PedAM

Pediatric Disease Annotations & Medicines


	thoracic outlet syndrome

Disease ID	563
Disease	thoracic outlet syndrome
Definition	A neurovascular syndrome associated with compression of the BRACHIAL PLEXUS; SUBCLAVIAN ARTERY; and SUBCLAVIAN VEIN at the superior thoracic outlet. This may result from a variety of anomalies such as a CERVICAL RIB, anomalous fascial bands, and abnormalities of the origin or insertion of the anterior or medial scalene muscles. Clinical features may include pain in the shoulder and neck region which radiates into the arm, PARESIS or PARALYSIS of brachial plexus innervated muscles, PARESTHESIA, loss of sensation, reduction of arterial pulses in the affected extremity, ISCHEMIA, and EDEMA. (Adams et al., Principles of Neurology, 6th ed, pp214-5).
Synonym	aperture syndrome, thoracic outlet cervicothoracic outlet syndrome neurovascular syndrome, thoracic outlet outlet syndrome thoracic outlet syndrome, thoracic outlet syndromes thoracic outlet syndromes, thoracic superior thoracic aperture syndrome syndrome, thoracic outlet syndromes, thoracic outlet thoracic outlet neurovascular syndrome thoracic outlet syndrome (disorder) thoracic outlet syndrome [ambiguous] thoracic outlet syndrome [disease/finding] thoracic outlet syndromes tos tos - thoracic outlet syndrome
Orphanet	ORPHANET:97330
DOID	DOID:3103
UMLS	C0039984
MeSH	D013901
SNOMED-CT	SNOMEDCT_US_2016_09_01:128210009
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:5) C0022116 \| ischemia \| 1 C0042900 \| vitiligo \| 1 C1335437 \| plexopathy \| 1 C0700251 \| brachial plexopathy \| 1 C0040053 \| thrombosis \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:30) 8935 \| SKAP2 \| DISEASES 2554 \| GABRA1 \| DISEASES 5327 \| PLAT \| DISEASES 7035 \| TFPI \| DISEASES 4836 \| NMT1 \| DISEASES 23531 \| MMD \| DISEASES 25939 \| SAMHD1 \| DISEASES 9424 \| KCNK6 \| DISEASES 3299 \| HSF4 \| DISEASES 793 \| CALB1 \| DISEASES 1998 \| ELF2 \| DISEASES 1181 \| CLCN2 \| DISEASES 5286 \| PIK3C2A \| DISEASES 740 \| MRPL49 \| DISEASES 5340 \| PLG \| DISEASES 9939 \| RBM8A \| DISEASES 342184 \| FMN1 \| DISEASES 2152 \| F3 \| DISEASES 2246 \| FGF1 \| DISEASES 1508 \| CTSB \| DISEASES 140885 \| SIRPA \| DISEASES 23644 \| EDC4 \| DISEASES 23607 \| CD2AP \| DISEASES 9446 \| GSTO1 \| DISEASES 1025 \| CDK9 \| DISEASES 5422 \| POLA1 \| DISEASES 2591 \| GALNT3 \| DISEASES 55733 \| HHAT \| DISEASES 820 \| CAMP \| DISEASES 102723508 \| KANTR \| DISEASES
Locus	(Waiting for update.)

Disease ID	563
Disease	thoracic outlet syndrome
Integrated Phenotype	HPO \| Name(Total Integrated Phenotypes:11) HP:0002829 \| Arthralgia HP:0003457 \| EMG abnormality HP:0004936 \| Venous thrombosis HP:0001324 \| Muscle weakness HP:0002619 \| Varicose veins HP:0000763 \| Sensory neuropathy HP:0000969 \| Edema HP:0000772 \| Abnormality of the ribs HP:0003401 \| Paresthesia HP:0003394 \| Muscle cramps HP:0003326 \| Myalgia
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:6) HP:0000891 \| Cervical ribs \| 2 HP:0012531 \| Pain \| 2 HP:0011675 \| Arrhythmias \| 1 HP:0001297 \| Cerebral vascular events \| 1 HP:0001727 \| Thromboembolic stroke \| 1 HP:0001045 \| Blotchy loss of skin color \| 1

Disease ID	563
Disease	thoracic outlet syndrome
Manually Symptom	UMLS \| Name(Total Manually Symptoms:8) C2364051 \| fatigue C2062866 \| acute arterial occlusion C1393529 \| vascular complications C0749087 \| subclavian vein thrombosis C0574014 \| axillary vein thrombosis C0458219 \| complex regional pain syndrome C0393593 \| dystonia C0008031 \| chest pain
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:1) C0749087 \| subclavian vein thrombosis \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:0)
(Waiting for update.)

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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