011	1.00E-06	Afro-Caribbean	5.31	[2.70-10.42]	21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controls	Afro-Caribbean(1031)	European(1252)	Hispanic(720)	ALL(3003)	HIS(720)	AFR(1031)	EUR(1252)	ALL(3003)	Preeclampsia	HPOID:0100602	Preeclampsia	DOID:10591	pre-eclampsia	D011225	Pre-Eclampsia	NA	NA	Pre-Eclampsia

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:10)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0032914	amlodipine	D017311	88150-42-9	pre-eclampsia	MESH:D011225	therapeutic	20006421
C0032914	betamethasone	D001623	378-44-9	pre-eclampsia	MESH:D011225	therapeutic	8193107
C0032914	bupivacaine	D002045	2180-92-9	pre-eclampsia	MESH:D011225	therapeutic	15310446
C0032914	diethylstilbestrol	D004054	56-53-1	pre-eclampsia	MESH:D011225	marker/mechanism	17601905
C0032914	labetalol	D007741	36894-69-6	pre-eclampsia	MESH:D011225	therapeutic	1316047
C0032914	metformin	D008687	657-24-9	pre-eclampsia	MESH:D011225	marker/mechanism	15910403
C0032914	metoprolol	D008790	37350-58-6	pre-eclampsia	MESH:D011225	therapeutic	15804228
C0032914	phenytoin	D010672	57-41-0	pre-eclampsia	MESH:D011225	marker/mechanism	2589455
C0032914	phenytoin	D010672	57-41-0	pre-eclampsia	MESH:D011225	therapeutic	8369243
C0032914	vitamin e	D014810	1406-18-4	pre-eclampsia	MESH:D011225	marker/mechanism	8584011

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)