PedAM

Pediatric Disease Annotations & Medicines


	tic disorder

Disease ID	854
Disease	tic disorder
Definition	Disorders characterized by recurrent TICS that may interfere with speech and other activities. Tics are sudden, rapid, nonrhythmic, stereotyped motor movements or vocalizations which may be exacerbated by stress and are generally attenuated during absorbing activities. Tic disorders are distinguished from conditions which feature other types of abnormal movements that may accompany another another condition. (From DSM-IV, 1994)
Synonym	[x]tic disorders [x]tic disorders (finding) disorders habit habit disorder tic tic (finding) tic [dup] (finding) tic dis tic disorder (disorder) tic disorder nos tic disorder unspecified tic disorder unspecified (disorder) tic disorder unspecified (finding) tic disorder, nos tic disorder, unspecified tic disorders tic disorders [disease/finding] tic nos tic nos (finding) tic, nos tics
OMIM	OMIM:614442
DOID	DOID:2769
ICD10	ICD10CM:F95.9
UMLS	C0040188
MeSH	D013981 D020323
SNOMED-CT	SNOMEDCT_US_2016_09_01:568005;SNOMEDCT_US_2016_09_01:386783003
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:275) C0036341 \| schizophrenia \| 20 C0025362 \| mental retardation \| 14 C0039730 \| thalassemia \| 11 C0011847 \| diabetes \| 10 C0004352 \| autism \| 8 C0679466 \| cognitive deficits \| 7 C0003467 \| anxiety \| 7 C0011570 \| depression \| 7 C0033975 \| psychosis \| 6 C0014544 \| epilepsy \| 6 C0497327 \| dementia \| 5 C0021053 \| immune disease \| 5 C0028754 \| obesity \| 5 C0020538 \| hypertension \| 5 C0005586 \| bipolar disorder \| 5 C0028768 \| obsessive-compulsive disorder \| 4 C0023895 \| liver disease \| 4 C0010674 \| cystic fibrosis \| 4 C0002871 \| anemia \| 4 C0023890 \| cirrhosis \| 4 C0040034 \| thrombocytopenia \| 4 C0030312 \| bone marrow failure \| 4 C0035078 \| renal failure \| 4 C0022658 \| kidney disease \| 3 C0022661 \| end-stage renal failure \| 3 C0018799 \| heart disease \| 3 C0029408 \| osteoarthritis \| 3 C0001125 \| lactic acidosis \| 3 C0751651 \| mitochondrial disease \| 3 C0020542 \| pulmonary hypertension \| 3 C0040053 \| thrombosis \| 3 C0019045 \| hemoglobinopathies \| 3 C0282193 \| iron overload \| 3 C0022658 \| renal disease \| 3 C0242379 \| lung cancer \| 3 C0031106 \| aggressive periodontitis \| 2 C0033953 \| sexual dysfunction \| 2 C0026850 \| muscular dystrophies \| 2 C0004936 \| mental disorders \| 2 C0016667 \| fragile x syndrome \| 2 C0085113 \| neurofibromatosis \| 2 C0751651 \| mitochondrial diseases \| 2 C0030486 \| paraplegia \| 2 C0001627 \| congenital adrenal hyperplasia \| 2 C0002020 \| alexithymia \| 2 C0476089 \| endometrial cancer \| 2 C0019158 \| hepatitis \| 2 C0023890 \| liver cirrhosis \| 2 C0040100 \| thymoma \| 2 C0022661 \| chronic kidney disease \| 2 C0017920 \| g6pd deficiency \| 2 C0011860 \| type 2 diabetes \| 2 C0018995 \| hemochromatosis \| 2 C0033975 \| psychoses \| 2 C0041696 \| major depressive disorder \| 2 C0038436 \| post-traumatic stress disorder \| 2 C0021053 \| immune disorder \| 2 C0024530 \| malaria \| 2 C0004153 \| atherosclerosis \| 2 C0035078 \| kidney failure \| 2 C0856761 \| budd-chiari syndrome \| 2 C0021053 \| immune disorders \| 2 C0031099 \| periodontitis \| 2 C0085413 \| autosomal dominant polycystic kidney disease \| 2 C0948265 \| metabolic syndrome \| 2 C0751265 \| learning disabilities \| 2 C0018552 \| hamartomas \| 2 C0024299 \| lymphoma \| 2 C0038436 \| posttraumatic stress disorder \| 2 C0002871 \| anaemia \| 2 C0476089 \| endometrial ca \| 2 C0022578 \| keratoconus \| 2 C0017601 \| glaucoma \| 2 C0018801 \| heart failure \| 2 C1621895 \| adrenal hyperplasia \| 2 C0027121 \| myositis \| 2 C0010068 \| coronary artery disease \| 2 C1136084 \| plasma cell dyscrasia \| 2 C0699893 \| nonmelanoma skin cancer \| 1 C0026691 \| kawasaki disease \| 1 C0002895 \| sickle cell anaemia \| 1 C0206728 \| plexiform neurofibroma \| 1 C0007361 \| cat scratch disease \| 1 C0026986 \| myelodysplastic syndromes \| 1 C0020443 \| hypercholesterolaemia \| 1 C0020437 \| hypercalcaemia \| 1 C0037280 \| infestation \| 1 C0033626 \| protein deficiency \| 1 C0023895 \| hepatic disease \| 1 C0013473 \| eating disorders \| 1 C0013080 \| trisomy 21 \| 1 C0027859 \| vestibular schwannomas \| 1 C0010403 \| cryoglobulinaemia \| 1 C0014859 \| esophageal cancer \| 1 C0403447 \| chronic renal insufficiency \| 1 C0027765 \| nervous system disease \| 1 C0003499 \| supravalvular aortic stenosis \| 1 C0020445 \| familial hypercholesterolemia \| 1 C0158266 \| disc degeneration \| 1 C0013421 \| dystonia \| 1 C0018021 \| goiter \| 1 C0271097 \| usher syndrome \| 1 C0031511 \| pheochromocytomas \| 1 C0031212 \| personality disorders \| 1 C0020541 \| portal hypertension \| 1 C0031117 \| peripheral neuropathy \| 1 C0022661 \| chronic renal failure \| 1 C0017205 \| gaucher's disease \| 1 C0018802 \| congestive heart failure \| 1 C0040128 \| thyroid disorders \| 1 C0149925 \| small cell lung cancer \| 1 C0025958 \| microcephaly \| 1 C0041408 \| turner syndrome \| 1 C0013720 \| ehlers-danlos syndrome \| 1 C0006840 \| candida infection \| 1 C0159069 \| impaired glucose tolerance \| 1 C0085278 \| antiphospholipid syndrome \| 1 C0014544 \| epileptic seizure \| 1 C0878544 \| cardiomyopathies \| 1 C0376358 \| prostate cancer \| 1 C0022661 \| end stage renal disease \| 1 C0079924 \| oligohydramnios \| 1 C0023470 \| myeloid leukemia \| 1 C0007114 \| skin cancers \| 1 C1561644 \| chronic kidney disease (ckd) \| 1 C0027873 \| neuromyelitis optica \| 1 C0031090 \| periodontal diseases \| 1 C0042373 \| vascular disease \| 1 C0022661 \| end stage renal disease (esrd) \| 1 C0030305 \| pancreatitis \| 1 C0158683 \| polycystic liver disease \| 1 C0042384 \| vasculitis \| 1 C0007114 \| skin cancer \| 1 C0019069 \| hemophilia \| 1 C0085078 \| lysosomal storage disease \| 1 C0010068 \| coronary heart disease \| 1 C0751882 \| congenital myasthenic syndrome \| 1 C0030567 \| parkinson's disease \| 1 C0041341 \| tuberous sclerosis \| 1 C0028768 \| obsessive compulsive disorder \| 1 C0002871 \| anemias \| 1 C0032580 \| familial adenomatous polyposis \| 1 C0003864 \| arthritis \| 1 C0153398 \| hypopharyngeal cancer \| 1 C0036439 \| scoliosis \| 1 C0878544 \| cardiomyopathy \| 1 C0021359 \| infertility \| 1 C0221757 \| aat deficiency \| 1 C0022972 \| myasthenic syndrome \| 1 C0235522 \| venous disease \| 1 C0011854 \| type 1 diabetes \| 1 C0018799 \| cardiac disease \| 1 C0747256 \| parasitic infection \| 1 C0011644 \| scleroderma \| 1 C0027859 \| vestibular schwannoma \| 1 C0022735 \| klinefelter syndrome \| 1 C0349464 \| korsakoff syndrome \| 1 C0003469 \| anxiety disorder \| 1 C0853193 \| bipolar i disorder \| 1 C0041341 \| tuberous sclerosis complex \| 1 C0035921 \| congenital rubella syndrome \| 1 C0002878 \| hemolytic anemia \| 1 C0014544 \| seizure disorder \| 1 C0026764 \| myeloma \| 1 C0003507 \| aortic stenosis \| 1 C0035921 \| congenital rubella \| 1 C0020445 \| familial hypercholesterolaemia \| 1 C0022104 \| irritable bowel syndrome \| 1 C0022661 \| end-stage renal disease \| 1 C0003635 \| apraxia \| 1 C0271650 \| glucose intolerance \| 1 C0221355 \| macrocephaly \| 1 C0175702 \| williams-beuren syndrome \| 1 C0003507 \| valvular aortic stenosis \| 1 C0020757 \| icthyosis \| 1 C0019618 \| histiocytosis \| 1 C0020635 \| hypopituitarism \| 1 C0005586 \| bipolar affective disorder \| 1 C0002895 \| sickle cell anemia \| 1 C0013473 \| eating disorder \| 1 C0024117 \| chronic obstructive pulmonary disease \| 1 C0031090 \| periodontal disease \| 1 C0010278 \| craniosynostosis \| 1 C0014544 \| epileptic seizures \| 1 C0032371 \| polio \| 1 C0027051 \| myocardial infarction (mi) \| 1 C0020492 \| hyperostosis \| 1 C0268483 \| tyrosinemia \| 1 C0004134 \| ataxia \| 1 C0748023 \| bacterial prostatitis \| 1 C0020555 \| hypertrichosis \| 1 C0004509 \| azoospermia \| 1 C0015397 \| ocular disease \| 1 C0040188 \| tic disorders \| 1 C0011854 \| type 1 diabetes mellitus \| 1 C0011849 \| diabetes mellitus \| 1 C0039446 \| telangiectases \| 1 C0241910 \| autoimmune hepatitis \| 1 C0007570 \| celiac disease \| 1 C0035372 \| rett syndrome \| 1 C0025286 \| meningiomas \| 1 C0026703 \| mucopolysaccharidoses \| 1 C0152021 \| congenital heart disease \| 1 C0026393 \| molluscum contagiosum \| 1 C0751651 \| mitochondrial disorders \| 1 C0221023 \| cyclic neutropenia \| 1 C0851578 \| sleep disorders \| 1 C0392525 \| nephrolithiasis \| 1 C0006840 \| candida infections \| 1 C0039730 \| thalassaemia \| 1 C0035435 \| rheumatism \| 1 C0035333 \| retinitis \| 1 C0002312 \| alpha thalassemia \| 1 C0020443 \| hypercholesterolemia \| 1 C0280131 \| ovarian teratoma \| 1 C0035304 \| retinal degeneration \| 1 C0004943 \| behcet's disease \| 1 C0023467 \| acute myeloid leukemia \| 1 C0024117 \| chronic obstructive pulmonary disease (copd) \| 1 C1565489 \| renal insufficiency \| 1 C0020598 \| hypoglycaemia \| 1 C0149931 \| migraine \| 1 C0022661 \| chronic renal disease \| 1 C0027765 \| nervous system diseases \| 1 C0026986 \| myelodysplastic syndrome \| 1 C0002395 \| senile dementia \| 1 C0024291 \| hemophagocytic lymphohistiocytosis \| 1 C0035920 \| rubella \| 1 C0030326 \| panniculitis \| 1 C0154246 \| urea cycle disorders \| 1 C0020456 \| hyperglycaemia \| 1 C0085576 \| microcytic anemia \| 1 C0037317 \| sleep disturbances \| 1 C0013384 \| dyskinesia \| 1 C0033581 \| prostatitis \| 1 C0162839 \| porokeratosis \| 1 C0002895 \| sickle cell disease \| 1 C0011265 \| presenile dementia \| 1 C0039538 \| teratomas \| 1 C0020544 \| renal hypertension \| 1 C0040053 \| thrombus \| 1 C0014556 \| temporal lobe epilepsy \| 1 C1263846 \| attention deficit hyperactivity disorder \| 1 C0027830 \| neurofibromas \| 1 C0020179 \| huntington disease \| 1 C0751651 \| mitochondrial disorder \| 1 C0003469 \| anxiety disorders \| 1 C0007570 \| coeliac disease \| 1 C0032580 \| adenomatous polyposis \| 1 C0028768 \| obsessive-compulsive disorders \| 1 C0003873 \| rheumatoid arthritis \| 1 C0042974 \| von willebrand disease \| 1 C0037317 \| sleep disturbance \| 1 C0271270 \| oculomotor apraxia \| 1 C0546837 \| oesophageal cancer \| 1 C0011860 \| type 2 diabetes mellitus \| 1 C0476089 \| endometrial cancers \| 1 C0026764 \| multiple myeloma \| 1 C0033687 \| proteinuria \| 1 C0014544 \| epilepsies \| 1 C0031347 \| pharyngeal cancer \| 1 C0020474 \| familial combined hyperlipidemia \| 1 C0001430 \| adenoma \| 1 C0085293 \| hepatitis e \| 1 C0456909 \| blindness \| 1 C0162309 \| adrenoleukodystrophy \| 1 C0035334 \| retinitis pigmentosa \| 1 C0027947 \| neutropenia \| 1 C0023891 \| alcoholic cirrhosis \| 1 C0236792 \| asperger syndrome \| 1 C0023646 \| lichen planus \| 1 C0206728 \| plexiform neurofibromas \| 1 C0036337 \| schizoaffective disorder \| 1 C0085078 \| lysosomal storage diseases \| 1 C0008370 \| cholestasis \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:4) DRD4 \| 1815 \| CTD_human SLITRK1 \| 114798 \| GHR PSD4 \| 23550 \| OMIM SLC6A3 \| 6531 \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:216) 1951 \| CELSR3 \| DISEASES 1815 \| DRD4 \| DISEASES 5607 \| MAP2K5 \| DISEASES 6820 \| SULT2B1 \| DISEASES 5816 \| PVALB \| DISEASES 10278 \| EFS \| DISEASES 6530 \| SLC6A2 \| DISEASES 83988 \| NCALD \| DISEASES 6449 \| SGTA \| DISEASES 4818 \| NKG7 \| DISEASES 7431 \| VIM \| DISEASES 969 \| CD69 \| DISEASES 81491 \| GPR63 \| DISEASES 13 \| AADAC \| DISEASES 9168 \| TMSB10 \| DISEASES 58512 \| DLGAP3 \| DISEASES 9409 \| PEX16 \| DISEASES 56269 \| IRGC \| DISEASES 53947 \| A4GALT \| DISEASES 10439 \| OLFM1 \| DISEASES 51659 \| GINS2 \| DISEASES 2161 \| F12 \| DISEASES 3337 \| DNAJB1 \| DISEASES 6616 \| SNAP25 \| DISEASES 1455 \| CSNK1G2 \| DISEASES 78986 \| DUSP26 \| DISEASES 1022 \| CDK7 \| DISEASES 3357 \| HTR2B \| DISEASES 51133 \| KCTD3 \| DISEASES 3557 \| IL1RN \| DISEASES 29113 \| C6orf15 \| DISEASES 9177 \| HTR3B \| DISEASES 10017 \| BCL2L10 \| DISEASES 23317 \| DNAJC13 \| DISEASES 1295 \| COL8A1 \| DISEASES 6532 \| SLC6A4 \| DISEASES 6505 \| SLC1A1 \| DISEASES 7515 \| XRCC1 \| DISEASES 57084 \| SLC17A6 \| DISEASES 2033 \| EP300 \| DISEASES 56925 \| LXN \| DISEASES 2557 \| GABRA4 \| DISEASES 2891 \| GRIA2 \| DISEASES 119 \| ADD2 \| DISEASES 2255 \| FGF10 \| DISEASES 11222 \| MRPL3 \| DISEASES 6507 \| SLC1A3 \| DISEASES 2568 \| GABRP \| DISEASES 1181 \| CLCN2 \| DISEASES 6585 \| SLIT1 \| DISEASES 3067 \| HDC \| DISEASES 1000 \| CDH2 \| DISEASES 409 \| ARRB2 \| DISEASES 147381 \| CBLN2 \| DISEASES 6531 \| SLC6A3 \| DISEASES 52 \| ACP1 \| DISEASES 4211 \| MEIS1 \| DISEASES 6581 \| SLC22A3 \| DISEASES 57502 \| NLGN4X \| DISEASES 3358 \| HTR2C \| DISEASES 3145 \| HMBS \| DISEASES 3176 \| HNMT \| DISEASES 150 \| ADRA2A \| DISEASES 25836 \| NIPBL \| DISEASES 3672 \| ITGA1 \| DISEASES 3192 \| HNRNPU \| DISEASES 23522 \| KAT6B \| DISEASES 3361 \| HTR5A \| DISEASES 9437 \| NCR1 \| DISEASES 3060 \| HCRT \| DISEASES 9965 \| FGF19 \| DISEASES 431707 \| LHX8 \| DISEASES 2565 \| GABRG1 \| DISEASES 85477 \| SCIN \| DISEASES 6571 \| SLC18A2 \| DISEASES 3251 \| HPRT1 \| DISEASES 2562 \| GABRB3 \| DISEASES 89832 \| CHRFAM7A \| DISEASES 5479 \| PPIB \| DISEASES 5347 \| PLK1 \| DISEASES 10982 \| MAPRE2 \| DISEASES 6632 \| SNRPD1 \| DISEASES 51305 \| KCNK9 \| DISEASES 6249 \| CLIP1 \| DISEASES 54538 \| ROBO4 \| DISEASES 53407 \| STX18 \| DISEASES 7399 \| USH2A \| DISEASES 1816 \| DRD5 \| DISEASES 2243 \| FGA \| DISEASES 255239 \| ANKK1 \| DISEASES 219833 \| C11orf45 \| DISEASES 140886 \| PABPC5 \| DISEASES 134 \| ADORA1 \| DISEASES 54715 \| RBFOX1 \| DISEASES 5707 \| PSMD1 \| DISEASES 1808 \| DPYSL2 \| DISEASES 56945 \| MRPS22 \| DISEASES 80025 \| PANK2 \| DISEASES 3352 \| HTR1D \| DISEASES 6844 \| VAMP2 \| DISEASES 3350 \| HTR1A \| DISEASES 9520 \| NPEPPS \| DISEASES 134957 \| STXBP5 \| DISEASES 3355 \| HTR1F \| DISEASES 10160 \| FARP1 \| DISEASES 8227 \| AKAP17A \| DISEASES 1272 \| CNTN1 \| DISEASES 4094 \| MAF \| DISEASES 1812 \| DRD1 \| DISEASES 121278 \| TPH2 \| DISEASES 83943 \| IMMP2L \| DISEASES 6900 \| CNTN2 \| DISEASES 10215 \| OLIG2 \| DISEASES 5813 \| PURA \| DISEASES 130574 \| LYPD6 \| DISEASES 139065 \| SLITRK4 \| DISEASES 1103 \| CHAT \| DISEASES 55775 \| TDP1 \| DISEASES 57142 \| RTN4 \| DISEASES 3363 \| HTR7 \| DISEASES 391 \| RHOG \| DISEASES 4697 \| NDUFA4 \| DISEASES 3762 \| KCNJ5 \| DISEASES 4128 \| MAOA \| DISEASES 59277 \| NTN4 \| DISEASES 84062 \| DTNBP1 \| DISEASES 27255 \| CNTN6 \| DISEASES 11255 \| HRH3 \| DISEASES 26053 \| AUTS2 \| DISEASES 144165 \| PRICKLE1 \| DISEASES 1861 \| TOR1A \| DISEASES 3064 \| HTT \| DISEASES 6904 \| TBCD \| DISEASES 3359 \| HTR3A \| DISEASES 85301 \| COL27A1 \| DISEASES 273 \| AMPH \| DISEASES 5789 \| PTPRD \| DISEASES 51256 \| TBC1D7 \| DISEASES 253260 \| RICTOR \| DISEASES 728378 \| POTEF \| DISEASES 2996 \| GYPE \| DISEASES 112476 \| PRRT2 \| DISEASES 3821 \| KLRC1 \| DISEASES 9179 \| AP4M1 \| DISEASES 23230 \| VPS13A \| DISEASES 1565 \| CYP2D6 \| DISEASES 5646 \| PRSS3 \| DISEASES 1312 \| COMT \| DISEASES 26047 \| CNTNAP2 \| DISEASES 9760 \| TOX \| DISEASES 1813 \| DRD2 \| DISEASES 114792 \| KLHL32 \| DISEASES 1268 \| CNR1 \| DISEASES 9446 \| GSTO1 \| DISEASES 3351 \| HTR1B \| DISEASES 115004 \| MB21D1 \| DISEASES 84631 \| SLITRK2 \| DISEASES 1486 \| CTBS \| DISEASES 11128 \| POLR3A \| DISEASES 5631 \| PRPS1 \| DISEASES 27328 \| PCDH11X \| DISEASES 2356 \| FPGS \| DISEASES 3061 \| HCRTR1 \| DISEASES 1104 \| RCC1 \| DISEASES 64420 \| SUSD1 \| DISEASES 3127 \| HLA-DRB5 \| DISEASES 267012 \| DAOA \| DISEASES 2262 \| GPC5 \| DISEASES 26050 \| SLITRK5 \| DISEASES 114798 \| SLITRK1 \| DISEASES 1804 \| DPP6 \| DISEASES 4129 \| MAOB \| DISEASES 3356 \| HTR2A \| DISEASES 4897 \| NRCAM \| DISEASES 54840 \| APTX \| DISEASES 390598 \| SKOR1 \| DISEASES 9960 \| USP3 \| DISEASES 148 \| ADRA1A \| DISEASES 2788 \| GNG7 \| DISEASES 116448 \| OLIG1 \| DISEASES 1814 \| DRD3 \| DISEASES 83696 \| TRAPPC9 \| DISEASES 22900 \| CARD8 \| DISEASES 1621 \| DBH \| DISEASES 8301 \| PICALM \| DISEASES 26468 \| LHX6 \| DISEASES 2643 \| GCH1 \| DISEASES 64221 \| ROBO3 \| DISEASES 55112 \| WDR60 \| DISEASES 9378 \| NRXN1 \| DISEASES 152 \| ADRA2C \| DISEASES 1363 \| CPE \| DISEASES 114781 \| BTBD9 \| DISEASES 93986 \| FOXP2 \| DISEASES 57282 \| SLC4A10 \| DISEASES 4204 \| MECP2 \| DISEASES 8910 \| SGCE \| DISEASES 136306 \| SVOPL \| DISEASES 2195 \| FAT1 \| DISEASES 1408 \| CRY2 \| DISEASES 1139 \| CHRNA7 \| DISEASES 2668 \| GDNF \| DISEASES 627 \| BDNF \| DISEASES 79012 \| CAMKV \| DISEASES 266553 \| OFCC1 \| DISEASES 221823 \| PRPS1L1 \| DISEASES 23286 \| WWC1 \| DISEASES 6586 \| SLIT3 \| DISEASES 3748 \| KCNC3 \| DISEASES 64478 \| CSMD1 \| DISEASES 6999 \| TDO2 \| DISEASES 80184 \| CEP290 \| DISEASES 321 \| APBA2 \| DISEASES 820 \| CAMP \| DISEASES 102723508 \| KANTR \| DISEASES 359809 \| PEG13 \| DISEASES
Locus	(Waiting for update.)

Disease ID	854
Disease	tic disorder
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:213) HP:0000737 \| Irritability \| 22 HP:0001249 \| Mental retardation \| 21 HP:0100753 \| Schizophrenia \| 20 HP:0100543 \| Cognitive deficits \| 18 HP:0001631 \| Atria septal defect \| 17 HP:0000717 \| Autism \| 8 HP:0000708 \| Behavioral problems \| 7 HP:0000716 \| Depression \| 7 HP:0000739 \| Anxiety \| 7 HP:0003774 \| End-stage renal failure \| 6 HP:0001250 \| Seizures \| 6 HP:0000738 \| Sensory hallucination \| 6 HP:0000746 \| Delusions \| 6 HP:0000709 \| Psychosis \| 6 HP:0001903 \| Anemia \| 6 HP:0002960 \| Autoimmune condition \| 6 HP:0007302 \| Bipolar disorder \| 6 HP:0000822 \| Hypertension \| 5 HP:0000726 \| Dementia \| 5 HP:0000718 \| Aggressive behaviour \| 5 HP:0000083 \| Renal insufficiency \| 5 HP:0000722 \| Obsessive compulsive disorder \| 5 HP:0001513 \| Obesity \| 5 HP:0000365 \| Hearing impairment \| 5 HP:0100033 \| Tic disorder \| 4 HP:0003287 \| Abnormality of mitochondrial metabolism \| 4 HP:0005528 \| Bone marrow hypoplasia \| 4 HP:0001394 \| Hepatic cirrhosis \| 4 HP:0001873 \| Low platelet count \| 4 HP:0000078 \| Genital abnormalities \| 3 HP:0004322 \| Stature below 3rd percentile \| 3 HP:0100785 \| Insomnia \| 3 HP:0011675 \| Arrhythmias \| 3 HP:0002092 \| Pulmonary artery hypertension \| 3 HP:0000787 \| Renal calculi \| 3 HP:0001067 \| Neurofibromas \| 3 HP:0001627 \| Congenital heart defects \| 3 HP:0002758 \| Osteoarthritis \| 3 HP:0004308 \| Ventricular arrhythmia \| 3 HP:0003128 \| Lactic acidosis \| 3 HP:0012622 \| Chronic kidney disease \| 2 HP:0012115 \| Liver inflammation \| 2 HP:0000704 \| Pyorrhea \| 2 HP:0008765 \| Auditory hallucinations \| 2 HP:0002902 \| Hyponatremia \| 2 HP:0002621 \| Atherosclerosis \| 2 HP:0008258 \| Congenital adrenal hyperplasia \| 2 HP:0001677 \| Coronary artery disease \| 2 HP:0001257 \| Spasticity \| 2 HP:0000113 \| Polycystic kidney dysplasia \| 2 HP:0002353 \| Abnormal EEG \| 2 HP:0000833 \| Glucose intolerance \| 2 HP:0100614 \| Muscle inflammation \| 2 HP:0008221 \| Enlarged adrenal glands \| 2 HP:0100710 \| Impulsivity \| 2 HP:0002721 \| Immunodeficiency \| 2 HP:0002315 \| Headaches \| 2 HP:0002665 \| Lymphoma \| 2 HP:0100522 \| Thymoma \| 2 HP:0001258 \| Spastic paraplegia, lower limb \| 2 HP:0010550 \| Paraplegia \| 2 HP:0005181 \| Premature coronary artery disease \| 2 HP:0012532 \| Chronic pain \| 2 HP:0000729 \| Pervasive developmental disorder \| 2 HP:0001397 \| Hepatic steatosis \| 2 HP:0001635 \| Congestive heart failure \| 2 HP:0001510 \| Growth deficiency \| 2 HP:0000501 \| Glaucoma \| 2 HP:0012531 \| Pain \| 2 HP:0000563 \| Conical cornea \| 2 HP:0007018 \| Attention deficits \| 2 HP:0000752 \| Hyperactive behavior \| 2 HP:0002639 \| Budd-Chiari syndrome \| 2 HP:0000027 \| Azoospermia \| 1 HP:0012490 \| Inflammation of fat tissue \| 1 HP:0000093 \| Proteinuria \| 1 HP:0006510 \| Chronic obstructive pulmonary disease \| 1 HP:0001268 \| Mental deterioration \| 1 HP:0011096 \| Demyelination \| 1 HP:0100727 \| Histiocytosis \| 1 HP:0002459 \| Dysautonomia \| 1 HP:0000924 \| Abnormality of the skeletal system \| 1 HP:0002071 \| Extrapyramidal dysfunction \| 1 HP:0012758 \| Neurodevelopmental delay \| 1 HP:0030357 \| Small cell lung carcinoma \| 1 HP:0001087 \| Childhood glaucoma \| 1 HP:0009589 \| Bilateral vestibular Schwannoma \| 1 HP:0005206 \| Pancreatic pseudocyst \| 1 HP:0009588 \| Vestibular Schwannoma \| 1 HP:0006706 \| Cystic liver disease \| 1 HP:0000657 \| Oculomotor apraxia \| 1 HP:0004936 \| Blood clot in vein \| 1 HP:0002953 \| Vertebral compression fractures \| 1 HP:0002186 \| Apraxia \| 1 HP:0003690 \| Limb weakness \| 1 HP:0011999 \| Paranoia \| 1 HP:0001943 \| Hypoglycemia \| 1 HP:0003323 \| Muscle weakness, progressive \| 1 HP:0000819 \| Diabetes mellitus \| 1 HP:0100660 \| Dyskinesis \| 1 HP:0001297 \| Cerebral vascular events \| 1 HP:0001324 \| Muscular weakness \| 1 HP:0100774 \| Hyperostosis \| 1 HP:0000750 \| Late-onset speech development \| 1 HP:0002608 \| Celiac disease \| 1 HP:0002500 \| Leukoaraiosis \| 1 HP:0002073 \| Cerebellar ataxia, progressive \| 1 HP:0000989 \| pruritis \| 1 HP:0100962 \| Shyness \| 1 HP:0009732 \| Plexiform neurofibroma \| 1 HP:0000107 \| Renal cyst \| 1 HP:0001650 \| Valvular aortic stenosis \| 1 HP:0001638 \| Cardiomyopathy \| 1 HP:0000998 \| Hypertrichosis \| 1 HP:0002283 \| Global brain atrophy \| 1 HP:0002958 \| Immune dysregulation \| 1 HP:0000618 \| Blindness \| 1 HP:0040075 \| Hypopituitarism \| 1 HP:0001396 \| Cholestasis \| 1 HP:0002591 \| Voracious appetite \| 1 HP:0000853 \| Goitre \| 1 HP:0003231 \| Increased tyrosine in blood \| 1 HP:0001300 \| Parkinsonism \| 1 HP:0003072 \| Hypercalcemia \| 1 HP:0006557 \| Polycystic liver disease \| 1 HP:0002076 \| Migraine headaches \| 1 HP:0001409 \| Portal hypertension \| 1 HP:0002863 \| Myelodysplastic syndrome \| 1 HP:0002313 \| Spastic paraparesis \| 1 HP:0012743 \| Central obesity \| 1 HP:0011947 \| Respiratory infection \| 1 HP:0000757 \| Lack of insight \| 1 HP:0004808 \| Acute myelogenous leukemia \| 1 HP:0001978 \| Extramedullary hematopoiesis \| 1 HP:0002180 \| Neurodegeneration \| 1 HP:0009826 \| limb shortening \| 1 HP:0003418 \| Back pain \| 1 HP:0004554 \| Generalized hypertrichosis \| 1 HP:0000510 \| Retinitis pigmentosa \| 1 HP:0004349 \| Reduced bone mineral density \| 1 HP:0000256 \| Macrocrania \| 1 HP:0002360 \| Sleep disturbance \| 1 HP:0000252 \| Small head circumference \| 1 HP:0002342 \| Intellectual disability, moderate \| 1 HP:0002385 \| Paraparesis \| 1 HP:0100034 \| Motor tics \| 1 HP:0001824 \| Weight loss \| 1 HP:0012075 \| Personality disorder \| 1 HP:0012444 \| Brain wasting \| 1 HP:0003510 \| Proportionate dwarfism \| 1 HP:0000713 \| Agitation \| 1 HP:0100324 \| Progressive systemic scleroderma \| 1 HP:0000556 \| Retinal dystrophy \| 1 HP:0002664 \| Neoplasia \| 1 HP:0001263 \| Developmental retardation \| 1 HP:0000825 \| Hyperinsulinaemic hypoglycaemia \| 1 HP:0200044 \| Porokeratosis \| 1 HP:0003202 \| Neurogenic muscle atrophy, especially in the lower limbs \| 1 HP:0000166 \| Severe periodontal disease \| 1 HP:0002155 \| Increased triglycerides \| 1 HP:0002650 \| Scoliosis \| 1 HP:0001935 \| Microcytic anemia \| 1 HP:0000010 \| Frequent urinary tract infections \| 1 HP:0000028 \| Cryptorchidism \| 1 HP:0004493 \| Hyperostosis of craniofacial bones \| 1 HP:0012226 \| Ovarian teratoma \| 1 HP:0000024 \| Inflammation of the prostate \| 1 HP:0012125 \| Prostate cancer \| 1 HP:0012378 \| Fatigue \| 1 HP:0001875 \| Neutropenia \| 1 HP:0002617 \| Aneurysmal dilatation \| 1 HP:0100022 \| Movement disorder \| 1 HP:0001363 \| Early fusion of cranial sutures \| 1 HP:0009830 \| Peripheral neuritis \| 1 HP:0002573 \| Bloody diarrhea \| 1 HP:0009775 \| Amniotic constriction ring \| 1 HP:0002901 \| Hypocalcemia \| 1 HP:0001643 \| Persistent ductus arteriosus \| 1 HP:0001733 \| Pancreatic inflammation \| 1 HP:0002625 \| Blood clot in a deep vein \| 1 HP:0000020 \| Bladder incontinence \| 1 HP:0001919 \| Acute renal failure \| 1 HP:0000789 \| Infertility \| 1 HP:0001370 \| Rheumatoid arthritis \| 1 HP:0001298 \| Encephalopathy \| 1 HP:0100820 \| Glomerulopathy \| 1 HP:0007199 \| Progressive spastic paraparesis \| 1 HP:0002659 \| Increased tendency to fractures \| 1 HP:0002633 \| Vasculitis \| 1 HP:0001562 \| Oligohydramnios \| 1 HP:0003537 \| Low blood uric acid levels \| 1 HP:0005484 \| Acquired microcephaly \| 1 HP:0100806 \| Sepsis \| 1 HP:0002719 \| infections, recurrent \| 1 HP:0001548 \| Overgrowth \| 1 HP:0000505 \| Poor vision \| 1 HP:0040012 \| Tendency to chromosomal breakage \| 1 HP:0000546 \| Retinal degeneration \| 1 HP:0006775 \| Multiple myeloma \| 1 HP:0001878 \| Haemolytic anaemia \| 1 HP:0012324 \| Myeloid leukemia \| 1 HP:0010310 \| Chylothorax \| 1 HP:0001332 \| Dystonia \| 1 HP:0001369 \| Arthritis \| 1 HP:0002072 \| Chorea \| 1 HP:0001009 \| Telangiectases \| 1 HP:0003124 \| Elevated serum cholesterol \| 1 HP:0001251 \| Ataxia \| 1 HP:0030083 \| Salt craving \| 1 HP:0000992 \| Skin photosensitivity \| 1 HP:0004381 \| Supravalvular aortic stenosis \| 1 HP:0001695 \| Cardiac arrest \| 1 HP:0005086 \| Knee osteoarthritis \| 1

Disease ID	854
Disease	tic disorder
Manually Symptom	(Waiting for update.)
Text Mined Symptom	(Waiting for update.)

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:1)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs6311	17241828	3356	HTR2A	umls:C0040188	BeFree	Nominally significant association was found at the HTR2A rs6311 polymorphism in subjects with tic disorder and OCD (p = .05), replicating a previous finding in Tourette syndrome and OCD.	0.000542884	2007	HTR2A	13	46897343	C	T

GWASdb Annotation(Total Genotypes:0)
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GWASdb Snp Trait(Total Genotypes:0)
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Mapped by lexical matching(Total Items:0)
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Mapped by homologous gene(Total Items:0)
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Chemical(Total Drugs:21)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0040188	aripiprazole	D000068180	-	tic disorders	MESH:D013981	therapeutic	15358981
C0040188	caffeine	D002110	1958/8/2	tic disorders	MESH:D013981	marker/mechanism	9606246
C0040188	carbamazepine	D002220	298-46-4	tic disorders	MESH:D013981	marker/mechanism	10937170
C0040188	citalopram	D015283	59729-33-8	tic disorders	MESH:D013981	marker/mechanism	15812270
C0040188	clonidine	D003000	4205-90-7	tic disorders	MESH:D013981	marker/mechanism	11392527
C0040188	clozapine	D003024	5786-21-0	tic disorders	MESH:D013981	marker/mechanism	15701074
C0040188	fluoxetine	D005473	54910-89-3	tic disorders	MESH:D013981	marker/mechanism	2356881
C0040188	fluvoxamine	D016666	54739-18-3	tic disorders	MESH:D013981	marker/mechanism	10434483
C0040188	haloperidol	D006220	52-86-8	tic disorders	MESH:D013981	marker/mechanism	1536082
C0040188	haloperidol	D006220	52-86-8	tic disorders	MESH:D013981	therapeutic	15358981
C0040188	methylphenidate	D008774	113-45-1	tic disorders	MESH:D013981	marker/mechanism	1061848
C0040188	methylphenidate	D008774	113-45-1	tic disorders	MESH:D013981	therapeutic	7560119
C0040188	ofloxacin	D015242	82419-36-1	tic disorders	MESH:D013981	marker/mechanism	8835045
C0040188	pramipexole	C061333	-	tic disorders	MESH:D013981	marker/mechanism	18181204
C0040188	valproic acid	D014635	99-66-1	tic disorders	MESH:D013981	therapeutic	15701074
C0040188	fluoxetine	D005473	54910-89-3	tics	MESH:D020323	therapeutic	2057015
C0040188	haloperidol	D006220	52-86-8	tics	MESH:D020323	therapeutic	269683
C0040188	methylphenidate	D008774	113-45-1	tics	MESH:D020323	marker/mechanism	2016228
C0040188	nicotine	D009538	-	tics	MESH:D020323	therapeutic	15774505
C0040188	nortriptyline	D009661	72-69-5	tics	MESH:D020323	marker/mechanism	2708560
C0040188	oxycodone	D010098	76-42-6	tics	MESH:D020323	therapeutic	2057015

FDA approved drug and dosage information(Total Drugs:0)
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FDA labeling changes(Total Drugs:0)
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