PedAM

Pediatric Disease Annotations & Medicines


	tick-borne encephalitis

Disease ID	754
Disease	tick-borne encephalitis
Definition	Encephalitis caused by neurotropic viruses that are transmitted via the bite of TICKS. In Europe, the diseases are caused by ENCEPHALITIS VIRUSES, TICK-BORNE, which give rise to Russian spring-summer encephalitis, central European encephalitis, louping ill encephalitis, and related disorders. Powassan encephalitis occurs in North America and Russia and is caused by the Powassan virus. ASEPTIC MENINGITIS and rarely encephalitis may complicate COLORADO TICK FEVER which is endemic to mountainous regions of the western United States. (From Joynt, Clinical Neurology, 1996, Ch26, pp14-5)
Synonym	[x]tick-borne viral encephalitis, unspecified [x]tick-borne viral encephalitis, unspecified (disorder) enceph tick borne encephalitides, tick-borne encephalitis due to tick-borne encephalitis virus (disorder) encephalitis due to tick-borne encephalitis virus (navigational concept) encephalitis, tick borne encephalitis, tick-borne encephalitis, tick-borne [disease/finding] tick borne enceph tick borne encephalitis tick-borne enceph nos tick-borne encephalitides tick-borne viral encephalitis tick-borne viral encephalitis (disorder) tick-borne viral encephalitis nos tick-borne viral encephalitis nos (disorder) tick-borne viral encephalitis, nos tick-borne viral encephalitis, unspecified viral encephalitis transmitted by tick viral encephalitis transmitted by tick (disorder) viral encephalitis transmitted by tick (navigational concept)
Orphanet	ORPHANET:297
DOID	DOID:0050175
UMLS	C0014061
MeSH	D004675
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:3) C0015464 \| facial palsy \| 1 C0014038 \| encephalitis \| 1 C0034362 \| q fever \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:85) 9716 \| AQR \| DISEASES 3385 \| ICAM3 \| DISEASES 638 \| BIK \| DISEASES 158 \| ADSL \| DISEASES 3002 \| GZMB \| DISEASES 973 \| CD79A \| DISEASES 6348 \| CCL3 \| DISEASES 6347 \| CCL2 \| DISEASES 4940 \| OAS3 \| DISEASES 3458 \| IFNG \| DISEASES 4188 \| MDFI \| DISEASES 63923 \| TNN \| DISEASES 8698 \| S1PR4 \| DISEASES 6351 \| CCL4 \| DISEASES 5894 \| RAF1 \| DISEASES 3958 \| LGALS3 \| DISEASES 1401 \| CRP \| DISEASES 3845 \| KRAS \| DISEASES 8638 \| OASL \| DISEASES 3569 \| IL6 \| DISEASES 1975 \| EIF4B \| DISEASES 9172 \| MYOM2 \| DISEASES 3553 \| IL1B \| DISEASES 59067 \| IL21 \| DISEASES 64083 \| GOLPH3 \| DISEASES 51608 \| GET4 \| DISEASES 5045 \| FURIN \| DISEASES 90952 \| ESAM \| DISEASES 51594 \| NBAS \| DISEASES 10563 \| CXCL13 \| DISEASES 23547 \| LILRA4 \| DISEASES 1234 \| CCR5 \| DISEASES 6352 \| CCL5 \| DISEASES 8320 \| EOMES \| DISEASES 213 \| ALB \| DISEASES 3600 \| IL15 \| DISEASES 7098 \| TLR3 \| DISEASES 10818 \| FRS2 \| DISEASES 201161 \| CENPV \| DISEASES 6866 \| TAC3 \| DISEASES 1901 \| S1PR1 \| DISEASES 3627 \| CXCL10 \| DISEASES 6373 \| CXCL11 \| DISEASES 30835 \| CD209 \| DISEASES 10938 \| EHD1 \| DISEASES 55342 \| STRBP \| DISEASES 117608 \| ZNF354B \| DISEASES 1668 \| DEFA3 \| DISEASES 4600 \| MX2 \| DISEASES 5641 \| LGMN \| DISEASES 4939 \| OAS2 \| DISEASES 92399 \| MRRF \| DISEASES 3455 \| IFNAR2 \| DISEASES 3638 \| INSIG1 \| DISEASES 10146 \| G3BP1 \| DISEASES 26136 \| TES \| DISEASES 2996 \| GYPE \| DISEASES 5116 \| PCNT \| DISEASES 7037 \| TFRC \| DISEASES 4513 \| MT-CO2 \| DISEASES 1660 \| DHX9 \| DISEASES 51175 \| TUBE1 \| DISEASES 7073 \| TIAL1 \| DISEASES 959 \| CD40LG \| DISEASES 2934 \| GSN \| DISEASES 2048 \| EPHB2 \| DISEASES 3456 \| IFNB1 \| DISEASES 1667 \| DEFA1 \| DISEASES 728358 \| DEFA1B \| DISEASES 55576 \| STAB2 \| DISEASES 136319 \| MTPN \| DISEASES 10521 \| DDX17 \| DISEASES 10618 \| TGOLN2 \| DISEASES 4938 \| OAS1 \| DISEASES 3384 \| ICAM2 \| DISEASES 7124 \| TNF \| DISEASES 79872 \| CBLL1 \| DISEASES 862 \| RUNX1T1 \| DISEASES 6892 \| TAPBP \| DISEASES 3586 \| IL10 \| DISEASES 30816 \| ERVW-1 \| DISEASES 57541 \| ZNF398 \| DISEASES 7019 \| TFAM \| DISEASES 23221 \| RHOBTB2 \| DISEASES 26766 \| RNU105C \| DISEASES
Locus	(Waiting for update.)

Disease ID	754
Disease	tick-borne encephalitis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:3) HP:0001945 \| Fever \| 1 HP:0002383 \| Encephalitis \| 1 HP:0010628 \| Facial palsy, unilateral or bilateral \| 1

Disease ID	754
Disease	tick-borne encephalitis
Manually Symptom	UMLS \| Name(Total Manually Symptoms:13) C2707258 \| infections C2364133 \| infection C1611280 \| allergy C1401790 \| kozhevnikov's epilepsy C0752303 \| urological manifestation C0458385 \| localized skin infection C0275524 \| mixed infection C0235031 \| neurological symptoms C0042749 \| viremia C0033774 \| pruritus C0032587 \| polyradiculoneuropathy C0025289 \| meningitis C0018799 \| cardiac diseases
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:2) C0009450 \| infection \| 3 C0021311 \| infections \| 2

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:5)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs3775291	23721942	7098	TLR3	umls:C0014061	BeFree	Association of single nucleotide polymorphism rs3775291 in the coding region of the TLR3 gene with predisposition to tick-borne encephalitis in a Russian population.	0.003724241	2013	TLR3	4	186082920	C	T,G
rs3775291	23962581	7098	TLR3	umls:C0014061	BeFree	A polymorphism in TLR3, rs3775291 (Leu412Phe), has been associated with the increased susceptibility to enteroviral myocarditis, protection against tick-borne encephalitis virus and HIV-1 infection.	0.003724241	2013	TLR3	4	186082920	C	T,G
rs3775291	23721942	1234	CCR5	umls:C0014061	BeFree	A possible association between predisposition to TBE in a Russian population and two polymorphisms, a 32bp deletion in the coding region of the chemokine receptor CCR5 gene and the rs3775291 single nucleotide polymorphism (SNP) (G/A, Leu412Phe) in exon 4 of the toll-like receptor TLR3 gene, was investigated.	0.002909916	2013	TLR3	4	186082920	C	T,G
rs386586050	23962581	7098	TLR3	umls:C0014061	BeFree	A polymorphism in TLR3, rs3775291 (Leu412Phe), has been associated with the increased susceptibility to enteroviral myocarditis, protection against tick-borne encephalitis virus and HIV-1 infection.	0.003724241	2013	NA	NA	NA	NA	NA
rs386586050	23721942	1234	CCR5	umls:C0014061	BeFree	A possible association between predisposition to TBE in a Russian population and two polymorphisms, a 32bp deletion in the coding region of the chemokine receptor CCR5 gene and the rs3775291 single nucleotide polymorphism (SNP) (G/A, Leu412Phe) in exon 4 of the toll-like receptor TLR3 gene, was investigated.	0.002909916	2013	NA	NA	NA	NA	NA

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:0)
(Waiting for update.)

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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