PedAM

Pediatric Disease Annotations & Medicines


	thyroid gland disease

Disease ID	1111
Disease	thyroid gland disease
Definition	Pathological processes involving the THYROID GLAND.
Synonym	abnormal thyroid abnormality of the thyroid gland disease of thyroid gland disease of thyroid gland (disorder) disease of thyroid gland, nos disease, thyroid diseases of the thyroid gland diseases, thyroid disorder of thyroid gland disorder of thyroid gland (disorder) disorder of thyroid gland, nos disorder of thyroid nos disorder thyroid disorders of thyroid gland thyroid thyroid abnormal thyroid abnormalities thyroid abnormality thyroid dis thyroid disease thyroid disease, nos thyroid diseases thyroid diseases [disease/finding] thyroid disorder thyroid disorder nos thyroid disorder nos (disorder) thyroid disorder, nos thyroid disorders thyroid gland diseases thyroid gland disorder thyroid gland disorders thyroid gland--diseases unspecified disorder of thyroid
DOID	DOID:50
UMLS	C0040128
MeSH	D013959
SNOMED-CT	SNOMEDCT_US_2016_09_01:14304000
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:27) NKX2-5 \| 1482 \| UniProtKB-KW SLC5A5 \| 6528 \| UniProtKB-KW;GHR TSHR \| 7253 \| UniProtKB-KW;GHR CCL2 \| 6347 \| CTD_human ID2 \| 3398 \| CTD_human ITGB5 \| 3693 \| CTD_human TG \| 7038 \| UniProtKB-KW;GHR GULP1 \| 51454 \| CTD_human DUOX2 \| 50506 \| UniProtKB-KW;GHR TSHB \| 7252 \| GHR PAX8 \| 7849 \| UniProtKB-KW;GHR GLIS3 \| 169792 \| UniProtKB-KW NKX2-1 \| 7080 \| UniProtKB-KW CNST \| 163882 \| CTD_human DIO1 \| 1733 \| CTD_human DIO2 \| 1734 \| CTD_human THRA \| 7067 \| UniProtKB-KW FOXE1 \| 2304 \| UniProtKB-KW IGSF1 \| 3547 \| UniProtKB-KW IYD \| 389434 \| UniProtKB-KW ZNF676 \| 163223 \| CTD_human ID3 \| 3399 \| CTD_human TBX3 \| 6926 \| CTD_human DUOXA2 \| 405753 \| UniProtKB-KW TPO \| 7173 \| UniProtKB-KW;GHR TGOLN2 \| 10618 \| CTD_human KLF9 \| 687 \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:12) 2776 \| GNAQ \| infer 2784 \| GNB3 \| infer 3479 \| IGF1 \| infer 3486 \| IGFBP3 \| infer 3553 \| IL1B \| infer 10846 \| PDE10A \| infer 5144 \| PDE4D \| infer 8622 \| PDE8B \| infer 5449 \| POU1F1 \| infer 7038 \| TG \| infer 7068 \| THRB \| infer 7253 \| TSHR \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:584) 54814 \| QPCTL \| DISEASES 6515 \| SLC2A3 \| DISEASES 2767 \| GNA11 \| DISEASES 50508 \| NOX3 \| DISEASES 7145 \| TNS1 \| DISEASES 1361 \| CPB2 \| DISEASES 6561 \| SLC13A1 \| DISEASES 359 \| AQP2 \| DISEASES 27102 \| EIF2AK1 \| DISEASES 1071 \| CETP \| DISEASES 57186 \| RALGAPA2 \| DISEASES 9552 \| SPAG7 \| DISEASES 2099 \| ESR1 \| DISEASES 4320 \| MMP11 \| DISEASES 25776 \| CBY1 \| DISEASES 23551 \| RASD2 \| DISEASES 5816 \| PVALB \| DISEASES 84844 \| PHF5A \| DISEASES 1113 \| CHGA \| DISEASES 5106 \| PCK2 \| DISEASES 5020 \| OXT \| DISEASES 10005 \| ACOT8 \| DISEASES 6907 \| TBL1X \| DISEASES 23439 \| ATP1B4 \| DISEASES 479 \| ATP12A \| DISEASES 54 \| ACP5 \| DISEASES 51285 \| RASL12 \| DISEASES 1512 \| CTSH \| DISEASES 55192 \| DNAJC17 \| DISEASES 7038 \| TG \| DISEASES 1666 \| DECR1 \| DISEASES 8797 \| TNFRSF10A \| DISEASES 268 \| AMH \| DISEASES 56729 \| RETN \| DISEASES 7040 \| TGFB1 \| DISEASES 973 \| CD79A \| DISEASES 1048 \| CEACAM5 \| DISEASES 6822 \| SULT2A1 \| DISEASES 9545 \| RAB3D \| DISEASES 6528 \| SLC5A5 \| DISEASES 5444 \| PON1 \| DISEASES 10135 \| NAMPT \| DISEASES 5054 \| SERPINE1 \| DISEASES 4353 \| MPO \| DISEASES 5691 \| PSMB3 \| DISEASES 80157 \| CWH43 \| DISEASES 3558 \| IL2 \| DISEASES 595 \| CCND1 \| DISEASES 10944 \| C11orf58 \| DISEASES 969 \| CD69 \| DISEASES 4256 \| MGP \| DISEASES 3458 \| IFNG \| DISEASES 2597 \| GAPDH \| DISEASES 2026 \| ENO2 \| DISEASES 3945 \| LDHB \| DISEASES 389434 \| IYD \| DISEASES 2690 \| GHR \| DISEASES 3565 \| IL4 \| DISEASES 2908 \| NR3C1 \| DISEASES 338 \| APOB \| DISEASES 3485 \| IGFBP2 \| DISEASES 3488 \| IGFBP5 \| DISEASES 4953 \| ODC1 \| DISEASES 5657 \| PRTN3 \| DISEASES 2023 \| ENO1 \| DISEASES 335 \| APOA1 \| DISEASES 7276 \| TTR \| DISEASES 134637 \| ADAT2 \| DISEASES 2691 \| GHRH \| DISEASES 5507 \| PPP1R3C \| DISEASES 1958 \| EGR1 \| DISEASES 57616 \| TSHZ3 \| DISEASES 847 \| CAT \| DISEASES 2693 \| GHSR \| DISEASES 2322 \| FLT3 \| DISEASES 4852 \| NPY \| DISEASES 7374 \| UNG \| DISEASES 3759 \| KCNJ2 \| DISEASES 6431 \| SRSF6 \| DISEASES 9572 \| NR1D1 \| DISEASES 7355 \| SLC35A2 \| DISEASES 2678 \| GGT1 \| DISEASES 11135 \| CDC42EP1 \| DISEASES 968 \| CD68 \| DISEASES 417 \| ART1 \| DISEASES 3630 \| INS \| DISEASES 3741 \| KCNA5 \| DISEASES 27112 \| FAM155B \| DISEASES 348 \| APOE \| DISEASES 2056 \| EPO \| DISEASES 92595 \| ZNF764 \| DISEASES 47 \| ACLY \| DISEASES 2538 \| G6PC \| DISEASES 50617 \| ATP6V0A4 \| DISEASES 1160 \| CKMT2 \| DISEASES 3958 \| LGALS3 \| DISEASES 6737 \| TRIM21 \| DISEASES 23378 \| RRP8 \| DISEASES 1401 \| CRP \| DISEASES 759 \| CA1 \| DISEASES 10752 \| CHL1 \| DISEASES 7252 \| TSHB \| DISEASES 2694 \| GIF \| DISEASES 80896 \| NPL \| DISEASES 3569 \| IL6 \| DISEASES 2572 \| GAD2 \| DISEASES 5168 \| ENPP2 \| DISEASES 29113 \| C6orf15 \| DISEASES 1588 \| CYP19A1 \| DISEASES 1559 \| CYP2C9 \| DISEASES 51163 \| DBR1 \| DISEASES 29953 \| TRHDE \| DISEASES 6857 \| SYT1 \| DISEASES 4069 \| LYZ \| DISEASES 7450 \| VWF \| DISEASES 8924 \| HERC2 \| DISEASES 9172 \| MYOM2 \| DISEASES 4025 \| LPO \| DISEASES 4591 \| TRIM37 \| DISEASES 2775 \| GNAO1 \| DISEASES 495 \| ATP4A \| DISEASES 5465 \| PPARA \| DISEASES 671 \| BPI \| DISEASES 25939 \| SAMHD1 \| DISEASES 2769 \| GNA15 \| DISEASES 7350 \| UCP1 \| DISEASES 10133 \| OPTN \| DISEASES 6855 \| SYP \| DISEASES 2033 \| EP300 \| DISEASES 3552 \| IL1A \| DISEASES 3553 \| IL1B \| DISEASES 54414 \| SIAE \| DISEASES 56751 \| BARHL1 \| DISEASES 51430 \| SUCO \| DISEASES 89884 \| LHX4 \| DISEASES 56981 \| PRDM11 \| DISEASES 4036 \| LRP2 \| DISEASES 3791 \| KDR \| DISEASES 60482 \| SLC5A7 \| DISEASES 80303 \| EFHD1 \| DISEASES 4811 \| NID1 \| DISEASES 79594 \| MUL1 \| DISEASES 832 \| CAPZB \| DISEASES 941 \| CD80 \| DISEASES 56925 \| LXN \| DISEASES 590 \| BCHE \| DISEASES 7840 \| ALMS1 \| DISEASES 2247 \| FGF2 \| DISEASES 7067 \| THRA \| DISEASES 6774 \| STAT3 \| DISEASES 23530 \| NNT \| DISEASES 5443 \| POMC \| DISEASES 3383 \| ICAM1 \| DISEASES 8622 \| PDE8B \| DISEASES 6389 \| SDHA \| DISEASES 1950 \| EGF \| DISEASES 5307 \| PITX1 \| DISEASES 793 \| CALB1 \| DISEASES 25824 \| PRDX5 \| DISEASES 51083 \| GAL \| DISEASES 5172 \| SLC26A4 \| DISEASES 5286 \| PIK3C2A \| DISEASES 6252 \| RTN1 \| DISEASES 3705 \| ITPK1 \| DISEASES 90527 \| DUOXA1 \| DISEASES 3480 \| IGF1R \| DISEASES 9611 \| NCOR1 \| DISEASES 7157 \| TP53 \| DISEASES 5409 \| PNMT \| DISEASES 3487 \| IGFBP4 \| DISEASES 5211 \| PFKL \| DISEASES 207 \| AKT1 \| DISEASES 5226 \| PGD \| DISEASES 5972 \| REN \| DISEASES 805 \| CALM2 \| DISEASES 23549 \| DNPEP \| DISEASES 523 \| ATP6V1A \| DISEASES 2044 \| EPHA5 \| DISEASES 100996939 \| PYURF \| DISEASES 134864 \| TAAR1 \| DISEASES 3484 \| IGFBP1 \| DISEASES 6567 \| SLC16A2 \| DISEASES 84636 \| GPR174 \| DISEASES 2796 \| GNRH1 \| DISEASES 8795 \| TNFRSF10B \| DISEASES 6770 \| STAR \| DISEASES 1392 \| CRH \| DISEASES 3439 \| IFNA1 \| DISEASES 4851 \| NOTCH1 \| DISEASES 4863 \| NPAT \| DISEASES 3606 \| IL18 \| DISEASES 3948 \| LDHC \| DISEASES 7069 \| THRSP \| DISEASES 5741 \| PTH \| DISEASES 814 \| CAMK4 \| DISEASES 2321 \| FLT1 \| DISEASES 2697 \| GJA1 \| DISEASES 3087 \| HHEX \| DISEASES 23250 \| ATP11A \| DISEASES 7070 \| THY1 \| DISEASES 4900 \| NRGN \| DISEASES 9601 \| PDIA4 \| DISEASES 1836 \| SLC26A2 \| DISEASES 23522 \| KAT6B \| DISEASES 7547 \| ZIC3 \| DISEASES 6750 \| SST \| DISEASES 5468 \| PPARG \| DISEASES 3156 \| HMGCR \| DISEASES 3815 \| KIT \| DISEASES 26060 \| APPL1 \| DISEASES 222696 \| ZSCAN23 \| DISEASES 539 \| ATP5O \| DISEASES 9992 \| KCNE2 \| DISEASES 197131 \| UBR1 \| DISEASES 1636 \| ACE \| DISEASES 181 \| AGRP \| DISEASES 808 \| CALM3 \| DISEASES 326 \| AIRE \| DISEASES 221914 \| GPC2 \| DISEASES 3101 \| HK3 \| DISEASES 85451 \| UNK \| DISEASES 6755 \| SSTR5 \| DISEASES 114984 \| FLYWCH2 \| DISEASES 115 \| ADCY9 \| DISEASES 23358 \| USP24 \| DISEASES 7412 \| VCAM1 \| DISEASES 2215 \| FCGR3B \| DISEASES 3973 \| LHCGR \| DISEASES 4760 \| NEUROD1 \| DISEASES 5798 \| PTPRN \| DISEASES 213 \| ALB \| DISEASES 8820 \| HESX1 \| DISEASES 9607 \| CARTPT \| DISEASES 27242 \| TNFRSF21 \| DISEASES 1437 \| CSF2 \| DISEASES 94120 \| SYTL3 \| DISEASES 6469 \| SHH \| DISEASES 4982 \| TNFRSF11B \| DISEASES 4846 \| NOS3 \| DISEASES 7253 \| TSHR \| DISEASES 11067 \| C10orf10 \| DISEASES 3990 \| LIPC \| DISEASES 60686 \| C14orf93 \| DISEASES 1152 \| CKB \| DISEASES 4160 \| MC4R \| DISEASES 7184 \| HSP90B1 \| DISEASES 6447 \| SCG5 \| DISEASES 1159 \| CKMT1B \| DISEASES 3904 \| LAIR2 \| DISEASES 1581 \| CYP7A1 \| DISEASES 27166 \| PRELID1 \| DISEASES 5617 \| PRL \| DISEASES 8460 \| TPST1 \| DISEASES 27254 \| CSDC2 \| DISEASES 3479 \| IGF1 \| DISEASES 43 \| ACHE \| DISEASES 7200 \| TRH \| DISEASES 1493 \| CTLA4 \| DISEASES 8941 \| CDK5R2 \| DISEASES 2299 \| FOXI1 \| DISEASES 6588 \| SLN \| DISEASES 3627 \| CXCL10 \| DISEASES 5066 \| PAM \| DISEASES 2353 \| FOS \| DISEASES 147 \| ADRA1B \| DISEASES 6373 \| CXCL11 \| DISEASES 9451 \| EIF2AK3 \| DISEASES 4176 \| MCM7 \| DISEASES 5122 \| PCSK1 \| DISEASES 79660 \| PPP1R3B \| DISEASES 2147 \| F2 \| DISEASES 2820 \| GPD2 \| DISEASES 170261 \| ZCCHC12 \| DISEASES 5340 \| PLG \| DISEASES 4023 \| LPL \| DISEASES 7201 \| TRHR \| DISEASES 3265 \| HRAS \| DISEASES 947 \| CD34 \| DISEASES 27165 \| GLS2 \| DISEASES 253558 \| LCLAT1 \| DISEASES 10008 \| KCNE3 \| DISEASES 126006 \| PCP2 \| DISEASES 147323 \| STARD6 \| DISEASES 836 \| CASP3 \| DISEASES 5626 \| PROP1 \| DISEASES 80227 \| PAAF1 \| DISEASES 7351 \| UCP2 \| DISEASES 3952 \| LEP \| DISEASES 2688 \| GH1 \| DISEASES 81832 \| NETO1 \| DISEASES 5198 \| PFAS \| DISEASES 10868 \| USP20 \| DISEASES 79966 \| SCD5 \| DISEASES 3291 \| HSD11B2 \| DISEASES 201164 \| PLD6 \| DISEASES 22864 \| R3HDM2 \| DISEASES 53905 \| DUOX1 \| DISEASES 4684 \| NCAM1 \| DISEASES 7173 \| TPO \| DISEASES 405753 \| DUOXA2 \| DISEASES 132243 \| H1FOO \| DISEASES 81533 \| ITFG1 \| DISEASES 2692 \| GHRHR \| DISEASES 2193 \| FARSA \| DISEASES 9370 \| ADIPOQ \| DISEASES 64787 \| EPS8L2 \| DISEASES 6517 \| SLC2A4 \| DISEASES 8648 \| NCOA1 \| DISEASES 6863 \| TAC1 \| DISEASES 4018 \| LPA \| DISEASES 3039 \| HBA1 \| DISEASES 2274 \| FHL2 \| DISEASES 7352 \| UCP3 \| DISEASES 2027 \| ENO3 \| DISEASES 353500 \| BMP8A \| DISEASES 1482 \| NKX2-5 \| DISEASES 3768 \| KCNJ12 \| DISEASES 8784 \| TNFRSF18 \| DISEASES 114786 \| XKR4 \| DISEASES 3739 \| KCNA4 \| DISEASES 6906 \| SERPINA7 \| DISEASES 10231 \| RCAN2 \| DISEASES 29110 \| TBK1 \| DISEASES 9021 \| SOCS3 \| DISEASES 3953 \| LEPR \| DISEASES 146852 \| ODF4 \| DISEASES 2520 \| GAST \| DISEASES 6401 \| SELE \| DISEASES 796 \| CALCA \| DISEASES 942 \| CD86 \| DISEASES 8338 \| HIST2H2AC \| DISEASES 5727 \| PTCH1 \| DISEASES 3751 \| KCND2 \| DISEASES 3043 \| HBB \| DISEASES 353164 \| TAS2R42 \| DISEASES 2152 \| F3 \| DISEASES 23760 \| PITPNB \| DISEASES 5133 \| PDCD1 \| DISEASES 51738 \| GHRL \| DISEASES 135 \| ADORA2A \| DISEASES 4221 \| MEN1 \| DISEASES 1103 \| CHAT \| DISEASES 1641 \| DCX \| DISEASES 3363 \| HTR7 \| DISEASES 554 \| AVPR2 \| DISEASES 23583 \| SMUG1 \| DISEASES 51337 \| THEM6 \| DISEASES 6002 \| RGS12 \| DISEASES 3117 \| HLA-DQA1 \| DISEASES 8459 \| TPST2 \| DISEASES 8805 \| TRIM24 \| DISEASES 84144 \| SYDE2 \| DISEASES 3770 \| KCNJ14 \| DISEASES 1508 \| CTSB \| DISEASES 132884 \| EVC2 \| DISEASES 9536 \| PTGES \| DISEASES 921 \| CD5 \| DISEASES 866 \| SERPINA6 \| DISEASES 5449 \| POU1F1 \| DISEASES 23405 \| DICER1 \| DISEASES 2100 \| ESR2 \| DISEASES 3605 \| IL17A \| DISEASES 10617 \| STAMBP \| DISEASES 31 \| ACACA \| DISEASES 7316 \| UBC \| DISEASES 84706 \| GPT2 \| DISEASES 2624 \| GATA2 \| DISEASES 3767 \| KCNJ11 \| DISEASES 1861 \| TOR1A \| DISEASES 5213 \| PFKM \| DISEASES 6050 \| RNH1 \| DISEASES 7080 \| NKX2-1 \| DISEASES 5979 \| RET \| DISEASES 5265 \| SERPINA1 \| DISEASES 146059 \| CDAN1 \| DISEASES 4624 \| MYH6 \| DISEASES 7068 \| THRB \| DISEASES 170685 \| NUDT10 \| DISEASES 801 \| CALM1 \| DISEASES 487 \| ATP2A1 \| DISEASES 987 \| LRBA \| DISEASES 10390 \| CEPT1 \| DISEASES 60 \| ACTB \| DISEASES 23032 \| USP33 \| DISEASES 6752 \| SSTR2 \| DISEASES 2764 \| GMFB \| DISEASES 26136 \| TES \| DISEASES 10004 \| NAALADL1 \| DISEASES 54413 \| NLGN3 \| DISEASES 1735 \| DIO3 \| DISEASES 26191 \| PTPN22 \| DISEASES 4151 \| MB \| DISEASES 6258 \| RXRG \| DISEASES 10092 \| ARPC5 \| DISEASES 51150 \| SDF4 \| DISEASES 3123 \| HLA-DRB1 \| DISEASES 2157 \| F8 \| DISEASES 4133 \| MAP2 \| DISEASES 80274 \| SCUBE1 \| DISEASES 5646 \| PRSS3 \| DISEASES 1733 \| DIO1 \| DISEASES 10724 \| MGEA5 \| DISEASES 4283 \| CXCL9 \| DISEASES 3880 \| KRT19 \| DISEASES 779 \| CACNA1S \| DISEASES 54617 \| INO80 \| DISEASES 23038 \| WDTC1 \| DISEASES 7052 \| TGM2 \| DISEASES 183 \| AGT \| DISEASES 22796 \| COG2 \| DISEASES 28514 \| DLL1 \| DISEASES 4139 \| MARK1 \| DISEASES 6993 \| DYNLT1 \| DISEASES 7432 \| VIP \| DISEASES 5788 \| PTPRC \| DISEASES 462 \| SERPINC1 \| DISEASES 356 \| FASLG \| DISEASES 55811 \| ADCY10 \| DISEASES 2214 \| FCGR3A \| DISEASES 336 \| APOA2 \| DISEASES 844 \| CASQ1 \| DISEASES 3766 \| KCNJ10 \| DISEASES 115352 \| FCRL3 \| DISEASES 632 \| BGLAP \| DISEASES 253738 \| EBF3 \| DISEASES 64077 \| LHPP \| DISEASES 117247 \| SLC16A10 \| DISEASES 262 \| AMD1 \| DISEASES 8349 \| HIST2H2BE \| DISEASES 8337 \| HIST2H2AA3 \| DISEASES 9557 \| CHD1L \| DISEASES 153 \| ADRB1 \| DISEASES 3283 \| HSD3B1 \| DISEASES 6975 \| TECTB \| DISEASES 4803 \| NGF \| DISEASES 2832 \| NPBWR2 \| DISEASES 9118 \| INA \| DISEASES 2316 \| FLNA \| DISEASES 2332 \| FMR1 \| DISEASES 2805 \| GOT1 \| DISEASES 6658 \| SOX3 \| DISEASES 959 \| CD40LG \| DISEASES 3547 \| IGSF1 \| DISEASES 2778 \| GNAS \| DISEASES 8675 \| STX16 \| DISEASES 4774 \| NFIA \| DISEASES 3725 \| JUN \| DISEASES 115209 \| OMA1 \| DISEASES 5950 \| RBP4 \| DISEASES 4998 \| ORC1 \| DISEASES 112970 \| KTI12 \| DISEASES 3745 \| KCNB1 \| DISEASES 8022 \| LHX3 \| DISEASES 5728 \| PTEN \| DISEASES 7422 \| VEGFA \| DISEASES 958 \| CD40 \| DISEASES 23404 \| EXOSC2 \| DISEASES 80712 \| ESX1 \| DISEASES 340543 \| TCEAL5 \| DISEASES 100 \| ADA \| DISEASES 90550 \| MCU \| DISEASES 1025 \| CDK9 \| DISEASES 252995 \| FNDC5 \| DISEASES 9968 \| MED12 \| DISEASES 1043 \| CD52 \| DISEASES 8518 \| IKBKAP \| DISEASES 6257 \| RXRB \| DISEASES 367 \| AR \| DISEASES 2304 \| FOXE1 \| DISEASES 2155 \| F7 \| DISEASES 3055 \| HCK \| DISEASES 3397 \| ID1 \| DISEASES 50943 \| FOXP3 \| DISEASES 1041 \| CDSN \| DISEASES 4879 \| NPPB \| DISEASES 4878 \| NPPA \| DISEASES 6992 \| PPP1R11 \| DISEASES 3105 \| HLA-A \| DISEASES 1471 \| CST3 \| DISEASES 687 \| KLF9 \| DISEASES 8718 \| TNFRSF25 \| DISEASES 4609 \| MYC \| DISEASES 26586 \| CKAP2 \| DISEASES 8573 \| CASK \| DISEASES 51335 \| NGRN \| DISEASES 1906 \| EDN1 \| DISEASES 5160 \| PDHA1 \| DISEASES 3559 \| IL2RA \| DISEASES 7010 \| TEK \| DISEASES 3440 \| IFNA2 \| DISEASES 3456 \| IFNB1 \| DISEASES 551 \| AVP \| DISEASES 6462 \| SHBG \| DISEASES 3486 \| IGFBP3 \| DISEASES 5214 \| PFKP \| DISEASES 7054 \| TH \| DISEASES 53919 \| SLCO1C1 \| DISEASES 29126 \| CD274 \| DISEASES 2618 \| GART \| DISEASES 1497 \| CTNS \| DISEASES 169792 \| GLIS3 \| DISEASES 5618 \| PRLR \| DISEASES 83650 \| SLC35G5 \| DISEASES 4155 \| MBP \| DISEASES 2706 \| GJB2 \| DISEASES 7932 \| OR2H2 \| DISEASES 50506 \| DUOX2 \| DISEASES 3898 \| LAD1 \| DISEASES 3703 \| STT3A \| DISEASES 6996 \| TDG \| DISEASES 1621 \| DBH \| DISEASES 164 \| AP1G1 \| DISEASES 91683 \| SYT12 \| DISEASES 6152 \| RPL24 \| DISEASES 4828 \| NMB \| DISEASES 64400 \| AKTIP \| DISEASES 2875 \| GPT \| DISEASES 174 \| AFP \| DISEASES 5744 \| PTHLH \| DISEASES 7920 \| ABHD16A \| DISEASES 144195 \| SLC2A14 \| DISEASES 116372 \| LYPD1 \| DISEASES 594857 \| NPS \| DISEASES 6345 \| SRL \| DISEASES 10587 \| TXNRD2 \| DISEASES 9612 \| NCOR2 \| DISEASES 2492 \| FSHR \| DISEASES 728441 \| GGT2 \| DISEASES 7018 \| TF \| DISEASES 10989 \| IMMT \| DISEASES 3267 \| AGFG1 \| DISEASES 2641 \| GCG \| DISEASES 1385 \| CREB1 \| DISEASES 3481 \| IGF2 \| DISEASES 5649 \| RELN \| DISEASES 201456 \| FBXO15 \| DISEASES 146713 \| RBFOX3 \| DISEASES 2260 \| FGFR1 \| DISEASES 8031 \| NCOA4 \| DISEASES 7849 \| PAX8 \| DISEASES 6329 \| SCN4A \| DISEASES 7124 \| TNF \| DISEASES 51562 \| MBIP \| DISEASES 84290 \| CAPNS2 \| DISEASES 548596 \| CKMT1A \| DISEASES 3612 \| IMPA1 \| DISEASES 3451 \| IFNA17 \| DISEASES 3586 \| IL10 \| DISEASES 627 \| BDNF \| DISEASES 10665 \| C6orf10 \| DISEASES 6513 \| SLC2A1 \| DISEASES 8801 \| SUCLG2 \| DISEASES 846 \| CASR \| DISEASES 2317 \| FLNB \| DISEASES 56147 \| PCDHA1 \| DISEASES 256987 \| SERINC5 \| DISEASES 51428 \| DDX41 \| DISEASES 8635 \| RNASET2 \| DISEASES 8992 \| ATP6V0E1 \| DISEASES 2197 \| FAU \| DISEASES 503542 \| SPRN \| DISEASES 7296 \| TXNRD1 \| DISEASES 9774 \| BCLAF1 \| DISEASES 4975 \| OMP \| DISEASES 930 \| CD19 \| DISEASES 10846 \| PDE10A \| DISEASES 83695 \| RHNO1 \| DISEASES 488 \| ATP2A2 \| DISEASES 23312 \| DMXL2 \| DISEASES 246744 \| STH \| DISEASES 3939 \| LDHA \| DISEASES 160728 \| SLC5A8 \| DISEASES 7421 \| VDR \| DISEASES 8972 \| MGAM \| DISEASES 2972 \| BRF1 \| DISEASES 1734 \| DIO2 \| DISEASES 567 \| B2M \| DISEASES 102723508 \| KANTR \| DISEASES 348120 \| LINC01193 \| DISEASES 359809 \| PEG13 \| DISEASES 101928337 \| PTCSC2 \| DISEASES 23642 \| SNHG1 \| DISEASES 26812 \| SNORD37 \| DISEASES 27004 \| TCL6 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1111
Disease	thyroid gland disease
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	(Waiting for update.)

Disease ID	1111
Disease	thyroid gland disease
Manually Symptom	(Waiting for update.)
Text Mined Symptom	(Waiting for update.)

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:3)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs113488022	17542667	673	BRAF	umls:C0040128	BeFree	The incidence of BRAF(V600E) was studied in 85 microdissected cases of IM detected in two series of 334 and 398 patients operated on for benign thyroid disease in 2005 and in 2006, respectively.	0.003181358	2007	BRAF	7	140753336	A	T,G,C
rs2476601	22374238	52	ACP1	umls:C0040128	BeFree	Association of Protein Tyrosine Phosphatase Nonreceptor 22 (PTPN22) C1858T gene polymorphism with susceptibility to autoimmune thyroid diseases: a meta-analysis.	0.000542884	2012	PTPN22;AP4B1-AS1	1	113834946	A	G
rs2476601	22374238	26191	PTPN22	umls:C0040128	BeFree	Association of Protein Tyrosine Phosphatase Nonreceptor 22 (PTPN22) C1858T gene polymorphism with susceptibility to autoimmune thyroid diseases: a meta-analysis.	0.008001298	2012	PTPN22;AP4B1-AS1	1	113834946	A	G

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:160)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
1	19823329	rs873095	G	A	rs873095	20826269	4.70E-08	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
1	19827970	rs16822442	A	G	rs16822442	20826269	3.30E-08	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
1	19831939	rs11807599	C	T	rs11807599	20826269	6.00E-08	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
1	19832437	rs11806434	G	A	rs11806434	20826269	5.70E-08	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
1	19832987	rs12136721	C	G	rs12136721	20826269	5.70E-08	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
1	19837537	rs4394682	A	G	rs4394682	20826269	4.00E-08	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
1	19839115	rs12138950	A	C	rs12138950	20826269	3.50E-08	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
1	19839115	rs568931048	A	AC	rs12138950	20826269	3.50E-08	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
1	19841174	rs10799824	G	A	rs10799824	20826269	3.50E-08	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
1	19841174	rs10799824	G	A	rs10799824	23408906	1.00E-08	TSH - Males	0.1	[0.066-0.132] unit decrease	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
1	19841174	rs10799824	G	A	rs10799824	23408906	3.00E-14	TSH - Females	0.12	[0.092-0.154] unit decrease	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
1	19841174	rs10799824	G	A	rs10799824	23408906	4.00E-21	TSH	0.11	[0.089-0.137] unit decrease	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
1	19843576	rs10917469	A	G	rs10917469	20826269	3.20E-08	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
1	19861106	rs10917477	A	G	rs10917477	22494929	2.00E-08	NA	0.06	[0.038-0.078] unit decrease	3,736 European ancestry individuals	European(3736)	ALL(3736)	EUR(3736)	ALL(3736)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	rs10917477-A	Meta-Analysis	Research Support, Non-U.S. Gov't	A
1	19916784	rs1770480	C	T	rs1770480	22494929	4.41E-08	NA	NA	NA	3,736 European ancestry individuals	European(3736)	ALL(3736)	EUR(3736)	ALL(3736)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	A
1	19921747	rs2745217	C	T	rs2745217	22494929	1.46E-08	NA	NA	NA	3,736 European ancestry individuals	European(3736)	ALL(3736)	EUR(3736)	ALL(3736)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
1	19924662	rs2792043	A	C	rs2792043	22494929	2.77E-08	NA	NA	NA	3,736 European ancestry individuals	European(3736)	ALL(3736)	EUR(3736)	ALL(3736)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	C
1	19947973	rs1320978	A	G	rs1320978	22494929	2.25E-08	NA	NA	NA	3,736 European ancestry individuals	European(3736)	ALL(3736)	EUR(3736)	ALL(3736)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	C
1	54375570	rs2235544	C	A	rs2235544	23408906	3.00E-18	FT4-Females	0.13	[0.1-0.16] unit increase	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
1	54375570	rs2235544	C	A	rs2235544	23408906	5.00E-15	FT4-Males	0.14	[0.11-0.18] unit increase	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
1	54375570	rs2235544	C	A	rs2235544	23408906	8.00E-32	FT4	0.14	[0.11-0.16] unit increase	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
1	58743154	rs17117233	C	T	rs17117233	20826269	1.70E-06	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
1	58756648	rs11576201	G	A	rs11576201	20826269	9.00E-07	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
1	58764081	rs10493251	C	T	rs10493251	20826269	5.80E-07	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
1	61620496	rs334699	A	G	rs334699	23408906	2.00E-07	TSH - Females	0.14	[0.09-0.196] unit decrease	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
1	61620496	rs334699	A	G	rs334699	23408906	5.00E-12	TSH	0.14	[0.1-0.182] unit decrease	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
1	61620496	rs334699	A	G	rs334699	23408906	6.00E-07	TSH - Males	0.15	[0.09-0.208] unit decrease	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
2	133851844	rs1370596	T	C	rs1370596	20826269	3.70E-06	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
2	133852801	rs1437895	G	A	rs1437895	20826269	5.00E-06	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
2	205053197	rs16840880	C	T	rs16840880	20826269	1.20E-06	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
2	205057668	rs13401647	T	C	rs13401647	20826269	9.60E-07	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
2	217625523	rs13015993	G	A	rs13015993	23408906	2.00E-07	TSH - Females	0.07	[0.044-0.094] unit increase	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
2	217625523	rs13015993	G	A	rs13015993	23408906	3.00E-15	TSH	0.08	[0.058-0.098] unit increase	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
2	217625523	rs13015993	G	A	rs13015993	23408906	8.00E-11	TSH - Males	0.1	[0.066-0.124] unit increase	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
2	241247757	rs3935911	C	T	rs3935911	20826269	1.70E-06	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
2	241250109	rs12695016	A	G	rs12695016	20826269	1.50E-06	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
2	241252648	rs13383344	A	G	rs13383344	20826269	1.10E-06	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
2	241256135	rs2352816	A	G	rs2352816	20826269	2.40E-06	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
2	241256453	rs2352817	G	A	rs2352817	20826269	3.40E-06	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
2	241259159	rs4676361	C	A	rs4676361	20826269	2.80E-06	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
2	241261657	rs2352821	C	T	rs2352821	20826269	1.20E-06	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
4	65511843	rs11723142	A	G	rs11723142	20826269	3.60E-06	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
4	65511843	rs200694364	A	ATG	rs11723142	20826269	3.60E-06	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
4	113544152	rs6834538	T	C	rs6834538	24722205	5.00E-06	NA	0.3	[0.17-0.42] ng/dl decrease	2,789 Korean ancestry individuals	Korean(2789)	ALL(2789)	ASN(2789)	ALL(2789)	Free thyroxine concentration	HPOID:0000820	Abnormality of the thyroid gland	DOID:50	thyroid gland disease	NA	NA	NA	NA	Thyroid gland disease	rs6834538-T	Research Support, Non-U.S. Gov't	C	C4orf21
4	149650033	rs17025017	G	A	rs17025017	22494929	3.39E-08	NA	NA	NA	3,736 European ancestry individuals	European(3736)	ALL(3736)	EUR(3736)	ALL(3736)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	G
4	149651602	rs6535633	G	A	rs6535633	22494929	7.71E-08	NA	NA	NA	3,736 European ancestry individuals	European(3736)	ALL(3736)	EUR(3736)	ALL(3736)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	A
4	149652478	rs11935941	A	C	rs11935941	22494929	7.56E-08	NA	NA	NA	3,736 European ancestry individuals	European(3736)	ALL(3736)	EUR(3736)	ALL(3736)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	C
4	149652582	rs11945082	C	T	rs11945082	22494929	7.54E-08	NA	NA	NA	3,736 European ancestry individuals	European(3736)	ALL(3736)	EUR(3736)	ALL(3736)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	C
4	149652610	rs10028213	C	G	rs10028213	22494929	3.00E-10	NA	0.08	[0.059-0.109] unit increase	3,736 European ancestry individuals	European(3736)	ALL(3736)	EUR(3736)	ALL(3736)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	rs10028213-C	Meta-Analysis	Research Support, Non-U.S. Gov't	C
4	149653109	rs10008491	A	G	rs10008491	22494929	7.45E-08	NA	NA	NA	3,736 European ancestry individuals	European(3736)	ALL(3736)	EUR(3736)	ALL(3736)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	G
4	149653879	rs10009291	A	G	rs10009291	22494929	7.33E-08	NA	NA	NA	3,736 European ancestry individuals	European(3736)	ALL(3736)	EUR(3736)	ALL(3736)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	G
4	149655781	rs2358648	C	A	rs2358648	22494929	7.04E-08	NA	NA	NA	3,736 European ancestry individuals	European(3736)	ALL(3736)	EUR(3736)	ALL(3736)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
4	149657642	rs10021637	A	G,T	rs10021637	22494929	6.78E-08	NA	NA	NA	3,736 European ancestry individuals	European(3736)	ALL(3736)	EUR(3736)	ALL(3736)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
4	149658675	rs10002630	G	C	rs10002630	22494929	6.79E-08	NA	NA	NA	3,736 European ancestry individuals	European(3736)	ALL(3736)	EUR(3736)	ALL(3736)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	C
4	149660723	rs11728154	G	A	rs11728154	22494929	2.49E-08	NA	NA	NA	3,736 European ancestry individuals	European(3736)	ALL(3736)	EUR(3736)	ALL(3736)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	G
4	149660911	rs11942028	T	C	rs11942028	22494929	8.36E-08	NA	NA	NA	3,736 European ancestry individuals	European(3736)	ALL(3736)	EUR(3736)	ALL(3736)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
4	149661024	rs10857236	A	T	rs10857236	22494929	8.45E-08	NA	NA	NA	3,736 European ancestry individuals	European(3736)	ALL(3736)	EUR(3736)	ALL(3736)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
4	149662204	rs17025085	T	G	rs17025085	22494929	9.60E-08	NA	NA	NA	3,736 European ancestry individuals	European(3736)	ALL(3736)	EUR(3736)	ALL(3736)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	G
4	149662335	rs7695440	C	T	rs7695440	22494929	9.74E-08	NA	NA	NA	3,736 European ancestry individuals	European(3736)	ALL(3736)	EUR(3736)	ALL(3736)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	C
4	149664898	rs10004961	C	T	rs10004961	22494929	4.35E-08	NA	NA	NA	3,736 European ancestry individuals	European(3736)	ALL(3736)	EUR(3736)	ALL(3736)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	C
4	149665602	rs11732089	T	C	rs11732089	22494929	7.66E-08	NA	NA	NA	3,736 European ancestry individuals	European(3736)	ALL(3736)	EUR(3736)	ALL(3736)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
4	149669506	rs10032216	T	C	rs10032216	22494929	8.24E-08	NA	NA	NA	3,736 European ancestry individuals	European(3736)	ALL(3736)	EUR(3736)	ALL(3736)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
4	149669506	rs10032216	T	C	rs10032216	23408906	2.00E-13	TSH - Females	0.11	[0.079-0.133] unit increase	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
4	149669506	rs10032216	T	C	rs10032216	23408906	9.00E-16	TSH	0.09	[0.065-0.109] unit increase	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
4	171053519	rs11726248	G	A	rs11726248	23408906	4.00E-07	FT4-Females	0.12	[0.076-0.17] unit increase	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
4	171053519	rs11726248	G	A	rs11726248	23408906	5.00E-09	FT4	0.11	[0.074-0.148] unit increase	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
5	76515824	rs9687206	A	G	rs9687206	22494929	8.21E-11	NA	NA	NA	3,736 European ancestry individuals	European(3736)	ALL(3736)	EUR(3736)	ALL(3736)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	G
5	76518442	rs4704397	G	A	rs4704397	22494929	3.82E-10	NA	NA	NA	3,736 European ancestry individuals	European(3736)	ALL(3736)	EUR(3736)	ALL(3736)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	A
5	76521868	rs1382879	T	C	rs1382879	22494929	7.79E-13	NA	NA	NA	3,736 European ancestry individuals	European(3736)	ALL(3736)	EUR(3736)	ALL(3736)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	G
5	76528022	rs1479567	G	A	rs1479567	22494929	7.65E-13	NA	NA	NA	3,736 European ancestry individuals	European(3736)	ALL(3736)	EUR(3736)	ALL(3736)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
5	76530349	rs6885099	A	G	rs6885099	22494929	6.92E-13	NA	NA	NA	3,736 European ancestry individuals	European(3736)	ALL(3736)	EUR(3736)	ALL(3736)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	G
5	76530349	rs6885099	A	G	rs6885099	23408906	2.00E-26	TSH	0.14	[0.12-0.16] unit decrease	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
5	76530349	rs6885099	A	G	rs6885099	23408906	3.00E-38	TSH - Males	0.17	[0.14-0.19] unit decrease	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
5	76530349	rs6885099	A	G	rs6885099	23408906	6.00E-24	TSH - Females	0.12	[0.096-0.144] unit decrease	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
5	76531648	rs2061909	C	A	rs2061909	22494929	7.60E-13	NA	NA	NA	3,736 European ancestry individuals	European(3736)	ALL(3736)	EUR(3736)	ALL(3736)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	G
5	76531648	rs70988661	C	CA	rs2061909	22494929	7.60E-13	NA	NA	NA	3,736 European ancestry individuals	European(3736)	ALL(3736)	EUR(3736)	ALL(3736)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	G
5	76535811	rs2046045	T	G	rs2046045	22494929	3.00E-27	NA	0.12	[0.093-0.137] unit decrease	3,736 European ancestry individuals	European(3736)	ALL(3736)	EUR(3736)	ALL(3736)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	rs2046045-T	Meta-Analysis	Research Support, Non-U.S. Gov't	C,G
5	76539997	rs10056404	T	C	rs10056404	22494929	2.79E-11	NA	NA	NA	3,736 European ancestry individuals	European(3736)	ALL(3736)	EUR(3736)	ALL(3736)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
5	76540496	rs11950697	T	A	rs11950697	22494929	4.00E-11	NA	NA	NA	3,736 European ancestry individuals	European(3736)	ALL(3736)	EUR(3736)	ALL(3736)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
5	76541325	rs10037599	A	C	rs10037599	22494929	5.79E-13	NA	NA	NA	3,736 European ancestry individuals	European(3736)	ALL(3736)	EUR(3736)	ALL(3736)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	A
5	76543603	rs10036386	C	T	rs10036386	22494929	1.25E-09	NA	NA	NA	3,736 European ancestry individuals	European(3736)	ALL(3736)	EUR(3736)	ALL(3736)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	C
5	76543768	rs6867654	G	A	rs6867654	22494929	1.35E-09	NA	NA	NA	3,736 European ancestry individuals	European(3736)	ALL(3736)	EUR(3736)	ALL(3736)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	A
5	76544051	rs1351284	A	C	rs1351284	22494929	1.52E-09	NA	NA	NA	3,736 European ancestry individuals	European(3736)	ALL(3736)	EUR(3736)	ALL(3736)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	G
5	76544157	rs1479565	G	A	rs1479565	22494929	1.59E-09	NA	NA	NA	3,736 European ancestry individuals	European(3736)	ALL(3736)	EUR(3736)	ALL(3736)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
5	76544412	rs1479564	A	G	rs1479564	22494929	1.78E-09	NA	NA	NA	3,736 European ancestry individuals	European(3736)	ALL(3736)	EUR(3736)	ALL(3736)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	C
5	76544942	rs1351283	A	G	rs1351283	22494929	4.89E-08	NA	NA	NA	3,736 European ancestry individuals	European(3736)	ALL(3736)	EUR(3736)	ALL(3736)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
5	76544960	rs989758	G	A	rs989758	22494929	7.84E-08	NA	NA	NA	3,736 European ancestry individuals	European(3736)	ALL(3736)	EUR(3736)	ALL(3736)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
5	76547212	rs7729842	C	T	rs7729842	22494929	5.77E-08	NA	NA	NA	3,736 European ancestry individuals	European(3736)	ALL(3736)	EUR(3736)	ALL(3736)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
5	76568292	rs832790	C	A	rs832790	22494929	8.89E-08	NA	NA	NA	3,736 European ancestry individuals	European(3736)	ALL(3736)	EUR(3736)	ALL(3736)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	G
6	43811762	rs9472138	C	T	rs9472138	23408906	5.00E-06	TSH - Males	0.07	[0.038-0.092] unit decrease	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
6	43811762	rs9472138	C	T	rs9472138	23408906	6.00E-12	TSH - Females	0.09	[0.065-0.115] unit decrease	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
6	43811762	rs9472138	C	T	rs9472138	23408906	7.00E-16	TSH	0.08	[0.059-0.099] unit decrease	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
6	43904780	rs11755845	C	T	rs11755845	23408906	2.00E-10	TSH	0.07	[0.045-0.085] unit decrease	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
6	43904780	rs11755845	C	T	rs11755845	23408906	3.00E-07	TSH - Males	0.08	[0.047-0.105] unit decrease	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
6	116014608	rs9374564	C	T	rs9374564	20826269	3.20E-06	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
6	148521292	rs9497965	C	T	rs9497965	23408906	2.00E-08	TSH	0.05	[0.033-0.069] unit increase	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
6	148521292	rs9497965	C	T	rs9497965	23408906	3.00E-08	TSH - Females	0.07	[0.043-0.091] unit increase	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
6	166046483	rs753760	C	G	rs753760	23408906	1.00E-24	TSH	0.1	[0.08-0.12] unit increase	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
6	166046483	rs753760	C	G	rs753760	23408906	5.00E-09	TSH - Females	0.08	[0.051-0.101] unit increase	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
6	166046483	rs753760	C	G	rs753760	23408906	6.00E-20	TSH - Males	0.13	[0.1-0.16] unit increase	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
7	28096199	rs7785730	A	G	rs7785730	24722205	6.00E-06	NA	0.11	[0.061-0.151] ng/dl increase	2,789 Korean ancestry individuals	Korean(2789)	ALL(2789)	ASN(2789)	ALL(2789)	Free thyroxine concentration	HPOID:0000820	Abnormality of the thyroid gland	DOID:50	thyroid gland disease	NA	NA	NA	NA	Thyroid gland disease	rs7785730-G	Research Support, Non-U.S. Gov't	G	JAZF1
7	94527827	rs10231524	C	T	rs10231524	20826269	4.40E-06	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
7	94534886	rs1527680	A	G	rs1527680	20826269	1.90E-06	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
7	110078237	rs211797	C	G	rs211797	20826269	2.60E-06	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
7	110078549	rs169833	G	A	rs169833	20826269	2.60E-06	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
7	110083052	rs211812	C	G	rs211812	20826269	2.80E-06	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
7	110083672	rs211811	A	G	rs211811	20826269	3.30E-07	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
7	110088524	rs211810	T	A,C,G	rs211810	20826269	2.90E-06	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
7	110089321	rs211808	A	C	rs211808	20826269	2.40E-06	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
7	110091460	rs211804	A	C	rs211804	20826269	2.70E-06	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
7	110091748	rs211803	T	G	rs211803	20826269	2.70E-06	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
7	110095056	rs402946	T	G	rs402946	20826269	2.30E-06	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
7	110095211	rs416050	G	A	rs416050	20826269	2.30E-06	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
7	110096685	rs396911	A	G	rs396911	20826269	4.50E-06	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
7	110097040	rs367898	C	G	rs367898	20826269	4.50E-06	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
7	110101546	rs442451	A	G	rs442451	20826269	3.80E-06	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
7	110101603	rs398554	G	A	rs398554	20826269	3.80E-06	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
7	110104450	rs409006	A	G	rs409006	20826269	4.10E-06	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
7	110106507	rs388129	G	C	rs388129	20826269	3.90E-06	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
7	110107348	rs10226721	G	A	rs10226721	20826269	4.10E-06	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
8	32416274	rs7825175	G	A	rs7825175	23408906	2.00E-08	TSH - Females	0.08	[0.055-0.113] unit decrease	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
8	32416274	rs7825175	G	A	rs7825175	23408906	3.00E-09	TSH	0.07	[0.044-0.088] unit decrease	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
8	125204721	rs4531036	G	C	rs4531036	20826269	2.60E-06	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
8	125206503	rs4242363	T	C	rs4242363	20826269	3.20E-06	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
9	4267209	rs1571583	A	G	rs1571583	23408906	1.00E-06	TSH - Males	0.07	[0.045-0.103] unit increase	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
9	4267209	rs1571583	A	G	rs1571583	23408906	3.00E-08	TSH	0.06	[0.037-0.077] unit increase	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
9	100591463	rs7045138	C	T	rs7045138	23408906	2.00E-11	FT4	0.1	[0.069-0.127] unit increase	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
9	100591463	rs7045138	C	T	rs7045138	23408906	3.00E-06	FT4-Females	0.09	[0.054-0.132] unit increase	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
9	100591463	rs7045138	C	T	rs7045138	23408906	5.00E-07	FT4-Males	0.11	[0.064-0.146] unit increase	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
9	136139265	rs657152	C	A	rs657152	23408906	1.00E-06	TSH - Males	0.07	[0.04-0.094] unit increase	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
9	136139265	rs657152	C	A	rs657152	23408906	4.00E-10	TSH	0.06	[0.04-0.076] unit increase	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
9	139089679	rs7860634	G	A	rs7860634	23408906	2.00E-08	FT4-Males	0.11	[0.071-0.145] unit increase	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
9	139089679	rs7860634	G	A	rs7860634	23408906	2.00E-14	FT4	0.1	[0.077-0.127] unit increase	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
9	139089679	rs7860634	G	A	rs7860634	23408906	5.00E-08	FT4-Females	0.1	[0.063-0.133] unit increase	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
11	39031793	rs7951105	T	G	rs7951105	24722205	5.00E-07	NA	0.16	[0.098-0.224] ng/dl decrease	2,789 Korean ancestry individuals	Korean(2789)	ALL(2789)	ASN(2789)	ALL(2789)	Free thyroxine concentration	HPOID:0000820	Abnormality of the thyroid gland	DOID:50	thyroid gland disease	NA	NA	NA	NA	Thyroid gland disease	rs7951105-T	Research Support, Non-U.S. Gov't	T	NA
11	45227567	rs17723470	C	T	rs17723470	23408906	3.00E-07	TSH - Females	0.07	[0.044-0.094] unit decrease	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
11	45227567	rs17723470	C	T	rs17723470	23408906	9.00E-11	TSH	0.07	[0.045-0.085] unit decrease	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
12	69470327	rs10878908	G	A	rs10878908	20826269	1.20E-06	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
12	69478038	rs1908679	G	C	rs1908679	20826269	8.00E-07	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
14	36574018	rs1537424	C	T	rs1537424	23408906	1.00E-08	TSH	0.05	[0.034-0.07] unit decrease	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
14	93595591	rs11624776	A	C	rs11624776	23408906	2.00E-09	TSH	0.06	[0.042-0.086] unit decrease	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
14	93595591	rs11624776	A	C	rs11624776	23408906	3.00E-06	TSH - Males	0.07	[0.04-0.098] unit decrease	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
15	49746364	rs10519227	T	A	rs10519227	23408906	1.00E-11	TSH	0.07	[0.05-0.094] unit decrease	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
15	49746364	rs10519227	T	A	rs10519227	23408906	6.00E-10	TSH - Males	0.1	[0.066-0.124] unit decrease	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
15	89119104	rs17776563	G	A	rs17776563	23408906	3.00E-10	TSH	0.06	[0.04-0.08] unit decrease	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
15	89119104	rs17776563	G	A	rs17776563	23408906	6.00E-07	TSH - Males	0.07	[0.042-0.096] unit decrease	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
16	55604128	rs6499766	A	T	rs6499766	23408906	1.00E-06	FT4	0.06	[0.032-0.08] unit increase	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
16	55604128	rs6499766	A	T	rs6499766	23408906	5.00E-08	FT4-Males	0.1	[0.064-0.134] unit increase	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
16	79749353	rs3813582	T	C	rs3813582	22494929	6.00E-10	NA	0.07	[0.046-0.090] unit increase	3,736 European ancestry individuals	European(3736)	ALL(3736)	EUR(3736)	ALL(3736)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	rs3813582-T	Meta-Analysis	Research Support, Non-U.S. Gov't	T
16	79749353	rs3813582	T	C	rs3813582	23408906	6.00E-17	TSH - Males	0.12	[0.088-0.142] unit increase	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
16	79749353	rs3813582	T	C	rs3813582	23408906	8.00E-18	TSH	0.08	[0.062-0.102] unit increase	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
16	79756197	rs4334315	A	T	rs4334315	22494929	6.65E-08	NA	NA	NA	3,736 European ancestry individuals	European(3736)	ALL(3736)	EUR(3736)	ALL(3736)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	A
17	70127536	rs9915657	T	C	rs9915657	23408906	1.00E-07	TSH - Females	0.06	[0.039-0.087] unit decrease	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
17	70127536	rs9915657	T	C	rs9915657	23408906	2.00E-07	TSH - Males	0.07	[0.043-0.093] unit decrease	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
17	70127536	rs9915657	T	C	rs9915657	23408906	8.00E-13	TSH	0.06	[0.046-0.082] unit decrease	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
18	71167752	rs7240777	G	A	rs7240777	23408906	3.00E-08	FT4-Females	0.08	[0.054-0.112] unit decrease	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
19	7223848	rs4804416	T	G	rs4804416	23408906	2.00E-06	TSH - Females	0.06	[0.034-0.082] unit decrease	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
19	7223848	rs4804416	T	G	rs4804416	23408906	3.00E-10	TSH	0.06	[0.039-0.075] unit decrease	up to 12,289 European ancestry females; up to 9,019 European ancestry males; up to 433 Old Order Amish females; up to 592 Old Order Amish males; 2,170 Sardinian females; 1,917 Sardinian males	Sardinian(4087)	European(21308)	Amish(1025)	ALL(26420)	EUR(26420)	ALL(26420)	Thyroid hormone levels	HPOID:0000820	Abnormality of the thyroid gland	DOID:1459	DOID:7998	hypothyroidism	hyperthyroidism	D013963	Thyroid Hormones	EFOID:0004748	thyroxine measurement	Hypothyroidism
20	40994094	rs6030171	T	C	rs6030171	20826269	1.90E-06	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
22	44774700	rs7285004	T	C	rs7285004	20826269	4.80E-06	NA	NA	NA	2,014 UK twins	UK(2014)	ALL(2014)	EUR(2014)	ALL(2014)	Thyroid function	HPOID:0000820	Abnormality of the thyroid gland	DOID:8433	thyroid malformation	D013959	Thyroid Diseases	EFOID:0004296	thyroid function	Thyroid gland disease	NA	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:2)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0040128	levonorgestrel	D016912	797-63-7	thyroid diseases	MESH:D013959	marker/mechanism	21705715
C0040128	propylthiouracil	D011441	51-52-5	thyroid diseases	MESH:D013959	marker/mechanism	21800831

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)