PedAM

Pediatric Disease Annotations & Medicines


	thyroid cancer

Disease ID	1047
Disease	thyroid cancer
Definition	A primary or metastatic malignant neoplasm affecting the thyroid gland.
Synonym	#NAME? cancer of the thyroid cancer of thyroid malign neopl thyroid malignant neoplasm of the thyroid malignant neoplasm of the thyroid gland malignant neoplasm of thyroid malignant neoplasm of thyroid gland malignant neoplasm thyroid malignant thyroid gland neoplasm malignant thyroid gland tumor malignant thyroid neoplasm malignant thyroid tumor malignant tumor of the thyroid malignant tumor of the thyroid gland malignant tumor of thyroid malignant tumor of thyroid gland malignant tumor of thyroid gland (disorder) malignant tumour of thyroid gland malignant tumour of thyroid gland (disorder) thyroid ca thyroid cancers thyroid gland cancer thyroid neoplasm malignant
DOID	DOID:1781
ICD10	ICD10CM:C73
UMLS	C0007115
SNOMED-CT	SNOMEDCT_US_2016_09_01:363478007
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:109) C0040137 \| thyroid nodule \| 15 C0040147 \| thyroiditis \| 15 C0040137 \| thyroid nodules \| 14 C0018023 \| nodular goiter \| 10 C0006142 \| breast cancer \| 10 C0018213 \| graves' disease \| 10 C0028754 \| obesity \| 9 C0686619 \| lymph node metastases \| 9 C0011847 \| diabetes \| 8 C0677607 \| hashimoto's thyroiditis \| 7 C0020550 \| hyperthyroidism \| 6 C0018021 \| goiter \| 6 C0549473 \| thyroid carcinoma \| 5 C0007115 \| thyroid ca \| 5 C0040128 \| thyroid disease \| 5 C0342208 \| multinodular goiter \| 5 C0020676 \| hypothyroidism \| 4 C0153676 \| lung metastases \| 4 C0153676 \| pulmonary metastases \| 4 C0011860 \| type 2 diabetes \| 3 C0677607 \| hashimoto thyroiditis \| 3 C0011849 \| diabetes mellitus \| 3 C0494165 \| liver metastases \| 3 C0032580 \| familial adenomatous polyposis \| 3 C0020502 \| hyperparathyroidism \| 3 C0040156 \| thyrotoxicosis \| 3 C0001206 \| acromegaly \| 3 C0007133 \| papillary carcinoma \| 3 C0032580 \| adenomatous polyposis \| 3 C0153676 \| lung metastasis \| 3 C0221002 \| primary hyperparathyroidism \| 3 C0238463 \| papillary thyroid cancer \| 3 C0153676 \| pulmonary metastasis \| 2 C0002170 \| alopecia \| 2 C0018023 \| nodular goiters \| 2 C0677607 \| lymphocytic thyroiditis \| 2 C0011860 \| type 2 diabetes mellitus \| 2 C0677607 \| hashimoto's disease \| 2 C0206682 \| follicular thyroid carcinoma \| 2 C0018553 \| cowden syndrome \| 2 C0025202 \| melanoma \| 2 C0025202 \| malignant melanoma \| 2 C0024141 \| systemic lupus erythematosus \| 2 C0677607 \| chronic lymphocytic thyroiditis \| 2 C0334440 \| giant congenital nevus \| 1 C0020626 \| hypoparathyroidism \| 1 C0019158 \| hepatitis \| 1 C0018213 \| grave's disease \| 1 C0018021 \| goiters \| 1 C0019196 \| hepatitis c \| 1 C0019829 \| hodgkin lymphoma \| 1 C0011633 \| dermatomyositis \| 1 C0002171 \| alopecia areata \| 1 C0043119 \| werner syndrome \| 1 C0279702 \| clear cell renal carcinoma \| 1 C0025268 \| men 2a \| 1 C0035078 \| renal failure \| 1 C0028754 \| adiposity \| 1 C0018024 \| substernal goiter \| 1 C0745140 \| hyperthyroid \| 1 C0002726 \| amyloidosis \| 1 C0740457 \| kidney cancer \| 1 C0221777 \| non-toxic goiter \| 1 C0238033 \| male breast cancer \| 1 C0024523 \| malabsorption \| 1 C0151779 \| cutaneous malignant melanoma \| 1 C0238461 \| anaplastic thyroid carcinoma \| 1 C0007570 \| celiac disease \| 1 C0280131 \| ovarian teratoma \| 1 C0024299 \| lymphoma \| 1 C0235250 \| hyperemesis \| 1 C0009402 \| colorectal cancer \| 1 C0238462 \| medullary thyroid carcinoma \| 1 C0376358 \| prostate cancer \| 1 C0042373 \| vascular diseases \| 1 C0020676 \| hypothyroid \| 1 C0007134 \| renal carcinoma \| 1 C0085253 \| adult onset still's disease \| 1 C0342127 \| plummer's disease \| 1 C0040583 \| tracheal stenosis \| 1 C0334121 \| inflammatory pseudotumor \| 1 C0031046 \| pericarditis \| 1 C0018801 \| cardiac failure \| 1 C0342127 \| toxic nodular goiter \| 1 C0042373 \| vascular disease \| 1 C0398623 \| hypercoagulability \| 1 C0024305 \| non-hodgkin lymphoma \| 1 C0007104 \| carcinoma of the breast \| 1 C0029927 \| ovarian cysts \| 1 C0342199 \| iodine deficiency \| 1 C0238462 \| medullary thyroid cancer \| 1 C0027662 \| multiple endocrine neoplasia \| 1 C0018021 \| struma \| 1 C0154143 \| toxic multinodular goiter \| 1 C0039730 \| thalassemia \| 1 C0029927 \| ovarian cyst \| 1 C0003467 \| anxiety \| 1 C0007113 \| rectal cancer \| 1 C0242379 \| lung cancer \| 1 C0494165 \| liver metastasis \| 1 C0920350 \| autoimmune thyroiditis \| 1 C0854178 \| adrenal metastases \| 1 C0018916 \| hemangioma \| 1 C0206682 \| follicular thyroid cancer \| 1 C0037317 \| sleep disturbance \| 1 C0040034 \| thrombocytopenia \| 1 C0020635 \| pituitary insufficiency \| 1 C0153677 \| mediastinal metastasis \| 1 C0020538 \| hypertension \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:120) 43 \| ACHE \| infer 268 \| AMH \| infer 405 \| ARNT \| infer 409 \| ARRB2 \| infer 572 \| BAD \| infer 673 \| BRAF \| infer 8030 \| CCDC6 \| infer 6352 \| CCL5 \| infer 9425 \| CDYL \| infer 1081 \| CGA \| infer 1437 \| CSF2 \| infer 55790 \| CSGALNACT1 \| infer 115908 \| CTHRC1 \| infer 7852 \| CXCR4 \| infer 1543 \| CYP1A1 \| infer 1733 \| DIO1 \| infer 53905 \| DUOX1 \| infer 2033 \| EP300 \| infer 2068 \| ERCC2 \| infer 355 \| FAS \| infer 356 \| FASLG \| infer 2260 \| FGFR1 \| infer 2264 \| FGFR4 \| infer 2335 \| FN1 \| infer 2304 \| FOXE1 \| infer 2674 \| GFRA1 \| infer 2675 \| GFRA2 \| infer 2676 \| GFRA3 \| infer 2690 \| GHR \| infer 2944 \| GSTM1 \| infer 9446 \| GSTO1 \| infer 2950 \| GSTP1 \| infer 2952 \| GSTT1 \| infer 3117 \| HLA-DQA1 \| infer 3119 \| HLA-DQB1 \| infer 3123 \| HLA-DRB1 \| infer 3265 \| HRAS \| infer 3284 \| HSD3B2 \| infer 3454 \| IFNAR1 \| infer 3484 \| IGFBP1 \| infer 3551 \| IKBKB \| infer 3562 \| IL3 \| infer 133396 \| IL31RA \| infer 3563 \| IL3RA \| infer 3572 \| IL6ST \| infer 3667 \| IRS1 \| infer 3672 \| ITGA1 \| infer 3675 \| ITGA3 \| infer 3689 \| ITGB2 \| infer 3708 \| ITPR1 \| infer 3710 \| ITPR3 \| infer 3716 \| JAK1 \| infer 3717 \| JAK2 \| infer 30818 \| KCNIP3 \| infer 3815 \| KIT \| infer 3956 \| LGALS1 \| infer 3958 \| LGALS3 \| infer 3959 \| LGALS3BP \| infer 7786 \| MAP3K12 \| infer 5594 \| MAPK1 \| infer 4147 \| MATN2 \| infer 9969 \| MED13 \| infer 4292 \| MLH1 \| infer 4316 \| MMP7 \| infer 4437 \| MSH3 \| infer 4609 \| MYC \| infer 8031 \| NCOA4 \| infer 9612 \| NCOR2 \| infer 7080 \| NKX2-1 \| infer 4914 \| NTRK1 \| infer 7849 \| PAX8 \| infer 5290 \| PIK3CA \| infer 22925 \| PLA2R1 \| infer 5327 \| PLAT \| infer 5328 \| PLAU \| infer 5395 \| PMS2 \| infer 5468 \| PPARG \| infer 5573 \| PRKAR1A \| infer 5727 \| PTCH1 \| infer 5745 \| PTH1R \| infer 5744 \| PTHLH \| infer 5795 \| PTPRJ \| infer 5894 \| RAF1 \| infer 5979 \| RET \| infer 391 \| RHOG \| infer 10313 \| RTN3 \| infer 6281 \| S100A10 \| infer 6390 \| SDHB \| infer 6391 \| SDHC \| infer 6392 \| SDHD \| infer 6400 \| SEL1L \| infer 6469 \| SHH \| infer 6478 \| SIAH2 \| infer 5172 \| SLC26A4 \| infer 160728 \| SLC5A8 \| infer 4089 \| SMAD4 \| infer 4092 \| SMAD7 \| infer 6608 \| SMO \| infer 399979 \| SNX19 \| infer 6714 \| SRC \| infer 6773 \| STAT2 \| infer 6774 \| STAT3 \| infer 9263 \| STK17A \| infer 9262 \| STK17B \| infer 6938 \| TCF12 \| infer 7038 \| TG \| infer 63892 \| THADA \| infer 7067 \| THRA \| infer 4982 \| TNFRSF11B \| infer 7173 \| TPO \| infer 9321 \| TRIP11 \| infer 9320 \| TRIP12 \| infer 7252 \| TSHB \| infer 7253 \| TSHR \| infer 7297 \| TYK2 \| infer 7350 \| UCP1 \| infer 7448 \| VTN \| infer 7450 \| VWF \| infer 7490 \| WT1 \| infer 7515 \| XRCC1 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:652) 100885775 \| BANCR \| DISEASES 92070 \| CTBP1-AS2 \| DISEASES 3675 \| ITGA3 \| DISEASES 4830 \| NME1 \| DISEASES 6591 \| SNAI2 \| DISEASES 1015 \| CDH17 \| DISEASES 6515 \| SLC2A3 \| DISEASES 9950 \| GOLGA5 \| DISEASES 54474 \| KRT20 \| DISEASES 23609 \| MKRN2 \| DISEASES 7145 \| TNS1 \| DISEASES 771 \| CA12 \| DISEASES 2191 \| FAP \| DISEASES 4680 \| CEACAM6 \| DISEASES 28954 \| REM1 \| DISEASES 2802 \| GOLGA3 \| DISEASES 2099 \| ESR1 \| DISEASES 151887 \| CCDC80 \| DISEASES 23411 \| SIRT1 \| DISEASES 4320 \| MMP11 \| DISEASES 25776 \| CBY1 \| DISEASES 4174 \| MCM5 \| DISEASES 5836 \| PYGL \| DISEASES 1113 \| CHGA \| DISEASES 1591 \| CYP24A1 \| DISEASES 7076 \| TIMP1 \| DISEASES 2862 \| MLNR \| DISEASES 4313 \| MMP2 \| DISEASES 7038 \| TG \| DISEASES 8857 \| FCGBP \| DISEASES 7040 \| TGFB1 \| DISEASES 1089 \| CEACAM4 \| DISEASES 1048 \| CEACAM5 \| DISEASES 6528 \| SLC5A5 \| DISEASES 3082 \| HGF \| DISEASES 6198 \| RPS6KB1 \| DISEASES 708 \| C1QBP \| DISEASES 9144 \| SYNGR2 \| DISEASES 51225 \| ABI3 \| DISEASES 173 \| AFM \| DISEASES 3558 \| IL2 \| DISEASES 595 \| CCND1 \| DISEASES 5829 \| PXN \| DISEASES 2735 \| GLI1 \| DISEASES 1027 \| CDKN1B \| DISEASES 3458 \| IFNG \| DISEASES 2597 \| GAPDH \| DISEASES 2026 \| ENO2 \| DISEASES 9896 \| FIG4 \| DISEASES 1611 \| DAP \| DISEASES 1839 \| HBEGF \| DISEASES 3565 \| IL4 \| DISEASES 4292 \| MLH1 \| DISEASES 9168 \| TMSB10 \| DISEASES 4436 \| MSH2 \| DISEASES 5534 \| PPP3R1 \| DISEASES 84634 \| KISS1R \| DISEASES 4317 \| MMP8 \| DISEASES 134637 \| ADAT2 \| DISEASES 9429 \| ABCG2 \| DISEASES 84417 \| C2orf40 \| DISEASES 8405 \| SPOP \| DISEASES 10342 \| TFG \| DISEASES 8743 \| TNFSF10 \| DISEASES 2322 \| FLT3 \| DISEASES 7291 \| TWIST1 \| DISEASES 6615 \| SNAI1 \| DISEASES 5184 \| PEPD \| DISEASES 26268 \| FBXO9 \| DISEASES 696 \| BTN1A1 \| DISEASES 1026 \| CDKN1A \| DISEASES 1948 \| EFNB2 \| DISEASES 5623 \| PSPN \| DISEASES 148022 \| TICAM1 \| DISEASES 2952 \| GSTT1 \| DISEASES 3976 \| LIF \| DISEASES 22933 \| SIRT2 \| DISEASES 968 \| CD68 \| DISEASES 3169 \| FOXA1 \| DISEASES 83855 \| KLF16 \| DISEASES 3630 \| INS \| DISEASES 5894 \| RAF1 \| DISEASES 60625 \| DHX35 \| DISEASES 8735 \| MYH13 \| DISEASES 25796 \| PGLS \| DISEASES 51690 \| LSM7 \| DISEASES 9518 \| GDF15 \| DISEASES 55422 \| ZNF331 \| DISEASES 9476 \| NAPSA \| DISEASES 3958 \| LGALS3 \| DISEASES 6754 \| SSTR4 \| DISEASES 1455 \| CSNK1G2 \| DISEASES 23608 \| MKRN1 \| DISEASES 4922 \| NTS \| DISEASES 3845 \| KRAS \| DISEASES 78986 \| DUSP26 \| DISEASES 891 \| CCNB1 \| DISEASES 10752 \| CHL1 \| DISEASES 7252 \| TSHB \| DISEASES 2922 \| GRP \| DISEASES 2346 \| FOLH1 \| DISEASES 5156 \| PDGFRA \| DISEASES 11095 \| ADAMTS8 \| DISEASES 301 \| ANXA1 \| DISEASES 65080 \| MRPL44 \| DISEASES 55619 \| DOCK10 \| DISEASES 55654 \| TMEM127 \| DISEASES 3569 \| IL6 \| DISEASES 3364 \| HUS1 \| DISEASES 9568 \| GABBR2 \| DISEASES 55363 \| HEMGN \| DISEASES 29113 \| C6orf15 \| DISEASES 5460 \| POU5F1 \| DISEASES 64066 \| MMP27 \| DISEASES 7057 \| THBS1 \| DISEASES 3417 \| IDH1 \| DISEASES 894 \| CCND2 \| DISEASES 64097 \| EPB41L4A \| DISEASES 23326 \| USP22 \| DISEASES 999 \| CDH1 \| DISEASES 384 \| ARG2 \| DISEASES 5159 \| PDGFRB \| DISEASES 2324 \| FLT4 \| DISEASES 4087 \| SMAD2 \| DISEASES 81671 \| VMP1 \| DISEASES 8312 \| AXIN1 \| DISEASES 29855 \| UBN1 \| DISEASES 5126 \| PCSK2 \| DISEASES 1031 \| CDKN2C \| DISEASES 7077 \| TIMP2 \| DISEASES 25939 \| SAMHD1 \| DISEASES 7515 \| XRCC1 \| DISEASES 8455 \| ATRN \| DISEASES 5595 \| MAPK3 \| DISEASES 8030 \| CCDC6 \| DISEASES 6855 \| SYP \| DISEASES 2033 \| EP300 \| DISEASES 3553 \| IL1B \| DISEASES 55717 \| WDR11 \| DISEASES 29842 \| TFCP2L1 \| DISEASES 4072 \| EPCAM \| DISEASES 10000 \| AKT3 \| DISEASES 6801 \| STRN \| DISEASES 3791 \| KDR \| DISEASES 5290 \| PIK3CA \| DISEASES 25791 \| NGEF \| DISEASES 832 \| CAPZB \| DISEASES 2247 \| FGF2 \| DISEASES 7067 \| THRA \| DISEASES 6774 \| STAT3 \| DISEASES 5443 \| POMC \| DISEASES 3797 \| KIF3C \| DISEASES 6389 \| SDHA \| DISEASES 1004 \| CDH6 \| DISEASES 1950 \| EGF \| DISEASES 5172 \| SLC26A4 \| DISEASES 11033 \| ADAP1 \| DISEASES 26297 \| SERGEF \| DISEASES 7078 \| TIMP3 \| DISEASES 23598 \| PATZ1 \| DISEASES 283358 \| B4GALNT3 \| DISEASES 429 \| ASCL1 \| DISEASES 1017 \| CDK2 \| DISEASES 2065 \| ERBB3 \| DISEASES 6751 \| SSTR1 \| DISEASES 26277 \| TINF2 \| DISEASES 3480 \| IGF1R \| DISEASES 8826 \| IQGAP1 \| DISEASES 81631 \| MAP1LC3B \| DISEASES 2622 \| GAS8 \| DISEASES 28987 \| NOB1 \| DISEASES 85464 \| SSH2 \| DISEASES 4355 \| MPP2 \| DISEASES 1000 \| CDH2 \| DISEASES 7157 \| TP53 \| DISEASES 2064 \| ERBB2 \| DISEASES 207 \| AKT1 \| DISEASES 10469 \| TIMM44 \| DISEASES 6282 \| S100A11 \| DISEASES 388 \| RHOB \| DISEASES 64969 \| MRPS5 \| DISEASES 6502 \| SKP2 \| DISEASES 9180 \| OSMR \| DISEASES 5295 \| PIK3R1 \| DISEASES 2561 \| GABRB2 \| DISEASES 2676 \| GFRA3 \| DISEASES 1956 \| EGFR \| DISEASES 6567 \| SLC16A2 \| DISEASES 1392 \| CRH \| DISEASES 7013 \| TERF1 \| DISEASES 1030 \| CDKN2B \| DISEASES 4851 \| NOTCH1 \| DISEASES 3026 \| HABP2 \| DISEASES 23052 \| ENDOD1 \| DISEASES 472 \| ATM \| DISEASES 10205 \| MPZL2 \| DISEASES 1848 \| DUSP6 \| DISEASES 27250 \| PDCD4 \| DISEASES 7424 \| VEGFC \| DISEASES 11098 \| PRSS23 \| DISEASES 4613 \| MYCN \| DISEASES 2059 \| EPS8 \| DISEASES 5741 \| PTH \| DISEASES 2321 \| FLT1 \| DISEASES 10413 \| YAP1 \| DISEASES 3087 \| HHEX \| DISEASES 22934 \| RPIA \| DISEASES 55364 \| IMPACT \| DISEASES 8470 \| SORBS2 \| DISEASES 54149 \| C21orf91 \| DISEASES 760 \| CA2 \| DISEASES 53938 \| PPIL3 \| DISEASES 6750 \| SST \| DISEASES 5468 \| PPARG \| DISEASES 3815 \| KIT \| DISEASES 673 \| BRAF \| DISEASES 5291 \| PIK3CB \| DISEASES 5909 \| RAP1GAP \| DISEASES 6781 \| STC1 \| DISEASES 11054 \| OGFR \| DISEASES 539 \| ATP5O \| DISEASES 8209 \| C21orf33 \| DISEASES 3101 \| HK3 \| DISEASES 3856 \| KRT8 \| DISEASES 10197 \| PSME3 \| DISEASES 6755 \| SSTR5 \| DISEASES 10630 \| PDPN \| DISEASES 51072 \| MEMO1 \| DISEASES 27306 \| HPGDS \| DISEASES 7039 \| TGFA \| DISEASES 151556 \| GPR155 \| DISEASES 886 \| CCKAR \| DISEASES 3577 \| CXCR1 \| DISEASES 3549 \| IHH \| DISEASES 213 \| ALB \| DISEASES 6259 \| RYK \| DISEASES 7047 \| TGM4 \| DISEASES 308 \| ANXA5 \| DISEASES 3248 \| HPGD \| DISEASES 6059 \| ABCE1 \| DISEASES 55751 \| TMEM184C \| DISEASES 1437 \| CSF2 \| DISEASES 6469 \| SHH \| DISEASES 81034 \| SLC25A32 \| DISEASES 115825 \| WDFY2 \| DISEASES 7253 \| TSHR \| DISEASES 7570 \| ZNF22 \| DISEASES 6621 \| SNAPC4 \| DISEASES 57447 \| NDRG2 \| DISEASES 53981 \| CPSF2 \| DISEASES 60686 \| C14orf93 \| DISEASES 9071 \| CLDN10 \| DISEASES 3611 \| ILK \| DISEASES 1014 \| CDH16 \| DISEASES 5347 \| PLK1 \| DISEASES 762 \| CA4 \| DISEASES 29123 \| ANKRD11 \| DISEASES 558 \| AXL \| DISEASES 7001 \| PRDX2 \| DISEASES 23524 \| SRRM2 \| DISEASES 54949 \| SDHAF2 \| DISEASES 9081 \| PRY \| DISEASES 5604 \| MAP2K1 \| DISEASES 598 \| BCL2L1 \| DISEASES 8796 \| SCEL \| DISEASES 8313 \| AXIN2 \| DISEASES 4902 \| NRTN \| DISEASES 3479 \| IGF1 \| DISEASES 6795 \| AURKC \| DISEASES 3308 \| HSPA4 \| DISEASES 84632 \| AFAP1L2 \| DISEASES 442862 \| PRY2 \| DISEASES 7200 \| TRH \| DISEASES 442866 \| PRYP4 \| DISEASES 7857 \| SCG2 \| DISEASES 171558 \| PTCRA \| DISEASES 260425 \| MAGI3 \| DISEASES 5093 \| PCBP1 \| DISEASES 3627 \| CXCL10 \| DISEASES 84376 \| HOOK3 \| DISEASES 5066 \| PAM \| DISEASES 2353 \| FOS \| DISEASES 84309 \| NUDT16L1 \| DISEASES 9451 \| EIF2AK3 \| DISEASES 113189 \| CHST14 \| DISEASES 9902 \| MRC2 \| DISEASES 9925 \| ZBTB5 \| DISEASES 54205 \| CYCS \| DISEASES 27087 \| B3GAT1 \| DISEASES 10885 \| WDR3 \| DISEASES 4323 \| MMP14 \| DISEASES 197259 \| MLKL \| DISEASES 8637 \| EIF4EBP3 \| DISEASES 170261 \| ZCCHC12 \| DISEASES 7015 \| TERT \| DISEASES 7201 \| TRHR \| DISEASES 3265 \| HRAS \| DISEASES 947 \| CD34 \| DISEASES 8567 \| MADD \| DISEASES 836 \| CASP3 \| DISEASES 2944 \| GSTM1 \| DISEASES 10007 \| GNPDA1 \| DISEASES 54961 \| SSH3 \| DISEASES 8837 \| CFLAR \| DISEASES 3952 \| LEP \| DISEASES 245928 \| DEFB114 \| DISEASES 55885 \| LMO3 \| DISEASES 3172 \| HNF4A \| DISEASES 63967 \| CLSPN \| DISEASES 3184 \| HNRNPD \| DISEASES 285 \| ANGPT2 \| DISEASES 10240 \| MRPS31 \| DISEASES 51025 \| PAM16 \| DISEASES 8560 \| DEGS1 \| DISEASES 8904 \| CPNE1 \| DISEASES 4233 \| MET \| DISEASES 53905 \| DUOX1 \| DISEASES 4684 \| NCAM1 \| DISEASES 7173 \| TPO \| DISEASES 79317 \| OR4K5 \| DISEASES 405753 \| DUOXA2 \| DISEASES 56892 \| C8orf4 \| DISEASES 9120 \| SLC16A6 \| DISEASES 8834 \| TMEM11 \| DISEASES 2146 \| EZH2 \| DISEASES 5315 \| PKM \| DISEASES 114876 \| OSBPL1A \| DISEASES 53829 \| P2RY13 \| DISEASES 27436 \| EML4 \| DISEASES 6863 \| TAC1 \| DISEASES 3039 \| HBA1 \| DISEASES 4312 \| MMP1 \| DISEASES 2274 \| FHL2 \| DISEASES 6657 \| SOX2 \| DISEASES 5241 \| PGR \| DISEASES 9110 \| MTMR4 \| DISEASES 3590 \| IL11RA \| DISEASES 7675 \| ZNF121 \| DISEASES 5108 \| PCM1 \| DISEASES 10473 \| HMGN4 \| DISEASES 754 \| PTTG1IP \| DISEASES 114786 \| XKR4 \| DISEASES 66008 \| TRAK2 \| DISEASES 3855 \| KRT7 \| DISEASES 8651 \| SOCS1 \| DISEASES 6753 \| SSTR3 \| DISEASES 9121 \| SLC16A5 \| DISEASES 842 \| CASP9 \| DISEASES 5155 \| PDGFB \| DISEASES 2520 \| GAST \| DISEASES 796 \| CALCA \| DISEASES 25840 \| METTL7A \| DISEASES 2621 \| GAS6 \| DISEASES 3418 \| IDH2 \| DISEASES 5915 \| RARB \| DISEASES 5727 \| PTCH1 \| DISEASES 4088 \| SMAD3 \| DISEASES 682 \| BSG \| DISEASES 3320 \| HSP90AA1 \| DISEASES 157567 \| ANKRD46 \| DISEASES 7568 \| ZNF20 \| DISEASES 887 \| CCKBR \| DISEASES 885 \| CCK \| DISEASES 27090 \| ST6GALNAC4 \| DISEASES 9547 \| CXCL14 \| DISEASES 4221 \| MEN1 \| DISEASES 29015 \| SLC43A3 \| DISEASES 7095 \| SEC62 \| DISEASES 23583 \| SMUG1 \| DISEASES 2885 \| GRB2 \| DISEASES 857 \| CAV1 \| DISEASES 728621 \| CCDC30 \| DISEASES 5329 \| PLAUR \| DISEASES 2309 \| FOXO3 \| DISEASES 10524 \| KAT5 \| DISEASES 8805 \| TRIM24 \| DISEASES 1978 \| EIF4EBP1 \| DISEASES 122809 \| SOCS4 \| DISEASES 4089 \| SMAD4 \| DISEASES 29087 \| THYN1 \| DISEASES 1508 \| CTSB \| DISEASES 2272 \| FHIT \| DISEASES 442865 \| PRYP3 \| DISEASES 921 \| CD5 \| DISEASES 7517 \| XRCC3 \| DISEASES 864 \| RUNX3 \| DISEASES 23405 \| DICER1 \| DISEASES 2100 \| ESR2 \| DISEASES 5170 \| PDPK1 \| DISEASES 1499 \| CTNNB1 \| DISEASES 5757 \| PTMA \| DISEASES 4771 \| NF2 \| DISEASES 6284 \| S100A13 \| DISEASES 25797 \| QPCT \| DISEASES 9232 \| PTTG1 \| DISEASES 3767 \| KCNJ11 \| DISEASES 10168 \| ZNF197 \| DISEASES 797 \| CALCB \| DISEASES 302 \| ANXA2 \| DISEASES 6861 \| SYT5 \| DISEASES 6275 \| S100A4 \| DISEASES 2335 \| FN1 \| DISEASES 7080 \| NKX2-1 \| DISEASES 57522 \| SRGAP1 \| DISEASES 55750 \| AGK \| DISEASES 331 \| XIAP \| DISEASES 5979 \| RET \| DISEASES 355 \| FAS \| DISEASES 89122 \| TRIM4 \| DISEASES 122786 \| FRMD6 \| DISEASES 10142 \| AKAP9 \| DISEASES 137902 \| PXDNL \| DISEASES 7068 \| THRB \| DISEASES 11065 \| UBE2C \| DISEASES 441478 \| NRARP \| DISEASES 11186 \| RASSF1 \| DISEASES 60 \| ACTB \| DISEASES 6752 \| SSTR2 \| DISEASES 10987 \| COPS5 \| DISEASES 1612 \| DAPK1 \| DISEASES 744 \| MPPED2 \| DISEASES 6714 \| SRC \| DISEASES 4763 \| NF1 \| DISEASES 841 \| CASP8 \| DISEASES 389658 \| FAM150A \| DISEASES 5573 \| PRKAR1A \| DISEASES 54815 \| GATAD2A \| DISEASES 2526 \| FUT4 \| DISEASES 9332 \| CD163 \| DISEASES 7516 \| XRCC2 \| DISEASES 4192 \| MDK \| DISEASES 6258 \| RXRG \| DISEASES 93034 \| NT5C1B \| DISEASES 79016 \| DDA1 \| DISEASES 4478 \| MSN \| DISEASES 5599 \| MAPK8 \| DISEASES 8828 \| NRP2 \| DISEASES 4311 \| MME \| DISEASES 1803 \| DPP4 \| DISEASES 6536 \| SLC6A9 \| DISEASES 2993 \| GYPA \| DISEASES 23085 \| ERC1 \| DISEASES 4916 \| NTRK3 \| DISEASES 10367 \| MICU1 \| DISEASES 6935 \| ZEB1 \| DISEASES 2475 \| MTOR \| DISEASES 1733 \| DIO1 \| DISEASES 3880 \| KRT19 \| DISEASES 7052 \| TGM2 \| DISEASES 54737 \| MPHOSPH8 \| DISEASES 9804 \| TOMM20 \| DISEASES 142 \| PARP1 \| DISEASES 5208 \| PFKFB2 \| DISEASES 26034 \| IPCEF1 \| DISEASES 26254 \| OPTC \| DISEASES 7432 \| VIP \| DISEASES 5788 \| PTPRC \| DISEASES 79577 \| CDC73 \| DISEASES 5743 \| PTGS2 \| DISEASES 116496 \| FAM129A \| DISEASES 9293 \| GPR52 \| DISEASES 356 \| FASLG \| DISEASES 6391 \| SDHC \| DISEASES 4720 \| NDUFS2 \| DISEASES 632 \| BGLAP \| DISEASES 4582 \| MUC1 \| DISEASES 7170 \| TPM3 \| DISEASES 253738 \| EBF3 \| DISEASES 26097 \| CHTOP \| DISEASES 6277 \| S100A6 \| DISEASES 284486 \| THEM5 \| DISEASES 262 \| AMD1 \| DISEASES 4170 \| MCL1 \| DISEASES 1893 \| ECM1 \| DISEASES 4803 \| NGF \| DISEASES 4893 \| NRAS \| DISEASES 7272 \| TTK \| DISEASES 4102 \| MAGEA3 \| DISEASES 255631 \| COL24A1 \| DISEASES 2778 \| GNAS \| DISEASES 1791 \| DNTT \| DISEASES 3725 \| JUN \| DISEASES 4070 \| TACSTD2 \| DISEASES 860 \| RUNX2 \| DISEASES 27158 \| NDOR1 \| DISEASES 112970 \| KTI12 \| DISEASES 1289 \| COL5A1 \| DISEASES 5728 \| PTEN \| DISEASES 79812 \| MMRN2 \| DISEASES 7422 \| VEGFA \| DISEASES 8643 \| PTCH2 \| DISEASES 4318 \| MMP9 \| DISEASES 5328 \| PLAU \| DISEASES 2740 \| GLP1R \| DISEASES 79009 \| DDX50 \| DISEASES 51441 \| YTHDF2 \| DISEASES 2517 \| FUCA1 \| DISEASES 3399 \| ID3 \| DISEASES 6257 \| RXRB \| DISEASES 367 \| AR \| DISEASES 58476 \| TP53INP2 \| DISEASES 2304 \| FOXE1 \| DISEASES 3014 \| H2AFX \| DISEASES 195828 \| ZNF367 \| DISEASES 6390 \| SDHB \| DISEASES 6392 \| SDHD \| DISEASES 3376 \| IARS \| DISEASES 1164 \| CKS2 \| DISEASES 23254 \| KAZN \| DISEASES 3397 \| ID1 \| DISEASES 50943 \| FOXP3 \| DISEASES 9249 \| DHRS3 \| DISEASES 220213 \| OTUD1 \| DISEASES 1910 \| EDNRB \| DISEASES 27131 \| SNX5 \| DISEASES 4609 \| MYC \| DISEASES 81688 \| C6orf62 \| DISEASES 768 \| CA9 \| DISEASES 1114 \| CHGB \| DISEASES 4897 \| NRCAM \| DISEASES 1964 \| EIF1AX \| DISEASES 1543 \| CYP1A1 \| DISEASES 283297 \| OR10A4 \| DISEASES 7010 \| TEK \| DISEASES 6462 \| SHBG \| DISEASES 6541 \| SLC7A1 \| DISEASES 2762 \| GMDS \| DISEASES 8110 \| DPF3 \| DISEASES 29126 \| CD274 \| DISEASES 2576 \| GAGE4 \| DISEASES 2543 \| GAGE1 \| DISEASES 2618 \| GART \| DISEASES 1497 \| CTNS \| DISEASES 10568 \| SLC34A2 \| DISEASES 83650 \| SLC35G5 \| DISEASES 11200 \| CHEK2 \| DISEASES 220164 \| DOK6 \| DISEASES 5268 \| SERPINB5 \| DISEASES 55680 \| RUFY2 \| DISEASES 2878 \| GPX3 \| DISEASES 3875 \| KRT18 \| DISEASES 238 \| ALK \| DISEASES 208 \| AKT2 \| DISEASES 284443 \| ZNF493 \| DISEASES 220988 \| HNRNPA3 \| DISEASES 3703 \| STT3A \| DISEASES 7187 \| TRAF3 \| DISEASES 145270 \| PRIMA1 \| DISEASES 4831 \| NME2 \| DISEASES 10018 \| BCL2L11 \| DISEASES 8301 \| PICALM \| DISEASES 6439 \| SFTPB \| DISEASES 2719 \| GPC3 \| DISEASES 4501 \| MT1X \| DISEASES 64400 \| AKTIP \| DISEASES 8697 \| CDC23 \| DISEASES 6696 \| SPP1 \| DISEASES 983 \| CDK1 \| DISEASES 9829 \| DNAJC6 \| DISEASES 6387 \| CXCL12 \| DISEASES 5744 \| PTHLH \| DISEASES 83989 \| FAM172A \| DISEASES 55293 \| UEVLD \| DISEASES 91452 \| ACBD5 \| DISEASES 2120 \| ETV6 \| DISEASES 144195 \| SLC2A14 \| DISEASES 6202 \| RPS8 \| DISEASES 116372 \| LYPD1 \| DISEASES 5609 \| MAP2K7 \| DISEASES 2950 \| GSTP1 \| DISEASES 10587 \| TXNRD2 \| DISEASES 8091 \| HMGA2 \| DISEASES 29951 \| PDZRN4 \| DISEASES 285016 \| FAM150B \| DISEASES 3098 \| HK1 \| DISEASES 6611 \| SMS \| DISEASES 63892 \| THADA \| DISEASES 2104 \| ESRRG \| DISEASES 7852 \| CXCR4 \| DISEASES 9048 \| ARTN \| DISEASES 2641 \| GCG \| DISEASES 1385 \| CREB1 \| DISEASES 91664 \| ZNF845 \| DISEASES 4435 \| CITED1 \| DISEASES 729582 \| DIRC3 \| DISEASES 6336 \| SCN10A \| DISEASES 4495 \| MT1G \| DISEASES 3481 \| IGF2 \| DISEASES 100144748 \| KLLN \| DISEASES 2260 \| FGFR1 \| DISEASES 2674 \| GFRA1 \| DISEASES 1029 \| CDKN2A \| DISEASES 8031 \| NCOA4 \| DISEASES 7849 \| PAX8 \| DISEASES 11105 \| PRDM7 \| DISEASES 64065 \| PERP \| DISEASES 757 \| TMEM50B \| DISEASES 83876 \| MRO \| DISEASES 960 \| CD44 \| DISEASES 7124 \| TNF \| DISEASES 51562 \| MBIP \| DISEASES 5795 \| PTPRJ \| DISEASES 6464 \| SHC1 \| DISEASES 2145 \| EZH1 \| DISEASES 55607 \| PPP1R9A \| DISEASES 10908 \| PNPLA6 \| DISEASES 2668 \| GDNF \| DISEASES 2263 \| FGFR2 \| DISEASES 114883 \| OSBPL9 \| DISEASES 283987 \| HID1 \| DISEASES 8842 \| PROM1 \| DISEASES 79921 \| TCEAL4 \| DISEASES 56649 \| TMPRSS4 \| DISEASES 6513 \| SLC2A1 \| DISEASES 4193 \| MDM2 \| DISEASES 84301 \| DDI2 \| DISEASES 672 \| BRCA1 \| DISEASES 846 \| CASR \| DISEASES 127933 \| UHMK1 \| DISEASES 6949 \| TCOF1 \| DISEASES 1977 \| EIF4E \| DISEASES 2675 \| GFRA2 \| DISEASES 90161 \| HS6ST2 \| DISEASES 7033 \| TFF3 \| DISEASES 4914 \| NTRK1 \| DISEASES 53373 \| TPCN1 \| DISEASES 7694 \| ZNF135 \| DISEASES 5027 \| P2RX7 \| DISEASES 84133 \| ZNRF3 \| DISEASES 3939 \| LDHA \| DISEASES 160728 \| SLC5A8 \| DISEASES 7421 \| VDR \| DISEASES 1649 \| DDIT3 \| DISEASES 8437 \| RASAL1 \| DISEASES 1734 \| DIO2 \| DISEASES 51741 \| WWOX \| DISEASES 9212 \| AURKB \| DISEASES 30837 \| SOCS7 \| DISEASES 147841 \| SPC24 \| DISEASES 100874054 \| FALEC \| DISEASES 284593 \| FAM41C \| DISEASES 104326057 \| GACAT1 \| DISEASES 104797537 \| GACAT3 \| DISEASES 750 \| GAS8-AS1 \| DISEASES 768096 \| HAR1A \| DISEASES 594842 \| HAS2-AS1 \| DISEASES 100131814 \| LINC00271 \| DISEASES 114036 \| LINC00310 \| DISEASES 100302522 \| PTCSC1 \| DISEASES 101928337 \| PTCSC2 \| DISEASES 100886964 \| PTCSC3 \| DISEASES 26771 \| SNORD102 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1047
Disease	thyroid cancer
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:67) HP:0002664 \| Neoplasia \| 31 HP:0100646 \| Thyroiditis \| 15 HP:0030731 \| Carcinoma \| 12 HP:0000872 \| Hashimoto's thyroiditis \| 11 HP:0005994 \| Nodular goiter \| 10 HP:0003002 \| Breast carcinoma \| 10 HP:0000718 \| Aggressive behaviour \| 9 HP:0001513 \| Obesity \| 9 HP:0002835 \| Aspiration \| 6 HP:0000853 \| Goitre \| 6 HP:0000836 \| Overactive thyroid \| 6 HP:0005987 \| Multinodular goiter \| 5 HP:0000820 \| Thyroid abnormality \| 5 HP:0002890 \| Thyroid carcinoma \| 5 HP:0012378 \| Fatigue \| 4 HP:0000821 \| Underactive thyroid \| 4 HP:0008200 \| Primary hyperparathyroidism \| 3 HP:0000819 \| Diabetes mellitus \| 3 HP:0000845 \| Acromegalic growth \| 3 HP:0000843 \| Hyperparathyroidism \| 3 HP:0002960 \| Autoimmune condition \| 3 HP:0010518 \| Thyroglossal cyst \| 2 HP:0006731 \| Follicular thyroid carcinoma \| 2 HP:0002861 \| Melanoma \| 2 HP:0002725 \| Systemic lupus erythematosus \| 2 HP:0002930 \| Resistance to thyroid hormone \| 2 HP:0001596 \| Hair loss \| 2 HP:0000138 \| Ovarian cyst \| 1 HP:0002777 \| Tracheal stenosis \| 1 HP:0002039 \| Anorexia \| 1 HP:0008249 \| Large thyroid \| 1 HP:0001701 \| Pericarditis \| 1 HP:0100013 \| Tumours of the breast \| 1 HP:0002360 \| Sleep disturbance \| 1 HP:0011779 \| Anaplastic thyroid carcinoma \| 1 HP:0003201 \| Rhabdomyolysis \| 1 HP:0002716 \| Lymph node hyperplasia \| 1 HP:0012189 \| Hodgkin disease \| 1 HP:0012115 \| Liver inflammation \| 1 HP:0002865 \| Medullary thyroid carcinoma \| 1 HP:0100735 \| Hypertensive crisis \| 1 HP:0001873 \| Low platelet count \| 1 HP:0012226 \| Ovarian teratoma \| 1 HP:0000855 \| Insulin resistance \| 1 HP:0000739 \| Anxiety \| 1 HP:0011034 \| Amyloid disease \| 1 HP:0001635 \| Congestive heart failure \| 1 HP:0012539 \| Non-Hodgkin lymphoma \| 1 HP:0002901 \| Hypocalcemia \| 1 HP:0002902 \| Hyponatremia \| 1 HP:0001250 \| Seizures \| 1 HP:0002229 \| Alopecia areata \| 1 HP:0100028 \| Abnormal thryoid location \| 1 HP:0012125 \| Prostate cancer \| 1 HP:0003073 \| Hypoalbuminaemia \| 1 HP:0100568 \| Endocrine neoplasia \| 1 HP:0001028 \| Strawberry mark \| 1 HP:0000822 \| Hypertension \| 1 HP:0003764 \| Naevus \| 1 HP:0002024 \| Intestinal malabsorption \| 1 HP:0000829 \| Hypoparathyroidism \| 1 HP:0000083 \| Renal insufficiency \| 1 HP:0100724 \| Hypercoagulability \| 1 HP:0002665 \| Lymphoma \| 1 HP:0100730 \| Bronchogenic cyst \| 1 HP:0002608 \| Celiac disease \| 1 HP:0005584 \| Renal cell carcinoma \| 1

Disease ID	1047
Disease	thyroid cancer
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:22) C0018213 \| graves' disease \| 10 C0006142 \| breast cancer \| 10 C0686619 \| lymph node metastases \| 9 C0153690 \| bone metastases \| 9 C0020550 \| hyperthyroidism \| 6 C0549473 \| thyroid carcinoma \| 5 C0029896 \| ent disease \| 4 C0153676 \| lung metastases \| 4 C0153676 \| pulmonary metastases \| 4 C0040156 \| thyrotoxicosis \| 3 C0153676 \| lung metastasis \| 3 C0677607 \| chronic lymphocytic thyroiditis \| 2 C0153690 \| bone metastasis \| 2 C0677607 \| hashimoto thyroiditis \| 2 C0677607 \| hashimoto's disease \| 2 C0020626 \| hypoparathyroidism \| 1 C0011633 \| dermatomyositis \| 1 C0024228 \| lymphadenopathy \| 1 C0153687 \| cutaneous metastasis \| 1 C0153676 \| pulmonary metastasis \| 1 C0003467 \| anxiety \| 1 C0002793 \| dedifferentiation \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:94)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1042522	24037912	7157	TP53	umls:C0007115	BeFree	Association between p53 Arg72Pro polymorphism and thyroid cancer risk: a meta-analysis.	0.008143256	2013	TP53	17	7676154	G	T,C
rs113488022	24570209	673	BRAF	umls:C0007115	BeFree	Immunohistochemistry for BRAF(V600E) antibody VE1 performed in core needle biopsy samples identifies mutated papillary thyroid cancers.	0.032030141	2015	BRAF	7	140753336	A	T,G,C
rs113488022	19850689	673	BRAF	umls:C0007115	BeFree	We developed an allele-specific real-time PCR method for the detection of BRAF(T1799A) in blood samples and studied prospectively blood samples from 193 patients with thyroid cancer (173 PTC, 20 non-PTC) attending for routine follow-up.	0.032030141	2009	BRAF	7	140753336	A	T,G,C
rs113488022	19040996	673	BRAF	umls:C0007115	BeFree	Mitogen-inducible gene-6 expression correlates with survival and is an independent predictor of recurrence in BRAF(V600E) positive papillary thyroid cancers.	0.032030141	2008	BRAF	7	140753336	A	T,G,C
rs113488022	25266729	673	BRAF	umls:C0007115	BeFree	The BRAF V600E mutation is the most common genetic alteration in thyroid cancer.	0.032030141	2015	BRAF	7	140753336	A	T,G,C
rs113488022	25333496	2158	F9	umls:C0007115	BeFree	Relevance of BRAF(V600E) mutation testing versus RAS point mutations and RET/PTC rearrangements evaluation in the diagnosis of thyroid cancer.	0.00868614	2015	BRAF	7	140753336	A	T,G,C
rs113488022	25333496	8030	CCDC6	umls:C0007115	BeFree	Relevance of BRAF(V600E) mutation testing versus RAS point mutations and RET/PTC rearrangements evaluation in the diagnosis of thyroid cancer.	0.009500466	2015	BRAF	7	140753336	A	T,G,C
rs113488022	24400871	673	BRAF	umls:C0007115	BeFree	PCCl3 rat thyroid cells, PCCl3 cells overexpressing BRAF(V600E), or primary cultured tumor cells from a thyroid cancer mouse model, under TSH stimulation were treated with various reagents for 24 hours.	0.032030141	2015	BRAF	7	140753336	A	T,G,C
rs113488022	24677749	673	BRAF	umls:C0007115	BeFree	BRAF V600E mutational status in pediatric thyroid cancer.	0.032030141	2013	BRAF	7	140753336	A	T,G,C
rs113488022	25333496	5726	TAS2R38	umls:C0007115	BeFree	Relevance of BRAF(V600E) mutation testing versus RAS point mutations and RET/PTC rearrangements evaluation in the diagnosis of thyroid cancer.	0.00868614	2015	BRAF	7	140753336	A	T,G,C
rs113488022	24382015	1591	CYP24A1	umls:C0007115	BeFree	Furthermore, BRAF(V600E) inhibitor PLX4720 can significantly down-regulate CYP24A1 expression and enhance the antiproliferative effects of calcitriol in thyroid cancer cell lines.	0.000271442	2013	BRAF	7	140753336	A	T,G,C
rs113488022	17854396	7173	TPO	umls:C0007115	BeFree	BRAF(V600E) mutation, in both primary and metastatic thyroid cancers, is associated with a marked drop in thyroperoxidase (29-fold) and pendrin (20-fold) expression and a considerable increase (five-fold) in GLUT-1 expression.	0.002985861	2008	BRAF	7	140753336	A	T,G,C
rs113488022	21803329	673	BRAF	umls:C0007115	BeFree	From September 2008 to December 2009, we performed routine analysis of the BRAF(V600E) mutation using thyroid cancer tissue from 424 patients who underwent thyroidectomy with cervical lymph node dissection.	0.032030141	2012	BRAF	7	140753336	A	T,G,C
rs113488022	23559083	673	BRAF	umls:C0007115	BeFree	When BRAF(V600E)-positive thyroid cancer cells were incubated with the specific BRAF inhibitor PLX4032, sensitivity to gefitinib was restored.	0.032030141	2013	BRAF	7	140753336	A	T,G,C
rs113488022	21879273	3383	ICAM1	umls:C0007115	BeFree	Furthermore, ICAM-1 upregulation correlated with aggressive tumor features such as BRAF V600E mutation, ETE, and lymph node metastasis, suggesting that ICAM-1 plays a role in thyroid cancer progression.	0.000271442	2012	BRAF	7	140753336	A	T,G,C
rs113488022	25333496	5979	RET	umls:C0007115	BeFree	Relevance of BRAF(V600E) mutation testing versus RAS point mutations and RET/PTC rearrangements evaluation in the diagnosis of thyroid cancer.	0.031487257	2015	BRAF	7	140753336	A	T,G,C
rs113488022	20926530	673	BRAF	umls:C0007115	BeFree	The inability of MEK and RAF inhibitors, U0126 and sorafenib, respectively, to block the mitochondrial localization of BRAF(V600E) has additional therapeutic implications for BRAF(V600E)-positive thyroid cancers.	0.032030141	2011	BRAF	7	140753336	A	T,G,C
rs113488022	21447745	673	BRAF	umls:C0007115	BeFree	BRAF(V600E) and microenvironment in thyroid cancer: a functional link to drive cancer progression.	0.032030141	2011	BRAF	7	140753336	A	T,G,C
rs113488022	22090271	5604	MAP2K1	umls:C0007115	BeFree	We tested the combinations of the Akt inhibitors MK2206 or perifosine with the BRAF(V600E) inhibitor PLX4032 or the MEK1/2 inhibitor AZD6244 in thyroid cancer cells harboring both the BRAF(V600E) and PIK3CA mutations.	0.001085767	2012	BRAF	7	140753336	A	T,G,C
rs113488022	22118425	673	BRAF	umls:C0007115	BeFree	Notch functions as an oncogene or tumor suppressor according to the type of malignancy, and the BRAF(V600E) mutation is commonly observed in thyroid cancer.	0.032030141	2012	BRAF	7	140753336	A	T,G,C
rs113488022	24382015	673	BRAF	umls:C0007115	BeFree	Furthermore, BRAF(V600E) inhibitor PLX4720 can significantly down-regulate CYP24A1 expression and enhance the antiproliferative effects of calcitriol in thyroid cancer cell lines.	0.032030141	2013	BRAF	7	140753336	A	T,G,C
rs113488022	26384551	673	BRAF	umls:C0007115	BeFree	Differential effects of MAPK pathway inhibitors on migration and invasiveness of BRAF(V600E) mutant thyroid cancer cells in 2D and 3D culture.	0.032030141	2015	BRAF	7	140753336	A	T,G,C
rs113488022	18202121	673	BRAF	umls:C0007115	BeFree	The CREM complex is seen in the normal thyroid cells and BRAF (V600E) thyroid cancer cells (BHP 17-10) but is missing in rearranged in transformation/papillary thyroid carcinoma-1 rearrangement thyroid cancer cells (BHP 2-7).	0.032030141	2008	BRAF	7	140753336	A	T,G,C
rs113488022	21795305	2048	EPHB2	umls:C0007115	BeFree	Together, the results indicate that AICAR-induced AMPK activation in BRAF V600E-mutant thyroid cancer cell lines resulted in increases in apoptosis and S-phase arrest via downregulation of ERK and p70S6K activity.	0.001628651	2011	BRAF	7	140753336	A	T,G,C
rs113488022	22442268	673	BRAF	umls:C0007115	BeFree	The effect of activating somatic mutations in the KRAS and BRAF genes on the responsiveness to sunitinib was evaluated in a panel of thyroid cancer cell lines harboring wild-type KRAS and BRAF genes, the RET/PTC1 rearrangement, the G12R KRAS, or the V600E BRAF mutation.	0.032030141	2012	BRAF	7	140753336	A	T,G,C
rs113488022	24362526	673	BRAF	umls:C0007115	BeFree	In this article, we will summarize results on preclinical testing of selective and nonselective single compounds in orthotopic mouse models based on validated human thyroid cancer cell lines harboring the BRAF(V600E) mutation or with wild-type BRAF.	0.032030141	2013	BRAF	7	140753336	A	T,G,C
rs113488022	22858857	673	BRAF	umls:C0007115	BeFree	It is evident that the detection of the BRAF V600E mutation is crucial in order to identify novel avenues for thyroid cancer treatment.	0.032030141	2012	BRAF	7	140753336	A	T,G,C
rs113488022	22105775	673	BRAF	umls:C0007115	BeFree	This study tests the prevalence of BRAF (V600E) mutation in thyroid cancer patients in Indian subcontinental population.	0.032030141	2012	BRAF	7	140753336	A	T,G,C
rs113488022	16551863	1588	CYP19A1	umls:C0007115	BeFree	They also potently blocked MEK phosphorylation in human thyroid cancer cell lines with either RET/PTC1 (TPC1) or BRAF(V600E) (NPA, ARO, and FRO) mutations.	0.001628651	2006	BRAF	7	140753336	A	T,G,C
rs113488022	22090271	673	BRAF	umls:C0007115	BeFree	We demonstrated, unexpectedly, opposite outcomes of MK2206 and perifosine in their combinational treatments with BRAF(V600E)/MEK inhibitors in thyroid cancer cells.	0.032030141	2012	BRAF	7	140753336	A	T,G,C
rs113488022	21185263	673	BRAF	umls:C0007115	BeFree	Thus, this study has confirmed that the BRAF(T1799A) mutation confers cancer cells sensitivity to PLX4032 and demonstrated its specific potential as an effective and BRAF(T1799A) mutation-selective therapeutic agent for thyroid cancer.	0.032030141	2011	BRAF	7	140753336	A	T,G,C
rs113488022	18202121	1390	CREM	umls:C0007115	BeFree	The CREM complex is seen in the normal thyroid cells and BRAF (V600E) thyroid cancer cells (BHP 17-10) but is missing in rearranged in transformation/papillary thyroid carcinoma-1 rearrangement thyroid cancer cells (BHP 2-7).	0.000271442	2008	BRAF	7	140753336	A	T,G,C
rs113488022	25262966	673	BRAF	umls:C0007115	BeFree	Expression of haem oxygenase-1 correlates with tumour aggressiveness and BRAF V600E expression in thyroid cancer.	0.032030141	2014	BRAF	7	140753336	A	T,G,C
rs113488022	21249150	2309	FOXO3	umls:C0007115	BeFree	The negative regulators of the cell cycle, p21 and p27, are strongly induced by transcriptional activation of FoxO3 in BRAF(V600E) positive thyroid cancer cells.	0.000542884	2011	BRAF	7	140753336	A	T,G,C
rs113488022	22535974	673	BRAF	umls:C0007115	BeFree	The diagnostic sensitivity for thyroid cancer is significantly increased by BRAF V600E mutation analysis, indicating that the screening for BRAF mutation in FNAB samples has a relevant diagnostic potential.	0.032030141	2012	BRAF	7	140753336	A	T,G,C
rs113488022	17854396	5172	SLC26A4	umls:C0007115	BeFree	BRAF(V600E) mutation, in both primary and metastatic thyroid cancers, is associated with a marked drop in thyroperoxidase (29-fold) and pendrin (20-fold) expression and a considerable increase (five-fold) in GLUT-1 expression.	0.001085767	2008	BRAF	7	140753336	A	T,G,C
rs113488022	22012135	673	BRAF	umls:C0007115	BeFree	BRAF V600E protein was expressed in BM of 42/76 (55.3%) melanomas, 1/15 (6.7%) ovarian cancers, 4/72 (5.5%) colorectal cancers, 1/355 (0.3%) lung cancers, 2/6 thyroid cancers and 1/2 choriocarcinomas.	0.032030141	2012	BRAF	7	140753336	A	T,G,C
rs113488022	21795305	673	BRAF	umls:C0007115	BeFree	The influence of the BRAF V600E mutation in thyroid cancer cell lines on the anticancer effects of 5-aminoimidazole-4-carboxamide-ribonucleoside.	0.032030141	2011	BRAF	7	140753336	A	T,G,C
rs113488022	21795305	5594	MAPK1	umls:C0007115	BeFree	Together, the results indicate that AICAR-induced AMPK activation in BRAF V600E-mutant thyroid cancer cell lines resulted in increases in apoptosis and S-phase arrest via downregulation of ERK and p70S6K activity.	0.001900093	2011	BRAF	7	140753336	A	T,G,C
rs113488022	17854396	673	BRAF	umls:C0007115	BeFree	BRAF(V600E) mutation, in both primary and metastatic thyroid cancers, is associated with a marked drop in thyroperoxidase (29-fold) and pendrin (20-fold) expression and a considerable increase (five-fold) in GLUT-1 expression.	0.032030141	2008	BRAF	7	140753336	A	T,G,C
rs113488022	18310287	673	BRAF	umls:C0007115	BeFree	BRAF((V600E)) mutation is the most frequent genetic alteration in papillary thyroid carcinomas (PTCs) that are 80-90% of all thyroid cancers.	0.032030141	2008	BRAF	7	140753336	A	T,G,C
rs113488022	21048359	673	BRAF	umls:C0007115	BeFree	While BRAF(V600E) is a highly specific marker of thyroid cancer, RET rearrangements have been disclosed also in non malignant thyroid lesions and their biological significance is debated.	0.032030141	2010	BRAF	7	140753336	A	T,G,C
rs113488022	22442268	3845	KRAS	umls:C0007115	BeFree	The effect of activating somatic mutations in the KRAS and BRAF genes on the responsiveness to sunitinib was evaluated in a panel of thyroid cancer cell lines harboring wild-type KRAS and BRAF genes, the RET/PTC1 rearrangement, the G12R KRAS, or the V600E BRAF mutation.	0.001628651	2012	BRAF	7	140753336	A	T,G,C
rs113488022	22504197	673	BRAF	umls:C0007115	BeFree	BRAF(T1799A) mutation is the most prevalent genetic alteration in thyroid cancers and is specific for PTC, characteristics that make it the most potentially helpful genetic tool to improve the diagnostic accuracy of FNAB.	0.032030141	2012	BRAF	7	140753336	A	T,G,C
rs113488022	23427907	673	BRAF	umls:C0007115	BeFree	The Korean population has a high iodine intake, high prevalence of BRAF V600E mutations, and family histories of thyroid cancer.	0.032030141	2014	BRAF	7	140753336	A	T,G,C
rs113488022	15126572	673	BRAF	umls:C0007115	BeFree	These data clearly confirm that BRAF(V599E) is the more common genetic alteration found to date in adult sporadic PTCs, that it is unique for this thyroid cancer histotype, and that it might drive the development of PTCs of the classic papillary subtype.	0.032030141	2004	BRAF	7	140753336	A	T,G,C
rs113488022	25029414	2475	MTOR	umls:C0007115	BeFree	PCCL3 cells conditionally expressing RET/PTC3, HRAS(G12V), or BRAF(V600E) and human thyroid cancer cells harboring mutations of these genes were used to test pathways controlling mTOR and its requirement for growth.	0.001628651	2015	BRAF	7	140753336	A	T,G,C
rs113488022	21185263	27352	SGSM3	umls:C0007115	BeFree	This study investigated the therapeutic potential of a BRAF(V600E)-selective inhibitor, PLX4032 (RG7204), for thyroid cancer by examining its effects on the MAP kinase signaling and proliferation of 10 thyroid cancer cell lines with wild-type BRAF or BRAF(T1799A) mutation.	0.001357209	2011	BRAF	7	140753336	A	T,G,C
rs113488022	16551863	673	BRAF	umls:C0007115	BeFree	They also potently blocked MEK phosphorylation in human thyroid cancer cell lines with either RET/PTC1 (TPC1) or BRAF(V600E) (NPA, ARO, and FRO) mutations.	0.032030141	2006	BRAF	7	140753336	A	T,G,C
rs113488022	23931930	5172	SLC26A4	umls:C0007115	BeFree	Circulating cell-free DNA, SLC5A8 and SLC26A4 hypermethylation, BRAF(V600E): A non-invasive tool panel for early detection of thyroid cancer.	0.001085767	2013	BRAF	7	140753336	A	T,G,C
rs113488022	23435375	673	BRAF	umls:C0007115	BeFree	(V600E)BRAF promotes invasiveness of thyroid cancer cells by decreasing E-cadherin expression through a Snail-dependent mechanism.	0.032030141	2013	BRAF	7	140753336	A	T,G,C
rs113488022	25333496	673	BRAF	umls:C0007115	BeFree	Relevance of BRAF(V600E) mutation testing versus RAS point mutations and RET/PTC rearrangements evaluation in the diagnosis of thyroid cancer.	0.032030141	2015	BRAF	7	140753336	A	T,G,C
rs113488022	17054470	673	BRAF	umls:C0007115	BeFree	The BRAF(V600E) mutation was present in 93 (83%) of 112 thyroid cancers.	0.032030141	2006	BRAF	7	140753336	A	T,G,C
rs113488022	21937738	673	BRAF	umls:C0007115	BeFree	they were normally maintained hypomethylated and over-expressed by BRAF V600E in thyroid cancer cells).	0.032030141	2011	BRAF	7	140753336	A	T,G,C
rs113488022	24955518	673	BRAF	umls:C0007115	BeFree	Overall, BRAF(V600E) PTC tumors display a broadly immunosuppressive profile and evidence of disturbed host tumor immune surveillance that may contribute to the poorer outcomes observed in this subset of patients with thyroid cancer.	0.032030141	2015	BRAF	7	140753336	A	T,G,C
rs113488022	23775351	673	BRAF	umls:C0007115	BeFree	Immunohistochemical detection of mutated BRAF V600E supports the clonal origin of BRAF-induced thyroid cancers along the spectrum of disease progression.	0.032030141	2013	BRAF	7	140753336	A	T,G,C
rs113488022	23931930	673	BRAF	umls:C0007115	BeFree	Circulating cell-free DNA, SLC5A8 and SLC26A4 hypermethylation, BRAF(V600E): A non-invasive tool panel for early detection of thyroid cancer.	0.032030141	2013	BRAF	7	140753336	A	T,G,C
rs113488022	25333496	5727	PTCH1	umls:C0007115	BeFree	Relevance of BRAF(V600E) mutation testing versus RAS point mutations and RET/PTC rearrangements evaluation in the diagnosis of thyroid cancer.	0.010857675	2015	BRAF	7	140753336	A	T,G,C
rs113488022	21249150	673	BRAF	umls:C0007115	BeFree	Transgenic induction of BRAF(V600E)in the thyroid gland results in cancers resembling human papillary thyroid cancers.	0.032030141	2011	BRAF	7	140753336	A	T,G,C
rs113488022	24243688	673	BRAF	umls:C0007115	BeFree	Our findings not only reveal an epigenetic mechanism for BRAF V600E-promoted NIS silencing involving histone deacetylation at critical regulatory regions of the NIS promoter but also provide further support for our previously proposed combination therapy targeting major signaling pathways and histone deacetylase to restore thyroid gene expression for radioiodine treatment of thyroid cancer.	0.032030141	2014	BRAF	7	140753336	A	T,G,C
rs113488022	17854396	6513	SLC2A1	umls:C0007115	BeFree	BRAF(V600E) mutation, in both primary and metastatic thyroid cancers, is associated with a marked drop in thyroperoxidase (29-fold) and pendrin (20-fold) expression and a considerable increase (five-fold) in GLUT-1 expression.	0.001357209	2008	BRAF	7	140753336	A	T,G,C
rs113488022	24617711	7015	TERT	umls:C0007115	BeFree	TERT promoter mutations and their association with BRAF V600E mutation and aggressive clinicopathological characteristics of thyroid cancer.	0.002442977	2014	BRAF	7	140753336	A	T,G,C
rs113488022	18462259	673	BRAF	umls:C0007115	BeFree	Dideoxy sequencing is the most commonly used method for detecting the BRAF(V600E) mutation in thyroid cancer and melanoma.	0.032030141	2009	BRAF	7	140753336	A	T,G,C
rs113488022	22090271	5290	PIK3CA	umls:C0007115	BeFree	We tested the combinations of the Akt inhibitors MK2206 or perifosine with the BRAF(V600E) inhibitor PLX4032 or the MEK1/2 inhibitor AZD6244 in thyroid cancer cells harboring both the BRAF(V600E) and PIK3CA mutations.	0.006786047	2012	BRAF	7	140753336	A	T,G,C
rs113488022	16533790	673	BRAF	umls:C0007115	BeFree	BRAF provides signals crucial for proliferation of thyroid carcinoma cells spontaneously harboring the (V600E)BRAF mutation and, therefore, BRAF suppression might have therapeutic potential in (V600E)BRAF-positive thyroid cancer.	0.032030141	2006	BRAF	7	140753336	A	T,G,C
rs113488022	24617711	673	BRAF	umls:C0007115	BeFree	TERT promoter mutations and their association with BRAF V600E mutation and aggressive clinicopathological characteristics of thyroid cancer.	0.032030141	2014	BRAF	7	140753336	A	T,G,C
rs113488022	23161556	673	BRAF	umls:C0007115	BeFree	The BRAF(V600E) mutation can be detected peripherally in the serum of patients with thyroid cancer.	0.032030141	2012	BRAF	7	140753336	A	T,G,C
rs1136410	22922830	142	PARP1	umls:C0007115	BeFree	Our results do not reveal a significant involvement of XRCC1 Arg194Trp and Arg399Gln, OGG1 Ser326Cys, APEX1 Asp148Glu, MUTYH Gln335His and PARP1 Val762Ala polymorphisms on the individual susceptibility towards TC, mostly in agreement with the limited available evidence.	0.000542884	2012	PARP1	1	226367601	A	G
rs11540654	24037912	7157	TP53	umls:C0007115	BeFree	Association between p53 Arg72Pro polymorphism and thyroid cancer risk: a meta-analysis.	0.008143256	2013	TP53	17	7676040	C	T,G,A
rs121913530	22442268	673	BRAF	umls:C0007115	BeFree	The effect of activating somatic mutations in the KRAS and BRAF genes on the responsiveness to sunitinib was evaluated in a panel of thyroid cancer cell lines harboring wild-type KRAS and BRAF genes, the RET/PTC1 rearrangement, the G12R KRAS, or the V600E BRAF mutation.	0.032030141	2012	KRAS	12	25245351	C	T,G,A
rs121913530	22442268	3845	KRAS	umls:C0007115	BeFree	The effect of activating somatic mutations in the KRAS and BRAF genes on the responsiveness to sunitinib was evaluated in a panel of thyroid cancer cell lines harboring wild-type KRAS and BRAF genes, the RET/PTC1 rearrangement, the G12R KRAS, or the V600E BRAF mutation.	0.001628651	2012	KRAS	12	25245351	C	T,G,A
rs12628	23150177	3265	HRAS	umls:C0007115	BeFree	Lack of mutational events of RAS genes in sporadic thyroid cancer but high risk associated with HRAS T81C single nucleotide polymorphism (case-control study).	0.001357209	2013	HRAS;LRRC56	11	534242	A	G
rs1503185	15384144	5795	PTPRJ	umls:C0007115	BeFree	We demonstrate these features by typing two SNPs (Q276P and R326Q) in the human phosphatase gene PTPrj, which has been implicated in the aetiology of colon, lung, breast and thyroid cancers.	0.000271442	2004	PTPRJ	11	48125070	G	A
rs1566734	15384144	5795	PTPRJ	umls:C0007115	BeFree	We demonstrate these features by typing two SNPs (Q276P and R326Q) in the human phosphatase gene PTPrj, which has been implicated in the aetiology of colon, lung, breast and thyroid cancers.	0.000271442	2004	PTPRJ	11	48123823	A	C
rs17849071	23185308	5290	PIK3CA	umls:C0007115	BeFree	This provides an explanation for the reciprocal relationship of rs17849071G/T with FTC, since PIK3CA amplification is an important oncogenic mechanism in thyroid cancer, particularly FTC.	0.006786047	2012	PIK3CA	3	179218439	T	G
rs1799782	23464463	7515	XRCC1	umls:C0007115	BeFree	Our results suggest that the XRCC1 Arg399Gln polymorphism may be associated with decreased thyroid cancer risk among Caucasians and XRCC1 Arg194Trp may be associated with a tendency for increased thyroid cancer risk in the two larger sample size trials.	0.001085767	2014	XRCC1	19	43553422	G	A
rs1867277	19730683	7391	USF1	umls:C0007115	BeFree	The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.	0.000271442	2009	FOXE1;PTCSC2	9	97853632	A	G
rs1867277	19730683	7392	USF2	umls:C0007115	BeFree	The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.	0.000271442	2009	FOXE1;PTCSC2	9	97853632	A	G
rs1867277	19730683	2304	FOXE1	umls:C0007115	BeFree	The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.	0.002171535	2009	FOXE1;PTCSC2	9	97853632	A	G
rs1867277	25562676	2304	FOXE1	umls:C0007115	BeFree	In a multicenter retrospective case-control study, five thyroid cancer-related SNPs-rs966513 (9q22.33, FOXE1), rs944289 (14q13.3, PTCSC3), rs2439302 (8p12, NRG1), rs1867277 (9q22.23, FOXE1), and rs6983267 (8q24, POU5F1B)-were genotyped in 959 cases of histologically verified FA, 535 papillary thyroid carcinomas (PTC), and 2766 population controls.	0.002171535	2015	FOXE1;PTCSC2	9	97853632	A	G
rs2228480	19519176	2099	ESR1	umls:C0007115	BeFree	In this study we investigated the association of one SNP (rs2228480, T594T) and one microsatellite marker (D6S440) within the ESR1 gene and a dinucleotide repeat (D17S2189) within the THRA gene, with thyroid cancer risk.	0.000814326	2009	ESR1	6	152098960	G	A
rs2439302	25562676	2304	FOXE1	umls:C0007115	BeFree	In a multicenter retrospective case-control study, five thyroid cancer-related SNPs-rs966513 (9q22.33, FOXE1), rs944289 (14q13.3, PTCSC3), rs2439302 (8p12, NRG1), rs1867277 (9q22.23, FOXE1), and rs6983267 (8q24, POU5F1B)-were genotyped in 959 cases of histologically verified FA, 535 papillary thyroid carcinomas (PTC), and 2766 population controls.	0.002171535	2015	NRG1	8	32574851	G	C
rs25487	23464463	7515	XRCC1	umls:C0007115	BeFree	Our results suggest that the XRCC1 Arg399Gln polymorphism may be associated with decreased thyroid cancer risk among Caucasians and XRCC1 Arg194Trp may be associated with a tendency for increased thyroid cancer risk in the two larger sample size trials.	0.001085767	2014	XRCC1	19	43551574	T	C
rs3751143	25178922	5027	P2RX7	umls:C0007115	BeFree	A polymorphism in exon 13 of the P2X7 receptor gene at the +1513 position (Glu496Ala substitution, corresponding to SNP rs3751143) has been shown to eradicate the function of this receptor and has been correlated with histological variants and clinical parameters in thyroid cancer.	0.000271442	2014	P2RX7;LOC105370032	12	121184501	A	C
rs386493716	23464463	7515	XRCC1	umls:C0007115	BeFree	Our results suggest that the XRCC1 Arg399Gln polymorphism may be associated with decreased thyroid cancer risk among Caucasians and XRCC1 Arg194Trp may be associated with a tendency for increased thyroid cancer risk in the two larger sample size trials.	0.001085767	2014	NA	NA	NA	NA	NA
rs386545546	23464463	7515	XRCC1	umls:C0007115	BeFree	Our results suggest that the XRCC1 Arg399Gln polymorphism may be associated with decreased thyroid cancer risk among Caucasians and XRCC1 Arg194Trp may be associated with a tendency for increased thyroid cancer risk in the two larger sample size trials.	0.001085767	2014	NA	NA	NA	NA	NA
rs6983267	25562676	2304	FOXE1	umls:C0007115	BeFree	In a multicenter retrospective case-control study, five thyroid cancer-related SNPs-rs966513 (9q22.33, FOXE1), rs944289 (14q13.3, PTCSC3), rs2439302 (8p12, NRG1), rs1867277 (9q22.23, FOXE1), and rs6983267 (8q24, POU5F1B)-were genotyped in 959 cases of histologically verified FA, 535 papillary thyroid carcinomas (PTC), and 2766 population controls.	0.002171535	2015	CASC8;CCAT2	8	127401060	G	T
rs7028661	25855579	2304	FOXE1	umls:C0007115	BeFree	The association between the variation at the 9q22 locus near FOXE1 and thyroid cancer risk was consistent across all series, with several SNPs identified (rs7028661: OR = 1.64, p = 1.0 × 10(-22) , rs7037324: OR = 1.54, p = 1.2 × 10(-17) ).	0.002171535	2015	PTCSC2	9	97776188	A	G
rs7037324	25855579	2304	FOXE1	umls:C0007115	BeFree	The association between the variation at the 9q22 locus near FOXE1 and thyroid cancer risk was consistent across all series, with several SNPs identified (rs7028661: OR = 1.64, p = 1.0 × 10(-22) , rs7037324: OR = 1.54, p = 1.2 × 10(-17) ).	0.002171535	2015	C9orf156	9	97896036	A	G
rs78014899	16736292	5979	RET	umls:C0007115	BeFree	The RET E768D mutation is associated with MTC with a later age at presentation, incomplete penetrance and less aggressive course compared with other high risk RET mutations.	0.031487257	2006	RET	10	43118392	G	A,C,T
rs944289	25562676	2304	FOXE1	umls:C0007115	BeFree	In a multicenter retrospective case-control study, five thyroid cancer-related SNPs-rs966513 (9q22.33, FOXE1), rs944289 (14q13.3, PTCSC3), rs2439302 (8p12, NRG1), rs1867277 (9q22.23, FOXE1), and rs6983267 (8q24, POU5F1B)-were genotyped in 959 cases of histologically verified FA, 535 papillary thyroid carcinomas (PTC), and 2766 population controls.	0.002171535	2015	NA	14	36180040	C	T
rs944289	25562676	100886964	PTCSC3	umls:C0007115	BeFree	Association of rs944289, which was previously known to confer risk for thyroid cancer, with FA, and the correlation between PTCSC3 and NRG1 expression demonstrates that predisposing genetic factors are partly common for benign and malignant thyroid tumors, and imply broader roles of the pathways they underlie in thyroid tumorigenesis, not limited to carcinogenesis.	0.000271442	2015	NA	14	36180040	C	T
rs944289	25562676	3084	NRG1	umls:C0007115	BeFree	Association of rs944289, which was previously known to confer risk for thyroid cancer, with FA, and the correlation between PTCSC3 and NRG1 expression demonstrates that predisposing genetic factors are partly common for benign and malignant thyroid tumors, and imply broader roles of the pathways they underlie in thyroid tumorigenesis, not limited to carcinogenesis.	0.000271442	2015	NA	14	36180040	C	T
rs966513	25562676	2304	FOXE1	umls:C0007115	BeFree	In a multicenter retrospective case-control study, five thyroid cancer-related SNPs-rs966513 (9q22.33, FOXE1), rs944289 (14q13.3, PTCSC3), rs2439302 (8p12, NRG1), rs1867277 (9q22.23, FOXE1), and rs6983267 (8q24, POU5F1B)-were genotyped in 959 cases of histologically verified FA, 535 papillary thyroid carcinomas (PTC), and 2766 population controls.	0.002171535	2015	EPHB1;LOC102724019	3	135147609	C	G

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:30)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
2	218271719	rs6759952	T	C	rs6759952	23894154	6.00E-10	NA	1.25	[1.16-1.34]	690 European ancestry cases; 497 European ancestry controls	European(1187)	ALL(1187)	EUR(1187)	ALL(1187)	Thyroid cancer	HPOID:0100031	Neoplasm of the thyroid gland	DOID:1781	thyroid cancer	D013964	Thyroid Neoplasms	EFOID:0002892	thyroid carcinoma	Thyroid cancer	rs6759952-T	Research Support, Non-U.S. Gov't	T	DIRC3
2	218295406	rs13388294	G	A	rs13388294	23894154	4.13E-05	NA	1.48	NA	690 European ancestry cases; 497 European ancestry controls	European(1187)	ALL(1187)	EUR(1187)	ALL(1187)	Thyroid cancer	HPOID:0100031	Neoplasm of the thyroid gland	DOID:1781	thyroid cancer	D013964	Thyroid Neoplasms	EFOID:0002892	thyroid carcinoma	Thyroid cancer	rs13388294-A	Research Support, Non-U.S. Gov't	G	DIRC3
2	218296003	rs1382435	T	C	rs1382435	23894154	7.16E-06	NA	1.51	NA	690 European ancestry cases; 497 European ancestry controls	European(1187)	ALL(1187)	EUR(1187)	ALL(1187)	Thyroid cancer	HPOID:0100031	Neoplasm of the thyroid gland	DOID:1781	thyroid cancer	D013964	Thyroid Neoplasms	EFOID:0002892	thyroid carcinoma	Thyroid cancer	rs1382435-A	Research Support, Non-U.S. Gov't	T	DIRC3
2	218310340	rs966423	C	T	rs966423	22267200	1.00E-09	NA	1.34	[1.22-1.47]	27,758 European ancestry individuals	European(27758)	ALL(27758)	EUR(27758)	ALL(27758)	Thyroid cancer	HPOID:0100031	Neoplasm of the thyroid gland	DOID:1781	thyroid cancer	D013964	Thyroid Neoplasms	EFOID:0002892	thyroid carcinoma	Thyroid cancer	rs966423-C	Research Support, N.I.H., Extramural	C	DIRC3
3	158463101	rs7617304	G	A	rs7617304	23894154	7.00E-04	NA	1.17	[1.07-1.27]	690 European ancestry cases; 497 European ancestry controls	European(1187)	ALL(1187)	EUR(1187)	ALL(1187)	Thyroid cancer	HPOID:0100031	Neoplasm of the thyroid gland	DOID:1781	thyroid cancer	D013964	Thyroid Neoplasms	EFOID:0002892	thyroid carcinoma	Thyroid cancer	rs7617304-A	Research Support, Non-U.S. Gov't	G	NA
8	32432369	rs2439302	G	C	rs2439302	22267200	2.00E-09	NA	1.36	[1.23-1.50]	27,758 European ancestry individuals	European(27758)	ALL(27758)	EUR(27758)	ALL(27758)	Thyroid cancer	HPOID:0100031	Neoplasm of the thyroid gland	DOID:1781	thyroid cancer	D013964	Thyroid Neoplasms	EFOID:0002892	thyroid carcinoma	Thyroid cancer	rs2439302-G	Research Support, N.I.H., Extramural	G	NRG1
9	100543880	rs1877432	G	A	rs1877432	23894154	2.93E-05	NA	1.47	NA	690 European ancestry cases; 497 European ancestry controls	European(1187)	ALL(1187)	EUR(1187)	ALL(1187)	Thyroid cancer	HPOID:0100031	Neoplasm of the thyroid gland	DOID:1781	thyroid cancer	D013964	Thyroid Neoplasms	EFOID:0002892	thyroid carcinoma	Thyroid cancer	rs1877432-G	Research Support, Non-U.S. Gov't	G	NA
9	100549013	rs7850258	A	G	rs7850258	23894154	3.47E-10	NA	1.77	NA	690 European ancestry cases; 497 European ancestry controls	European(1187)	ALL(1187)	EUR(1187)	ALL(1187)	Thyroid cancer	HPOID:0100031	Neoplasm of the thyroid gland	DOID:1781	thyroid cancer	D013964	Thyroid Neoplasms	EFOID:0002892	thyroid carcinoma	Thyroid cancer	rs7850258-A	Research Support, Non-U.S. Gov't	G	NA
9	100550028	rs1443438	T	C	rs1443438	23894154	3.47E-10	NA	1.77	NA	690 European ancestry cases; 497 European ancestry controls	European(1187)	ALL(1187)	EUR(1187)	ALL(1187)	Thyroid cancer	HPOID:0100031	Neoplasm of the thyroid gland	DOID:1781	thyroid cancer	D013964	Thyroid Neoplasms	EFOID:0002892	thyroid carcinoma	Thyroid cancer	rs1443438-A	Research Support, Non-U.S. Gov't	G	NA
9	100556109	rs965513	A	G	rs965513	19198613	2.00E-27	NA	1.75	[1.59-1.94]	192 cases; 37,196 controls	NOPOP(37388)	ALL(37388)	NOPOP(37388)	ALL(37388)	Thyroid cancer	HPOID:0100031	Neoplasm of the thyroid gland	DOID:1781	thyroid cancer	D013964	Thyroid Neoplasms	EFOID:0002892	thyroid carcinoma	Thyroid cancer	rs965513-A	Research Support, N.I.H., Extramural	G	NA
9	100556109	rs965513	A	G	rs965513	22267200	6.90E-15	NA	NA	NA	27,758 European ancestry individuals	European(27758)	ALL(27758)	EUR(27758)	ALL(27758)	Thyroid cancer	HPOID:0100031	Neoplasm of the thyroid gland	DOID:1781	thyroid cancer	D013964	Thyroid Neoplasms	EFOID:0002892	thyroid carcinoma	Thyroid cancer	NA	Research Support, N.I.H., Extramural	G	NA
9	100556109	rs965513	A	G	rs965513	23894154	3.00E-10	NA	1.78	NA	690 European ancestry cases; 497 European ancestry controls	European(1187)	ALL(1187)	EUR(1187)	ALL(1187)	Thyroid cancer	HPOID:0100031	Neoplasm of the thyroid gland	DOID:1781	thyroid cancer	D013964	Thyroid Neoplasms	EFOID:0002892	thyroid carcinoma	Thyroid cancer	rs965513-A	Research Support, Non-U.S. Gov't	G	NA
9	100556972	rs10759944	A	G	rs10759944	19198613	1.70E-19	NA	NA	NA	192 cases; 37,196 controls	NOPOP(37388)	ALL(37388)	NOPOP(37388)	ALL(37388)	Thyroid cancer	HPOID:0100031	Neoplasm of the thyroid gland	DOID:1781	thyroid cancer	D013964	Thyroid Neoplasms	EFOID:0002892	thyroid carcinoma	Thyroid cancer	NA	Research Support, N.I.H., Extramural	G	NA
9	100556972	rs10759944	A	G	rs10759944	23894154	2.67E-10	NA	1.78	NA	690 European ancestry cases; 497 European ancestry controls	European(1187)	ALL(1187)	EUR(1187)	ALL(1187)	Thyroid cancer	HPOID:0100031	Neoplasm of the thyroid gland	DOID:1781	thyroid cancer	D013964	Thyroid Neoplasms	EFOID:0002892	thyroid carcinoma	Thyroid cancer	rs10759944-A	Research Support, Non-U.S. Gov't	G	NA
9	100574120	rs7870795	T	C	rs7870795	23894154	4.84E-06	NA	1.53	NA	690 European ancestry cases; 497 European ancestry controls	European(1187)	ALL(1187)	EUR(1187)	ALL(1187)	Thyroid cancer	HPOID:0100031	Neoplasm of the thyroid gland	DOID:1781	thyroid cancer	D013964	Thyroid Neoplasms	EFOID:0002892	thyroid carcinoma	Thyroid cancer	rs7870795-A	Research Support, Non-U.S. Gov't	C	NA
9	100588839	rs7848973	A	G	rs7848973	23894154	1.58E-09	NA	1.71	NA	690 European ancestry cases; 497 European ancestry controls	European(1187)	ALL(1187)	EUR(1187)	ALL(1187)	Thyroid cancer	HPOID:0100031	Neoplasm of the thyroid gland	DOID:1781	thyroid cancer	D013964	Thyroid Neoplasms	EFOID:0002892	thyroid carcinoma	Thyroid cancer	rs7848973-A	Research Support, Non-U.S. Gov't	G	NA
9	100595238	rs7024345	A	G	rs7024345	19198613	1.90E-12	NA	NA	NA	192 cases; 37,196 controls	NOPOP(37388)	ALL(37388)	NOPOP(37388)	ALL(37388)	Thyroid cancer	HPOID:0100031	Neoplasm of the thyroid gland	DOID:1781	thyroid cancer	D013964	Thyroid Neoplasms	EFOID:0002892	thyroid carcinoma	Thyroid cancer	NA	Research Support, N.I.H., Extramural	G	NA
9	100608682	rs12348691	G	A	rs12348691	23894154	1.45E-08	NA	1.65	NA	690 European ancestry cases; 497 European ancestry controls	European(1187)	ALL(1187)	EUR(1187)	ALL(1187)	Thyroid cancer	HPOID:0100031	Neoplasm of the thyroid gland	DOID:1781	thyroid cancer	D013964	Thyroid Neoplasms	EFOID:0002892	thyroid carcinoma	Thyroid cancer	rs12348691-G	Research Support, Non-U.S. Gov't	G	NA
9	100608745	rs10759960	A	G	rs10759960	23894154	2.41E-06	NA	1.55	NA	690 European ancestry cases; 497 European ancestry controls	European(1187)	ALL(1187)	EUR(1187)	ALL(1187)	Thyroid cancer	HPOID:0100031	Neoplasm of the thyroid gland	DOID:1781	thyroid cancer	D013964	Thyroid Neoplasms	EFOID:0002892	thyroid carcinoma	Thyroid cancer	rs10759960-A	Research Support, Non-U.S. Gov't	G	NA
9	100617479	rs1443434	G	T	rs1443434	19198613	2.80E-09	NA	NA	NA	192 cases; 37,196 controls	NOPOP(37388)	ALL(37388)	NOPOP(37388)	ALL(37388)	Thyroid cancer	HPOID:0100031	Neoplasm of the thyroid gland	DOID:1781	thyroid cancer	D013964	Thyroid Neoplasms	EFOID:0002892	thyroid carcinoma	Thyroid cancer	NA	Research Support, N.I.H., Extramural	G	FOXE1
9	100617583	rs1443435	T	C	rs1443435	23894154	2.48E-08	NA	1.64	NA	690 European ancestry cases; 497 European ancestry controls	European(1187)	ALL(1187)	EUR(1187)	ALL(1187)	Thyroid cancer	HPOID:0100031	Neoplasm of the thyroid gland	DOID:1781	thyroid cancer	D013964	Thyroid Neoplasms	EFOID:0002892	thyroid carcinoma	Thyroid cancer	rs1443435-A	Research Support, Non-U.S. Gov't	T	FOXE1
9	100622597	rs907580	T	C	rs907580	19198613	1.10E-14	NA	NA	NA	192 cases; 37,196 controls	NOPOP(37388)	ALL(37388)	NOPOP(37388)	ALL(37388)	Thyroid cancer	HPOID:0100031	Neoplasm of the thyroid gland	DOID:1781	thyroid cancer	D013964	Thyroid Neoplasms	EFOID:0002892	thyroid carcinoma	Thyroid cancer	NA	Research Support, N.I.H., Extramural	G	NA
9	100636398	rs925487	C	T	rs925487	19198613	2.60E-13	NA	NA	NA	192 cases; 37,196 controls	NOPOP(37388)	ALL(37388)	NOPOP(37388)	ALL(37388)	Thyroid cancer	HPOID:0100031	Neoplasm of the thyroid gland	DOID:1781	thyroid cancer	D013964	Thyroid Neoplasms	EFOID:0002892	thyroid carcinoma	Thyroid cancer	NA	Research Support, N.I.H., Extramural	G	NA
9	100636398	rs925487	C	T	rs925487	23894154	2.31E-08	NA	1.65	NA	690 European ancestry cases; 497 European ancestry controls	European(1187)	ALL(1187)	EUR(1187)	ALL(1187)	Thyroid cancer	HPOID:0100031	Neoplasm of the thyroid gland	DOID:1781	thyroid cancer	D013964	Thyroid Neoplasms	EFOID:0002892	thyroid carcinoma	Thyroid cancer	rs925487-G	Research Support, Non-U.S. Gov't	G	NA
9	100639275	rs10984103	A	C	rs10984103	19198613	2.20E-13	NA	NA	NA	192 cases; 37,196 controls	NOPOP(37388)	ALL(37388)	NOPOP(37388)	ALL(37388)	Thyroid cancer	HPOID:0100031	Neoplasm of the thyroid gland	DOID:1781	thyroid cancer	D013964	Thyroid Neoplasms	EFOID:0002892	thyroid carcinoma	Thyroid cancer	NA	Research Support, N.I.H., Extramural	A	NA
9	100650096	rs7866436	G	A	rs7866436	23894154	4.19E-08	NA	1.63	NA	690 European ancestry cases; 497 European ancestry controls	European(1187)	ALL(1187)	EUR(1187)	ALL(1187)	Thyroid cancer	HPOID:0100031	Neoplasm of the thyroid gland	DOID:1781	thyroid cancer	D013964	Thyroid Neoplasms	EFOID:0002892	thyroid carcinoma	Thyroid cancer	rs7866436-G	Research Support, Non-U.S. Gov't	A	NA
9	139269338	rs10781500	C	T	rs10781500	23894154	1.10E-04	NA	1.17	[1.08-1.27]	690 European ancestry cases; 497 European ancestry controls	European(1187)	ALL(1187)	EUR(1187)	ALL(1187)	Thyroid cancer	HPOID:0100031	Neoplasm of the thyroid gland	DOID:1781	thyroid cancer	D013964	Thyroid Neoplasms	EFOID:0002892	thyroid carcinoma	Thyroid cancer	rs10781500-C	Research Support, Non-U.S. Gov't	C	CARD9
14	36649246	rs944289	C	T	rs944289	19198613	2.00E-09	NA	1.37	[1.24-1.52]	192 cases; 37,196 controls	NOPOP(37388)	ALL(37388)	NOPOP(37388)	ALL(37388)	Thyroid cancer	HPOID:0100031	Neoplasm of the thyroid gland	DOID:1781	thyroid cancer	D013964	Thyroid Neoplasms	EFOID:0002892	thyroid carcinoma	Thyroid cancer	rs944289-T	Research Support, N.I.H., Extramural	C	NA
14	36738361	rs116909374	C	T	rs116909374	22267200	5.00E-11	NA	2.09	[1.68-2.60]	27,758 European ancestry individuals	European(27758)	ALL(27758)	EUR(27758)	ALL(27758)	Thyroid cancer	HPOID:0100031	Neoplasm of the thyroid gland	DOID:1781	thyroid cancer	D013964	Thyroid Neoplasms	EFOID:0002892	thyroid carcinoma	Thyroid cancer	rs116909374-T	Research Support, N.I.H., Extramural	C	NA
18	68957961	rs9951245	G	A	rs9951245	23894154	8.00E-04	NA	1.16	[1.06-1.26]	690 European ancestry cases; 497 European ancestry controls	European(1187)	ALL(1187)	EUR(1187)	ALL(1187)	Thyroid cancer	HPOID:0100031	Neoplasm of the thyroid gland	DOID:1781	thyroid cancer	D013964	Thyroid Neoplasms	EFOID:0002892	thyroid carcinoma	Thyroid cancer	rs9951245-G	Research Support, Non-U.S. Gov't	A	NA

Mapped by lexical matching(Total Items:0)
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Mapped by homologous gene(Total Items:0)
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Chemical(Total Drugs:0)
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FDA approved drug and dosage information(Total Drugs:0)
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FDA labeling changes(Total Drugs:0)
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